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Aliases for SSBP3 Gene

Aliases for SSBP3 Gene

  • Single Stranded DNA Binding Protein 3 2 3
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 3 4
  • Single-Stranded DNA-Binding Protein 3 2 3
  • SSDP1 3 4
  • SSDP 3 4
  • CSDP 3

External Ids for SSBP3 Gene

Summaries for SSBP3 Gene

GeneCards Summary for SSBP3 Gene

SSBP3 (Single Stranded DNA Binding Protein 3) is a Protein Coding gene. Diseases associated with SSBP3 include thyroid lymphoma. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot for SSBP3 Gene

  • May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Wiki entry for SSBP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP3 Gene

Genomics for SSBP3 Gene

Genomic Location for SSBP3 Gene

Start:
54,225,431 bp from pter
End:
54,413,479 bp from pter
Size:
188,049 bases
Orientation:
Minus strand

Genomic View for SSBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP3 Gene

Regulatory Elements for SSBP3 Gene

Proteins for SSBP3 Gene

  • Protein details for SSBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW4-SSBP3_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 3
    Protein Accession:
    Q9BWW4
    Secondary Accessions:
    • A8K0A9
    • Q5T860
    • Q5T861
    • Q9BTM0
    • Q9BWW3

    Protein attributes for SSBP3 Gene

    Size:
    388 amino acids
    Molecular mass:
    40421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP3 Gene

Proteomics data for SSBP3 Gene at MOPED

Post-translational modifications for SSBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys19

No data available for DME Specific Peptides for SSBP3 Gene

Domains for SSBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWW4

UniProtKB/Swiss-Prot:

SSBP3_HUMAN
Domain:
  • Contains 1 LisH domain.:
    • Q9BWW4
genes like me logo Genes that share domains with SSBP3: view

No data available for Gene Families for SSBP3 Gene

Function for SSBP3 Gene

Molecular function for SSBP3 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Ontology (GO) - Molecular Function for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SSBP3: view
genes like me logo Genes that share phenotypes with SSBP3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SSBP3 Gene

Localization for SSBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSBP3 Gene COMPARTMENTS Subcellular localization image for SSBP3 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SSBP3: view

Pathways for SSBP3 Gene

SuperPathways for SSBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006461 protein complex assembly IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0021501 prechordal plate formation IEA --
genes like me logo Genes that share ontologies with SSBP3: view

No data available for Pathways by source for SSBP3 Gene

Compounds for SSBP3 Gene

(18) Novoseek inferred chemical compound relationships for SSBP3 Gene

Compound -log(P) Hits PubMed IDs
zinc 42.5 11
oligonucleotide 41.2 3
leucine 26 3
cytosine 14.5 1
biotin 14.3 1
genes like me logo Genes that share compounds with SSBP3: view

Transcripts for SSBP3 Gene

Unigene Clusters for SSBP3 Gene

Single stranded DNA binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:

Relevant External Links for SSBP3 Gene

GeneLoc Exon Structure for
SSBP3
ECgene alternative splicing isoforms for
SSBP3

Expression for SSBP3 Gene

mRNA expression in normal human tissues for SSBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSBP3 Gene

SOURCE GeneReport for Unigene cluster for SSBP3 Gene Hs.658676

mRNA Expression by UniProt/SwissProt for SSBP3 Gene

Q9BWW4-SSBP3_HUMAN
Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle
genes like me logo Genes that share expressions with SSBP3: view

No data available for mRNA differential expression in normal tissues for SSBP3 Gene

Orthologs for SSBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSBP3 35
  • 94.85 (n)
  • 93.5 (a)
SSBP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSBP3 35
  • 96.39 (n)
  • 99.74 (a)
SSBP3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSBP3 35
  • 94.57 (n)
  • 97.47 (a)
SSBP3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp3 35
  • 95.36 (n)
  • 100 (a)
Ssbp3 16
Ssbp3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP3 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp3 35
  • 94.83 (n)
  • 99.45 (a)
chicken
(Gallus gallus)
Aves SSBP3 35
  • 85.69 (n)
  • 98.37 (a)
SSBP3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSBP3 36
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ssbp3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75859 35
ssbp3 35
  • 80.68 (n)
  • 95.82 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28337 35
ssbp3a 35
  • 76.75 (n)
  • 86.47 (a)
ssbp3a 36
  • 85 (a)
OneToMany
ssbp3b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010909 35
  • 62.99 (n)
  • 69.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 35
  • 55.92 (n)
  • 60.61 (a)
Ssdp 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 36
  • 22 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4608 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 36
  • 60 (a)
OneToMany
Species with no ortholog for SSBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP3 Gene

ENSEMBL:
Gene Tree for SSBP3 (if available)
TreeFam:
Gene Tree for SSBP3 (if available)

Paralogs for SSBP3 Gene

Paralogs for SSBP3 Gene

Selected SIMAP similar genes for SSBP3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SSBP3 Gene

genes like me logo Genes that share paralogs with SSBP3: view

Variants for SSBP3 Gene

Sequence variations from dbSNP and Humsavar for SSBP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs43902 -- 54,252,053(+) TAGCT(A/C)TAACT intron-variant
rs104136 -- 54,253,492(+) TGGCC(C/T)ACAAA intron-variant
rs213479 -- 54,396,154(-) AGTGC(A/C)ATGGC intron-variant
rs213480 -- 54,396,141(-) GATCT(C/T)GGCTC intron-variant
rs213481 -- 54,395,867(-) TAGCA(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP3 Gene

Variant ID Type Subtype PubMed ID
nsv829893 CNV Loss 17160897
nsv509291 CNV Insertion 20534489
nsv461550 CNV Loss 19166990
nsv470713 CNV Loss 18288195
esv2748308 CNV Deletion 23290073
nsv870514 CNV Gain 21882294
nsv822631 CNV Gain 20364138
nsv461561 CNV Gain 19166990

Relevant External Links for SSBP3 Gene

HapMap Linkage Disequilibrium report
SSBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP3 Gene

Disorders for SSBP3 Gene

(1) MalaCards Diseases for SSBP3 Gene

Search for SSBP3 Gene in MalaCards »

(11) Novoseek inferred disease relationships for SSBP3 Gene

Disease -log(P) Hits PubMed IDs
xeroderma pigmentosum 52.8 7
cockayne syndrome 27.6 1
retinoblastoma 19.5 2
herpes simplex 15.8 3
immunodeficiency 10.7 2

Relevant External Links for SSBP3

Genetic Association Database (GAD)
SSBP3
Human Genome Epidemiology (HuGE) Navigator
SSBP3
genes like me logo Genes that share disorders with SSBP3: view

No data available for UniProtKB/Swiss-Prot for SSBP3 Gene

Publications for SSBP3 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence- specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P.D. … Nagarajan L. (Genomics 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. (PMID: 10524251) Raval-Fernandes S. … Rome L.H. (Gene 1999) 3 23

Products for SSBP3 Gene

Sources for SSBP3 Gene

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