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Aliases for SSBP3 Gene

Aliases for SSBP3 Gene

  • Single Stranded DNA Binding Protein 3 2 3 5
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 3 4
  • Single-Stranded DNA-Binding Protein 3 2 3
  • SSDP1 3 4
  • SSDP 3 4
  • CSDP 3

External Ids for SSBP3 Gene

Previous GeneCards Identifiers for SSBP3 Gene

  • GC01M054521
  • GC01M053580
  • GC01M054049
  • GC01M054062
  • GC01M054404
  • GC01M054464
  • GC01M054692
  • GC01M052807

Summaries for SSBP3 Gene

GeneCards Summary for SSBP3 Gene

SSBP3 (Single Stranded DNA Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot for SSBP3 Gene

  • May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Wiki entry for SSBP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP3 Gene

Genomics for SSBP3 Gene

Regulatory Elements for SSBP3 Gene

Enhancers for SSBP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G054271 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +136.9 136944 10.6 HDGF PKNOX1 ARNT FEZF1 ZNF2 YY1 CBX5 ZNF143 FOS KLF13 SSBP3-AS1 SSBP3 TMEM59 HSPB11 TCEANC2 ENSG00000237453 TTC22 ENSG00000225632 GC01P054263
GH01G054486 2 FANTOM5 Ensembl ENCODE dbSUPER 13.5 -75.3 -75337 4.8 FOXA2 ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A ZNF2 ZBTB7B ZNF766 SSBP3 ENSG00000237453 TTC22 TCEANC2 LOC105378735 ENSG00000232245
GH01G054258 1.6 dbSUPER 14.7 +153.7 153678 2.6 ZFHX2 NFIC NFIB NFE2 NFE2L2 EGR2 SSBP3-AS1 SSBP3 ENSG00000225632 GC01P054263
GH01G054297 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +114.6 114563 3.6 HDGF FOXA2 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SSBP3 SSBP3-AS1 CDCP2 ENSG00000237453 TTC22 MROH7 ENSG00000225632 GC01M054384
GH01G054259 1.5 dbSUPER 14.7 +153.2 153210 2.0 ZFHX2 SCRT2 NFE2 NFE2L2 EGR2 SSBP3-AS1 SSBP3 ENSG00000225632 GC01P054263
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSBP3 Gene

Chromosome:
1
Start:
54,225,431 bp from pter
End:
54,413,485 bp from pter
Size:
188,055 bases
Orientation:
Minus strand

Genomic View for SSBP3 Gene

Genes around SSBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP3 Gene

Proteins for SSBP3 Gene

  • Protein details for SSBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW4-SSBP3_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 3
    Protein Accession:
    Q9BWW4
    Secondary Accessions:
    • A8K0A9
    • Q5T860
    • Q5T861
    • Q9BTM0
    • Q9BWW3

    Protein attributes for SSBP3 Gene

    Size:
    388 amino acids
    Molecular mass:
    40421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP3 Gene

Post-translational modifications for SSBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSBP3 Gene

Domains & Families for SSBP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSBP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSBP3 Gene

Function for SSBP3 Gene

Molecular function for SSBP3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Ontology (GO) - Molecular Function for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SSBP3: view
genes like me logo Genes that share phenotypes with SSBP3: view

Animal Model Products

CRISPR Products

miRNA for SSBP3 Gene

miRTarBase miRNAs that target SSBP3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP3 Gene

Localization for SSBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SSBP3: view

Pathways & Interactions for SSBP3 Gene

SuperPathways for SSBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006461 protein complex assembly IEA --
genes like me logo Genes that share ontologies with SSBP3: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP3 Gene

Drugs & Compounds for SSBP3 Gene

(13) Drugs for SSBP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for SSBP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SSBP3: view

Transcripts for SSBP3 Gene

mRNA/cDNA for SSBP3 Gene

(7) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSBP3 Gene

Single stranded DNA binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:

Relevant External Links for SSBP3 Gene

GeneLoc Exon Structure for
SSBP3
ECgene alternative splicing isoforms for
SSBP3

Expression for SSBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP3 Gene

This gene is overexpressed in NK cells (13.2), Uterus (10.9), Tlymphocyte (10.3), Ovary (10.1), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSBP3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SSBP3 Gene:

SSBP3

SOURCE GeneReport for Unigene cluster for SSBP3 Gene:

Hs.658676

mRNA Expression by UniProt/SwissProt for SSBP3 Gene:

Q9BWW4-SSBP3_HUMAN
Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle.

Evidence on tissue expression from TISSUES for SSBP3 Gene

  • Nervous system(4.5)
  • Eye(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SSBP3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP3 Gene

Orthologs for SSBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSBP3 34 35
  • 96.39 (n)
mouse
(Mus musculus)
Mammalia Ssbp3 34 16 35
  • 95.36 (n)
chimpanzee
(Pan troglodytes)
Mammalia SSBP3 34 35
  • 94.85 (n)
rat
(Rattus norvegicus)
Mammalia Ssbp3 34
  • 94.83 (n)
dog
(Canis familiaris)
Mammalia SSBP3 34 35
  • 94.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP3 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSBP3 34 35
  • 85.69 (n)
lizard
(Anolis carolinensis)
Reptilia SSBP3 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp3 34
  • 80.68 (n)
MGC75859 34
African clawed frog
(Xenopus laevis)
Amphibia ssbp3-prov 34
zebrafish
(Danio rerio)
Actinopterygii ssbp3b 35
  • 81 (a)
OneToMany
ssbp3a 34 35
  • 76.75 (n)
Dr.28337 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010909 34
  • 62.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 34 35
  • 55.92 (n)
worm
(Caenorhabditis elegans)
Secernentea sam-10 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 35
  • 60 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4608 34
Species where no ortholog for SSBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP3 Gene

ENSEMBL:
Gene Tree for SSBP3 (if available)
TreeFam:
Gene Tree for SSBP3 (if available)

Paralogs for SSBP3 Gene

Paralogs for SSBP3 Gene

(3) SIMAP similar genes for SSBP3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SSBP3 Gene

genes like me logo Genes that share paralogs with SSBP3: view

Variants for SSBP3 Gene

Sequence variations from dbSNP and Humsavar for SSBP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000016002 -- 54,394,954(+) AGCCT(C/T)GGCCT intron-variant
rs1000024669 -- 54,240,177(+) GGGAG(A/G)GCTGG intron-variant
rs1000032209 -- 54,283,237(+) CACTC(C/T)AGCCT intron-variant
rs1000038275 -- 54,245,596(+) TCCAG(A/T)CAGGA intron-variant
rs1000044496 -- 54,349,253(+) CCACC(A/G)GCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP3 Gene

Variant ID Type Subtype PubMed ID
esv2748308 CNV deletion 23290073
esv3423065 CNV duplication 20981092
esv3586088 CNV loss 21293372
nsv1078412 CNV deletion 25765185
nsv1078417 CNV deletion 25765185
nsv1112532 CNV deletion 24896259
nsv1112533 CNV deletion 24896259
nsv1118119 CNV deletion 24896259
nsv1122346 CNV deletion 24896259
nsv461550 CNV loss 19166990
nsv461561 CNV gain 19166990
nsv470713 CNV loss 18288195
nsv472617 CNV novel sequence insertion 20440878
nsv509291 CNV insertion 20534489
nsv546266 CNV gain 21841781
nsv822631 CNV gain 20364138
nsv829893 CNV loss 17160897

Variation tolerance for SSBP3 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP3 Gene

Disorders for SSBP3 Gene

Relevant External Links for SSBP3

Genetic Association Database (GAD)
SSBP3
Human Genome Epidemiology (HuGE) Navigator
SSBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSBP3

No disorders were found for SSBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP3 Gene

Publications for SSBP3 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence- specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P.D. … Nagarajan L. (Genomics 2002) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. (PMID: 10524251) Raval-Fernandes S. … Rome L.H. (Gene 1999) 3 22 64

Products for SSBP3 Gene

Sources for SSBP3 Gene

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