Aliases for NUP62 Gene
External Ids for NUP62 Gene
Previous GeneCards Identifiers for NUP62 Gene
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
GeneCards Summary for NUP62 Gene
NUP62 (Nucleoporin 62) is a Protein Coding gene. Diseases associated with NUP62 include Striatonigral Degeneration, Infantile and Familial Infantile Bilateral Striatal Necrosis. Among its related pathways are Transport of Mature Transcript to Cytoplasm and Regulation of Glucokinase by Glucokinase Regulatory Protein. GO annotations related to this gene include chromatin binding and SH2 domain binding. An important paralog of this gene is NUP62CL.
UniProtKB/Swiss-Prot for NUP62 Gene
Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.