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Aliases for SSBP2 Gene

Aliases for SSBP2 Gene

  • Single Stranded DNA Binding Protein 2 2 3 5
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 2 3 4
  • Single-Stranded DNA-Binding Protein 2 2 3
  • Single-Stranded DNA Binding Protein 2 2
  • SOSS-B2 3
  • HSPC116 3
  • SSDP2 4

External Ids for SSBP2 Gene

Previous GeneCards Identifiers for SSBP2 Gene

  • GC05M079501
  • GC05M080954
  • GC05M080754
  • GC05M080799
  • GC05M080751
  • GC05M075924

Summaries for SSBP2 Gene

Entrez Gene Summary for SSBP2 Gene

  • This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]

GeneCards Summary for SSBP2 Gene

SSBP2 (Single Stranded DNA Binding Protein 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP3.

Gene Wiki entry for SSBP2 Gene

Additional gene information for SSBP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP2 Gene

Genomics for SSBP2 Gene

GeneHancer (GH) Regulatory Elements for SSBP2 Gene

Promoters and enhancers for SSBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I081748 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1258 4.5 CLOCK FEZF1 IRF4 YY1 ZNF213 SP3 ZNF610 GLIS1 NR2C1 NBN SSBP2 ZCCHC9 CKMT2-AS1 RPS23 ATG10 GC05M081517
GH05I081753 Enhancer 0.4 dbSUPER 550.8 -1.8 -1843 0.5 USF1 MNT RELA SSBP2 ENSG00000249483
GH05I081849 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.5 -100.2 -100208 4.8 PKNOX1 CLOCK SMAD1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ENSG00000249483 ZCCHC9 ATP6AP1L SSBP2 PPIAP11 SEM1P1
GH05I081393 Promoter 1.4 EPDnew Ensembl 5 +357.6 357596 1.2 CTCF ZBTB6 SIN3A REST RAD21 YY1 SP1 ZNF121 ZNF335 ZNF580 ACOT12 SSBP2 GC05M081414
GH05I081419 Enhancer 1.2 Ensembl ENCODE 5.2 +330.1 330148 4.9 PKNOX1 FOXA2 ARNT FEZF1 BRCA1 ETS1 YY1 ZNF302 ATF7 FOS ENSG00000248794 ACOT12 ATP6AP1L SSBP2 GC05M081414 GC05P081482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SSBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SSBP2 gene promoter:

Genomic Locations for SSBP2 Gene

Genomic Locations for SSBP2 Gene
chr5:81,413,021-81,751,797
(GRCh38/hg38)
Size:
338,777 bases
Orientation:
Minus strand
chr5:80,708,840-81,047,616
(GRCh37/hg19)

Genomic View for SSBP2 Gene

Genes around SSBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP2 Gene

Proteins for SSBP2 Gene

  • Protein details for SSBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81877-SSBP2_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 2
    Protein Accession:
    P81877
    Secondary Accessions:
    • B2R5W1
    • B7Z1J2
    • B7Z2L9
    • B7Z665
    • D6RH18
    • E9PB74
    • E9PDA8
    • Q8N2Q2
    • Q9BWW6
    • Q9Y4T7

    Protein attributes for SSBP2 Gene

    Size:
    361 amino acids
    Molecular mass:
    37828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP2 Gene

Post-translational modifications for SSBP2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SSBP2 Gene

Domains & Families for SSBP2 Gene

Gene Families for SSBP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSBP2: view

No data available for UniProtKB/Swiss-Prot for SSBP2 Gene

Function for SSBP2 Gene

Phenotypes From GWAS Catalog for SSBP2 Gene

Gene Ontology (GO) - Molecular Function for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA,NAS 12079286
genes like me logo Genes that share ontologies with SSBP2: view
genes like me logo Genes that share phenotypes with SSBP2: view

Animal Models for SSBP2 Gene

MGI Knock Outs for SSBP2:

Animal Model Products

miRNA for SSBP2 Gene

miRTarBase miRNAs that target SSBP2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSBP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSBP2 Gene

Localization for SSBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SSBP2: view

Pathways & Interactions for SSBP2 Gene

SuperPathways for SSBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 12079286
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with SSBP2: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP2 Gene

Drugs & Compounds for SSBP2 Gene

No Compound Related Data Available

Transcripts for SSBP2 Gene

Unigene Clusters for SSBP2 Gene

Single-stranded DNA binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSBP2

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP2 Gene

No ASD Table

Relevant External Links for SSBP2 Gene

GeneLoc Exon Structure for
SSBP2
ECgene alternative splicing isoforms for
SSBP2

Expression for SSBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP2 Gene

This gene is overexpressed in CD4 Tcells (15.2), Fetal ovary (14.0), Blymphocyte (8.1), CD8 Tcells (7.5), and Fetal heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSBP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SSBP2 Gene:

SSBP2

SOURCE GeneReport for Unigene cluster for SSBP2 Gene:

Hs.102735

mRNA Expression by UniProt/SwissProt for SSBP2 Gene:

P81877-SSBP2_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SSBP2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SSBP2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP2 Gene

Orthologs for SSBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP2 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia SSBP2 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SSBP2 33 34
  • 97.65 (n)
cow
(Bos Taurus)
Mammalia SSBP2 33 34
  • 97.14 (n)
mouse
(Mus musculus)
Mammalia Ssbp2 16 34 33
  • 95.66 (n)
chimpanzee
(Pan troglodytes)
Mammalia SSBP2 34 33
  • 95.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp2 33
  • 92.18 (n)
chicken
(Gallus gallus)
Aves SSBP2 33 34
  • 91.85 (n)
lizard
(Anolis carolinensis)
Reptilia SSBP2 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp2 33
  • 84.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia ssbp2-prov 33
zebrafish
(Danio rerio)
Actinopterygii SSBP2 (2 of 2) 34
  • 83 (a)
OneToMany
SSBP2 (1 of 2) 34
  • 81 (a)
OneToMany
LOC798086 33
  • 74.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7187 35
  • 91 (a)
Ssdp 34
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 34
  • 55 (a)
OneToMany
Species where no ortholog for SSBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP2 Gene

ENSEMBL:
Gene Tree for SSBP2 (if available)
TreeFam:
Gene Tree for SSBP2 (if available)

Paralogs for SSBP2 Gene

Paralogs for SSBP2 Gene

(3) SIMAP similar genes for SSBP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SSBP2 Gene

genes like me logo Genes that share paralogs with SSBP2: view

Variants for SSBP2 Gene

Sequence variations from dbSNP and Humsavar for SSBP2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs193920757 uncertain-significance, Malignant tumor of prostate 81,448,794(-) T/A/C coding_sequence_variant, missense_variant
rs1057518330 uncertain-significance, not specified 81,636,602(-) TTTTTTT/TTTTTT/TTTTTTTT 5_prime_UTR_variant, coding_sequence_variant, frameshift
rs1000008839 -- 81,743,041(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000009126 -- 81,485,704(-) T/G intron_variant
rs1000044031 -- 81,424,382(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1109e214 CNV loss 21293372
dgv3107n106 CNV deletion 24896259
esv1711772 CNV deletion 17803354
esv2034602 CNV deletion 18987734
esv2125406 CNV deletion 18987734
esv2524327 CNV deletion 19546169
esv2613325 CNV deletion 19546169
esv2668722 CNV deletion 23128226
esv2730382 CNV deletion 23290073
esv2730383 CNV deletion 23290073
esv2730385 CNV deletion 23290073
esv2730386 CNV deletion 23290073
esv2763467 CNV loss 21179565
esv3134 CNV loss 18987735
esv3566174 CNV deletion 23714750
esv3566175 CNV deletion 23714750
esv3605594 CNV gain 21293372
esv3605595 CNV gain 21293372
esv3605597 CNV gain 21293372
esv3605599 CNV gain 21293372
esv3605601 CNV loss 21293372
esv3605602 CNV gain 21293372
esv3605603 CNV loss 21293372
esv3605604 CNV loss 21293372
esv3890665 CNV loss 25118596
esv4616 CNV loss 18987735
esv993941 CNV deletion 20482838
nsv1028322 CNV gain 25217958
nsv1073900 CNV deletion 25765185
nsv1074849 CNV deletion 25765185
nsv1114697 CNV deletion 24896259
nsv1139842 CNV duplication 24896259
nsv1144112 CNV deletion 24896259
nsv1146271 CNV duplication 26484159
nsv1146766 CNV deletion 26484159
nsv1149956 CNV deletion 26484159
nsv327664 CNV deletion 16902084
nsv462221 CNV loss 19166990
nsv462222 CNV gain 19166990
nsv471018 CNV gain 18288195
nsv4900 CNV deletion 18451855
nsv519589 CNV gain+loss 19592680
nsv525225 CNV loss 19592680
nsv525437 CNV loss 19592680
nsv527374 CNV loss 19592680
nsv598751 CNV loss 21841781
nsv598752 CNV gain 21841781
nsv598753 CNV gain 21841781
nsv830361 CNV loss 17160897
nsv830362 CNV gain 17160897
nsv950097 CNV deletion 24416366
nsv956443 CNV deletion 24416366
nsv956479 CNV deletion 24416366

Variation tolerance for SSBP2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SSBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP2 Gene

Disorders for SSBP2 Gene

Additional Disease Information for SSBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SSBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP2 Gene

Publications for SSBP2 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. SSBP2 variants are associated with survival in glioblastoma patients. (PMID: 22472174) Xiao Y … Wrensch MR (Clinical cancer research : an official journal of the American Association for Cancer Research 2012) 3 44 58
  3. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. (PMID: 21079607) Wang K … Price Foundation Collaborative Group (Molecular psychiatry 2011) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. (PMID: 17311003) Fleisig HB … Nagarajan L (Oncogene 2007) 3 22 58

Products for SSBP2 Gene

Sources for SSBP2 Gene

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