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Aliases for SSBP2 Gene

Aliases for SSBP2 Gene

  • Single-Stranded DNA Binding Protein 2 2 3
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 2 3 4
  • Single-Stranded DNA-Binding Protein 2 2 3
  • HSPC116 3
  • SOSS-B2 3
  • SSDP2 4

External Ids for SSBP2 Gene

Previous GeneCards Identifiers for SSBP2 Gene

  • GC05M079501
  • GC05M080954
  • GC05M080754
  • GC05M080799
  • GC05M080751
  • GC05M075924

Summaries for SSBP2 Gene

Entrez Gene Summary for SSBP2 Gene

  • SSBP2 is a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

GeneCards Summary for SSBP2 Gene

SSBP2 (Single-Stranded DNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP4.

Gene Wiki entry for SSBP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP2 Gene

Genomics for SSBP2 Gene

Regulatory Elements for SSBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSBP2 Gene

Start:
81,413,021 bp from pter
End:
81,751,797 bp from pter
Size:
338,777 bases
Orientation:
Minus strand

Genomic View for SSBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP2 Gene

Proteins for SSBP2 Gene

  • Protein details for SSBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81877-SSBP2_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 2
    Protein Accession:
    P81877
    Secondary Accessions:
    • B2R5W1
    • B7Z1J2
    • B7Z2L9
    • B7Z665
    • D6RH18
    • E9PB74
    • E9PDA8
    • Q8N2Q2
    • Q9BWW6
    • Q9Y4T7

    Protein attributes for SSBP2 Gene

    Size:
    361 amino acids
    Molecular mass:
    37828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP2 Gene

Proteomics data for SSBP2 Gene at MOPED

Post-translational modifications for SSBP2 Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SSBP2 Gene

Domains for SSBP2 Gene

Graphical View of Domain Structure for InterPro Entry

P81877

UniProtKB/Swiss-Prot:

SSBP2_HUMAN :
  • P81877
Domain:
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with SSBP2: view

No data available for Gene Families for SSBP2 Gene

Function for SSBP2 Gene

Gene Ontology (GO) - Molecular Function for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding NAS 12079286
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SSBP2: view
genes like me logo Genes that share phenotypes with SSBP2: view

Animal Models for SSBP2 Gene

MGI Knock Outs for SSBP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSBP2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SSBP2 Gene

Localization for SSBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSBP2 Gene COMPARTMENTS Subcellular localization image for SSBP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SSBP2: view

Pathways for SSBP2 Gene

SuperPathways for SSBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 12079286
genes like me logo Genes that share ontologies with SSBP2: view

No data available for Pathways by source for SSBP2 Gene

Transcripts for SSBP2 Gene

Unigene Clusters for SSBP2 Gene

Single-stranded DNA binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP2 Gene

No ASD Table

Relevant External Links for SSBP2 Gene

GeneLoc Exon Structure for
SSBP2
ECgene alternative splicing isoforms for
SSBP2

Expression for SSBP2 Gene

mRNA expression in normal human tissues for SSBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSBP2 Gene

SOURCE GeneReport for Unigene cluster for SSBP2 Gene Hs.102735

mRNA Expression by UniProt/SwissProt for SSBP2 Gene

P81877-SSBP2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with SSBP2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SSBP2 Gene

Orthologs for SSBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSBP2 35
  • 95.07 (n)
  • 94.25 (a)
SSBP2 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSBP2 35
  • 97.14 (n)
  • 100 (a)
SSBP2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSBP2 35
  • 97.65 (n)
  • 100 (a)
SSBP2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp2 35
  • 95.66 (n)
  • 99.72 (a)
Ssbp2 16
Ssbp2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSBP2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ssbp2 35
  • 92.18 (n)
  • 96.05 (a)
chicken
(Gallus gallus)
Aves SSBP2 35
  • 91.85 (n)
  • 98.91 (a)
SSBP2 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSBP2 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ssbp2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp2 35
  • 84.77 (n)
  • 95.26 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC798086 35
  • 74.67 (n)
  • 86 (a)
SSBP2 (1 of 2) 36
  • 81 (a)
OneToMany
SSBP2 (2 of 2) 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 36
  • 46 (a)
OneToMany
CG7187 37
  • 91 (a)
worm
(Caenorhabditis elegans)
Secernentea sam-10 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 36
  • 55 (a)
OneToMany
Species with no ortholog for SSBP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP2 Gene

ENSEMBL:
Gene Tree for SSBP2 (if available)
TreeFam:
Gene Tree for SSBP2 (if available)

Paralogs for SSBP2 Gene

Paralogs for SSBP2 Gene

Selected SIMAP similar genes for SSBP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SSBP2 Gene

genes like me logo Genes that share paralogs with SSBP2: view

Variants for SSBP2 Gene

Sequence variations from dbSNP and Humsavar for SSBP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs9596 -- 81,440,625(+) CCAGG(A/G)CCCAT synonymous-codon, reference
rs9641 -- 81,420,094(-) ATTTT(A/C)ATTAT utr-variant-3-prime
rs10746 -- 81,420,344(+) CCGCT(G/T)TCTTC utr-variant-3-prime
rs253397 -- 81,617,322(+) ggagc(C/T)gatgc intron-variant
rs365147 -- 81,685,239(-) tgaga(C/T)tgggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP2 Gene

Variant ID Type Subtype PubMed ID
esv2730382 CNV Deletion 23290073
esv2524327 CNV Deletion 19546169
esv2125406 CNV Deletion 18987734
esv4616 CNV Deletion 18987735
esv2730383 CNV Deletion 23290073
esv993941 CNV Deletion 20482838
esv2668722 CNV Deletion 23128226
nsv462221 CNV Loss 19166990
nsv525225 CNV Loss 19592680
nsv882233 CNV Loss 21882294
nsv882234 CNV Loss 21882294
nsv525437 CNV Loss 19592680
nsv462222 CNV Gain 19166990
nsv882235 CNV Loss 21882294
nsv830361 CNV Loss 17160897
dgv6189n71 CNV Loss 21882294
nsv527374 CNV Loss 19592680
nsv519589 CNV Gain+Loss 19592680
nsv830362 CNV Gain 17160897
esv2730385 CNV Deletion 23290073
esv2613325 CNV Deletion 19546169
esv2034602 CNV Deletion 18987734
esv3134 CNV Deletion 18987735
esv2730386 CNV Deletion 23290073
esv1711772 CNV Deletion 17803354
nsv327664 CNV Loss 16902084
nsv4900 CNV Loss 18451855
nsv471018 CNV Gain 18288195

Relevant External Links for SSBP2 Gene

HapMap Linkage Disequilibrium report
SSBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP2 Gene

Disorders for SSBP2 Gene

Relevant External Links for SSBP2

Genetic Association Database (GAD)
SSBP2
Human Genome Epidemiology (HuGE) Navigator
SSBP2
genes like me logo Genes that share disorders with SSBP2: view

No data available for UniProtKB/Swiss-Prot for SSBP2 Gene

Publications for SSBP2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. A novel, evolutionarily conserved gene family with putative sequence- specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P.D. … Nagarajan L. (Genomics 2002) 3 4
  3. SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells. (PMID: 15782145) Liang H. … Nagarajan L. (Oncogene 2005) 3 23
  4. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. (PMID: 17311003) Fleisig H.B. … Nagarajan L. (Oncogene 2007) 3 23
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for SSBP2 Gene

  • Addgene plasmids for SSBP2

Sources for SSBP2 Gene

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