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Aliases for CA14 Gene

Aliases for CA14 Gene

  • Carbonic Anhydrase XIV 2 3 4
  • Carbonate Dehydratase XIV 3 4
  • CA-XIV 3 4
  • Carbonic Anhydrase 14 3
  • Carbonic Dehydratase 3
  • EC 4.2.1.1 4
  • CAXiV 3

External Ids for CA14 Gene

Summaries for CA14 Gene

Entrez Gene Summary for CA14 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA14 Gene

CA14 (Carbonic Anhydrase XIV) is a Protein Coding gene. Diseases associated with CA14 include proximal renal tubular acidosis. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA7.

UniProtKB/Swiss-Prot for CA14 Gene

  • Reversible hydration of carbon dioxide

Gene Wiki entry for CA14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA14 Gene

Genomics for CA14 Gene

Genomic Location for CA14 Gene

Start:
150,257,159 bp from pter
End:
150,265,078 bp from pter
Size:
7,920 bases
Orientation:
Plus strand

Genomic View for CA14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA14 Gene

Regulatory Elements for CA14 Gene

Proteins for CA14 Gene

  • Protein details for CA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULX7-CAH14_HUMAN
    Recommended name:
    Carbonic anhydrase 14
    Protein Accession:
    Q9ULX7
    Secondary Accessions:
    • Q5TB24
    • Q8NCF4

    Protein attributes for CA14 Gene

    Size:
    337 amino acids
    Molecular mass:
    37668 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA14 Gene

neXtProt entry for CA14 Gene

Proteomics data for CA14 Gene at MOPED

Post-translational modifications for CA14 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn213

Other Protein References for CA14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CA14 Gene

Domains for CA14 Gene

Gene Families for CA14 Gene

HGNC:
  • CA :Carbonic anhydrases

Suggested Antigen Peptide Sequences for CA14 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULX7

UniProtKB/Swiss-Prot:

CAH14_HUMAN
Family:
  • Belongs to the alpha-carbonic anhydrase family.:
    • Q9ULX7
genes like me logo Genes that share domains with CA14: view

Function for CA14 Gene

Molecular function for CA14 Gene

GENATLAS Biochemistry: carbonic anhydrase XIV,expressed in adult heart,brain,kidney,liver and skeletal muscle,highly homolog to CA12
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=7.9 mM for CO(2) {ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity: H(2)CO(3) = CO(2) + H(2)O
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function: Reversible hydration of carbon dioxide

Enzyme Numbers (IUBMB) for CA14 Gene

Gene Ontology (GO) - Molecular Function for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004089 carbonate dehydratase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CA14: view
genes like me logo Genes that share phenotypes with CA14: view

Animal Models for CA14 Gene

MGI Knock Outs for CA14:

miRNA for CA14 Gene

miRTarBase miRNAs that target CA14

No data available for Transcription Factor Targeting and HOMER Transcription for CA14 Gene

Localization for CA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA14 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CA14 Gene COMPARTMENTS Subcellular localization image for CA14 gene
Compartment Confidence
plasma membrane 4
chloroplast 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CA14: view

Pathways for CA14 Gene

genes like me logo Genes that share pathways with CA14: view

Pathways by source for CA14 Gene

2 Reactome pathways for CA14 Gene
1 KEGG pathway for CA14 Gene

Interacting Proteins for CA14 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358107%0d%0a9606.ENSP00000292180%0d%0a
Selected Interacting proteins: ENSP00000358107 for CA14 Gene via STRING

Symbol External ID(s) Details
FLAD1

Gene Ontology (GO) - Biological Process for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015701 bicarbonate transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CA14: view

Compounds for CA14 Gene

(4) HMDB Compounds for CA14 Gene

Compound Synonyms Cas Number PubMed IDs
Carbon dioxide
  • Carbon oxide
124-38-9
Carbonic acid
  • acid of air
463-79-6
Water
  • Dihydrogen oxide
7732-18-5
Zinc
  • Zinc
7440-66-6

(4) Drugbank Compounds for CA14 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acetazolamide
  • Acetamidothiadiazolesulfonamide
59-66-5 target inhibitor
Beta-D-Mannose
7322-31-8 target
Ellagic Acid
476-66-4 target inhibitor
Zonisamide
  • Zonisamida [Spanish]
68291-97-4 target inhibitor

(2) Novoseek inferred chemical compound relationships for CA14 Gene

Compound -log(P) Hits PubMed IDs
sulfonamide 71.4 1
bicarbonate 49.4 3
genes like me logo Genes that share compounds with CA14: view

Transcripts for CA14 Gene

Unigene Clusters for CA14 Gene

Carbonic anhydrase XIV:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CA14 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: -

Relevant External Links for CA14 Gene

GeneLoc Exon Structure for
CA14
ECgene alternative splicing isoforms for
CA14

Expression for CA14 Gene

mRNA expression in normal human tissues for CA14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA14 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.5) and Brain - Substantia nigra (5.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CA14 Gene

SOURCE GeneReport for Unigene cluster for CA14 Gene Hs.528988

mRNA Expression by UniProt/SwissProt for CA14 Gene

Q9ULX7-CAH14_HUMAN
Tissue specificity: High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle
genes like me logo Genes that share expressions with CA14: view

Orthologs for CA14 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA14 35
  • 99.01 (n)
  • 98.52 (a)
CA14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CA14 35
  • 89.32 (n)
  • 87.13 (a)
CA14 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CA14 35
  • 87.7 (n)
  • 87.2 (a)
CA14 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Car14 35
  • 84.77 (n)
  • 83.98 (a)
Car14 16
Car14 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CA14 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Car14 35
  • 85.06 (n)
  • 83.38 (a)
chicken
(Gallus gallus)
Aves CA14 35
  • 59.04 (n)
  • 53.41 (a)
CA14 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CA14 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ca14 35
  • 58.12 (n)
  • 52.85 (a)
zebrafish
(Danio rerio)
Actinopterygii ca14 35
  • 56.47 (n)
  • 54.79 (a)
ca14 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6074 37
  • 33 (a)
CG6906 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8628 36
  • 18 (a)
OneToMany
Species with no ortholog for CA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA14 Gene

ENSEMBL:
Gene Tree for CA14 (if available)
TreeFam:
Gene Tree for CA14 (if available)

Paralogs for CA14 Gene

Paralogs for CA14 Gene

Selected SIMAP similar genes for CA14 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CA14 Gene

genes like me logo Genes that share paralogs with CA14: view

Variants for CA14 Gene

Sequence variations from dbSNP and Humsavar for CA14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2296228 -- 150,260,371(+) CCTGA(C/T)TTGGC intron-variant
rs3738323 -- 150,263,124(+) GTGAG(C/G/T)GAGCC synonymous-codon, reference
rs3850839 -- 150,261,883(-) TCCAA(A/C)TTCAT intron-variant
rs4494176 -- 150,264,673(+) TCAGA(C/T)ACCAT utr-variant-3-prime, missense, reference
rs6681029 -- 150,255,632(+) AGAAC(A/T)AAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CA14 Gene

Variant ID Type Subtype PubMed ID
nsv872415 CNV Loss 21882294

Relevant External Links for CA14 Gene

HapMap Linkage Disequilibrium report
CA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CA14 Gene

Disorders for CA14 Gene

(1) University of Copenhagen DISEASES for CA14 Gene

(1) Novoseek inferred disease relationships for CA14 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for CA14

Genetic Association Database (GAD)
CA14
Human Genome Epidemiology (HuGE) Navigator
CA14
genes like me logo Genes that share disorders with CA14: view

No data available for UniProtKB/Swiss-Prot for CA14 Gene

Publications for CA14 Gene

  1. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. (PMID: 10512682) Fujikawa-Adachi K. … Onishi S. (Genomics 1999) 2 3 4 23
  2. Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. (PMID: 11172051) Parkkila S. … Sly W.S. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  3. Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. (PMID: 12028451) Kaunisto K. … Sly W.S. (Kidney Int. 2002) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CA14 Gene

Sources for CA14 Gene

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