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Aliases for CA14 Gene

Aliases for CA14 Gene

  • Carbonic Anhydrase 14 2 3
  • Carbonic Anhydrase XIV 2 3 4 5
  • Carbonate Dehydratase XIV 3 4
  • CA-XIV 3 4
  • Carbonic Dehydratase 3
  • EC 4
  • CAXiV 3

External Ids for CA14 Gene

Previous GeneCards Identifiers for CA14 Gene

  • GC01P147881
  • GC01P145972
  • GC01P147005
  • GC01P147446
  • GC01P147043
  • GC01P148488
  • GC01P150230
  • GC01P121608

Summaries for CA14 Gene

Entrez Gene Summary for CA14 Gene

  • Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

GeneCards Summary for CA14 Gene

CA14 (Carbonic Anhydrase 14) is a Protein Coding gene. Diseases associated with CA14 include Proximal Renal Tubular Acidosis. Among its related pathways are Nitrogen metabolism and Metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA12.

UniProtKB/Swiss-Prot for CA14 Gene

  • Reversible hydration of carbon dioxide.

Gene Wiki entry for CA14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CA14 Gene

Genomics for CA14 Gene

Regulatory Elements for CA14 Gene

Enhancers for CA14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CA14 on UCSC Golden Path with GeneCards custom track

Promoters for CA14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CA14 on UCSC Golden Path with GeneCards custom track

Genomic Location for CA14 Gene

150,257,159 bp from pter
150,265,078 bp from pter
7,920 bases
Plus strand

Genomic View for CA14 Gene

Genes around CA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CA14 Gene

Proteins for CA14 Gene

  • Protein details for CA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carbonic anhydrase 14
    Protein Accession:
    Secondary Accessions:
    • Q5TB24
    • Q8NCF4

    Protein attributes for CA14 Gene

    337 amino acids
    Molecular mass:
    37668 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CA14 Gene

neXtProt entry for CA14 Gene

Proteomics data for CA14 Gene at MOPED

Post-translational modifications for CA14 Gene

  • Glycosylation at Asn 213
  • Modification sites at PhosphoSitePlus

Other Protein References for CA14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CA14 Gene

Domains & Families for CA14 Gene

Gene Families for CA14 Gene

Suggested Antigen Peptide Sequences for CA14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the alpha-carbonic anhydrase family.
  • Belongs to the alpha-carbonic anhydrase family.
genes like me logo Genes that share domains with CA14: view

Function for CA14 Gene

Molecular function for CA14 Gene

GENATLAS Biochemistry:
carbonic anhydrase XIV,expressed in adult heart,brain,kidney,liver and skeletal muscle,highly homolog to CA12
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.9 mM for CO(2) {ECO:0000269 PubMed:18618712};
UniProtKB/Swiss-Prot CatalyticActivity:
H(2)CO(3) = CO(2) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
UniProtKB/Swiss-Prot Function:
Reversible hydration of carbon dioxide.

Enzyme Numbers (IUBMB) for CA14 Gene

genes like me logo Genes that share phenotypes with CA14: view

Animal Models for CA14 Gene

MGI Knock Outs for CA14:

Animal Model Products

  • Taconic Biosciences Mouse Models for CA14

miRNA for CA14 Gene

miRTarBase miRNAs that target CA14

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CA14 Gene

Localization for CA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CA14 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CA14 Gene COMPARTMENTS Subcellular localization image for CA14 gene
Compartment Confidence
plasma membrane 3
extracellular 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with CA14: view

Pathways & Interactions for CA14 Gene

genes like me logo Genes that share pathways with CA14: view

Pathways by source for CA14 Gene

2 Reactome pathways for CA14 Gene
1 KEGG pathway for CA14 Gene

Interacting Proteins for CA14 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000358107 for CA14 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CA14: view

No data available for SIGNOR curated interactions for CA14 Gene

Drugs & Compounds for CA14 Gene

(8) Drugs for CA14 Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetazolamide Approved Pharma inhibitor, Target 68
Zonisamide Approved, Investigational Pharma Target, inhibitor Antiepileptic with anticonvulsant and mechanistic effect 65
Brinzolamide Approved Pharma inhibitor CA II inhibitor 60
Chlorthalidone Approved Pharma blocker 59
Dorzolamide Approved Pharma inhibitor 65

(5) Additional Compounds for CA14 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Carbonic acid
  • Acid of air
  • Aerial acid
  • Bisodium carbonate
  • Calcined
  • Carbonic acid sodium salt
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with CA14: view

Transcripts for CA14 Gene

Unigene Clusters for CA14 Gene

Carbonic anhydrase XIV:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CA14 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP2: -
SP3: -

Relevant External Links for CA14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CA14 Gene

mRNA expression in normal human tissues for CA14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CA14 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.5) and Brain - Substantia nigra (x5.6).

Protein differential expression in normal tissues from HIPED for CA14 Gene

This gene is overexpressed in Retina (46.3) and Seminal vesicle (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CA14 Gene

SOURCE GeneReport for Unigene cluster for CA14 Gene Hs.528988

mRNA Expression by UniProt/SwissProt for CA14 Gene

Tissue specificity: High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.
genes like me logo Genes that share expression patterns with CA14: view

Primer Products

No data available for Protein tissue co-expression partners for CA14 Gene

Orthologs for CA14 Gene

This gene was present in the common ancestor of animals.

Orthologs for CA14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CA14 35
  • 89.32 (n)
  • 87.13 (a)
CA14 36
  • 87 (a)
(Canis familiaris)
Mammalia CA14 35
  • 87.7 (n)
  • 87.2 (a)
CA14 36
  • 80 (a)
(Mus musculus)
Mammalia Car14 35
  • 84.77 (n)
  • 83.98 (a)
Car14 16
Car14 36
  • 84 (a)
(Pan troglodytes)
Mammalia CA14 35
  • 99.01 (n)
  • 98.52 (a)
CA14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Car14 35
  • 85.06 (n)
  • 83.38 (a)
(Monodelphis domestica)
Mammalia CA14 36
  • 74 (a)
(Gallus gallus)
Aves CA14 35
  • 59.04 (n)
  • 53.41 (a)
CA14 36
  • 49 (a)
(Anolis carolinensis)
Reptilia CA14 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ca14 35
  • 58.12 (n)
  • 52.85 (a)
(Danio rerio)
Actinopterygii ca14 35
  • 56.47 (n)
  • 54.79 (a)
ca14 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6074 37
  • 33 (a)
CG6906 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8628 36
  • 18 (a)
Species with no ortholog for CA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CA14 Gene

Gene Tree for CA14 (if available)
Gene Tree for CA14 (if available)

Paralogs for CA14 Gene

Paralogs for CA14 Gene

(14) SIMAP similar genes for CA14 Gene using alignment to 4 proteins: Pseudogenes for CA14 Gene

genes like me logo Genes that share paralogs with CA14: view

Variants for CA14 Gene

Sequence variations from dbSNP and Humsavar for CA14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2296228 -- 150,260,371(+) CCTGA(C/T)TTGGC intron-variant
rs3738323 -- 150,263,124(-) GTGAG(A/C/G/T)GAGCC reference, synonymous-codon
rs3850839 -- 150,261,883(-) TCCAA(A/C)TTCAT intron-variant
rs4494176 -- 150,264,673(-) TCAGA(A/C/G/T)ACCAT reference, missense, utr-variant-3-prime
rs6681029 -- 150,255,632(+) AGAAC(A/G/T)AAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CA14 Gene

Variant ID Type Subtype PubMed ID
nsv872415 CNV Loss 21882294

Variation tolerance for CA14 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CA14 Gene

Disorders for CA14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CA14 Gene - From: GeneCards

Disorder Aliases PubMed IDs
proximal renal tubular acidosis
  • renal tubular acidosis type 2
- elite association - COSMIC cancer census association via MalaCards
Search CA14 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CA14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CA14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CA14 Gene

Publications for CA14 Gene

  1. Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1. (PMID: 10512682) Fujikawa-Adachi K. … Onishi S. (Genomics 1999) 2 3 4 23 67
  2. Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? (PMID: 19703035) De Simone G. … Supuran C.T. (Chem Biol Drug Des 2009) 25 26
  3. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. (PMID: 18537527) Supuran C.T. … De Simone G. (Expert Opin Emerg Drugs 2008) 25 26
  4. Therapeutic role of zonisamide in neuropsychiatric disorders. (PMID: 18782051) Farooq M.U. … Kassab M.Y. (Mini Rev Med Chem 2008) 25 26
  5. Zonisamide: new drug. No advantage in refractory partial epilepsy. (PMID: 17582922) (Prescrire Int 2007) 25 26

Products for CA14 Gene

Sources for CA14 Gene