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Aliases for CLEC5A Gene

Aliases for CLEC5A Gene

  • C-Type Lectin Domain Containing 5A 2 3
  • C-Type Lectin Domain Family 5 Member A 2 3 5
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 5 2 3
  • C-Type Lectin Superfamily Member 5 3 4
  • CLECSF5 3 4
  • MDL-1 3 4
  • MDL1 3 4
  • C-Type Lectin Domain Family 5, Member A 2
  • Myeloid DAP12-Associating Lectin-1 3
  • Myeloid DAP12-Associating Lectin 1 4

External Ids for CLEC5A Gene

Previous HGNC Symbols for CLEC5A Gene

  • CLECSF5

Previous GeneCards Identifiers for CLEC5A Gene

  • GC07M141081
  • GC07M141273
  • GC07M141627
  • GC07M135923

Summaries for CLEC5A Gene

Entrez Gene Summary for CLEC5A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC5A Gene

CLEC5A (C-Type Lectin Domain Containing 5A) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. GO annotations related to this gene include carbohydrate binding and virus receptor activity.

UniProtKB/Swiss-Prot for CLEC5A Gene

  • Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4.

  • (Microbial infection) May act as a receptor for dengue virus on macrophages. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Wiki entry for CLEC5A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC5A Gene

Genomics for CLEC5A Gene

Regulatory Elements for CLEC5A Gene

Enhancers for CLEC5A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G141960 1.4 FANTOM5 Ensembl ENCODE 22.8 -14.0 -13988 0.9 L3MBTL2 ZBED1 JUNB MAFG CEBPG ATF2 ZNF316 FOXK2 IKZF1 TCF7 CLEC5A WEE2-AS1 OR9A4 TAS2R38
GH07G141944 1.2 FANTOM5 Ensembl ENCODE 21.4 +1.2 1207 2.8 TFDP1 CTCF ZNF316 MAX EMSY MYC CLEC5A WEE2-AS1 OR9A4 TAS2R38 OR9N1P
GH07G141948 0.9 FANTOM5 23.5 -2.5 -2519 1.1 CTCF PKNOX1 MXI1 CEBPG BMI1 RAD21 ZNF143 SMC3 CREM RFX1 CLEC5A TAS2R38
GH07G142104 1.4 FANTOM5 Ensembl ENCODE 12.3 -158.1 -158143 2.0 ELF3 SOX13 FOXA2 SAP130 ARID4B MAX SIN3A CEBPG ZNF384 ZNF644 TAS2R38 CLEC5A MGAM2
GH07G141671 0.9 FANTOM5 ENCODE 19.1 +274.8 274778 1.0 NRF1 CEBPB TRIM24 CEBPG CLEC5A KIAA1147 WEE2 ENSG00000270157 PIR58736 GC07M141687
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLEC5A on UCSC Golden Path with GeneCards custom track

Genomic Location for CLEC5A Gene

Chromosome:
7
Start:
141,927,357 bp from pter
End:
141,947,007 bp from pter
Size:
19,651 bases
Orientation:
Minus strand

Genomic View for CLEC5A Gene

Genes around CLEC5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLEC5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLEC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC5A Gene

Proteins for CLEC5A Gene

  • Protein details for CLEC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY25-CLC5A_HUMAN
    Recommended name:
    C-type lectin domain family 5 member A
    Protein Accession:
    Q9NY25
    Secondary Accessions:
    • Q52M11
    • Q9UKQ0

    Protein attributes for CLEC5A Gene

    Size:
    188 amino acids
    Molecular mass:
    21521 Da
    Quaternary structure:
    • Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.
    • (Microbial infection) Interacts with dengue virus envelope protein E (PubMed:18496526, PubMed:21566123).

    Three dimensional structures from OCA and Proteopedia for CLEC5A Gene

    Alternative splice isoforms for CLEC5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC5A Gene

Post-translational modifications for CLEC5A Gene

  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at Asn32, Asn93, Asn144, and Asn151

No data available for DME Specific Peptides for CLEC5A Gene

Domains & Families for CLEC5A Gene

Gene Families for CLEC5A Gene

Protein Domains for CLEC5A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CLEC5A: view

No data available for UniProtKB/Swiss-Prot for CLEC5A Gene

Function for CLEC5A Gene

Molecular function for CLEC5A Gene

UniProtKB/Swiss-Prot Function:
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4.
UniProtKB/Swiss-Prot Function:
(Microbial infection) May act as a receptor for dengue virus on macrophages. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Ontology (GO) - Molecular Function for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 18496526
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC5A: view
genes like me logo Genes that share phenotypes with CLEC5A: view

Animal Models for CLEC5A Gene

MGI Knock Outs for CLEC5A:

Animal Model Products

  • Taconic Biosciences Mouse Models for CLEC5A

CRISPR Products

miRNA for CLEC5A Gene

miRTarBase miRNAs that target CLEC5A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CLEC5A Gene

Localization for CLEC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC5A Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLEC5A gene
Compartment Confidence
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10449773
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLEC5A: view

Pathways & Interactions for CLEC5A Gene

genes like me logo Genes that share pathways with CLEC5A: view

Pathways by source for CLEC5A Gene

Gene Ontology (GO) - Biological Process for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002076 osteoblast development ISS --
GO:0002376 immune system process IEA --
GO:0006968 cellular defense response TAS 10449773
GO:0007165 signal transduction TAS 10449773
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CLEC5A: view

No data available for SIGNOR curated interactions for CLEC5A Gene

Drugs & Compounds for CLEC5A Gene

(1) Drugs for CLEC5A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CLEC5A: view

Transcripts for CLEC5A Gene

Unigene Clusters for CLEC5A Gene

C-type lectin domain family 5, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC5A Gene

No ASD Table

Relevant External Links for CLEC5A Gene

GeneLoc Exon Structure for
CLEC5A
ECgene alternative splicing isoforms for
CLEC5A

Expression for CLEC5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLEC5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLEC5A Gene

This gene is overexpressed in Whole Blood (x18.0).

NURSA nuclear receptor signaling pathways regulating expression of CLEC5A Gene:

CLEC5A

SOURCE GeneReport for Unigene cluster for CLEC5A Gene:

Hs.446235

mRNA Expression by UniProt/SwissProt for CLEC5A Gene:

Q9NY25-CLC5A_HUMAN
Tissue specificity: Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
genes like me logo Genes that share expression patterns with CLEC5A: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLEC5A Gene

Orthologs for CLEC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC5A 34 35
  • 99.65 (n)
mouse
(Mus musculus)
Mammalia Clec5a 34 16 35
  • 82.34 (n)
cow
(Bos Taurus)
Mammalia CLEC5A 34 35
  • 82.16 (n)
rat
(Rattus norvegicus)
Mammalia Clec5a 34
  • 81.98 (n)
dog
(Canis familiaris)
Mammalia CLEC5A 34 35
  • 80.07 (n)
oppossum
(Monodelphis domestica)
Mammalia CLEC5A 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
-- 35
  • 17 (a)
OneToMany
Species where no ortholog for CLEC5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC5A Gene

ENSEMBL:
Gene Tree for CLEC5A (if available)
TreeFam:
Gene Tree for CLEC5A (if available)

Paralogs for CLEC5A Gene

(4) SIMAP similar genes for CLEC5A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CLEC5A: view

No data available for Paralogs for CLEC5A Gene

Variants for CLEC5A Gene

Sequence variations from dbSNP and Humsavar for CLEC5A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000256614 -- 141,943,186(+) CATCA(A/G)CAGAT intron-variant
rs1000399374 -- 141,926,974(+) TTTCT(A/G)TCTTT downstream-variant-500B
rs1001050482 -- 141,937,449(+) AGAAA(A/G)GGGAG intron-variant
rs1001081301 -- 141,937,212(+) GTAAA(A/G)GTCAG intron-variant
rs1001139024 -- 141,937,856(+) AAAGT(A/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CLEC5A Gene

Variant ID Type Subtype PubMed ID
nsv5974 CNV deletion 18451855
nsv831161 CNV loss 17160897

Variation tolerance for CLEC5A Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLEC5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CLEC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC5A Gene

Disorders for CLEC5A Gene

Relevant External Links for CLEC5A

Human Genome Epidemiology (HuGE) Navigator
CLEC5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLEC5A

No disorders were found for CLEC5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLEC5A Gene

Publications for CLEC5A Gene

  1. CLEC5A is critical for dengue-virus-induced lethal disease. (PMID: 18496526) Chen S.T. … Hsieh S.L. (Nature 2008) 3 4 22 64
  2. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. (PMID: 10449773) Bakker A.B.H. … Lanier L.L. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 64
  3. Structural flexibility of the macrophage dengue virus receptor CLEC5A: Implications for ligand binding and signaling. (PMID: 21566123) Watson A.A. … O'Callaghan C.A. (J. Biol. Chem. 2011) 3 4 64
  4. Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor. (PMID: 20057064) Watson A.A. … O'Callaghan C.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CLEC5A Gene

Sources for CLEC5A Gene

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