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Aliases for CLEC5A Gene

Aliases for CLEC5A Gene

  • C-Type Lectin Domain Family 5, Member A 2 3
  • CLECSF5 3 4 6
  • MDL1 3 4 6
  • C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 5 2 3
  • Myeloid DAP12-Associating Lectin 1 3 4
  • C-Type Lectin Superfamily Member 5 3 4
  • MDL-1 3 4
  • C-Type Lectin Domain Family 5 Member A 3
  • Myeloid DAP12-Associating Lectin-1 3

External Ids for CLEC5A Gene

Previous HGNC Symbols for CLEC5A Gene

  • CLECSF5

Previous GeneCards Identifiers for CLEC5A Gene

  • GC07M141081
  • GC07M141273
  • GC07M141627
  • GC07M135923

Summaries for CLEC5A Gene

Entrez Gene Summary for CLEC5A Gene

  • This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CLEC5A Gene

CLEC5A (C-Type Lectin Domain Family 5, Member A) is a Protein Coding gene. Diseases associated with CLEC5A include dengue disease. Among its related pathways are Signaling by FGFR. GO annotations related to this gene include carbohydrate binding and virus receptor activity.

UniProtKB/Swiss-Prot for CLEC5A Gene

  • Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Wiki entry for CLEC5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLEC5A Gene

Genomics for CLEC5A Gene

Regulatory Elements for CLEC5A Gene

Genomic Location for CLEC5A Gene

Start:
141,927,357 bp from pter
End:
141,947,007 bp from pter
Size:
19,651 bases
Orientation:
Minus strand

Genomic View for CLEC5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CLEC5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLEC5A Gene

Proteins for CLEC5A Gene

  • Protein details for CLEC5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY25-CLC5A_HUMAN
    Recommended name:
    C-type lectin domain family 5 member A
    Protein Accession:
    Q9NY25
    Secondary Accessions:
    • Q52M11
    • Q9UKQ0

    Protein attributes for CLEC5A Gene

    Size:
    188 amino acids
    Molecular mass:
    21521 Da
    Quaternary structure:
    • Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.

    Three dimensional structures from OCA and Proteopedia for CLEC5A Gene

    Alternative splice isoforms for CLEC5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLEC5A Gene

Proteomics data for CLEC5A Gene at MOPED

Post-translational modifications for CLEC5A Gene

  • N-glycosylated. Contains sialic acid residues (By similarity).
  • Glycosylation at Asn32, Asn93, Asn144, and Asn151

Other Protein References for CLEC5A Gene

Antibody Products

  • R&D Systems Antibodies for CLEC5A (MDL-1/CLEC5A)

No data available for DME Specific Peptides for CLEC5A Gene

Domains for CLEC5A Gene

Gene Families for CLEC5A Gene

HGNC:
  • CLEC :C-type lectin domain containing

Protein Domains for CLEC5A Gene

Suggested Antigen Peptide Sequences for CLEC5A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NY25

UniProtKB/Swiss-Prot:

CLC5A_HUMAN :
  • Q9NY25
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CLEC5A: view

Function for CLEC5A Gene

Molecular function for CLEC5A Gene

UniProtKB/Swiss-Prot Function: Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation (By similarity). Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Gene Ontology (GO) - Molecular Function for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 18496526
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CLEC5A: view

Phenotypes for CLEC5A Gene

genes like me logo Genes that share phenotypes with CLEC5A: view

Animal Models for CLEC5A Gene

MGI Knock Outs for CLEC5A:

Animal Model Products

CRISPR Products

miRNA for CLEC5A Gene

miRTarBase miRNAs that target CLEC5A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CLEC5A Gene

Localization for CLEC5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLEC5A Gene

Cell membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLEC5A Gene COMPARTMENTS Subcellular localization image for CLEC5A gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10449773
GO:0009986 cell surface ISS --
genes like me logo Genes that share ontologies with CLEC5A: view

Pathways for CLEC5A Gene

SuperPathways for CLEC5A Gene

Superpath Contained pathways
1 Signaling by FGFR
genes like me logo Genes that share pathways with CLEC5A: view

Pathways by source for CLEC5A Gene

1 Reactome pathway for CLEC5A Gene

Interacting Proteins for CLEC5A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000449999%0d%0a9606.ENSP00000262629%0d%0a9606.ENSP00000246551%0d%0a
Selected Interacting proteins: ENSP00000449999 Q9NY25-CLC5A_HUMAN for CLEC5A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CLEC5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002076 osteoblast development ISS --
GO:0006968 cellular defense response TAS 10449773
GO:0007165 signal transduction TAS 10449773
GO:0009615 response to virus IEA --
GO:0016032 viral process --
genes like me logo Genes that share ontologies with CLEC5A: view

Compounds for CLEC5A Gene

(1) HMDB Compounds for CLEC5A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CLEC5A: view

Transcripts for CLEC5A Gene

Unigene Clusters for CLEC5A Gene

C-type lectin domain family 5, member A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CLEC5A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLEC5A Gene

No ASD Table

Relevant External Links for CLEC5A Gene

GeneLoc Exon Structure for
CLEC5A
ECgene alternative splicing isoforms for
CLEC5A

Expression for CLEC5A Gene

mRNA expression in normal human tissues for CLEC5A Gene

mRNA differential expression in normal tissues according to GTEx for CLEC5A Gene

This gene is overexpressed in Whole Blood (18.0).

SOURCE GeneReport for Unigene cluster for CLEC5A Gene Hs.446235

mRNA Expression by UniProt/SwissProt for CLEC5A Gene

Q9NY25-CLC5A_HUMAN
Tissue specificity: Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
genes like me logo Genes that share expressions with CLEC5A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CLEC5A Gene

Orthologs for CLEC5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLEC5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLEC5A 35
  • 99.65 (n)
  • 99.47 (a)
CLEC5A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLEC5A 35
  • 82.16 (n)
  • 73.51 (a)
CLEC5A 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CLEC5A 35
  • 80.07 (n)
  • 67.93 (a)
CLEC5A 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clec5a 35
  • 82.34 (n)
  • 73.51 (a)
Clec5a 16
Clec5a 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLEC5A 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Clec5a 35
  • 81.98 (n)
  • 73.51 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
Species with no ortholog for CLEC5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CLEC5A Gene

ENSEMBL:
Gene Tree for CLEC5A (if available)
TreeFam:
Gene Tree for CLEC5A (if available)

Paralogs for CLEC5A Gene

Selected SIMAP similar genes for CLEC5A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CLEC5A: view

No data available for Paralogs for CLEC5A Gene

Variants for CLEC5A Gene

Sequence variations from dbSNP and Humsavar for CLEC5A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_050110 -

Structural Variations from Database of Genomic Variants (DGV) for CLEC5A Gene

Variant ID Type Subtype PubMed ID
nsv831161 CNV Loss 17160897
nsv5974 CNV Loss 18451855

Relevant External Links for CLEC5A Gene

HapMap Linkage Disequilibrium report
CLEC5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLEC5A Gene

Disorders for CLEC5A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CLEC5A Gene including...

Search for CLEC5A Gene in MalaCards »

(1) University of Copenhagen DISEASES for CLEC5A Gene

Relevant External Links for CLEC5A

Human Genome Epidemiology (HuGE) Navigator
CLEC5A
genes like me logo Genes that share disorders with CLEC5A: view

No data available for UniProtKB/Swiss-Prot for CLEC5A Gene

Publications for CLEC5A Gene

  1. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. (PMID: 10449773) Bakker A.B.H. … Lanier L.L. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4
  2. CLEC5A is critical for dengue-virus-induced lethal disease. (PMID: 18496526) Chen S.T. … Hsieh S.L. (Nature 2008) 3 4 23
  3. Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1), a dengue virus receptor. (PMID: 20057064) Watson A.A. … O'Callaghan C.A. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2010) 3 23
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Structural flexibility of the macrophage dengue virus receptor CLEC5A: Implications for ligand binding and signaling. (PMID: 21566123) Watson A.A. … O'Callaghan C.A. (J. Biol. Chem. 2011) 3 4

Products for CLEC5A Gene

Sources for CLEC5A Gene

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