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Aliases for ORC6 Gene

Aliases for ORC6 Gene

  • Origin Recognition Complex, Subunit 6 2 3
  • ORC6L 3 4 6
  • Origin Recognition Complex, Subunit 6 Homolog-Like (Yeast) 2
  • Origin Recognition Complex, Subunit 6 Like (Yeast) 2
  • Origin Recognition Complex Subunit 6 3

External Ids for ORC6 Gene

Previous Symbols for ORC6 Gene

  • ORC6L

Summaries for ORC6 Gene

Entrez Gene Summary for ORC6 Gene

  • The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

GeneCards Summary for ORC6 Gene

ORC6 (Origin Recognition Complex, Subunit 6) is a Protein Coding gene. Diseases associated with ORC6 include meier-gorlin syndrome 3 and microtia. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for ORC6 Gene

  • Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Wiki entry for ORC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ORC6 Gene

Genomics for ORC6 Gene

Genomic Location for ORC6 Gene

Start:
46,689,643 bp from pter
End:
46,698,394 bp from pter
Size:
8,752 bases
Orientation:
Plus strand

Genomic View for ORC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ORC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ORC6 Gene

No data available for Regulatory Elements for ORC6 Gene

Proteins for ORC6 Gene

  • Protein details for ORC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5N6-ORC6_HUMAN
    Recommended name:
    Origin recognition complex subunit 6
    Protein Accession:
    Q9Y5N6
    Secondary Accessions:
    • B3KN89

    Protein attributes for ORC6 Gene

    Size:
    252 amino acids
    Molecular mass:
    28107 Da
    Quaternary structure:
    • Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4 (By similarity).

    Three dimensional structures from OCA and Proteopedia for ORC6 Gene

neXtProt entry for ORC6 Gene

Proteomics data for ORC6 Gene at MOPED

Post-translational modifications for ORC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ORC6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ORC6 Gene

Domains for ORC6 Gene

Protein Domains for ORC6 Gene

UniProtKB/Swiss-Prot:

ORC6_HUMAN
Family:
  • Belongs to the ORC6 family.:
    • Q9Y5N6
genes like me logo Genes that share domains with ORC6: view

No data available for Gene Families for ORC6 Gene

Function for ORC6 Gene

Molecular function for ORC6 Gene

UniProtKB/Swiss-Prot Function: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene Ontology (GO) - Molecular Function for ORC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15232106
genes like me logo Genes that share ontologies with ORC6: view

Phenotypes for ORC6 Gene

genes like me logo Genes that share phenotypes with ORC6: view

miRNA for ORC6 Gene

miRTarBase miRNAs that target ORC6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ORC6 Gene

Localization for ORC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ORC6 Gene

Gene Ontology (GO) - Cellular Components for ORC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000808 origin recognition complex IDA 17716973
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005664 nuclear origin of replication recognition complex IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ORC6: view

Pathways for ORC6 Gene

genes like me logo Genes that share pathways with ORC6: view

Pathways by source for ORC6 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ORC6 Gene
1 Qiagen pathway for ORC6 Gene
1 Cell Signaling Technology pathway for ORC6 Gene

Gene Ontology (GO) - Biological Process for ORC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0006261 DNA-dependent DNA replication IEA --
genes like me logo Genes that share ontologies with ORC6: view

Transcripts for ORC6 Gene

Unigene Clusters for ORC6 Gene

Origin recognition complex, subunit 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ORC6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ORC6 Gene

GeneLoc Exon Structure for
ORC6
ECgene alternative splicing isoforms for
ORC6

Expression for ORC6 Gene

mRNA expression in normal human tissues for ORC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ORC6 Gene

This gene is overexpressed in Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ORC6 Gene

SOURCE GeneReport for Unigene cluster for ORC6 Gene Hs.49760

genes like me logo Genes that share expressions with ORC6: view

Orthologs for ORC6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ORC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ORC6 36
  • 99.74 (n)
  • 99.21 (a)
ORC6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ORC6 36
  • 87.57 (n)
  • 84.92 (a)
ORC6 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ORC6 36
  • 86.24 (n)
  • 84.13 (a)
ORC6 37
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Orc6 36
  • 82.07 (n)
  • 77.69 (a)
Orc6 16
Orc6 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ORC6 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ORC6 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Orc6 36
  • 79.55 (n)
  • 74.1 (a)
chicken
(Gallus gallus)
Aves ORC6 36
  • 64.08 (n)
  • 57.14 (a)
ORC6 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ORC6 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8017 36
tropical clawed frog
(Silurana tropicalis)
Amphibia orc6 36
  • 62.92 (n)
  • 60.24 (a)
Str.6097 36
zebrafish
(Danio rerio)
Actinopterygii orc6 36
  • 60.63 (n)
  • 54.73 (a)
orc6 37
  • 52 (a)
OneToOne
wufc22h10 36
fruit fly
(Drosophila melanogaster)
Insecta Orc6 37
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ORC6 36
  • 47.49 (n)
  • 33.33 (a)
rice
(Oryza sativa)
Liliopsida Os07g0628600 36
  • 48.05 (n)
  • 31.6 (a)
Species with no ortholog for ORC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ORC6 Gene

ENSEMBL:
Gene Tree for ORC6 (if available)
TreeFam:
Gene Tree for ORC6 (if available)

Paralogs for ORC6 Gene

No data available for Paralogs for ORC6 Gene

Variants for ORC6 Gene

Sequence variations from dbSNP and Humsavar for ORC6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs36314 -- 46,692,730(-) ACGCC(A/T)CGCCC intron-variant
rs36315 -- 46,693,879(-) atcaa(A/T)aaaaa intron-variant
rs36316 -- 46,694,675(-) GTTTT(G/T)TTTTT intron-variant
rs36317 -- 46,695,359(-) GATCT(A/G)TTTTA intron-variant
rs39710 -- 46,694,004(-) aggcc(A/G)caggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ORC6 Gene

Variant ID Type Subtype PubMed ID
nsv526656 CNV Gain 19592680

Relevant External Links for ORC6 Gene

HapMap Linkage Disequilibrium report
ORC6
Human Gene Mutation Database (HGMD)
ORC6

Disorders for ORC6 Gene

(1) OMIM Diseases for ORC6 Gene (607213)

UniProtKB/Swiss-Prot

ORC6_HUMAN
  • Meier-Gorlin syndrome 3 (MGORS3) [MIM:613803]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ORC6: view

Publications for ORC6 Gene

  1. Identification and characterization of the human ORC6 homolog. (PMID: 10945994) Dhar S.K. … Dutta A. (J. Biol. Chem. 2000) 2 3 23
  2. ATP-dependent assembly of the human origin recognition complex. (PMID: 17716973) Siddiqui K. … Stillman B. (J. Biol. Chem. 2007) 3 4 23
  3. Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. (PMID: 12169736) Prasanth S.G. … Stillman B. (Science 2002) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Functional analysis of an Orc6 mutant in Drosophila. (PMID: 19541634) Balasov M. … Chesnokov I. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for ORC6 Gene

Sources for ORC6 Gene

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