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Aliases for FPR3 Gene

Aliases for FPR3 Gene

  • Formyl Peptide Receptor 3 2 3 5
  • Formyl Peptide Receptor-Like 2 2 3 4
  • FMLP-Related Receptor II 3 4
  • FMLP-R-II 3 4
  • FPRH1 3 4
  • FPRL2 3 4
  • FML2_HUMAN 3
  • RMLP-R-I 3
  • FPRH2 3
  • FMLPY 3

External Ids for FPR3 Gene

Previous HGNC Symbols for FPR3 Gene

  • FPRL2

Previous GeneCards Identifiers for FPR3 Gene

  • GC19P056992
  • GC19P052298
  • GC19P048629

Summaries for FPR3 Gene

GeneCards Summary for FPR3 Gene

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for FPR3 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Tocris Summary for FPR3 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR3 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR3 Gene

Genomics for FPR3 Gene

Regulatory Elements for FPR3 Gene

Enhancers for FPR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FPR3 on UCSC Golden Path with GeneCards custom track

Promoters for FPR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FPR3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FPR3 gene promoter:

Genomic Location for FPR3 Gene

Chromosome:
19
Start:
51,795,158 bp from pter
End:
51,826,474 bp from pter
Size:
31,317 bases
Orientation:
Plus strand

Genomic View for FPR3 Gene

Genes around FPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR3 Gene

Proteins for FPR3 Gene

  • Protein details for FPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25089-FPR3_HUMAN
    Recommended name:
    N-formyl peptide receptor 3
    Protein Accession:
    P25089

    Protein attributes for FPR3 Gene

    Size:
    353 amino acids
    Molecular mass:
    39965 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR3 Gene

Proteomics data for FPR3 Gene at MOPED

Post-translational modifications for FPR3 Gene

  • Glycosylation at Asn 4 and Asn 10
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FPR3 Gene

Domains & Families for FPR3 Gene

Gene Families for FPR3 Gene

Graphical View of Domain Structure for InterPro Entry

P25089

UniProtKB/Swiss-Prot:

FPR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR3: view

Function for FPR3 Gene

Molecular function for FPR3 Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
genes like me logo Genes that share phenotypes with FPR3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FPR3

miRNA for FPR3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FPR3 Gene

Localization for FPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPR3 Gene COMPARTMENTS Subcellular localization image for FPR3 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for FPR3 Gene

Pathways & Interactions for FPR3 Gene

genes like me logo Genes that share pathways with FPR3: view

Interacting Proteins for FPR3 Gene

Gene Ontology (GO) - Biological Process for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 8198572
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with FPR3: view

No data available for SIGNOR curated interactions for FPR3 Gene

Drugs & Compounds for FPR3 Gene

(9) Drugs for FPR3 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WKYMVM Pharma Full agonist, Agonist Selective FPR2 and FPR3 receptor agonist 0
annexin I-(2-26) Pharma Full agonist, Agonist 0
F2L Pharma Full agonist, Agonist 0
F2L-[<sup>125</sup>I]Tyr Pharma Full agonist, Agonist 0
fMet-Met-Tyr-Ala-Leu-Phe Pharma Full agonist, Agonist 0

(4) Additional Compounds for FPR3 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FPR A14
329691-12-5
MMK 1
271246-66-3
N-Formyl-Met-Leu-Phe
59880-97-6

(4) Tocris Compounds for FPR3 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4
genes like me logo Genes that share compounds with FPR3: view

Transcripts for FPR3 Gene

mRNA/cDNA for FPR3 Gene

Unigene Clusters for FPR3 Gene

Formyl peptide receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FPR3 Gene

No ASD Table

Relevant External Links for FPR3 Gene

GeneLoc Exon Structure for
FPR3
ECgene alternative splicing isoforms for
FPR3

Expression for FPR3 Gene

mRNA expression in normal human tissues for FPR3 Gene

mRNA differential expression in normal tissues according to GTEx for FPR3 Gene

This gene is overexpressed in Lung (x4.7).

SOURCE GeneReport for Unigene cluster for FPR3 Gene Hs.445466

genes like me logo Genes that share expression patterns with FPR3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FPR3 Gene

Orthologs for FPR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR3 35
  • 99.62 (n)
  • 99.43 (a)
FPR3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Fpr-rs3 36
  • 57 (a)
OneToMany
Fpr-rs4 36
  • 59 (a)
OneToMany
Fpr-rs6 36
  • 54 (a)
OneToMany
Fpr-rs7 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX649278.1 36
  • 17 (a)
ManyToMany
Species with no ortholog for FPR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR3 Gene

ENSEMBL:
Gene Tree for FPR3 (if available)
TreeFam:
Gene Tree for FPR3 (if available)

Paralogs for FPR3 Gene

Paralogs for FPR3 Gene

(17) SIMAP similar genes for FPR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FPR3: view

Variants for FPR3 Gene

Sequence variations from dbSNP and Humsavar for FPR3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12978748 -- 51,793,562(+) TGTGG(A/T)GTGTA upstream-variant-2KB
rs16983056 -- 51,794,490(+) CTTTC(A/G)TTTTC upstream-variant-2KB
rs16983059 -- 51,794,548(+) TTGAT(A/G)TTTGG upstream-variant-2KB
rs16983063 -- 51,796,039(+) TAAGA(C/G)AGAAG intron-variant
rs961551 -- 51,798,528(+) TTATA(C/T)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FPR3 Gene

Variant ID Type Subtype PubMed ID
esv638 CNV CNV 17122850
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159
dgv1112e1 CNV Complex 17122850
dgv425n27 CNV Gain 19166990

Variation tolerance for FPR3 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FPR3 Gene

Disorders for FPR3 Gene

Relevant External Links for FPR3

Genetic Association Database (GAD)
FPR3
Human Genome Epidemiology (HuGE) Navigator
FPR3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPR3

No disorders were found for FPR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FPR3 Gene

Publications for FPR3 Gene

  1. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. (PMID: 8198572) Durstin M. … Murphy P.M. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 67
  2. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. (PMID: 19342677) Devosse T. … Parmentier M. (J. Immunol. 2009) 3 23
  3. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. (PMID: 16002663) Kang H.K. … Bae Y.S. (J. Immunol. 2005) 3 23
  4. Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation. (PMID: 12223529) Yang D. … Oppenheim J.J. (J. Leukoc. Biol. 2002) 3 23
  5. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. (PMID: 12410796) Christophe T. … Dahlgren C. (Scand. J. Immunol. 2002) 3 23

Products for FPR3 Gene

Sources for FPR3 Gene

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