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Aliases for FPR1 Gene

Aliases for FPR1 Gene

  • Formyl Peptide Receptor 1 2 3 5
  • N-Formylpeptide Chemoattractant Receptor 3 4
  • FMLP Receptor 3 4
  • FPR 3 4
  • N-Formyl Peptide Receptor 4
  • FMLP 3

External Ids for FPR1 Gene

Previous GeneCards Identifiers for FPR1 Gene

  • GC19M052879
  • GC19M052610
  • GC19M056924
  • GC19M056940
  • GC19M052249
  • GC19M048579

Summaries for FPR1 Gene

Entrez Gene Summary for FPR1 Gene

  • This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

GeneCards Summary for FPR1 Gene

FPR1 (Formyl Peptide Receptor 1) is a Protein Coding gene. Diseases associated with FPR1 include aggressive periodontitis and specific bursitis often of occupational origin. Among its related pathways are Peptide ligand-binding receptors and Ras signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and RAGE receptor binding. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for FPR1 Gene

  • High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Tocris Summary for FPR1 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR1 Gene

Genomics for FPR1 Gene

Regulatory Elements for FPR1 Gene

Enhancers for FPR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FPR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FPR1 Gene

Chromosome:
19
Start:
51,745,172 bp from pter
End:
51,804,110 bp from pter
Size:
58,939 bases
Orientation:
Minus strand

Genomic View for FPR1 Gene

Genes around FPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR1 Gene

Proteins for FPR1 Gene

  • Protein details for FPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21462-FPR1_HUMAN
    Recommended name:
    fMet-Leu-Phe receptor
    Protein Accession:
    P21462
    Secondary Accessions:
    • Q14939
    • Q7Z6A4
    • Q86U52
    • Q9NS48

    Protein attributes for FPR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    38446 Da
    Quaternary structure:
    • Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.

neXtProt entry for FPR1 Gene

Proteomics data for FPR1 Gene at MOPED

Post-translational modifications for FPR1 Gene

  • Phosphorylated; which is necessary for desensitization.
  • Glycosylation at Asn 4 and Asn 10
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for FPR1

No data available for DME Specific Peptides for FPR1 Gene

Domains & Families for FPR1 Gene

Gene Families for FPR1 Gene

Suggested Antigen Peptide Sequences for FPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21462

UniProtKB/Swiss-Prot:

FPR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR1: view

Function for FPR1 Gene

Molecular function for FPR1 Gene

GENATLAS Biochemistry:
formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte activation,(formyl-Met-Leu-Phe),G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function:
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Gene Ontology (GO) - Molecular Function for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22447027
GO:0050786 RAGE receptor binding IEA --
genes like me logo Genes that share ontologies with FPR1: view
genes like me logo Genes that share phenotypes with FPR1: view

Animal Models for FPR1 Gene

MGI Knock Outs for FPR1:

Animal Model Products

miRNA for FPR1 Gene

miRTarBase miRNAs that target FPR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR1 Gene

Localization for FPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPR1 Gene COMPARTMENTS Subcellular localization image for FPR1 gene
Compartment Confidence
plasma membrane 5
endosome 4
extracellular 2
cytoskeleton 1
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for FPR1 Gene

Pathways & Interactions for FPR1 Gene

genes like me logo Genes that share pathways with FPR1: view

Gene Ontology (GO) - Biological Process for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10882119
GO:0007165 signal transduction TAS 10820279
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 10823817
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA 22859307
genes like me logo Genes that share ontologies with FPR1: view

No data available for SIGNOR curated interactions for FPR1 Gene

Drugs & Compounds for FPR1 Gene

(58) Drugs for FPR1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nedocromil Approved Pharma Target, antagonist 5
chenodeoxycholic acid Approved Pharma Antagonist 27
deoxycholic acid Approved Pharma Antagonist 39
WKYMVM Pharma Full agonist, Agonist Selective FPR2 and FPR3 receptor agonist 0
Cyclosporin A Pharma Antagonist, inhibitor Immunosuppressive agent, Calcineurin inhibitor 0

(47) Additional Compounds for FPR1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FPR A14
329691-12-5
MMK 1
271246-66-3
N-Formyl-Met-Leu-Phe
59880-97-6

(4) Tocris Compounds for FPR1 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4
genes like me logo Genes that share compounds with FPR1: view

Transcripts for FPR1 Gene

Unigene Clusters for FPR1 Gene

Formyl peptide receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FPR1 Gene

No ASD Table

Relevant External Links for FPR1 Gene

GeneLoc Exon Structure for
FPR1
ECgene alternative splicing isoforms for
FPR1

Expression for FPR1 Gene

mRNA expression in normal human tissues for FPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FPR1 Gene

This gene is overexpressed in Whole Blood (x47.4).

Protein differential expression in normal tissues from HIPED for FPR1 Gene

This gene is overexpressed in Monocytes (33.3) and Neutrophil (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FPR1 Gene



SOURCE GeneReport for Unigene cluster for FPR1 Gene Hs.753

mRNA Expression by UniProt/SwissProt for FPR1 Gene

P21462-FPR1_HUMAN
Tissue specificity: Neutrophils.
genes like me logo Genes that share expression patterns with FPR1: view

Protein tissue co-expression partners for FPR1 Gene

Primer Products

In Situ Assay Products

Orthologs for FPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Fpr1 35
  • 78.64 (n)
  • 78.34 (a)
Fpr1 16
Fpr1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FPR1 35
  • 98.95 (n)
  • 98.57 (a)
FPR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fpr1 35
  • 76.26 (n)
  • 75.07 (a)
dog
(Canis familiaris)
Mammalia FPR1 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-113g13.2 36
  • 19 (a)
ManyToMany
Species with no ortholog for FPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR1 Gene

ENSEMBL:
Gene Tree for FPR1 (if available)
TreeFam:
Gene Tree for FPR1 (if available)

Paralogs for FPR1 Gene

Paralogs for FPR1 Gene

Pseudogenes.org Pseudogenes for FPR1 Gene

genes like me logo Genes that share paralogs with FPR1: view

Variants for FPR1 Gene

Sequence variations from dbSNP and Humsavar for FPR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2070745 - 51,746,694(-) AATTC(A/C/G)TCTTT reference, missense
rs1042229 - 51,746,419(-) ATAAA(C/G/T)GTGGC reference, missense
rs867228 - 51,745,958(-) GGTGG(A/C)GTTAC reference, missense
rs5030878 - 51,746,963(-) GAACA(C/T)CTCTG reference, missense
rs5030880 - 51,746,427(-) AAGAG(A/T)GGATA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FPR1 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159

Variation tolerance for FPR1 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.67; 82.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FPR1 Gene

HapMap Linkage Disequilibrium report
FPR1
Human Gene Mutation Database (HGMD)
FPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR1 Gene

Disorders for FPR1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FPR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aggressive periodontitis
  • juvenile periodontitis
specific bursitis often of occupational origin
  • specific bursitides often of occupational origin
olecranon bursitis
  • bursitis of elbow
shwachman-diamond syndrome
  • pancreatic insufficiency and bone marrow dysfunction
orofaciodigital syndrome viii
  • edwards syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FPR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FPR1

Genetic Association Database (GAD)
FPR1
Human Genome Epidemiology (HuGE) Navigator
FPR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FPR1
genes like me logo Genes that share disorders with FPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPR1 Gene

Publications for FPR1 Gene

  1. Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. (PMID: 12595898) Zhang Y. … Hart T.C. (Genes Immun. 2003) 2 3 23 48 67
  2. The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells. (PMID: 20197768) Huang J. … Wang J.M. (Br. J. Cancer 2010) 3 23
  3. Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation. (PMID: 19037090) Huang J. … Wang J.M. (Carcinogenesis 2009) 3 23
  4. Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophils. (PMID: 19414538) Svensson L. … WennerAYs C. (J. Leukoc. Biol. 2009) 3 23
  5. Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis. (PMID: 19722801) Maney P. … Walters J.D. (J. Periodontol. 2009) 3 23

Products for FPR1 Gene

Sources for FPR1 Gene

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