Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FPR1 Gene

Aliases for FPR1 Gene

  • Formyl Peptide Receptor 1 2 3
  • N-Formylpeptide Chemoattractant Receptor 3 4
  • FMLP Receptor 3 4
  • FPR 3 4
  • N-Formyl Peptide Receptor 4
  • FMet-Leu-Phe Receptor 3
  • FMLP 3

External Ids for FPR1 Gene

Previous GeneCards Identifiers for FPR1 Gene

  • GC19M052879
  • GC19M052610
  • GC19M056924
  • GC19M056940
  • GC19M052249
  • GC19M048579

Summaries for FPR1 Gene

Entrez Gene Summary for FPR1 Gene

  • This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

GeneCards Summary for FPR1 Gene

FPR1 (Formyl Peptide Receptor 1) is a Protein Coding gene. Diseases associated with FPR1 include aggressive periodontitis and malignant glioma. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for FPR1 Gene

  • High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Tocris Summary for FPR1 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes and found at lower expression levels on endothelial cells, neurons, astrocytes and hepatocytes. Formyl peptide receptors are involved in antibacterial host defence and inflammation. Activation of FPRs mediates induction of neutrophil chemotaxis, production of reactive oxygen species (ROS) to clear damaged cells and stimulation of degranulation of neutrophils. In addition, FPRs have a role in neutrophil transcriptional regulation and cytokine production, and induce neutrophil apoptosis in a ROS-dependent manner. Recently, FPRs have been implicated in the pathogenesis of amyloidosis, Alzheimer's disease, prion diseases and HIV. Ligand diversity is a prominent and unusual feature of FPR family receptors, suggesting that these receptors may have more complex functions than are currently appreciated. The human genes encoding FPR1, FPR2 and FPR3 are clustered on chromosome 19q13.3-13.4.

Gene Wiki entry for FPR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR1 Gene

Genomics for FPR1 Gene

Regulatory Elements for FPR1 Gene

Genomic Location for FPR1 Gene

Start:
51,745,172 bp from pter
End:
51,804,110 bp from pter
Size:
58,939 bases
Orientation:
Minus strand

Genomic View for FPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR1 Gene

Proteins for FPR1 Gene

  • Protein details for FPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21462-FPR1_HUMAN
    Recommended name:
    fMet-Leu-Phe receptor
    Protein Accession:
    P21462
    Secondary Accessions:
    • Q14939
    • Q7Z6A4
    • Q86U52
    • Q9NS48

    Protein attributes for FPR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    38446 Da
    Quaternary structure:
    • Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.

neXtProt entry for FPR1 Gene

Proteomics data for FPR1 Gene at MOPED

Post-translational modifications for FPR1 Gene

  • Phosphorylated; which is necessary for desensitization.
  • Glycosylation at Asn4 and Asn10
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FPR1 Gene

Domains for FPR1 Gene

Gene Families for FPR1 Gene

HGNC:
  • FPR :GPCR / Class A : Formyl peptide receptors
IUPHAR :

Suggested Antigen Peptide Sequences for FPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21462

UniProtKB/Swiss-Prot:

FPR1_HUMAN :
  • P21462
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR1: view

Function for FPR1 Gene

Molecular function for FPR1 Gene

GENATLAS Biochemistry: formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte activation,(formyl-Met-Leu-Phe),G protein coupled,secretin receptor superfamily
UniProtKB/Swiss-Prot Function: High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Gene Ontology (GO) - Molecular Function for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10857861
GO:0004930 G-protein coupled receptor activity --
GO:0004982 N-formyl peptide receptor activity IDA 12218158
GO:0005515 protein binding IPI 22447027
GO:0050786 RAGE receptor binding IEA --
genes like me logo Genes that share ontologies with FPR1: view
genes like me logo Genes that share phenotypes with FPR1: view

Animal Models for FPR1 Gene

MGI Knock Outs for FPR1:

Animal Model Products

CRISPR Products

miRNA for FPR1 Gene

miRTarBase miRNAs that target FPR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FPR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FPR1 Gene

Localization for FPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FPR1 Gene COMPARTMENTS Subcellular localization image for FPR1 gene
Compartment Confidence
plasma membrane 5
endosome 4
cytoskeleton 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome TAS 10823817
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FPR1: view

Pathways for FPR1 Gene

genes like me logo Genes that share pathways with FPR1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10857861
GO:0006928 movement of cell or subcellular component TAS 10882119
GO:0006935 chemotaxis IEA --
GO:0007165 signal transduction TAS 10820279
GO:0007186 G-protein coupled receptor signaling pathway TAS 10823817
genes like me logo Genes that share ontologies with FPR1: view

Compounds for FPR1 Gene

(5) Tocris Compounds for FPR1 Gene

Compound Action Cas Number
Ac9-25 Annexin I N-terminal peptide; acts as a FPR1 ligand [284040-76-2]
Boc-MLF FPR1 antagonist [67247-12-5]
WKYMVm FPR1, FPR2 and FPR3 receptor agonist [187986-17-0]
WKYMVM Selective FPR2 and FPR3 receptor agonist [187986-11-4]
WRW4 Selective FPR2 antagonist [878557-55-2]

(1) HMDB Compounds for FPR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for FPR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Nedocromil
69049-73-6 target antagonist

(32) IUPHAR Ligand for FPR1 Gene

Ligand Type Action Affinity Pubmed IDs
fMet-Ile-Phe-Leu Agonist Full agonist 10.5
fMet-Leu-Phe Agonist Full agonist 10.2
[3H]fMet-Leu-Phe Agonist Full agonist 9.3
fMet-Met-Trp-Leu-Leu Agonist Full agonist 9
Met-Met-Trp-Leu-Leu Agonist Full agonist 9
fMet-Ile-Val-Ile-Leu Agonist Full agonist 8.7
fMet-Ile-Val-Thr-Leu-Phe Agonist Full agonist 8.6
T20(DP178) Agonist Full agonist 8.3
[125I]CHIPS Antagonist Antagonist 7.5
AG-14 Agonist Full agonist 7.4
cyclosporin H Antagonist Antagonist 7.1
BVT173187 Antagonist Antagonist 7
3570-0208 [PMID:19807662] Antagonist Antagonist 7
[125I]cathepsin G (human) Agonist Full agonist 7
annexin I-(2-26) Agonist Full agonist 7
t-Boc-FLFLF Antagonist Antagonist 6.6
i-Boc-Met-Leu-Phe Antagonist Antagonist 6.6
diamide 7 Antagonist Antagonist 6.5
methionine benzimidazole 6 Antagonist Antagonist 6.3
gG-2p20 Agonist Full agonist 6.3
t-Boc-Met-Leu-Phe Antagonist Antagonist 6.2
fMet-Met-Tyr-Ala-Leu-Phe Agonist Full agonist 6
R-(-)-6-methyl-2,4-disubstituted pyridazin-3(2H)-one Agonist Full agonist 6
AG-09/1 Agonist Full agonist 5.6
AG-11/03 Agonist Full agonist 5.6
WKYMVm Agonist Full agonist 5.52
group E 1682-2106 [PMID:16118363] Antagonist Antagonist 5.3
sufinpyrazone Antagonist Antagonist 5
spinorphin Antagonist Antagonist 4.3
deoxycholic acid Antagonist Antagonist 4
chenodeoxycholic acid Antagonist Antagonist 4
cyclosporin A Inhibitor Inhibition

(71) Novoseek inferred chemical compound relationships for FPR1 Gene

Compound -log(P) Hits PubMed IDs
fmlp 96.2 310
n-formylmethionyl-leucylphenylalanine 91.2 53
cyclosporin h 89.2 10
fr 901459 81.7 2
fnlpntl 73.1 2
genes like me logo Genes that share compounds with FPR1: view

Transcripts for FPR1 Gene

Unigene Clusters for FPR1 Gene

Formyl peptide receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FPR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FPR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FPR1 Gene

No ASD Table

Relevant External Links for FPR1 Gene

GeneLoc Exon Structure for
FPR1
ECgene alternative splicing isoforms for
FPR1

Expression for FPR1 Gene

mRNA expression in normal human tissues for FPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FPR1 Gene

This gene is overexpressed in Whole Blood (47.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FPR1 Gene

SOURCE GeneReport for Unigene cluster for FPR1 Gene Hs.753

mRNA Expression by UniProt/SwissProt for FPR1 Gene

P21462-FPR1_HUMAN
Tissue specificity: Neutrophils
genes like me logo Genes that share expressions with FPR1: view

In Situ Assay Products

Orthologs for FPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR1 35
  • 98.95 (n)
  • 98.57 (a)
FPR1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FPR1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fpr1 35
  • 78.64 (n)
  • 78.34 (a)
Fpr1 16
Fpr1 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fpr1 35
  • 76.26 (n)
  • 75.07 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-113g13.2 36
  • 19 (a)
ManyToMany
Species with no ortholog for FPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR1 Gene

ENSEMBL:
Gene Tree for FPR1 (if available)
TreeFam:
Gene Tree for FPR1 (if available)

Paralogs for FPR1 Gene

Pseudogenes.org Pseudogenes for FPR1 Gene

genes like me logo Genes that share paralogs with FPR1: view

Variants for FPR1 Gene

Sequence variations from dbSNP and Humsavar for FPR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs867228 - 51,745,958(-) GGTGG(A/C)GTTAC reference, missense
rs867229 -- 51,745,746(-) TTGGA(C/T)CTCAG downstream-variant-500B
rs867341 -- 51,745,867(-) CAGGC(A/G)TTTCC utr-variant-3-prime
rs1042229 - 51,746,419(-) ATAAA(C/G/T)GTGGC synonymous-codon, missense, reference
rs1806443 -- 51,745,313(+) ACTAC(A/G)CCCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FPR1 Gene

Variant ID Type Subtype PubMed ID
dgv1109e1 CNV Complex 17122850
esv638 CNV CNV 17122850
dgv1110e1 CNV Complex 17122850
nsv524403 CNV Gain 19592680
nsv470151 CNV Gain 18288195
nsv458733 CNV Gain 19166990
dgv143e55 CNV Gain 17911159

Relevant External Links for FPR1 Gene

HapMap Linkage Disequilibrium report
FPR1
Human Gene Mutation Database (HGMD)
FPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR1 Gene

Disorders for FPR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for FPR1 Gene including...

Search for FPR1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for FPR1 Gene

(17) Novoseek inferred disease relationships for FPR1 Gene

Disease -log(P) Hits PubMed IDs
periodontitis juvenile 67.3 3
leukemia basophilic 56.9 5
malignant glioma 45.7 6
glioblastoma 44.3 27
inflammation 39.7 11

Relevant External Links for FPR1

Genetic Association Database (GAD)
FPR1
Human Genome Epidemiology (HuGE) Navigator
FPR1
genes like me logo Genes that share disorders with FPR1: view

No data available for UniProtKB/Swiss-Prot for FPR1 Gene

Publications for FPR1 Gene

  1. Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. (PMID: 12595898) Zhang Y. … Hart T.C. (Genes Immun. 2003) 2 3 23 48
  2. Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression. (PMID: 1445895) Perez H.D. … Andrews W.H. (Biochemistry 1992) 3 4 23
  3. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. (PMID: 10514456) Maestes D.C. … Prossnitz E.R. (J. Biol. Chem. 1999) 3 4 23
  4. Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent beta-arrestin association and indices of inflammation. (PMID: 16953235) Bhattacharya M. … Ferguson S.S. (Pharmacogenomics J. 2007) 3 23 48
  5. Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. (PMID: 17927965) Gunji T. … Ishikawa I. (Biochem. Biophys. Res. Commun. 2007) 3 23 48

Products for FPR1 Gene

  • Addgene plasmids for FPR1

Sources for FPR1 Gene

Back to Top

Content