Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF346 Gene

Aliases for ZNF346 Gene

  • Zinc Finger Protein 346 2 3 5
  • Just Another Zinc Finger Protein 3 4
  • JAZ 3 4
  • Double-Stranded RNA-Binding Zinc Finger Protein JAZ 3
  • Zfp346 3

External Ids for ZNF346 Gene

Previous GeneCards Identifiers for ZNF346 Gene

  • GC05P176431
  • GC05P176382
  • GC05P171371
  • GC05P176451

Summaries for ZNF346 Gene

Entrez Gene Summary for ZNF346 Gene

  • The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for ZNF346 Gene

ZNF346 (Zinc Finger Protein 346) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and enzyme binding. An important paralog of this gene is KRCC1.

UniProtKB/Swiss-Prot for ZNF346 Gene

  • Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.

Gene Wiki entry for ZNF346 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF346 Gene

Genomics for ZNF346 Gene

Regulatory Elements for ZNF346 Gene

Enhancers for ZNF346 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF346 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF346 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF346 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF346 Gene

177,022,680 bp from pter
177,081,189 bp from pter
58,510 bases
Plus strand

Genomic View for ZNF346 Gene

Genes around ZNF346 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF346 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF346 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF346 Gene

Proteins for ZNF346 Gene

  • Protein details for ZNF346 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 346
    Protein Accession:
    Secondary Accessions:
    • B7Z367
    • Q68CV9
    • Q6ZMW1

    Protein attributes for ZNF346 Gene

    294 amino acids
    Molecular mass:
    32933 Da
    Quaternary structure:
    • Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.

    Three dimensional structures from OCA and Proteopedia for ZNF346 Gene

    Alternative splice isoforms for ZNF346 Gene


neXtProt entry for ZNF346 Gene

Proteomics data for ZNF346 Gene at MOPED

Post-translational modifications for ZNF346 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF346 Gene

Domains & Families for ZNF346 Gene

Protein Domains for ZNF346 Gene


Graphical View of Domain Structure for InterPro Entry



  • The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
  • Contains 4 matrin-type zinc fingers.
  • The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
  • Contains 4 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF346: view

No data available for Gene Families for ZNF346 Gene

Function for ZNF346 Gene

Molecular function for ZNF346 Gene

UniProtKB/Swiss-Prot Function:
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.

Gene Ontology (GO) - Molecular Function for ZNF346 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0005515 protein binding IEA,IPI 21903422
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF346: view
genes like me logo Genes that share phenotypes with ZNF346: view

Animal Models for ZNF346 Gene

MGI Knock Outs for ZNF346:

Animal Model Products

CRISPR Products

miRNA for ZNF346 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF346 Gene

Localization for ZNF346 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF346 Gene

Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.

Subcellular locations from

Jensen Localization Image for ZNF346 Gene COMPARTMENTS Subcellular localization image for ZNF346 gene
Compartment Confidence
nucleus 5
cytosol 2
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF346 Gene

Pathways & Interactions for ZNF346 Gene

SuperPathways for ZNF346 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF346 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF346 Gene

Drugs & Compounds for ZNF346 Gene

(1) Drugs for ZNF346 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2102
genes like me logo Genes that share compounds with ZNF346: view

Transcripts for ZNF346 Gene

Unigene Clusters for ZNF346 Gene

Zinc finger protein 346:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF346 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - - - -

ExUns: 11c · 11d · 11e · 11f ^ 12a · 12b
SP6: - - - -
SP10: - - - -

Relevant External Links for ZNF346 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF346 Gene

mRNA expression in normal human tissues for ZNF346 Gene

Protein differential expression in normal tissues from HIPED for ZNF346 Gene

This gene is overexpressed in Lung (37.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF346 Gene

SOURCE GeneReport for Unigene cluster for ZNF346 Gene Hs.484259

genes like me logo Genes that share expression patterns with ZNF346: view

Protein tissue co-expression partners for ZNF346 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF346 Gene

Orthologs for ZNF346 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF346 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF346 35
  • 92.38 (n)
  • 92.15 (a)
ZNF346 36
  • 87 (a)
(Canis familiaris)
Mammalia ZNF346 35
  • 92.63 (n)
  • 92.86 (a)
ZNF346 36
  • 88 (a)
(Mus musculus)
Mammalia Zfp346 35
  • 88.1 (n)
  • 84.01 (a)
Zfp346 16
Zfp346 36
  • 84 (a)
(Pan troglodytes)
Mammalia ZNF346 35
  • 99.55 (n)
  • 98.64 (a)
ZNF346 36
  • 91 (a)
(Rattus norvegicus)
Mammalia Zfp346 35
  • 85.21 (n)
  • 81.91 (a)
(Monodelphis domestica)
Mammalia ZNF346 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF346 36
  • 55 (a)
(Gallus gallus)
Aves ZNF346 35
  • 73.25 (n)
  • 68.49 (a)
ZNF346 36
  • 43 (a)
(Anolis carolinensis)
Reptilia ZNF346 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8765 35
znf346 35
  • 62.62 (n)
  • 61.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia jaz-prov 35
(Danio rerio)
Actinopterygii -- 35
LOC100538272 35
  • 61.43 (n)
  • 58.57 (a)
CU914629.1 36
  • 46 (a)
znf346 36
  • 41 (a)
Species with no ortholog for ZNF346:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF346 Gene

Gene Tree for ZNF346 (if available)
Gene Tree for ZNF346 (if available)

Paralogs for ZNF346 Gene

Paralogs for ZNF346 Gene

(1) SIMAP similar genes for ZNF346 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF346: view

Variants for ZNF346 Gene

Sequence variations from dbSNP and Humsavar for ZNF346 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs149307 -- 177,044,590(-) TGGCA(A/G)TAGTG intron-variant
rs166138 -- 177,045,338(+) CAAAG(A/G)TAGGG intron-variant
rs168488 -- 177,030,929(-) aaaaa(A/C)ccaaa intron-variant
rs168489 -- 177,065,882(-) ACACA(A/C)ACACA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs173301 -- 177,075,027(-) gtgca(C/G)tggcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF346 Gene

Variant ID Type Subtype PubMed ID
dgv363n21 CNV Gain 19592680
nsv509101 CNV Insertion 20534489
esv995054 CNV Deletion 20482838

Variation tolerance for ZNF346 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF346 Gene

Disorders for ZNF346 Gene

Relevant External Links for ZNF346

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF346 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF346 Gene

Publications for ZNF346 Gene

  1. JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. (PMID: 10488071) Yang M. … Ito T. (J. Biol. Chem. 1999) 2 3 4 67
  2. Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer. (PMID: 19828471) Kijanka G. … Kenny D. (Gut 2010) 3 23
  3. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PMID: 15254228) Chen T. … Macara I.G. (Mol. Cell. Biol. 2004) 3 23
  4. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. (PMID: 25875936) O'Reilly J.A. … Kijanka G.S. (PLoS ONE 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ZNF346 Gene

Sources for ZNF346 Gene