Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF346 Gene

Aliases for ZNF346 Gene

  • Zinc Finger Protein 346 2 3
  • Just Another Zinc Finger Protein 3 4
  • JAZ 3 4
  • Double-Stranded RNA-Binding Zinc Finger Protein JAZ 3
  • Zfp346 3

External Ids for ZNF346 Gene

Previous GeneCards Identifiers for ZNF346 Gene

  • GC05P176431
  • GC05P176382
  • GC05P171371
  • GC05P176451

Summaries for ZNF346 Gene

Entrez Gene Summary for ZNF346 Gene

  • The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF346 Gene

ZNF346 (Zinc Finger Protein 346) is a Protein Coding gene. GO annotations related to this gene include double-stranded RNA binding. An important paralog of this gene is KRCC1.

UniProtKB/Swiss-Prot for ZNF346 Gene

  • Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.

Gene Wiki entry for ZNF346 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF346 Gene

Genomics for ZNF346 Gene

Regulatory Elements for ZNF346 Gene

Genomic Location for ZNF346 Gene

Start:
177,022,680 bp from pter
End:
177,081,189 bp from pter
Size:
58,510 bases
Orientation:
Plus strand

Genomic View for ZNF346 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF346 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF346 Gene

Proteins for ZNF346 Gene

  • Protein details for ZNF346 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL40-ZN346_HUMAN
    Recommended name:
    Zinc finger protein 346
    Protein Accession:
    Q9UL40
    Secondary Accessions:
    • B7Z367
    • Q68CV9
    • Q6ZMW1

    Protein attributes for ZNF346 Gene

    Size:
    294 amino acids
    Molecular mass:
    32933 Da
    Quaternary structure:
    • Forms a heteromeric complex with XPO5 and ILF3. Found in a nuclear export complex with XPO5, RAN, ILF3, ZNF346 and double-stranded RNA. Interacts with XPO5. Interacts with ILF3 in an RNA-independent manner.

    Three dimensional structures from OCA and Proteopedia for ZNF346 Gene

    Alternative splice isoforms for ZNF346 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF346 Gene

Proteomics data for ZNF346 Gene at MOPED

Post-translational modifications for ZNF346 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF346 Gene

Domains for ZNF346 Gene

Protein Domains for ZNF346 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UL40

UniProtKB/Swiss-Prot:

ZN346_HUMAN :
  • Q9UL40
Domain:
  • The zinc-finger domains are required for binding to dsRNA, and also for nuclear localization.
Similarity:
  • Contains 4 matrin-type zinc fingers.
genes like me logo Genes that share domains with ZNF346: view

No data available for Gene Families for ZNF346 Gene

Function for ZNF346 Gene

Molecular function for ZNF346 Gene

UniProtKB/Swiss-Prot Function: Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity.

Gene Ontology (GO) - Molecular Function for ZNF346 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003725 double-stranded RNA binding IDA 10488071
GO:0005515 protein binding IPI 21903422
GO:0008270 zinc ion binding IEA --
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with ZNF346: view

Phenotypes for ZNF346 Gene

GenomeRNAi human phenotypes for ZNF346:
genes like me logo Genes that share phenotypes with ZNF346: view

Animal Model Products

CRISPR Products

miRNA for ZNF346 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF346 Gene

Localization for ZNF346 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF346 Gene

Nucleus, nucleolus. Cytoplasm. Note=Nuclear at steady state, primarily in the nucleolus. Shuttles between the nucleus and cytoplasm when associated with XPO5.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF346 Gene COMPARTMENTS Subcellular localization image for ZNF346 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF346 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF346: view

Pathways for ZNF346 Gene

SuperPathways for ZNF346 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF346 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with ZNF346: view

No data available for Pathways by source for ZNF346 Gene

Compounds for ZNF346 Gene

(1) HMDB Compounds for ZNF346 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6
genes like me logo Genes that share compounds with ZNF346: view

Transcripts for ZNF346 Gene

Unigene Clusters for ZNF346 Gene

Zinc finger protein 346:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF346

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF346 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - -
SP10: - - - - - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - - - -
SP15:
SP16:
SP17:
SP18:

ExUns: 11c · 11d · 11e · 11f ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for ZNF346 Gene

GeneLoc Exon Structure for
ZNF346
ECgene alternative splicing isoforms for
ZNF346

Expression for ZNF346 Gene

mRNA expression in normal human tissues for ZNF346 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF346 Gene

SOURCE GeneReport for Unigene cluster for ZNF346 Gene Hs.484259

genes like me logo Genes that share expressions with ZNF346: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF346 Gene

Orthologs for ZNF346 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF346 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF346 35
  • 99.55 (n)
  • 98.64 (a)
ZNF346 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF346 35
  • 92.38 (n)
  • 92.15 (a)
ZNF346 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF346 35
  • 92.63 (n)
  • 92.86 (a)
ZNF346 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp346 35
  • 88.1 (n)
  • 84.01 (a)
Zfp346 16
Zfp346 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF346 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF346 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp346 35
  • 85.21 (n)
  • 81.91 (a)
chicken
(Gallus gallus)
Aves ZNF346 35
  • 73.25 (n)
  • 68.49 (a)
ZNF346 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF346 36
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia jaz-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8765 35
znf346 35
  • 62.62 (n)
  • 61.68 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
CU914629.1 36
  • 46 (a)
OneToMany
LOC100538272 35
  • 61.43 (n)
  • 58.57 (a)
znf346 36
  • 41 (a)
OneToMany
Species with no ortholog for ZNF346:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF346 Gene

ENSEMBL:
Gene Tree for ZNF346 (if available)
TreeFam:
Gene Tree for ZNF346 (if available)

Paralogs for ZNF346 Gene

Paralogs for ZNF346 Gene

Selected SIMAP similar genes for ZNF346 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF346: view

Variants for ZNF346 Gene

Sequence variations from dbSNP and Humsavar for ZNF346 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs149307 -- 177,044,590(-) TGGCA(A/G)TAGTG intron-variant
rs166138 -- 177,045,338(+) CAAAG(A/G)TAGGG intron-variant
rs168488 -- 177,030,929(-) aaaaa(A/C)ccaaa intron-variant
rs168489 -- 177,065,882(-) ACACA(A/C)ACACA utr-variant-3-prime, nc-transcript-variant
rs183686 -- 177,067,101(-) acacc(C/T)ggcta downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF346 Gene

Variant ID Type Subtype PubMed ID
dgv363n21 CNV Gain 19592680
nsv509101 CNV Insertion 20534489
esv995054 CNV Deletion 20482838

Relevant External Links for ZNF346 Gene

HapMap Linkage Disequilibrium report
ZNF346

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF346 Gene

Disorders for ZNF346 Gene

(1) University of Copenhagen DISEASES for ZNF346 Gene

genes like me logo Genes that share disorders with ZNF346: view

No data available for UniProtKB/Swiss-Prot for ZNF346 Gene

Publications for ZNF346 Gene

  1. JAZ requires the double-stranded RNA-binding zinc finger motifs for nuclear localization. (PMID: 10488071) Yang M. … Ito T. (J. Biol. Chem. 1999) 2 3 4
  2. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin- 5. (PMID: 15254228) Chen T. … Macara I.G. (Mol. Cell. Biol. 2004) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3

Products for ZNF346 Gene

Sources for ZNF346 Gene

Back to Top

Content