External Ids for FOSL2 Gene
Previous GeneCards Identifiers for FOSL2 Gene
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
GeneCards Summary for FOSL2 Gene
FOSL2 (FOS-Like Antigen 2) is a Protein Coding gene. Diseases associated with FOSL2 include breast cancer. Among its related pathways are ERK Signaling and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOSL1.
UniProtKB/Swiss-Prot for FOSL2 Gene
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.