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Aliases for FOSL2 Gene

Aliases for FOSL2 Gene

  • FOS Like 2, AP-1 Transcription Factor Subunit 2 3 5
  • FOS Like Antigen 2 2 3
  • FRA-2 3 4
  • FRA2 3 4
  • FOS Like 2, AP-1 Trancription Factor Subunit 3
  • Fos-Related Antigen 2 3

External Ids for FOSL2 Gene

Previous GeneCards Identifiers for FOSL2 Gene

  • GC02P028537
  • GC02P028708
  • GC02P028590
  • GC02P028527
  • GC02P028615
  • GC02P028356

Summaries for FOSL2 Gene

Entrez Gene Summary for FOSL2 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL2 Gene

FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Among its related pathways are SMAD Signaling Network and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOS.

UniProtKB/Swiss-Prot for FOSL2 Gene

  • Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.

Gene Wiki entry for FOSL2 Gene

Additional gene information for FOSL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOSL2 Gene

Genomics for FOSL2 Gene

Regulatory Elements for FOSL2 Gene

Enhancers for FOSL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H028358 2 FANTOM5 Ensembl ENCODE dbSUPER 41.2 -32.1 -32094 3 PKNOX1 FOXA2 ARID4B ZNF766 ZNF143 FOS JUNB SMARCB1 ZNF592 SREBF1 FOSL2 EIF2B4 LOC100505716 FLJ31356 TRMT61B WDR43 GPN1 RBKS SUPT7L ZNF512
GH02H027953 1.8 FANTOM5 Ensembl ENCODE dbSUPER 32.8 -435.2 -435216 8 PKNOX1 MLX SIN3A YY1 FOS RUNX3 REST PPARG NFIL3 SSRP1 FOSL2 RBKS FLJ31356 FNDC4 C2orf16 CGREF1 LINC01460 BABAM2 GCKR LOC100422227
GH02H028404 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.3 +16.0 16029 7 ELF3 FOXA2 ARID4B KLF17 RAD21 RARA YY1 EGR2 SMARCA5 USF2 FOSL2 LOC102723530 PLB1 SNRPGP7 ENSG00000270210 PPP1CB ENSG00000270640
GH02H028445 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +55.4 55425 5 PKNOX1 ATF1 GLIS2 ELK1 ATF7 FOS RUNX3 SP3 JUNB TSHZ1 FOSL2 ENSG00000270210 PPP1CB LOC102723530
GH02H028273 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.2 -116.8 -116801 3 PKNOX1 ATF1 GLIS2 FOS RUNX3 JUNB TSHZ1 ZNF518A MAFF SMARCA4 FOSL2 LOC100505716 RBKS LOC100505774 PPP1CB RPL23AP34 LOC100505736
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FOSL2 on UCSC Golden Path with GeneCards custom track

Promoters for FOSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000114594 1952 5601 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for FOSL2 Gene

Chromosome:
2
Start:
28,392,448 bp from pter
End:
28,417,312 bp from pter
Size:
24,865 bases
Orientation:
Plus strand

Genomic View for FOSL2 Gene

Genes around FOSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL2 Gene

Proteins for FOSL2 Gene

  • Protein details for FOSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15408-FOSL2_HUMAN
    Recommended name:
    Fos-related antigen 2
    Protein Accession:
    P15408
    Secondary Accessions:
    • B2RD58
    • B3KP27
    • B4DYV4
    • Q6FG46

    Protein attributes for FOSL2 Gene

    Size:
    326 amino acids
    Molecular mass:
    35193 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL2 Gene

Post-translational modifications for FOSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOSL2 Gene

No data available for DME Specific Peptides for FOSL2 Gene

Domains & Families for FOSL2 Gene

Gene Families for FOSL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOSL2 Gene

Suggested Antigen Peptide Sequences for FOSL2 Gene

Graphical View of Domain Structure for InterPro Entry

P15408

UniProtKB/Swiss-Prot:

FOSL2_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL2: view

Function for FOSL2 Gene

Molecular function for FOSL2 Gene

GENATLAS Biochemistry:
fos-related antigen 2
UniProtKB/Swiss-Prot Function:
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.

Phenotypes From GWAS Catalog for FOSL2 Gene

Gene Ontology (GO) - Molecular Function for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 13679379
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 13679379
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 8954781
genes like me logo Genes that share ontologies with FOSL2: view
genes like me logo Genes that share phenotypes with FOSL2: view

Animal Models for FOSL2 Gene

MGI Knock Outs for FOSL2:

Animal Model Products

CRISPR Products

miRNA for FOSL2 Gene

miRTarBase miRNAs that target FOSL2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FOSL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOSL2 Gene

Localization for FOSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOSL2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8954781
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FOSL2: view

Pathways & Interactions for FOSL2 Gene

genes like me logo Genes that share pathways with FOSL2: view

Gene Ontology (GO) - Biological Process for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,TAS 8954781
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FOSL2: view

No data available for SIGNOR curated interactions for FOSL2 Gene

Drugs & Compounds for FOSL2 Gene

(3) Drugs for FOSL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FOSL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSL2: view

Transcripts for FOSL2 Gene

Unigene Clusters for FOSL2 Gene

FOS-like antigen 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FOSL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - -

Relevant External Links for FOSL2 Gene

GeneLoc Exon Structure for
FOSL2
ECgene alternative splicing isoforms for
FOSL2

Expression for FOSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOSL2 Gene

This gene is overexpressed in Adrenal (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOSL2 Gene



Protein tissue co-expression partners for FOSL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOSL2 Gene:

FOSL2

SOURCE GeneReport for Unigene cluster for FOSL2 Gene:

Hs.220971

Evidence on tissue expression from TISSUES for FOSL2 Gene

  • Lung(4.5)
  • Heart(4.4)
  • Eye(4.1)
  • Nervous system(3.2)
  • Adrenal gland(2.7)
  • Skin(2.5)
  • Bone marrow(2.2)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FOSL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSL2 Gene

Orthologs for FOSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOSL2 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia FOSL2 33 34
  • 92.72 (n)
cow
(Bos Taurus)
Mammalia FOSL2 33 34
  • 92.23 (n)
mouse
(Mus musculus)
Mammalia Fosl2 33 16 34
  • 89.74 (n)
rat
(Rattus norvegicus)
Mammalia Fosl2 33
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia FOSL2 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOSL2 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOSL2 33 34
  • 80.02 (n)
lizard
(Anolis carolinensis)
Reptilia FOSL2 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fosl2 33
  • 73.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia gene 33
zebrafish
(Danio rerio)
Actinopterygii fosl2 33 34
  • 67.5 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6126 33
fruit fly
(Drosophila melanogaster)
Insecta kay 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
OneToMany
Species where no ortholog for FOSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSL2 Gene

ENSEMBL:
Gene Tree for FOSL2 (if available)
TreeFam:
Gene Tree for FOSL2 (if available)

Paralogs for FOSL2 Gene

Paralogs for FOSL2 Gene

(6) SIMAP similar genes for FOSL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOSL2: view

Variants for FOSL2 Gene

Sequence variations from dbSNP and Humsavar for FOSL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000056026 -- 28,414,267(+) AGACA(A/C)ACAGA utr-variant-3-prime
rs1000212971 -- 28,403,096(+) CCTGG(G/T)TTCCA intron-variant
rs1000395338 -- 28,397,007(+) TTCCA(C/G)TCCCA intron-variant
rs1000414547 -- 28,403,395(+) TGCCT(A/G)TGTAG intron-variant
rs1000475229 -- 28,412,539(+) CGTGA(A/G)GGCAA downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOSL2 Gene

Variant ID Type Subtype PubMed ID
nsv1006830 CNV gain 25217958
nsv828664 CNV gain 20364138

Variation tolerance for FOSL2 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL2 Gene

Disorders for FOSL2 Gene

Relevant External Links for FOSL2

Genetic Association Database (GAD)
FOSL2
Human Genome Epidemiology (HuGE) Navigator
FOSL2
Tumor Gene Database (TGDB):
FOSL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOSL2

No disorders were found for FOSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOSL2 Gene

Publications for FOSL2 Gene

  1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M … Ishizaki R (Oncogene 1990) 3 4 22 60
  2. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield JP … Hakonarson H (PLoS genetics 2011) 3 45 60
  3. The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. (PMID: 20039427) Reich N … Distler JH (Arthritis and rheumatism 2010) 3 22 60
  4. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. (PMID: 19933934) Maurer B … Distler O (Circulation 2009) 3 22 60
  5. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 45 60

Products for FOSL2 Gene

Sources for FOSL2 Gene

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