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Aliases for DNPEP Gene

Aliases for DNPEP Gene

  • Aspartyl Aminopeptidase 2 3
  • ASPEP 3 4 6
  • DAP 3 4 6
  • EC 4 63

External Ids for DNPEP Gene

Previous GeneCards Identifiers for DNPEP Gene

  • GC02M218261
  • GC02M218959
  • GC02M220201
  • GC02M220440
  • GC02M220063
  • GC02M219946
  • GC02M220238
  • GC02M212091

Summaries for DNPEP Gene

Entrez Gene Summary for DNPEP Gene

  • The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNPEP Gene

DNPEP (Aspartyl Aminopeptidase) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity.

UniProtKB/Swiss-Prot for DNPEP Gene

  • Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Gene Wiki entry for DNPEP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNPEP Gene

Genomics for DNPEP Gene

Regulatory Elements for DNPEP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNPEP Gene

219,373,458 bp from pter
219,400,022 bp from pter
26,565 bases
Minus strand

Genomic View for DNPEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNPEP Gene

Proteins for DNPEP Gene

  • Protein details for DNPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aspartyl aminopeptidase
    Protein Accession:
    Secondary Accessions:
    • Q9BW44
    • Q9NUV5

    Protein attributes for DNPEP Gene

    475 amino acids
    Molecular mass:
    52428 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Tetrahedron-shaped homododecamer built from six homodimers.
    • Sequence=BAA92014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNPEP Gene

neXtProt entry for DNPEP Gene

Proteomics data for DNPEP Gene at MOPED

Post-translational modifications for DNPEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DNPEP Gene

Gene Families for DNPEP Gene

Protein Domains for DNPEP Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9ULA0
  • Belongs to the peptidase M18 family.
genes like me logo Genes that share domains with DNPEP: view

Function for DNPEP Gene

Molecular function for DNPEP Gene

UniProtKB/Swiss-Prot CatalyticActivity: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
UniProtKB/Swiss-Prot EnzymeRegulation: One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity.
UniProtKB/Swiss-Prot Function: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Enzyme Numbers (IUBMB) for DNPEP Gene

Gene Ontology (GO) - Molecular Function for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DNPEP: view

Phenotypes for DNPEP Gene

GenomeRNAi human phenotypes for DNPEP:
genes like me logo Genes that share phenotypes with DNPEP: view

Animal Model Products

CRISPR Products

miRNA for DNPEP Gene

miRTarBase miRNAs that target DNPEP

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DNPEP Gene

Localization for DNPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNPEP Gene


Subcellular locations from

Jensen Localization Image for DNPEP Gene COMPARTMENTS Subcellular localization image for DNPEP gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with DNPEP: view

Pathways for DNPEP Gene

genes like me logo Genes that share pathways with DNPEP: view

Pathways by source for DNPEP Gene

1 Cell Signaling Technology pathway for DNPEP Gene
1 BioSystems pathway for DNPEP Gene

Gene Ontology (GO) - Biological Process for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process TAS 9632644
genes like me logo Genes that share ontologies with DNPEP: view

Compounds for DNPEP Gene

(1) HMDB Compounds for DNPEP Gene

Compound Synonyms Cas Number PubMed IDs
L-Glutamic acid
  • (2S)-2-Aminopentanedioate

(1) Drugbank Compounds for DNPEP Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Glutamic Acid
  • (2S)-2-Aminopentanedioic acid
56-86-0 target
genes like me logo Genes that share compounds with DNPEP: view

Transcripts for DNPEP Gene

Unigene Clusters for DNPEP Gene

Aspartyl aminopeptidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNPEP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNPEP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP11: -

ExUns: 15b ^ 16a · 16b · 16c ^ 17a · 17b

Relevant External Links for DNPEP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNPEP Gene

mRNA expression in normal human tissues for DNPEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNPEP Gene

SOURCE GeneReport for Unigene cluster for DNPEP Gene Hs.258551

mRNA Expression by UniProt/SwissProt for DNPEP Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with DNPEP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DNPEP Gene

Orthologs for DNPEP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNPEP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNPEP 35
  • 99.09 (n)
  • 98.53 (a)
  • 99 (a)
(Bos Taurus)
Mammalia DNPEP 35
  • 89.53 (n)
  • 92.14 (a)
  • 92 (a)
(Canis familiaris)
Mammalia DNPEP 35
  • 89.59 (n)
  • 92.03 (a)
  • 92 (a)
(Mus musculus)
Mammalia Dnpep 35
  • 86.46 (n)
  • 89.89 (a)
Dnpep 16
Dnpep 36
  • 90 (a)
(Monodelphis domestica)
Mammalia DNPEP 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Dnpep 35
  • 86.53 (n)
  • 90.11 (a)
(Gallus gallus)
Aves DNPEP 35
  • 74.8 (n)
  • 78.37 (a)
  • 77 (a)
(Anolis carolinensis)
Reptilia DNPEP 36
  • 61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20819 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dnpep 35
  • 70.24 (n)
  • 72.53 (a)
Str.2142 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10876 35
(Danio rerio)
Actinopterygii dnpep 35
  • 68.03 (n)
  • 70.54 (a)
dnpep 36
  • 69 (a)
zgc55944 35
(Caenorhabditis elegans)
Secernentea dnpp-1 35
  • 55.51 (n)
  • 52.11 (a)
dnpp-1 36
  • 49 (a)
F01F1.9 37
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APE4 35
  • 49.41 (n)
  • 47.14 (a)
APE4 36
  • 43 (a)
APE4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21297g 35
  • 51.1 (n)
  • 47.14 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1803 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60160 35
  • 54.24 (n)
  • 52.63 (a)
(Hordeum vulgare)
Liliopsida Hv.1571 35
(Oryza sativa)
Liliopsida Os.16710 35
Os12g0236500 35
  • 54.57 (n)
  • 51.84 (a)
(Triticum aestivum)
Liliopsida Ta.7128 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00122 35
  • 57.52 (n)
  • 52.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes aap1 35
  • 49.56 (n)
  • 49.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10534 36
  • 54 (a)
Species with no ortholog for DNPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNPEP Gene

Gene Tree for DNPEP (if available)
Gene Tree for DNPEP (if available)

Paralogs for DNPEP Gene

No data available for Paralogs for DNPEP Gene

Variants for DNPEP Gene

Sequence variations from dbSNP and Humsavar for DNPEP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs878437 -- 219,385,600(-) AGGGC(G/T)GCAGA intron-variant
rs907679 -- 219,385,425(+) TCACC(A/G)CAGGC reference, missense
rs1040009 -- 219,386,486(+) ATAAG(C/T)AACAG intron-variant
rs1132736 -- 219,386,078(-) CGGCT(A/G)GAGCA synonymous-codon, reference
rs1235397 -- 219,377,333(+) cttta(A/G)aaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNPEP Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv483018 CNV Gain 15286789

Relevant External Links for DNPEP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNPEP Gene

Disorders for DNPEP Gene

No disorders were found for DNPEP Gene.

No data available for UniProtKB/Swiss-Prot for DNPEP Gene

Publications for DNPEP Gene

  1. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. (PMID: 9632644) Wilk S. … Magnusson R.P. (J. Biol. Chem. 1998) 2 3 4 23
  2. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase. (PMID: 12413488) Wilk S. … Magnusson R.P. (Arch. Biochem. Biophys. 2002) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. (PMID: 22720794) Chaikuad A. … Yue W.W. (BMC Struct. Biol. 2012) 3 4

Products for DNPEP Gene

  • Addgene plasmids for DNPEP

Sources for DNPEP Gene

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