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Aliases for PIK3R5 Gene

Aliases for PIK3R5 Gene

  • Phosphoinositide-3-Kinase Regulatory Subunit 5 2 3 5
  • Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Regulatory Subunit 3 4
  • Phosphoinositide-3-Kinase, Regulatory Subunit 5 2 3
  • PI3-Kinase P101 Subunit 3 4
  • PtdIns-3-Kinase P101 3 4
  • Protein FOAP-2 3 4
  • P101-PI3K 3 4
  • Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Regulatory Subunit 3
  • PtdIns-3-Kinase Regulatory Subunit 4
  • PI3-Kinase Regulatory Subunit 5 4
  • F730038I15Rik 3
  • FOAP-2 3
  • P101 3

External Ids for PIK3R5 Gene

Previous GeneCards Identifiers for PIK3R5 Gene

  • GC17M008724

Summaries for PIK3R5 Gene

Entrez Gene Summary for PIK3R5 Gene

  • Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

GeneCards Summary for PIK3R5 Gene

PIK3R5 (Phosphoinositide-3-Kinase Regulatory Subunit 5) is a Protein Coding gene. Diseases associated with PIK3R5 include ataxia-oculomotor apraxia 3 and spinocerebellar ataxia, autosomal recessive 1. Among its related pathways are Endometrial cancer and cGMP-PKG signaling pathway. GO annotations related to this gene include G-protein beta/gamma-subunit complex binding and 1-phosphatidylinositol-3-kinase regulator activity. An important paralog of this gene is PIK3R6.

UniProtKB/Swiss-Prot for PIK3R5 Gene

  • Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).

Tocris Summary for PIK3R5 Gene

  • PI 3-Kinases (phosphoinositide 3-kinases, PI 3-Ks) are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival.

Gene Wiki entry for PIK3R5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R5 Gene

Genomics for PIK3R5 Gene

Regulatory Elements for PIK3R5 Gene

Enhancers for PIK3R5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIK3R5 on UCSC Golden Path with GeneCards custom track

Promoters for PIK3R5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIK3R5 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIK3R5 Gene

Chromosome:
17
Start:
8,878,911 bp from pter
End:
8,965,712 bp from pter
Size:
86,802 bases
Orientation:
Minus strand

Genomic View for PIK3R5 Gene

Genes around PIK3R5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3R5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3R5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R5 Gene

Proteins for PIK3R5 Gene

  • Protein details for PIK3R5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYR1-PI3R5_HUMAN
    Recommended name:
    Phosphoinositide 3-kinase regulatory subunit 5
    Protein Accession:
    Q8WYR1
    Secondary Accessions:
    • B0LPH4
    • D3DTS3
    • Q5G936
    • Q5G938
    • Q5G939
    • Q8IZ23
    • Q9Y2Y2

    Protein attributes for PIK3R5 Gene

    Size:
    880 amino acids
    Molecular mass:
    97348 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with beta-gamma G protein dimers.

    Alternative splice isoforms for PIK3R5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIK3R5 Gene

Proteomics data for PIK3R5 Gene at MOPED

Post-translational modifications for PIK3R5 Gene

  • Ubiquitination at Lys 429
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIK3R5 (PIK3R5)

No data available for DME Specific Peptides for PIK3R5 Gene

Domains & Families for PIK3R5 Gene

Protein Domains for PIK3R5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIK3R5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYR1

UniProtKB/Swiss-Prot:

PI3R5_HUMAN :
  • The heterodimerization region allows the binding to the catalytic subunit.
Domain:
  • The heterodimerization region allows the binding to the catalytic subunit.
genes like me logo Genes that share domains with PIK3R5: view

No data available for Gene Families for PIK3R5 Gene

Function for PIK3R5 Gene

Molecular function for PIK3R5 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Greatly activated by G gamma proteins.
UniProtKB/Swiss-Prot Function:
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity).
genes like me logo Genes that share phenotypes with PIK3R5: view

Human Phenotype Ontology for PIK3R5 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PIK3R5 Gene

MGI Knock Outs for PIK3R5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for PIK3R5 Gene

Localization for PIK3R5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3R5 Gene

Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250 UniProtKB:O02696}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIK3R5 Gene COMPARTMENTS Subcellular localization image for PIK3R5 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for PIK3R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005942 phosphatidylinositol 3-kinase complex IEA --
genes like me logo Genes that share ontologies with PIK3R5: view

Pathways & Interactions for PIK3R5 Gene

genes like me logo Genes that share pathways with PIK3R5: view

Gene Ontology (GO) - Biological Process for PIK3R5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
GO:0043406 positive regulation of MAP kinase activity ISS --
GO:0046854 phosphatidylinositol phosphorylation TAS --
genes like me logo Genes that share ontologies with PIK3R5: view

No data available for SIGNOR curated interactions for PIK3R5 Gene

Drugs & Compounds for PIK3R5 Gene

(34) Drugs for PIK3R5 Gene - From: ApexBio, DGIdb, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Quercetin Experimental Nutra Antitumor agent, Non-selective PI 3-kinase inhibitor 36
XL147 Investigational Pharma inhibitor PI3K inhibitor,selective and reversible, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0
GSK2636771 Pharma inhibitor PIK3 inhibitor, Kinase Inhibitors 0
Wortmannin Pharma PI3K inhibitor,selective and irreversible, Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 0

(2) Additional Compounds for PIK3R5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LY 294002 hydrochloride
934389-88-5
LY 303511
154447-38-8

(5) Tocris Compounds for PIK3R5 Gene

Compound Action Cas Number
740 Y-P Cell-permeable PI 3-kinase activator 1236188-16-1
LY 294002 hydrochloride Prototypical PI 3-kinase inhibitor; also inhibits other kinases 934389-88-5
LY 303511 Negative control of LY 294002 (Cat. No. 1130) 154447-38-8
Quercetin Non-selective PI 3-kinase inhibitor 117-39-5
Wortmannin Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1 19545-26-7

(13) ApexBio Compounds for PIK3R5 Gene

Compound Action Cas Number
A66 P110α inhibitor 1166227-08-2
AS-605240 Potent and selective PI 3-Kγ inhibitor 648450-29-7
BEZ235 Tosylate MTOR/P13K inhibitor 1028385-32-1
GSK2636771 PIK3 inhibitor 1372540-25-4
HS-173 1276110-06-5
IC-87114 PI3Kδ inhibitor 371242-69-2
IPI-145 (INK1197) PI3K-δ/PI3K-γ inhibitor 1201438-56-3
PI-3065 P110δkinase inhibitor 955977-50-1
SAR245409 (XL765) mTOR/PI3K inhibitor 1349796-36-6
TG100-115 PI3Kγ/PI3Kδ inhibitor 677297-51-7
TG100713 925705-73-3
Wortmannin PI3K inhibitor,selective and irreversible 19545-26-7
XL147 PI3K inhibitor,selective and reversible 956958-53-5
genes like me logo Genes that share compounds with PIK3R5: view

Transcripts for PIK3R5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5: -
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for PIK3R5 Gene

GeneLoc Exon Structure for
PIK3R5
ECgene alternative splicing isoforms for
PIK3R5

Expression for PIK3R5 Gene

mRNA expression in normal human tissues for PIK3R5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIK3R5 Gene

This gene is overexpressed in Whole Blood (x22.8) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for PIK3R5 Gene

This gene is overexpressed in Heart (45.3) and CD8 Tcells (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIK3R5 Gene



SOURCE GeneReport for Unigene cluster for PIK3R5 Gene Hs.278901

mRNA Expression by UniProt/SwissProt for PIK3R5 Gene

Q8WYR1-PI3R5_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
genes like me logo Genes that share expression patterns with PIK3R5: view

Protein tissue co-expression partners for PIK3R5 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PIK3R5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIK3R5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIK3R5 35
  • 87.1 (n)
  • 88.67 (a)
PIK3R5 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIK3R5 35
  • 88.52 (n)
  • 91.53 (a)
PIK3R5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pik3r5 35
  • 84.69 (n)
  • 86.68 (a)
Pik3r5 16
Pik3r5 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIK3R5 35
  • 99.36 (n)
  • 99.66 (a)
PIK3R5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pik3r5 35
  • 84.75 (n)
  • 86.81 (a)
oppossum
(Monodelphis domestica)
Mammalia PIK3R5 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIK3R5 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIK3R5 35
  • 68 (n)
  • 65.33 (a)
-- 36
  • 60 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
PIK3R5 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PIK3R5 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r5 35
  • 60.9 (n)
  • 53.92 (a)
Str.19584 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2361 35
zebrafish
(Danio rerio)
Actinopterygii pik3r5 35
  • 53.76 (n)
  • 49.17 (a)
pik3r5 36
  • 45 (a)
OneToOne
Species with no ortholog for PIK3R5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIK3R5 Gene

ENSEMBL:
Gene Tree for PIK3R5 (if available)
TreeFam:
Gene Tree for PIK3R5 (if available)

Paralogs for PIK3R5 Gene

Paralogs for PIK3R5 Gene

genes like me logo Genes that share paralogs with PIK3R5: view

Variants for PIK3R5 Gene

Sequence variations from dbSNP and Humsavar for PIK3R5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_036227 A colorectal cancer sample
rs61761068 Ataxia-oculomotor apraxia 3 (AOA3) 8,887,116(-) ACCTG(C/T)CCCCT reference, missense
rs14681 -- 8,879,094(+) GAGAC(G/T)GCCAG utr-variant-3-prime
rs25598 -- 8,882,879(+) CCTAA(-/TTTCT)CTTCT intron-variant
rs92535 -- 8,905,758(-) CATTC(C/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R5 Gene

Variant ID Type Subtype PubMed ID
nsv1970 CNV Loss 18451855
nsv510696 CNV Loss 20534489
esv2715621 CNV Deletion 23290073
esv2282824 CNV Deletion 18987734
esv2715622 CNV Deletion 23290073
esv2715623 CNV Deletion 23290073
nsv827881 CNV Loss 20364138
esv259863 OTHER Complex 20981092
nsv833354 CNV Loss 17160897
esv2658276 CNV Deletion 23128226

Variation tolerance for PIK3R5 Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3R5 Gene

HapMap Linkage Disequilibrium report
PIK3R5
Human Gene Mutation Database (HGMD)
PIK3R5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R5 Gene

Disorders for PIK3R5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PIK3R5 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ataxia-oculomotor apraxia 3
  • aoa3
spinocerebellar ataxia, autosomal recessive 1
  • ataxia with oculomotor apraxia type 2
apraxia
  • dyspraxia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PI3R5_HUMAN
  • Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. {ECO:0000269 PubMed:22065524}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for PIK3R5

Genetic Association Database (GAD)
PIK3R5
Human Genome Epidemiology (HuGE) Navigator
PIK3R5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3R5
genes like me logo Genes that share disorders with PIK3R5: view

No data available for Genatlas for PIK3R5 Gene

Publications for PIK3R5 Gene

  1. A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia. (PMID: 22065524) Tassan N.A. … Bohlega S. (Hum. Mutat. 2012) 3 4 67
  2. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. (PMID: 12507995) Brock C. … NA1rnberg B. (J. Cell Biol. 2003) 2 3
  3. Different inhibition of GI^I^-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a GI^I^-dependent regulator of PI3KI^ enzymatic activity. (PMID: 26173259) Shymanets A. … NA1rnberg B. (Biochem. J. 2015) 3
  4. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. (PMID: 25241761) Chen T.C. … Huang C.Y. (J. Proteome Res. 2014) 3
  5. Screening of differential promoter hypermethylated genes in primary oral squamous cell carcinoma. (PMID: 25374236) Khor G.H. … Thong K.L. (Asian Pac. J. Cancer Prev. 2014) 3

Products for PIK3R5 Gene

Sources for PIK3R5 Gene

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