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Aliases for FOS Gene

Aliases for FOS Gene

  • FBJ Murine Osteosarcoma Viral Oncogene Homolog 2 3
  • G0/G1 Switch Regulatory Protein 7 3 4
  • FBJ Murine Osteosarcoma Viral (V-Fos) Oncogene Homolog (Oncogene FOS) 3
  • V-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog 2
  • Cellular Oncogene C-Fos 3
  • Cellular Oncogene Fos 4
  • Proto-Oncogene C-Fos 3
  • Activator Protein 1 3
  • C-FOS 3
  • AP-1 3
  • G0S7 4
  • P55 3

External Ids for FOS Gene

Previous GeneCards Identifiers for FOS Gene

  • GC14P073251
  • GC14P069562
  • GC14P073735
  • GC14P074815
  • GC14P075745
  • GC14P055913

Summaries for FOS Gene

Entrez Gene Summary for FOS Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOS Gene

FOS (FBJ Murine Osteosarcoma Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with FOS include fumarate hydratase deficiency and audiogenic seizures. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOSL1.

UniProtKB/Swiss-Prot for FOS Gene

  • Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gene Wiki entry for FOS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOS Gene

Genomics for FOS Gene

Regulatory Elements for FOS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOS Gene

Start:
75,278,774 bp from pter
End:
75,282,234 bp from pter
Size:
3,461 bases
Orientation:
Plus strand

Genomic View for FOS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOS Gene

Proteins for FOS Gene

  • Protein details for FOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01100-FOS_HUMAN
    Recommended name:
    Proto-oncogene c-Fos
    Protein Accession:
    P01100
    Secondary Accessions:
    • A8K4E2
    • B4DQ65
    • P18849

    Protein attributes for FOS Gene

    Size:
    380 amino acids
    Molecular mass:
    40695 Da
    Quaternary structure:
    • Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for synergistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with CDS1 and PI4K2A (By similarity).

    Three dimensional structures from OCA and Proteopedia for FOS Gene

    Alternative splice isoforms for FOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOS Gene

Proteomics data for FOS Gene at MOPED

Post-translational modifications for FOS Gene

  • Constitutively sumoylated with SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
  • In quiescent cells, the small amount of FOS present is phosphorylated at Tyr-10 and Tyr-30 by SRC. This Tyr-phosphorylated form is cytosolic. In growing cells, dephosphorylated by PTPN2. Dephosphorylation leads to the association with endoplasmic reticulum membranes and activation of phospholipid synthesis.
  • Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
  • Ubiquitination at Lys113
  • Modification sites at PhosphoSitePlus

Other Protein References for FOS Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FOS (Fos)

No data available for DME Specific Peptides for FOS Gene

Domains for FOS Gene

Gene Families for FOS Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for FOS Gene

Graphical View of Domain Structure for InterPro Entry

P01100

UniProtKB/Swiss-Prot:

FOS_HUMAN :
  • P01100
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOS: view

Function for FOS Gene

Molecular function for FOS Gene

GENATLAS Biochemistry:
murine FBJ osteosarcoma viral (v-fos) oncogene homolog,ligand induced,immediate (primary) early response gene
UniProtKB/Swiss-Prot Function:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Gene Ontology (GO) - Molecular Function for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 9732876
GO:0005515 protein binding IPI 12788789
genes like me logo Genes that share ontologies with FOS: view
genes like me logo Genes that share phenotypes with FOS: view

Animal Models for FOS Gene

MGI Knock Outs for FOS:

Transcription Factor Targeting for FOS Gene

Selected GeneGlobe predicted Target genes for FOS
Targeting motifs for FOS Gene
HOMER Transcription Factor Regulatory Elements motif FOS
  • Consensus sequence: ATGACTCATC Submotif: canonical Cell Type: ThioMac GeoId: GSE21512

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for FOS Gene

Localization for FOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOS Gene

Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOS Gene COMPARTMENTS Subcellular localization image for FOS gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
extracellular 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9443941
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FOS: view

Pathways for FOS Gene

SuperPathways for FOS Gene

genes like me logo Genes that share pathways with FOS: view

Pathways by source for FOS Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for FOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001661 conditioned taste aversion IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006306 DNA methylation TAS 9888853
genes like me logo Genes that share ontologies with FOS: view

Compounds for FOS Gene

(3) Tocris Compounds for FOS Gene

Compound Action Cas Number
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction [610273-01-3]
SP 100030 NF-kappaB and AP-1 dual inhibitor [154563-54-9]
SR 11302 Inhibitor of AP-1 transcription factor; antitumor agent [160162-42-5]

(1) Drugbank Compounds for FOS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Nadroparin
9041-08-1 target inhibitor

(138) Novoseek inferred chemical compound relationships for FOS Gene

Compound -log(P) Hits PubMed IDs
12-o-tetradecanoylphorbol 13-acetate 73.6 99
tyrosine 69.4 127
pyroglutamyl-histidyl-glycine 67.1 1
pd 98,059 66.7 48
phorbol 66.4 22
genes like me logo Genes that share compounds with FOS: view

Transcripts for FOS Gene

Unigene Clusters for FOS Gene

FBJ murine osteosarcoma viral oncogene homolog:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOS Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - - -

Relevant External Links for FOS Gene

GeneLoc Exon Structure for
FOS
ECgene alternative splicing isoforms for
FOS

Expression for FOS Gene

mRNA expression in normal human tissues for FOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOS Gene

This gene is overexpressed in Fallopian Tube (7.2).

Protein differential expression in normal tissues for FOS Gene

This gene is overexpressed in Monocytes (68.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOS Gene

SOURCE GeneReport for Unigene cluster for FOS Gene Hs.25647

genes like me logo Genes that share expressions with FOS: view

Expression partners for FOS Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FOS Gene

Orthologs for FOS Gene

This gene was present in the common ancestor of animals.

Orthologs for FOS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOS 35
  • 92.11 (n)
  • 96.32 (a)
FOS 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOS 35
  • 92.28 (n)
  • 97.11 (a)
FOS 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fos 35
  • 88.33 (n)
  • 93.68 (a)
Fos 16
Fos 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FOS 35
  • 99.65 (n)
  • 99.74 (a)
C-FOS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fos 35
  • 88.51 (n)
  • 94.21 (a)
oppossum
(Monodelphis domestica)
Mammalia FOS 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOS 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOS 35
  • 76.7 (n)
  • 80.11 (a)
FOS 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOS 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fos 35
  • 66.02 (n)
  • 69.06 (a)
Str.20514 35
zebrafish
(Danio rerio)
Actinopterygii fos 35
  • 61.82 (n)
  • 61.13 (a)
fos 36
  • 59 (a)
OneToMany
FOS (2 of 3) 36
  • 45 (a)
OneToMany
FOS (3 of 3) 36
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta kay 36
  • 14 (a)
OneToMany
Species with no ortholog for FOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOS Gene

ENSEMBL:
Gene Tree for FOS (if available)
TreeFam:
Gene Tree for FOS (if available)

Paralogs for FOS Gene

Paralogs for FOS Gene

genes like me logo Genes that share paralogs with FOS: view

Variants for FOS Gene

Sequence variations from dbSNP and Humsavar for FOS Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7101 -- 75,278,923(+) CTGCT(C/T)CACAG utr-variant-5-prime
rs14371 -- 75,282,090(-) atCTG(A/G)GAATC utr-variant-3-prime
rs932257 -- 75,277,601(+) GCCGC(G/T)CCTGG upstream-variant-2KB
rs1046117 -- 75,279,987(+) TCCTC(C/T)GTGGC reference, synonymous-codon
rs1046283 -- 75,281,565(+) CCAGG(C/G)TGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FOS Gene

Variant ID Type Subtype PubMed ID
nsv832833 CNV Gain 17160897

Relevant External Links for FOS Gene

HapMap Linkage Disequilibrium report
FOS
Human Gene Mutation Database (HGMD)
FOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOS Gene

Disorders for FOS Gene

(91) Novoseek inferred disease relationships for FOS Gene

Disease -log(P) Hits PubMed IDs
tumors 46.7 138
leukemia t-cell 45 4
retinoblastoma 44.1 25
neoplastic transformation 37.6 4
osteosarcoma 36.6 36

Relevant External Links for FOS

Genetic Association Database (GAD)
FOS
Human Genome Epidemiology (HuGE) Navigator
FOS
Tumor Gene Database (TGDB):
FOS
genes like me logo Genes that share disorders with FOS: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for FOS Gene

Publications for FOS Gene

  1. Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. (PMID: 16055710) Bossis G. … Piechaczyk M. (Mol. Cell. Biol. 2005) 2 3 4 23
  2. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. (PMID: 16123044) Monje P. … Gutkind J.S. (J. Biol. Chem. 2005) 2 3 23
  3. [Effects of basic fibroblast growth factor on protein kinase B activity and c-fos expression in CNE- I nasopharyngeal carcinoma cell line]. (PMID: 15835820) Wang X.P. … Shan Y.Q. (Zhonghua Er Bi Yan Hou Ke Za Zhi 2004) 3 23
  4. Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors. (PMID: 14741347) Holmes D.I. … Zachary I. (FEBS Lett. 2004) 3 23
  5. Effect of c-fos antisense probe on prostaglandin E2-induced upregulation of vascular endothelial growth factor mRNA in human liver cancer cells. (PMID: 16038047) Li Y.Q. … Wang Y.H. (World J. Gastroenterol. 2005) 3 23

Products for FOS Gene

  • Addgene plasmids for FOS

Sources for FOS Gene

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