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Aliases for ZNF281 Gene

Aliases for ZNF281 Gene

  • Zinc Finger Protein 281 2 3
  • GC-Box-Binding Zinc Finger Protein 1 3 4
  • Zinc Finger DNA-Binding Protein 99 3 4
  • Transcription Factor ZBP-99 3 4
  • ZNP-99 Transcription Factor 3
  • ZBP-99 3
  • ZNP-99 3
  • ZBP99 4
  • GZP1 4

External Ids for ZNF281 Gene

Previous GeneCards Identifiers for ZNF281 Gene

  • GC01M198105
  • GC01M195834
  • GC01M196842
  • GC01M197664
  • GC01M197663
  • GC01M197107
  • GC01M198642
  • GC01M200375
  • GC01M171541

Summaries for ZNF281 Gene

GeneCards Summary for ZNF281 Gene

ZNF281 (Zinc Finger Protein 281) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is ZNF740.

UniProtKB/Swiss-Prot for ZNF281 Gene

  • Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

Gene Wiki entry for ZNF281 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF281 Gene

Genomics for ZNF281 Gene

Regulatory Elements for ZNF281 Gene

Genomic Location for ZNF281 Gene

Start:
200,404,940 bp from pter
End:
200,410,058 bp from pter
Size:
5,119 bases
Orientation:
Minus strand

Genomic View for ZNF281 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF281 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF281 Gene

Proteins for ZNF281 Gene

  • Protein details for ZNF281 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X9-ZN281_HUMAN
    Recommended name:
    Zinc finger protein 281
    Protein Accession:
    Q9Y2X9
    Secondary Accessions:
    • A6NF48
    • B3KMX2
    • Q5RKW5
    • Q9NY92

    Protein attributes for ZNF281 Gene

    Size:
    895 amino acids
    Molecular mass:
    96915 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70967.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF281 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF281 Gene

Proteomics data for ZNF281 Gene at MOPED

Post-translational modifications for ZNF281 Gene

  • Ubiquitination at Lys539, Lys661, and Lys840
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF281 Gene

No data available for DME Specific Peptides for ZNF281 Gene

Domains for ZNF281 Gene

Gene Families for ZNF281 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF281 Gene

Suggested Antigen Peptide Sequences for ZNF281 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2X9

UniProtKB/Swiss-Prot:

ZN281_HUMAN :
  • Q9Y2X9
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF281: view

Function for ZNF281 Gene

Molecular function for ZNF281 Gene

GENATLAS Biochemistry: zinc finger protein 281,regulating ornithine decarboxylase gene (ODC) expression,major transcript,highly expressed in placenta,adult kidney,liver,lymphocytes,binding to thhe GC rich promoter element of gastrin and ODC
UniProtKB/Swiss-Prot Function: Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.

Gene Ontology (GO) - Molecular Function for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10448078
GO:0001047 core promoter binding ISS --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 10448078
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10448078
GO:0003714 transcription corepressor activity ISS --
genes like me logo Genes that share ontologies with ZNF281: view

Phenotypes for ZNF281 Gene

MGI mutant phenotypes for ZNF281:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ZNF281: view

Animal Models for ZNF281 Gene

MGI Knock Outs for ZNF281:

miRNA for ZNF281 Gene

miRTarBase miRNAs that target ZNF281

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ZNF281 Gene

Localization for ZNF281 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF281 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF281 Gene COMPARTMENTS Subcellular localization image for ZNF281 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10448078
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF281: view

Pathways for ZNF281 Gene

SuperPathways for ZNF281 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF281 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 10448078
GO:0006351 transcription, DNA-templated IEA --
GO:0010172 embryonic body morphogenesis ISS --
GO:0010629 negative regulation of gene expression IMP 10448078
GO:0045892 negative regulation of transcription, DNA-templated IMP 10448078
genes like me logo Genes that share ontologies with ZNF281: view

No data available for Pathways by source for ZNF281 Gene

Transcripts for ZNF281 Gene

Unigene Clusters for ZNF281 Gene

Zinc finger protein 281:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF281 Gene

No ASD Table

Relevant External Links for ZNF281 Gene

GeneLoc Exon Structure for
ZNF281
ECgene alternative splicing isoforms for
ZNF281

Expression for ZNF281 Gene

mRNA expression in normal human tissues for ZNF281 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF281 Gene

SOURCE GeneReport for Unigene cluster for ZNF281 Gene Hs.59757

genes like me logo Genes that share expressions with ZNF281: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF281 Gene

Orthologs for ZNF281 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF281 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF281 35
  • 99.77 (n)
  • 99.77 (a)
ZNF281 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF281 35
  • 89.09 (n)
  • 93.01 (a)
ZNF281 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF281 35
  • 91.45 (n)
  • 94.63 (a)
mouse
(Mus musculus)
Mammalia Zfp281 35
  • 94.35 (n)
  • 95.91 (a)
Zfp281 16
Zfp281 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF281 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF281 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp281 35
  • 93.61 (n)
  • 96.5 (a)
chicken
(Gallus gallus)
Aves ZNF281 35
  • 83.11 (n)
  • 83.95 (a)
ZNF281 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF281 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30049 35
tropical clawed frog
(Silurana tropicalis)
Amphibia znf281 35
  • 67.38 (n)
  • 60.68 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100005963 35
  • 57.59 (n)
  • 51.79 (a)
ZNF281 (1 of 2) 36
  • 36 (a)
OneToMany
ZNF281 (2 of 2) 36
  • 39 (a)
OneToMany
Species with no ortholog for ZNF281:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF281 Gene

ENSEMBL:
Gene Tree for ZNF281 (if available)
TreeFam:
Gene Tree for ZNF281 (if available)

Paralogs for ZNF281 Gene

Paralogs for ZNF281 Gene

genes like me logo Genes that share paralogs with ZNF281: view

Variants for ZNF281 Gene

Sequence variations from dbSNP and Humsavar for ZNF281 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1128817 -- 200,406,081(-) TGTTA(C/T)GTATT utr-variant-3-prime
rs3204322 -- 200,406,718(-) AAAGA(A/C/T)AAAAA utr-variant-3-prime
rs3210270 -- 200,406,720(-) AAAAA(A/G)ACAAA utr-variant-3-prime
rs4244146 -- 200,411,186(+) GCTTA(C/T)TTACA upstream-variant-2KB
rs5780025 -- 200,405,863(+) ATGGG(-/T)TTTTT utr-variant-3-prime

Relevant External Links for ZNF281 Gene

HapMap Linkage Disequilibrium report
ZNF281

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF281 Gene

Disorders for ZNF281 Gene

Relevant External Links for ZNF281

Genetic Association Database (GAD)
ZNF281
Human Genome Epidemiology (HuGE) Navigator
ZNF281
genes like me logo Genes that share disorders with ZNF281: view

No data available for UniProtKB/Swiss-Prot for ZNF281 Gene

Publications for ZNF281 Gene

  1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. (PMID: 10448078) Law D.J. … Merchant J.L. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Identification of human GC-box-binding zinc finger protein, a new Krueppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. (PMID: 10405178) Lisowsky T. … Cantatore P. (FEBS Lett. 1999) 3 4
  3. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. (PMID: 12771217) Zhang X. … Zehner Z.E. (Nucleic Acids Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF281 Gene

Sources for ZNF281 Gene

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