Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACAP2 Gene

Aliases for ACAP2 Gene

  • ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2 2 3
  • Centaurin, Beta 2 2 3
  • Centaurin-Beta-2 3 4
  • CNT-B2 3 4
  • CENTB2 3 4
  • Arf GAP With Coiled Coil, ANK Repeat And PH Domains 2 3
  • KIAA0041 4

External Ids for ACAP2 Gene

Previous HGNC Symbols for ACAP2 Gene

  • CENTB2

Previous GeneCards Identifiers for ACAP2 Gene

  • GC03M196477
  • GC03M194995
  • GC03M192371

Summaries for ACAP2 Gene

GeneCards Summary for ACAP2 Gene

ACAP2 (ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 2) is a Protein Coding gene. Among its related pathways are Endocytosis and Arf6 signaling events. GO annotations related to this gene include GTPase activator activity and Rab GTPase binding. An important paralog of this gene is ASAP3.

UniProtKB/Swiss-Prot for ACAP2 Gene

  • GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Wiki entry for ACAP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAP2 Gene

Genomics for ACAP2 Gene

Regulatory Elements for ACAP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ACAP2 Gene

Chromosome:
3
Start:
195,274,736 bp from pter
End:
195,443,176 bp from pter
Size:
168,441 bases
Orientation:
Minus strand

Genomic View for ACAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ACAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAP2 Gene

Proteins for ACAP2 Gene

  • Protein details for ACAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15057-ACAP2_HUMAN
    Recommended name:
    Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
    Protein Accession:
    Q15057
    Secondary Accessions:
    • A8K2V4
    • Q8N5Z8
    • Q9UQR3

    Protein attributes for ACAP2 Gene

    Size:
    778 amino acids
    Molecular mass:
    88029 Da
    Quaternary structure:
    • Interacts with RAB35 (GTP-bound form); the interaction is direct and probably recruits ACAP2 to membranes. Interacts with MICALL1; the interaction is indirect through RAB35 (By similarity).
    SequenceCaution:
    • Sequence=BAA05064.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111; Evidence={ECO:0000305};

neXtProt entry for ACAP2 Gene

Proteomics data for ACAP2 Gene at MOPED

Post-translational modifications for ACAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACAP2 Gene

No data available for DME Specific Peptides for ACAP2 Gene

Domains & Families for ACAP2 Gene

Suggested Antigen Peptide Sequences for ACAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15057

UniProtKB/Swiss-Prot:

ACAP2_HUMAN :
  • Contains 1 Arf-GAP domain.
  • Contains 3 ANK repeats.
Domain:
  • Contains 1 Arf-GAP domain.
  • Contains 1 BAR domain.
  • Contains 1 PH domain.
Similarity:
  • Contains 3 ANK repeats.
genes like me logo Genes that share domains with ACAP2: view

Function for ACAP2 Gene

Molecular function for ACAP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).

Gene Ontology (GO) - Molecular Function for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding --
GO:0017137 Rab GTPase binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ACAP2: view
genes like me logo Genes that share phenotypes with ACAP2: view

Animal Model Products

miRNA for ACAP2 Gene

miRTarBase miRNAs that target ACAP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAP2 Gene

Localization for ACAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAP2 Gene

Endosome membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ACAP2 Gene COMPARTMENTS Subcellular localization image for ACAP2 gene
Compartment Confidence
endosome 4
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane ISS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ACAP2: view

Pathways & Interactions for ACAP2 Gene

SuperPathways for ACAP2 Gene

genes like me logo Genes that share pathways with ACAP2: view

Pathways by source for ACAP2 Gene

1 BioSystems pathway for ACAP2 Gene
1 KEGG pathway for ACAP2 Gene

Interacting Proteins for ACAP2 Gene

Gene Ontology (GO) - Biological Process for ACAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036010 protein localization to endosome ISS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:1990090 cellular response to nerve growth factor stimulus ISS --
genes like me logo Genes that share ontologies with ACAP2: view

No data available for SIGNOR curated interactions for ACAP2 Gene

Drugs & Compounds for ACAP2 Gene

(12) Additional Compounds for ACAP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with ACAP2: view

Transcripts for ACAP2 Gene

Unigene Clusters for ACAP2 Gene

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ACAP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1:
SP2:
SP3: - - - - -
SP4: - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - - -
SP9:
SP10:
SP11:
SP12: -

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACAP2 Gene

GeneLoc Exon Structure for
ACAP2
ECgene alternative splicing isoforms for
ACAP2

Expression for ACAP2 Gene

mRNA expression in normal human tissues for ACAP2 Gene

mRNA differential expression in normal tissues according to GTEx for ACAP2 Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for ACAP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.0) and Lymph node (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ACAP2 Gene



SOURCE GeneReport for Unigene cluster for ACAP2 Gene Hs.593373

mRNA Expression by UniProt/SwissProt for ACAP2 Gene

Q15057-ACAP2_HUMAN
Tissue specificity: Widely expressed. Highest level in lung.
genes like me logo Genes that share expression patterns with ACAP2: view

Protein tissue co-expression partners for ACAP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ACAP2 Gene

Orthologs for ACAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAP2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ACAP2 35
  • 92.46 (n)
  • 96.02 (a)
ACAP2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acap2 35
  • 89.31 (n)
  • 96.23 (a)
Acap2 16
Acap2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACAP2 35
  • 99.74 (n)
  • 100 (a)
ACAP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acap2 35
  • 89.26 (n)
  • 95.97 (a)
cow
(Bos Taurus)
Mammalia ACAP2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACAP2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACAP2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACAP2 35
  • 80.22 (n)
  • 88.55 (a)
ACAP2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 8 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia acap2 35
  • 75.66 (n)
  • 82.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68712 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2620 35
zebrafish
(Danio rerio)
Actinopterygii acap2 36
  • 70 (a)
OneToMany
ACAP2 (1 of 2) 36
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000563 35
  • 49.44 (n)
  • 46.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta cenB1A 35
  • 48.08 (n)
  • 41.29 (a)
cenB1A 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cnt-1 35
  • 46.32 (n)
  • 36.81 (a)
cnt-1 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE1 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AGD2 35
  • 47.08 (n)
  • 34.34 (a)
rice
(Oryza sativa)
Liliopsida Os02g0632500 35
  • 47.94 (n)
  • 34.02 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for ACAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACAP2 Gene

ENSEMBL:
Gene Tree for ACAP2 (if available)
TreeFam:
Gene Tree for ACAP2 (if available)

Paralogs for ACAP2 Gene

(3) SIMAP similar genes for ACAP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ACAP2: view

Variants for ACAP2 Gene

Sequence variations from dbSNP and Humsavar for ACAP2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs716898 -- 195,326,529(+) GCCCC(A/G)CAACA intron-variant
rs823297 -- 195,399,361(+) AGACA(A/G)GATCT intron-variant
rs823298 -- 195,400,343(+) ATATG(A/G)TTTCA intron-variant
rs823299 -- 195,401,438(+) GGTGG(C/G/T)TGGAT intron-variant
rs823300 -- 195,401,599(+) GAGGC(A/G)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ACAP2 Gene

Variant ID Type Subtype PubMed ID
esv269140 CNV Insertion 20981092
nsv526569 CNV Gain 19592680
nsv878138 CNV Gain 21882294
dgv5364n71 CNV Loss 21882294
nsv878140 CNV Loss 21882294
dgv1549e1 CNV Complex 17122850
nsv878142 CNV Loss 21882294
dgv5365n71 CNV Loss 21882294
esv2726463 CNV Deletion 23290073
esv2669458 CNV Deletion 23128226
esv8403 CNV Gain 19470904
nsv829824 CNV Loss 17160897
esv2657233 CNV Deletion 23128226
nsv508977 CNV Insertion 20534489
esv2662107 CNV Deletion 23128226

Variation tolerance for ACAP2 Gene

Residual Variation Intolerance Score: 18.29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ACAP2 Gene

HapMap Linkage Disequilibrium report
ACAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAP2 Gene

Disorders for ACAP2 Gene

Relevant External Links for ACAP2

Human Genome Epidemiology (HuGE) Navigator
ACAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ACAP2
genes like me logo Genes that share disorders with ACAP2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACAP2 Gene

Publications for ACAP2 Gene

  1. ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. (PMID: 11062263) Jackson T.R. … Randazzo P.A. (J. Cell Biol. 2000) 2 23 67
  2. Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs. (PMID: 20070612) Kanno E. … Fukuda M. (Traffic 2010) 23 67
  3. DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. (PMID: 11773070) Furman C. … Roberts T.M. (J. Biol. Chem. 2002) 23 67
  4. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. (PMID: 11001876) Dowler S.J. … Alessi D.R. (Biochem. J. 2000) 23 67
  5. Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. (PMID: 11050434) Jackson T.R. … Theibert A.B. (Trends Biochem. Sci. 2000) 2 67

Products for ACAP2 Gene

Sources for ACAP2 Gene

Back to Top

Content