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Aliases for PES1 Gene

Aliases for PES1 Gene

  • Pescadillo Ribosomal Biogenesis Factor 1 2 3
  • PES 3 6
  • Pescadillo (Zebrafish) Homolog 1, Containing BRCT Domain 2
  • Pescadillo Homolog 1, Containing BRCT Domain (Zebrafish) 2
  • Pescadillo Homolog 1, Containing BRCT Domain 3
  • Pescadillo Homolog 3

External Ids for PES1 Gene

Summaries for PES1 Gene

Entrez Gene Summary for PES1 Gene

  • This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

GeneCards Summary for PES1 Gene

PES1 (Pescadillo Ribosomal Biogenesis Factor 1) is a Protein Coding gene. Diseases associated with PES1 include breast cancer.

UniProtKB/Swiss-Prot for PES1 Gene

  • Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Gene Wiki entry for PES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PES1 Gene

Genomics for PES1 Gene

Genomic Location for PES1 Gene

30,576,625 bp from pter
30,607,083 bp from pter
30,459 bases
Minus strand

Genomic View for PES1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PES1 Gene

Regulatory Elements for PES1 Gene

Proteins for PES1 Gene

  • Protein details for PES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pescadillo homolog
    Protein Accession:
    Secondary Accessions:
    • Q6IC29

    Protein attributes for PES1 Gene

    588 amino acids
    Molecular mass:
    68003 Da
    Quaternary structure:
    • Interacts with IRS1 and UBTF. May interact with MAP1B (By similarity). Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.

    Three dimensional structures from OCA and Proteopedia for PES1 Gene

    Alternative splice isoforms for PES1 Gene


neXtProt entry for PES1 Gene

Proteomics data for PES1 Gene at MOPED

Post-translational modifications for PES1 Gene

No data available for DME Specific Peptides for PES1 Gene

Domains for PES1 Gene

Protein Domains for PES1 Gene



  • Contains 1 BRCT domain.:
    • O00541
  • Belongs to the pescadillo family.:
    • O00541
genes like me logo Genes that share domains with PES1: view

No data available for Gene Families for PES1 Gene

Function for PES1 Gene

Molecular function for PES1 Gene

GENATLAS Biochemistry: pescadillo zebrafish homolog 1,putatively expressed and involved during early embryogenesis
UniProtKB/Swiss-Prot Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
UniProtKB/Swiss-Prot Induction: By MYC.

Gene Ontology (GO) - Molecular Function for PES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16043514
GO:0043021 ribonucleoprotein complex binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PES1: view

Phenotypes for PES1 Gene

genes like me logo Genes that share phenotypes with PES1: view

Animal Models for PES1 Gene

MGI Knock Outs for PES1:

miRNA for PES1 Gene

miRTarBase miRNAs that target PES1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PES1 Gene

Localization for PES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PES1 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255 HAMAP-Rule:MF_03028}.

Subcellular locations from

Jensen Localization Image for PES1 Gene COMPARTMENTS Subcellular localization image for PES1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for PES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000793 condensed chromosome IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA 16738141
GO:0005694 chromosome --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with PES1: view

Pathways for PES1 Gene

SuperPathways for PES1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16738141
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP 16738141
GO:0006364 rRNA processing IMP 16738141
GO:0007000 nucleolus organization IEA --
GO:0008283 cell proliferation NAS 16043514
genes like me logo Genes that share ontologies with PES1: view

No data available for Pathways by source for PES1 Gene

Compounds for PES1 Gene

(1) Novoseek inferred chemical compound relationships for PES1 Gene

Compound -log(P) Hits PubMed IDs
12-o-tetradecanoylphorbol 13-acetate 53.9 1
genes like me logo Genes that share compounds with PES1: view

Transcripts for PES1 Gene

Unigene Clusters for PES1 Gene

Pescadillo ribosomal biogenesis factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PES1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5: -
SP6: - -
SP8: -
SP10: -
SP11: -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21

Relevant External Links for PES1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PES1 Gene

mRNA expression in normal human tissues for PES1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PES1 Gene

SOURCE GeneReport for Unigene cluster for PES1 Gene Hs.517543

mRNA Expression by UniProt/SwissProt for PES1 Gene

Tissue specificity: Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin
genes like me logo Genes that share expressions with PES1: view

Orthologs for PES1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PES1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PES1 36
  • 98.98 (n)
  • 99.32 (a)
PES1 37
  • 99 (a)
(Bos Taurus)
Mammalia PES1 36
  • 85.57 (n)
  • 85.69 (a)
PES1 37
  • 85 (a)
(Canis familiaris)
Mammalia PES1 36
  • 88.16 (n)
  • 90.05 (a)
PES1 37
  • 90 (a)
(Mus musculus)
Mammalia Pes1 36
  • 85.19 (n)
  • 89.71 (a)
Pes1 16
Pes1 37
  • 89 (a)
(Monodelphis domestica)
Mammalia PES1 37
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PES1 37
  • 97 (a)
(Rattus norvegicus)
Mammalia Pes1 36
  • 85.53 (n)
  • 89.91 (a)
(Gallus gallus)
Aves PES1 36
  • 75.96 (n)
  • 74.83 (a)
PES1 37
  • 77 (a)
(Anolis carolinensis)
Reptilia PES1 37
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia pes1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76219 36
pes1 36
  • 70.15 (n)
  • 74.22 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4417 36
(Danio rerio)
Actinopterygii pes 36
  • 69.67 (n)
  • 74 (a)
pes 37
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta PESC_ANOGA 36
  • 56.75 (n)
  • 50.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4364 36
  • 59.48 (n)
  • 54.8 (a)
CG4364 37
  • 40 (a)
CG4364 38
  • 51 (a)
(Caenorhabditis elegans)
Secernentea lpd-7 36
  • 54.55 (n)
  • 53.15 (a)
lpd-7 37
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR094W 36
  • 51.63 (n)
  • 44.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP7 36
  • 49.72 (n)
  • 44.92 (a)
NOP7 37
  • 38 (a)
NOP7 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15268g 36
  • 48.9 (n)
  • 43.11 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G14520 36
  • 52.95 (n)
  • 48.56 (a)
(Oryza sativa)
Liliopsida Os03g0699200 36
  • 53.83 (n)
  • 51.36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00925 36
  • 56.99 (n)
  • 49.88 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppp1 36
  • 51.18 (n)
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12349 36
Species with no ortholog for PES1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PES1 Gene

Gene Tree for PES1 (if available)
Gene Tree for PES1 (if available)

Paralogs for PES1 Gene Pseudogenes for PES1 Gene

genes like me logo Genes that share paralogs with PES1: view

No data available for Paralogs for PES1 Gene

Variants for PES1 Gene

Sequence variations from dbSNP and Humsavar for PES1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs42942 - 30,581,366(+) GTAGG(A/C/T)GCCCT reference, missense
rs737952 -- 30,582,086(+) CTTTG(C/T)TGCAT intron-variant
rs737953 -- 30,591,874(+) ACAGG(C/G)AGCTC utr-variant-5-prime, intron-variant
rs2057952 -- 30,598,204(+) cactg(G/T)gaagg intron-variant
rs2072196 -- 30,579,526(+) GTAAA(C/T)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PES1 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv834175 CNV Gain 17160897
esv1116333 CNV Insertion 17803354

Relevant External Links for PES1 Gene

HapMap Linkage Disequilibrium report

Disorders for PES1 Gene

(1) MalaCards Diseases for PES1 Gene

Search for PES1 Gene in MalaCards »
genes like me logo Genes that share disorders with PES1: view

No data available for UniProtKB/Swiss-Prot for PES1 Gene

Publications for PES1 Gene

  1. Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. (PMID: 8985183) Allende M.L. … Hopkins N. (Genes Dev. 1996) 2 3 4 23
  2. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. (PMID: 17353269) Rohrmoser M. … Eick D. (Mol. Cell. Biol. 2007) 2 3 4 23
  3. Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. (PMID: 16738141) Grimm T. … Eick D. (Nucleic Acids Res. 2006) 3 4 23
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  5. Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells. (PMID: 11071894) Kinoshita Y. … Morrison R.S. (J. Biol. Chem. 2001) 3 4

Products for PES1 Gene

  • Addgene plasmids for PES1

Sources for PES1 Gene

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