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Aliases for FOLR1 Gene

Aliases for FOLR1 Gene

  • Folate Receptor 1 (Adult) 2 3
  • Ovarian Tumor-Associated Antigen MOv18 3 4
  • Adult Folate-Binding Protein 3 4
  • Folate Receptor, Adult 3 4
  • KB Cells FBP 3 4
  • FR-Alpha 3 4
  • FOLR 3 4
  • FBP 3 4
  • Folate Binding Protein 3
  • Folate Receptor Alpha 3
  • Folate Receptor 1 4

External Ids for FOLR1 Gene

Previous HGNC Symbols for FOLR1 Gene

  • FOLR

Previous GeneCards Identifiers for FOLR1 Gene

  • GC11P074232
  • GC11P073440
  • GC11P072123
  • GC11P071626
  • GC11P071578
  • GC11P071900
  • GC11P068193

Summaries for FOLR1 Gene

Entrez Gene Summary for FOLR1 Gene

  • The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for FOLR1 Gene

FOLR1 (Folate Receptor 1 (Adult)) is a Protein Coding gene. Diseases associated with FOLR1 include neurodegeneration due to cerebral folate transport deficiency and cerebral folate deficiency. Among its related pathways are Endocytosis and Methotrexate Pathway, Pharmacokinetics. GO annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is IZUMO1R.

UniProtKB/Swiss-Prot for FOLR1 Gene

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Gene Wiki entry for FOLR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOLR1 Gene

Genomics for FOLR1 Gene

Regulatory Elements for FOLR1 Gene

Transcription factor binding sites by QIAGEN in the FOLR1 gene promoter:

Genomic Location for FOLR1 Gene

Start:
72,189,558 bp from pter
End:
72,196,323 bp from pter
Size:
6,766 bases
Orientation:
Plus strand

Genomic View for FOLR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOLR1 Gene

Proteins for FOLR1 Gene

  • Protein details for FOLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15328-FOLR1_HUMAN
    Recommended name:
    Folate receptor alpha
    Protein Accession:
    P15328
    Secondary Accessions:
    • Q53EW2
    • Q6FGT8
    • Q6LC90
    • Q9UCT2

    Protein attributes for FOLR1 Gene

    Size:
    257 amino acids
    Molecular mass:
    29819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FOLR1 Gene

neXtProt entry for FOLR1 Gene

Proteomics data for FOLR1 Gene at MOPED

Post-translational modifications for FOLR1 Gene

  • The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease
  • Glycosylation at Asn69, Asn161, and Asn201

Other Protein References for FOLR1 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for FOLR1 Gene

Domains for FOLR1 Gene

Protein Domains for FOLR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FOLR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P15328

UniProtKB/Swiss-Prot:

FOLR1_HUMAN :
  • P15328
Family:
  • Belongs to the folate receptor family.
genes like me logo Genes that share domains with FOLR1: view

No data available for Gene Families for FOLR1 Gene

Function for FOLR1 Gene

Molecular function for FOLR1 Gene

GENATLAS Biochemistry: folate receptor 1,adult
UniProtKB/Swiss-Prot Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Gene Ontology (GO) - Molecular Function for FOLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 10633085
GO:0005542 folic acid binding NAS 1840502
GO:0008517 folic acid transporter activity IMP 8033114
genes like me logo Genes that share ontologies with FOLR1: view
genes like me logo Genes that share phenotypes with FOLR1: view

Animal Models for FOLR1 Gene

MGI Knock Outs for FOLR1:

Animal Model Products

CRISPR Products

miRNA for FOLR1 Gene

miRTarBase miRNAs that target FOLR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOLR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for FOLR1 Gene

Localization for FOLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOLR1 Gene

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOLR1 Gene COMPARTMENTS Subcellular localization image for FOLR1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endosome 1

Gene Ontology (GO) - Cellular Components for FOLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23243496
GO:0005768 endosome IEA --
GO:0005886 plasma membrane NAS 1840502
GO:0005887 integral component of plasma membrane TAS 10633085
GO:0005903 brush border --
genes like me logo Genes that share ontologies with FOLR1: view

Pathways for FOLR1 Gene

genes like me logo Genes that share pathways with FOLR1: view

Pathways by source for FOLR1 Gene

1 PharmGKB pathway for FOLR1 Gene
1 KEGG pathway for FOLR1 Gene

Gene Ontology (GO) - Biological Process for FOLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS 9545095
GO:0008219 cell death --
GO:0015884 folic acid transport IMP 8033114
GO:0046655 folic acid metabolic process IEA --
genes like me logo Genes that share ontologies with FOLR1: view

Compounds for FOLR1 Gene

(1) HMDB Compounds for FOLR1 Gene

Compound Synonyms Cas Number PubMed IDs
Folic acid
  • Acifolic
59-30-3

(1) Drugbank Compounds for FOLR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Methotrexate
  • Amethopterin
59-05-2 transporter substrate

(25) Novoseek inferred chemical compound relationships for FOLR1 Gene

Compound -log(P) Hits PubMed IDs
folate 92.9 245
5-methyltetrahydrofolate 87.3 16
lometrexol 81.3 2
methotrexate 63.3 26
leucovorin 59 2
genes like me logo Genes that share compounds with FOLR1: view

Transcripts for FOLR1 Gene

Unigene Clusters for FOLR1 Gene

Folate receptor 1 (adult):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOLR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOLR1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for FOLR1 Gene

GeneLoc Exon Structure for
FOLR1
ECgene alternative splicing isoforms for
FOLR1

Expression for FOLR1 Gene

mRNA expression in normal human tissues for FOLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOLR1 Gene

This gene is overexpressed in Lung (13.8), Kidney - Cortex (11.8), Minor Salivary Gland (6.8), and Cervix - Endocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FOLR1 Gene

SOURCE GeneReport for Unigene cluster for FOLR1 Gene Hs.73769

mRNA Expression by UniProt/SwissProt for FOLR1 Gene

P15328-FOLR1_HUMAN
Tissue specificity: Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
genes like me logo Genes that share expressions with FOLR1: view

In Situ Assay Products

Orthologs for FOLR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOLR1 35
  • 97.54 (n)
  • 97.08 (a)
FOLR1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOLR1 35
  • 82.19 (n)
  • 77.35 (a)
FOLR1 36
  • 77 (a)
OneToMany
FOLR1 36
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
FOLR1 35
  • 86.87 (n)
  • 82.25 (a)
mouse
(Mus musculus)
Mammalia Folr1 35
  • 81.4 (n)
  • 79.75 (a)
Folr1 16
Folr1 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 61 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Folr1 35
  • 82.96 (n)
  • 82.35 (a)
chicken
(Gallus gallus)
Aves FOLR1 35
  • 69.38 (n)
  • 66.03 (a)
FOLR1 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia folr1 35
  • 64.61 (n)
  • 60.66 (a)
MGC76048 35
zebrafish
(Danio rerio)
Actinopterygii FOLR1 36
  • 51 (a)
OneToMany
zgc:165502 35
  • 63.65 (n)
  • 56.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
Species with no ortholog for FOLR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOLR1 Gene

ENSEMBL:
Gene Tree for FOLR1 (if available)
TreeFam:
Gene Tree for FOLR1 (if available)

Paralogs for FOLR1 Gene

Paralogs for FOLR1 Gene

Selected SIMAP similar genes for FOLR1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FOLR1 Gene

genes like me logo Genes that share paralogs with FOLR1: view

Variants for FOLR1 Gene

Sequence variations from dbSNP and Humsavar for FOLR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs499087 -- 72,190,200(-) CAGTG(A/G)AGCCC intron-variant, upstream-variant-2KB
rs630074 -- 72,193,893(-) GGCAG(A/G)AGAAT intron-variant
rs762621 -- 72,191,807(+) GAAAA(A/T)AATAT intron-variant, upstream-variant-2KB
rs1540087 -- 72,190,447(-) GCTTT(C/T)TCCTG intron-variant, upstream-variant-2KB
rs1801932 - 72,195,734(+) GGCTG(C/G)AACTG missense, reference

Relevant External Links for FOLR1 Gene

HapMap Linkage Disequilibrium report
FOLR1
Human Gene Mutation Database (HGMD)
FOLR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOLR1 Gene

Disorders for FOLR1 Gene

(1) OMIM Diseases for FOLR1 Gene (136430)

UniProtKB/Swiss-Prot

FOLR1_HUMAN
  • Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. {ECO:0000269 PubMed:19732866}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for FOLR1 Gene

(26) Novoseek inferred disease relationships for FOLR1 Gene

Disease -log(P) Hits PubMed IDs
folate deficiency 71.9 4
ovarian carcinoma 71.6 35
ovarian cancer 56.9 24
leukemia l1210 55.4 1
anencephaly 43.2 1

Relevant External Links for FOLR1

Genetic Association Database (GAD)
FOLR1
Human Genome Epidemiology (HuGE) Navigator
FOLR1
genes like me logo Genes that share disorders with FOLR1: view

Publications for FOLR1 Gene

  1. Folate-binding protein is a marker for ovarian cancer. (PMID: 1717147) Campbell I.G. … Trowsdale J. (Cancer Res. 1991) 2 3 4 23
  2. Novel insertion and deletion mutations in the 5'-UTR of the folate receptor-alpha gene: an additional contributor to hyperhomocysteinemia? (PMID: 14972645) Nilsson T.K. … BAPrjel A.K. (Clin. Biochem. 2004) 3 23 48
  3. Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein. (PMID: 1840502) Coney L.R. … Zurawski V.R. Jr. (Cancer Res. 1991) 3 4 23
  4. Genomic organization of the gene and a related pseudogene for a human folate binding protein. (PMID: 1581364) Sadasivan E. … Rothenberg S.P. (Biochim. Biophys. Acta 1992) 3 4 23
  5. Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population. (PMID: 15754024) Zhang G. … Lu Y.Y. (Int. J. Mol. Med. 2005) 3 23 48

Products for FOLR1 Gene

Sources for FOLR1 Gene

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