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Aliases for PHF3 Gene

Aliases for PHF3 Gene

  • PHD Finger Protein 3 2 3
  • KIAA0244 4 6

External Ids for PHF3 Gene

Summaries for PHF3 Gene

Entrez Gene Summary for PHF3 Gene

  • This gene encodes a member of a PHD finger-containing gene family. This gene may function as a transcription factor and may be involved in glioblastomas development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for PHF3 Gene

PHF3 (PHD Finger Protein 3) is a Protein Coding gene. An important paralog of this gene is DIDO1.

Gene Wiki entry for PHF3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PHF3 Gene

Genomics for PHF3 Gene

Genomic Location for PHF3 Gene

Start:
63,635,802 bp from pter
End:
63,779,336 bp from pter
Size:
143,535 bases
Orientation:
Plus strand

Genomic View for PHF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PHF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PHF3 Gene

Regulatory Elements for PHF3 Gene

Proteins for PHF3 Gene

  • Protein details for PHF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92576-PHF3_HUMAN
    Recommended name:
    PHD finger protein 3
    Protein Accession:
    Q92576
    Secondary Accessions:
    • A3KFI8
    • Q14CR5
    • Q5CZI1
    • Q5T1T6
    • Q9NQ16
    • Q9UI45

    Protein attributes for PHF3 Gene

    Size:
    2039 amino acids
    Molecular mass:
    229481 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13438.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PHF3 Gene

    Alternative splice isoforms for PHF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PHF3 Gene

Proteomics data for PHF3 Gene at MOPED

Post-translational modifications for PHF3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys964 and Lys1220

No data available for DME Specific Peptides for PHF3 Gene

Domains for PHF3 Gene

Gene Families for PHF3 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

PHF3_HUMAN
Domain:
  • Contains 1 TFIIS central domain.:
    • Q92576
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q92576
genes like me logo Genes that share domains with PHF3: view

Function for PHF3 Gene

Gene Ontology (GO) - Molecular Function for PHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with PHF3: view

Phenotypes for PHF3 Gene

genes like me logo Genes that share phenotypes with PHF3: view

miRNA for PHF3 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PHF3 Gene

Localization for PHF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PHF3 Gene COMPARTMENTS Subcellular localization image for PHF3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for PHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PHF3: view

Pathways for PHF3 Gene

SuperPathways for PHF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PHF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development NAS 11856869
genes like me logo Genes that share ontologies with PHF3: view

No data available for Pathways by source for PHF3 Gene

Transcripts for PHF3 Gene

Unigene Clusters for PHF3 Gene

PHD finger protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PHF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^
SP1: - - - - -
SP2:
SP3: -
SP4: -
SP5:
SP6: - - - -
SP7:
SP8:
SP9: - -
SP10: - -
SP11: - - - - - -
SP12:
SP13: - - - - - - - -
SP14:

ExUns: 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for PHF3 Gene

GeneLoc Exon Structure for
PHF3
ECgene alternative splicing isoforms for
PHF3

Expression for PHF3 Gene

mRNA expression in normal human tissues for PHF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PHF3 Gene

SOURCE GeneReport for Unigene cluster for PHF3 Gene Hs.348921

mRNA Expression by UniProt/SwissProt for PHF3 Gene

Q92576-PHF3_HUMAN
Tissue specificity: Ubiquitous. Expression is significantly reduced or lost in glioblastomas, glioblastoma cell lines, anaplastic astrocytomas, and astrocytomas.
genes like me logo Genes that share expressions with PHF3: view

Orthologs for PHF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PHF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHF3 36
  • 99.72 (n)
  • 99.51 (a)
PHF3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHF3 36
  • 87.69 (n)
  • 83.79 (a)
PHF3 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHF3 36
  • 91.38 (n)
  • 88.35 (a)
PHF3 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phf3 36
  • 83.05 (n)
  • 79.62 (a)
Phf3 16
Phf3 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHF3 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHF3 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Phf3 36
  • 83.19 (n)
  • 79.79 (a)
chicken
(Gallus gallus)
Aves PHF3 36
  • 68.54 (n)
  • 62.96 (a)
PHF3 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHF3 37
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30130 36
tropical clawed frog
(Silurana tropicalis)
Amphibia phf3 36
  • 59.72 (n)
  • 49.36 (a)
zebrafish
(Danio rerio)
Actinopterygii phf3 37
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pps 37
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToOne
Species with no ortholog for PHF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PHF3 Gene

ENSEMBL:
Gene Tree for PHF3 (if available)
TreeFam:
Gene Tree for PHF3 (if available)

Paralogs for PHF3 Gene

Paralogs for PHF3 Gene

Selected SIMAP similar genes for PHF3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PHF3: view

Variants for PHF3 Gene

Sequence variations from dbSNP and Humsavar for PHF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs958324 -- 63,656,813(+) TTTTC(C/T)TTCAA intron-variant
rs970339 -- 63,678,905(+) CCTTG(A/G)GGTTC utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs1045943 -- 63,714,895(+) TGAAA(A/C)CTATT utr-variant-3-prime, downstream-variant-500B
rs1050512 -- 63,714,281(+) ATTAC(C/T)ATATA utr-variant-3-prime
rs1197982 -- 63,654,177(+) tggaa(G/T)aattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PHF3 Gene

Variant ID Type Subtype PubMed ID
nsv830674 CNV Gain+Loss 17160897

Relevant External Links for PHF3 Gene

HapMap Linkage Disequilibrium report
PHF3
Human Gene Mutation Database (HGMD)
PHF3

Disorders for PHF3 Gene

(1) University of Copenhagen DISEASES for PHF3 Gene

Relevant External Links for PHF3

Genetic Association Database (GAD)
PHF3
Human Genome Epidemiology (HuGE) Navigator
PHF3
genes like me logo Genes that share disorders with PHF3: view

No data available for UniProtKB/Swiss-Prot for PHF3 Gene

Publications for PHF3 Gene

  1. PHF3 expression is frequently reduced in glioma. (PMID: 11856869) Fischer U. … Meese E. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PHF3 Gene

Sources for PHF3 Gene

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