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Aliases for NPTXR Gene

Aliases for NPTXR Gene

  • Neuronal Pentraxin Receptor 2 3 5
  • NPR 3

External Ids for NPTXR Gene

Previous GeneCards Identifiers for NPTXR Gene

  • GC22M035828
  • GC22M037457
  • GC22M037538
  • GC22M039214
  • GC22M022180

Summaries for NPTXR Gene

Entrez Gene Summary for NPTXR Gene

  • This gene encodes a protein similar to the rat neuronal pentraxin receptor. The rat pentraxin receptor is an integral membrane protein that is thought to mediate neuronal uptake of the snake venom toxin, taipoxin, and its transport into the synapses. Studies in rat indicate that translation of this mRNA initiates at a non-AUG (CUG) codon. This may also be true for mouse and human, based on strong sequence conservation amongst these species. [provided by RefSeq, Jul 2008]

GeneCards Summary for NPTXR Gene

NPTXR (Neuronal Pentraxin Receptor) is a Protein Coding gene. Diseases associated with NPTXR include Acromesomelic Dysplasia, Maroteaux Type and Acromesomelic Dysplasia. An important paralog of this gene is PTX3.

UniProtKB/Swiss-Prot for NPTXR Gene

  • May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

Gene Wiki entry for NPTXR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NPTXR Gene

Genomics for NPTXR Gene

Regulatory Elements for NPTXR Gene

Enhancers for NPTXR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NPTXR on UCSC Golden Path with GeneCards custom track

Promoters for NPTXR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NPTXR on UCSC Golden Path with GeneCards custom track

Genomic Location for NPTXR Gene

38,818,451 bp from pter
38,844,012 bp from pter
25,562 bases
Minus strand

Genomic View for NPTXR Gene

Genes around NPTXR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NPTXR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NPTXR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NPTXR Gene

Proteins for NPTXR Gene

  • Protein details for NPTXR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuronal pentraxin receptor
    Protein Accession:

    Protein attributes for NPTXR Gene

    500 amino acids
    Molecular mass:
    52846 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2). Interacts with KLHL2 (By similarity).
    • Sequence=CAA15430.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NPTXR Gene

Proteomics data for NPTXR Gene at MOPED

Post-translational modifications for NPTXR Gene

  • Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.
  • Glycosylation at Asn 42, Asn 216, and Asn 463
  • Modification sites at PhosphoSitePlus

Other Protein References for NPTXR Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for NPTXR (Neuronal Pentraxin R/NPTXR)

No data available for DME Specific Peptides for NPTXR Gene

Domains & Families for NPTXR Gene

Gene Families for NPTXR Gene

Protein Domains for NPTXR Gene


Suggested Antigen Peptide Sequences for NPTXR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 pentaxin domain.
  • Contains 1 pentaxin domain.
genes like me logo Genes that share domains with NPTXR: view

Function for NPTXR Gene

Molecular function for NPTXR Gene

GENATLAS Biochemistry:
neuronal pentraxin receptor,interacting with NPTX1,NPTX2 and taipoxin-associated calcium binding protein 49,putatively involved in the clearance of synaptic debris
UniProtKB/Swiss-Prot Function:
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
genes like me logo Genes that share phenotypes with NPTXR: view

Animal Models for NPTXR Gene

MGI Knock Outs for NPTXR:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NPTXR Gene

Localization for NPTXR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NPTXR Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for NPTXR Gene COMPARTMENTS Subcellular localization image for NPTXR gene
Compartment Confidence
endoplasmic reticulum 3
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NPTXR Gene

Pathways & Interactions for NPTXR Gene

SuperPathways for NPTXR Gene

No Data Available

Interacting Proteins for NPTXR Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000327545 O95502-NPTXR_HUMAN for NPTXR Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NPTXR Gene


No data available for Pathways by source and SIGNOR curated interactions for NPTXR Gene

Drugs & Compounds for NPTXR Gene

(2) Drugs for NPTXR Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for NPTXR Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NPTXR: view

Transcripts for NPTXR Gene

mRNA/cDNA for NPTXR Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(212) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NPTXR Gene

Neuronal pentraxin receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NPTXR Gene

No ASD Table

Relevant External Links for NPTXR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NPTXR Gene

mRNA expression in normal human tissues for NPTXR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NPTXR Gene

This gene is overexpressed in Brain - Hippocampus (x8.6), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Cortex (x6.0), Brain - Amygdala (x6.0), and Brain - Frontal Cortex (BA9) (x5.2).

Protein differential expression in normal tissues from HIPED for NPTXR Gene

This gene is overexpressed in Cerebrospinal fluid (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NPTXR Gene

SOURCE GeneReport for Unigene cluster for NPTXR Gene Hs.91622

genes like me logo Genes that share expression patterns with NPTXR: view

Protein tissue co-expression partners for NPTXR Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NPTXR Gene

Orthologs for NPTXR Gene

This gene was present in the common ancestor of chordates.

Orthologs for NPTXR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NPTXR 35
  • 91.13 (n)
  • 94.3 (a)
  • 94 (a)
(Mus musculus)
Mammalia Nptxr 35
  • 88.03 (n)
  • 90.47 (a)
Nptxr 16
Npcd 36
  • 59 (a)
Nptxr 36
  • 89 (a)
(Pan troglodytes)
Mammalia NPTXR 35
  • 95.34 (n)
  • 94.33 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Nptxr 35
  • 87.85 (n)
  • 90.49 (a)
(Canis familiaris)
Mammalia NPTXR 36
  • 47 (a)
(Monodelphis domestica)
Mammalia NPTXR 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia NPTXR 36
  • 48 (a)
(Gallus gallus)
Aves NPTXR 36
  • 36 (a)
(Anolis carolinensis)
Reptilia NPTXR 36
  • 33 (a)
(Danio rerio)
Actinopterygii nptxrb 35
  • 55.26 (n)
  • 48.36 (a)
nptxra 36
  • 23 (a)
nptxrb 36
  • 31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3519 35
Species with no ortholog for NPTXR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NPTXR Gene

Gene Tree for NPTXR (if available)
Gene Tree for NPTXR (if available)

Paralogs for NPTXR Gene

Paralogs for NPTXR Gene

(2) SIMAP similar genes for NPTXR Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NPTXR: view

Variants for NPTXR Gene

Sequence variations from dbSNP and Humsavar for NPTXR Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2103514 -- 38,836,454(+) cgcaa(C/T)aagcc intron-variant
rs2235135 -- 38,820,662(+) CTGAC(C/T)TCGCG utr-variant-3-prime
rs2235136 -- 38,820,911(+) TTTTT(C/T)TGAGA utr-variant-3-prime
rs2235137 -- 38,827,567(+) CCCCA(A/C/T)GTAAG intron-variant
rs2235138 -- 38,831,829(+) TTGGC(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NPTXR Gene

Variant ID Type Subtype PubMed ID
nsv915067 CNV Loss 21882294
nsv915068 CNV Loss 21882294
dgv769n67 CNV Gain 20364138
nsv471199 CNV Loss 18288195
nsv915069 CNV Loss 21882294
nsv915070 CNV Loss 21882294
esv2724233 CNV Deletion 23290073
esv2724234 CNV Deletion 23290073
nsv915071 CNV Loss 21882294

Variation tolerance for NPTXR Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 32.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NPTXR Gene

Disorders for NPTXR Gene

MalaCards: The human disease database

(2) MalaCards diseases for NPTXR Gene - From: DISEASES

Disorder Aliases PubMed IDs
acromesomelic dysplasia, maroteaux type
  • acromesomelic dysplasia maroteaux type
acromesomelic dysplasia
  • acromesomelic dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search NPTXR in MalaCards View complete list of genes associated with diseases

Relevant External Links for NPTXR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NPTXR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NPTXR Gene

Publications for NPTXR Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases. (PMID: 19368810) Yin G.N. … Suk K. (Brain Res. 2009) 3 23
  3. Regulation of neuronal type genes in congestive heart failure rats. (PMID: 16497176) Andersson K.B. … Christensen G. (Acta Physiol (Oxf) 2006) 2 3
  4. Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin. (PMID: 16115696) Poulsen T.T. … Poulsen H.S. (Lung Cancer 2005) 3 23
  5. Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49. (PMID: 9261167) Dodds D.C. … Perin M.S. (J. Biol. Chem. 1997) 3 23

Products for NPTXR Gene

Sources for NPTXR Gene