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Aliases for GRIP1 Gene

Aliases for GRIP1 Gene

  • Glutamate Receptor Interacting Protein 1 2 3
  • Glutamate Receptor-Interacting Protein 1 3
  • GRIP-1 4
  • GRIP 3

External Ids for GRIP1 Gene

Previous GeneCards Identifiers for GRIP1 Gene

  • GC12M066134
  • GC12U900033
  • GC12M066459
  • GC12M065028
  • GC12M066741
  • GC12M063792

Summaries for GRIP1 Gene

Entrez Gene Summary for GRIP1 Gene

  • This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]

GeneCards Summary for GRIP1 Gene

GRIP1 (Glutamate Receptor Interacting Protein 1) is a Protein Coding gene. Diseases associated with GRIP1 include cryptophthalmos and grip1-related fraser syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include transcription coactivator activity and beta-catenin binding.

UniProtKB/Swiss-Prot for GRIP1 Gene

  • May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Gene Wiki entry for GRIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIP1 Gene

Genomics for GRIP1 Gene

Regulatory Elements for GRIP1 Gene

Genomic Location for GRIP1 Gene

66,347,398 bp from pter
67,069,231 bp from pter
721,834 bases
Minus strand

Genomic View for GRIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GRIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIP1 Gene

Proteins for GRIP1 Gene

  • Protein details for GRIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glutamate receptor-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • C9JT59
    • Q1RLM0

    Protein attributes for GRIP1 Gene

    1128 amino acids
    Molecular mass:
    122422 Da
    Quaternary structure:
    • Interacts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRIPAP1/GRASP1, PPFIA1, PPFIA4, FRAS1, PLCD4, PTPRF and liprins-alpha. Can form homomultimers or heteromultimers with GRIP2. Forms a ternary complex with GRIA2 and CSPG4 (By similarity). Interacts with ATAD1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly (By similarity). Interacts with EFNB1, EFNB3 and the C-terminal tail of PRLHR. Interacts with SLC30A9 (By similarity). Interacts with WBSCR22.

    Three dimensional structures from OCA and Proteopedia for GRIP1 Gene

    Alternative splice isoforms for GRIP1 Gene


neXtProt entry for GRIP1 Gene

Proteomics data for GRIP1 Gene at MOPED

Post-translational modifications for GRIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for GRIP1 Gene

Domains for GRIP1 Gene

Protein Domains for GRIP1 Gene


Suggested Antigen Peptide Sequences for GRIP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y3R0
  • PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 and EPHB2 and with the C-terminus of PPFIA1 and PPFIA4. PDZ 4 and PDZ 5 mediate interaction with the C-terminus of GRIA2 and GRIA3. PDZ 4, PDZ 5 and PDZ 6 mediate homomultimers. PDZ 7 mediates interaction with PDZ domain of GRASP1. PDZ 7 domain binds CSPG4. PDZ 6 mediates interaction with the C-terminus of liprins-alpha. PDZ 1, PDZ 2 and PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (By similarity). PDZ 4 and PDZ 5 mediate interaction with PRLHR.
  • Contains 7 PDZ (DHR) domains.
genes like me logo Genes that share domains with GRIP1: view

No data available for Gene Families for GRIP1 Gene

Function for GRIP1 Gene

Molecular function for GRIP1 Gene

UniProtKB/Swiss-Prot Function:
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

Gene Ontology (GO) - Molecular Function for GRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 11641419
GO:0008013 beta-catenin binding TAS 16344550
GO:0008022 protein C-terminus binding IPI 16344550
GO:0030159 receptor signaling complex scaffold activity NAS 10197531
genes like me logo Genes that share ontologies with GRIP1: view
genes like me logo Genes that share phenotypes with GRIP1: view

Animal Models for GRIP1 Gene

MGI Knock Outs for GRIP1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for GRIP1 Gene

Localization for GRIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIP1 Gene

Cytoplasmic vesicle. Endoplasmic reticulum. Cell junction, synapse, postsynaptic cell membrane. Note=Cytoplasmic and membrane-associated with vesicles, peri-Golgi complexes and endoplasmic reticulum. Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for GRIP1 Gene COMPARTMENTS Subcellular localization image for GRIP1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
plasma membrane 3
cytoskeleton 2
endosome 2
golgi apparatus 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for GRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIP1: view

Pathways for GRIP1 Gene

genes like me logo Genes that share pathways with GRIP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for GRIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0008104 protein localization IEA --
GO:0016358 dendrite development IEA --
GO:0030521 androgen receptor signaling pathway NAS 15572661
GO:0035556 intracellular signal transduction NAS 10197531
genes like me logo Genes that share ontologies with GRIP1: view

Compounds for GRIP1 Gene

(9) Novoseek inferred chemical compound relationships for GRIP1 Gene

Compound -log(P) Hits PubMed IDs
glutamate 68.8 36
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid 49.9 1
nmda 49.3 3
1,25 dihydroxy vitamin d3 28.5 1
okadaic acid 24.7 1
genes like me logo Genes that share compounds with GRIP1: view

Transcripts for GRIP1 Gene

mRNA/cDNA for GRIP1 Gene

(8) Additional mRNA sequences :
(10) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GRIP1 Gene

Glutamate receptor interacting protein 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GRIP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c
SP1: -
SP2: - - - - - - - - - - - - - - - - -

Relevant External Links for GRIP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GRIP1 Gene

mRNA expression in normal human tissues for GRIP1 Gene

Protein differential expression in normal tissues for GRIP1 Gene

This gene is overexpressed in Fetal Brain (33.5), Placenta (10.3), and Stomach (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GRIP1 Gene

SOURCE GeneReport for Unigene cluster for GRIP1 Gene Hs.505946

genes like me logo Genes that share expressions with GRIP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for GRIP1 Gene

Orthologs for GRIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GRIP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GRIP1 35
  • 91.04 (n)
  • 93.85 (a)
GRIP1 36
  • 91 (a)
(Canis familiaris)
Mammalia GRIP1 35
  • 91.06 (n)
  • 95.78 (a)
GRIP1 36
  • 97 (a)
(Mus musculus)
Mammalia Grip1 35
  • 88.93 (n)
  • 95.94 (a)
Grip1 16
Grip1 36
  • 92 (a)
(Pan troglodytes)
Mammalia GRIP1 35
  • 99.66 (n)
  • 99.54 (a)
GRIP1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Grip1 35
  • 89 (n)
  • 96.04 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
-- 36
  • 76 (a)
-- 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia GRIP1 36
  • 72 (a)
(Gallus gallus)
Aves GRIP1 35
  • 81.3 (n)
  • 89.61 (a)
GRIP1 36
  • 79 (a)
(Anolis carolinensis)
Reptilia GRIP1 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia grip1 35
  • 76.8 (n)
  • 84.7 (a)
(Danio rerio)
Actinopterygii grip1 35
  • 71.82 (n)
  • 80.87 (a)
grip1 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Grip 36
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
Species with no ortholog for GRIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIP1 Gene

Gene Tree for GRIP1 (if available)
Gene Tree for GRIP1 (if available)

Paralogs for GRIP1 Gene Pseudogenes for GRIP1 Gene

genes like me logo Genes that share paralogs with GRIP1: view

No data available for Paralogs for GRIP1 Gene

Variants for GRIP1 Gene

Sequence variations from dbSNP and Humsavar for GRIP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1288 -- 66,453,008(+) TATGT(A/T)TATTG intron-variant
rs1289 -- 66,452,855(+) CCTCA(C/T)TTAAA intron-variant
rs1290 -- 66,452,946(+) TTTAT(G/T)GTTTG intron-variant
rs13277 -- 66,392,311(+) ACCTT(C/G)AGTTC reference, missense
rs710631 -- 67,023,543(+) atata(C/T)gctaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GRIP1 Gene

Variant ID Type Subtype PubMed ID
esv2665166 CNV Deletion 23128226
esv24958 CNV Loss 19812545
nsv832447 CNV Gain 17160897
esv2674648 CNV Deletion 23128226
esv27571 CNV Loss 19812545
nsv518043 CNV Loss 19592680
nsv469459 CNV Gain 19166990
nsv522810 CNV Loss 19592680
nsv832449 CNV Gain 17160897
esv33058 CNV Loss 17666407
nsv8985 CNV Gain 18304495
dgv518e1 CNV Complex 17122850
esv273201 CNV Insertion 20981092
esv268302 CNV Insertion 20981092
esv28890 CNV Loss 19812545
nsv518007 CNV Loss 19592680
esv34782 CNV Loss 17911159
esv8138 OTHER Inversion 19470904
esv2678667 CNV Deletion 23128226
nsv442275 CNV CNV 18776908
esv24259 CNV Gain 19812545
nsv53367 CNV Loss 16902084
nsv469461 CNV Loss 19166990
esv270552 CNV Insertion 20981092
esv273038 CNV Insertion 20981092
nsv527057 CNV Loss 19592680

Relevant External Links for GRIP1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIP1 Gene

Disorders for GRIP1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for GRIP1 Gene in MalaCards »

(3) Diseases for GRIP1 Gene including...

(1) OMIM Diseases for GRIP1 Gene (604597)


  • Fraser syndrome (FRASS) [MIM:219000]: Multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. {ECO:0000269 PubMed:22510445}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(7) Novoseek inferred disease relationships for GRIP1 Gene

Disease -log(P) Hits PubMed IDs
fraser syndrome 78.2 2
cryptophthalmos 72.5 1
renal agenesis 46.9 1
syndactyly 44.1 1
genetic disorder 21.6 1

Relevant External Links for GRIP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with GRIP1: view

No data available for University of Copenhagen DISEASES and Genatlas for GRIP1 Gene

Publications for GRIP1 Gene

  1. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. (PMID: 10197531) Brueckner K. … Klein R. (Neuron 1999) 2 3 4 23
  2. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionic acid receptor clustering. (PMID: 11641419) Lin S.H.S. … Civelli O. (Mol. Pharmacol. 2001) 3 4 23
  3. No association of GRIP1 gene polymorphisms with schizophrenia in Chinese population. (PMID: 17303296) Tsai S.J. … Hong C.J. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2007) 3 23 48
  4. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A. … Carracedo A. (Gynecol. Oncol. 2009) 3 48
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48

Products for GRIP1 Gene

  • Addgene plasmids for GRIP1

Sources for GRIP1 Gene

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