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Aliases for TDRD7 Gene

Aliases for TDRD7 Gene

  • Tudor Domain Containing 7 2 3
  • TRAP 3 4 6
  • PCTAIRE2-Binding Protein 3 4
  • PCTAIRE2BP 3 4
  • CATC4 3 6
  • Tudor Repeat Associator With PCTAIRE 2 3
  • Tudor Repeat Associator With PCTAIRE-2 4
  • Tudor Domain-Containing Protein 7 3
  • KIAA1529 6
  • CTRCT36 6

External Ids for TDRD7 Gene

Previous GeneCards Identifiers for TDRD7 Gene

  • GC09P095555
  • GC09P097253
  • GC09P099214
  • GC09P100174
  • GC09P069775

Summaries for TDRD7 Gene

Entrez Gene Summary for TDRD7 Gene

  • The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

GeneCards Summary for TDRD7 Gene

TDRD7 (Tudor Domain Containing 7) is a Protein Coding gene. Diseases associated with TDRD7 include cataract 36. Among its related pathways are Aurora A signaling. GO annotations related to this gene include protein N-terminus binding and mRNA binding. An important paralog of this gene is TDRKH.

UniProtKB/Swiss-Prot for TDRD7 Gene

  • Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.

Gene Wiki entry for TDRD7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD7 Gene

Genomics for TDRD7 Gene

Regulatory Elements for TDRD7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TDRD7 Gene

Start:
97,411,950 bp from pter
End:
97,496,125 bp from pter
Size:
84,176 bases
Orientation:
Plus strand

Genomic View for TDRD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD7 Gene

Proteins for TDRD7 Gene

  • Protein details for TDRD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHU6-TDRD7_HUMAN
    Recommended name:
    Tudor domain-containing protein 7
    Protein Accession:
    Q8NHU6
    Secondary Accessions:
    • A6NCI6
    • B2RBX3
    • B4DG99
    • B4DXF7
    • E7EQD4
    • Q5VV27
    • Q96JT1
    • Q9UFF0
    • Q9Y2M3

    Protein attributes for TDRD7 Gene

    Size:
    1098 amino acids
    Molecular mass:
    123586 Da
    Quaternary structure:
    • Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TDRD7 Gene

    Alternative splice isoforms for TDRD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD7 Gene

Proteomics data for TDRD7 Gene at MOPED

Post-translational modifications for TDRD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TDRD7 Gene

Domains for TDRD7 Gene

Gene Families for TDRD7 Gene

HGNC:
  • TDRD :Tudor domain containing

Protein Domains for TDRD7 Gene

Suggested Antigen Peptide Sequences for TDRD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NHU6

UniProtKB/Swiss-Prot:

TDRD7_HUMAN :
  • Q8NHU6
Domain:
  • Contains 3 HTH OST-type domains.
  • Contains 2 Tudor domains.
Family:
  • Belongs to the TDRD7 family.
genes like me logo Genes that share domains with TDRD7: view

Function for TDRD7 Gene

Molecular function for TDRD7 Gene

UniProtKB/Swiss-Prot Function: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.

Gene Ontology (GO) - Molecular Function for TDRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 21436445
GO:0005515 protein binding IPI 14603251
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with TDRD7: view
genes like me logo Genes that share phenotypes with TDRD7: view

Animal Models for TDRD7 Gene

MGI Knock Outs for TDRD7:

Animal Model Products

CRISPR Products

miRNA for TDRD7 Gene

miRTarBase miRNAs that target TDRD7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TDRD7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TDRD7 Gene

Localization for TDRD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD7 Gene

Cytoplasm. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TDRD7 Gene COMPARTMENTS Subcellular localization image for TDRD7 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TDRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005759 mitochondrial matrix IEA --
GO:0030529 ribonucleoprotein complex --
GO:0033391 chromatoid body ISS --
GO:0035770 ribonucleoprotein granule IDA 21436445
genes like me logo Genes that share ontologies with TDRD7: view

Pathways for TDRD7 Gene

SuperPathways for TDRD7 Gene

Superpath Contained pathways
1 Aurora A signaling
genes like me logo Genes that share pathways with TDRD7: view

Pathways by source for TDRD7 Gene

1 BioSystems pathway for TDRD7 Gene

Gene Ontology (GO) - Biological Process for TDRD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IMP 21436445
GO:0007281 germ cell development IEA --
GO:0007283 spermatogenesis ISS --
GO:0010608 posttranscriptional regulation of gene expression IMP 21436445
GO:0070306 lens fiber cell differentiation IMP 21436445
genes like me logo Genes that share ontologies with TDRD7: view

Transcripts for TDRD7 Gene

Unigene Clusters for TDRD7 Gene

Tudor domain containing 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TDRD7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18
SP1: - -
SP2: -
SP3:

Relevant External Links for TDRD7 Gene

GeneLoc Exon Structure for
TDRD7
ECgene alternative splicing isoforms for
TDRD7

Expression for TDRD7 Gene

mRNA expression in normal human tissues for TDRD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TDRD7 Gene

SOURCE GeneReport for Unigene cluster for TDRD7 Gene Hs.193842

genes like me logo Genes that share expressions with TDRD7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TDRD7 Gene

Orthologs for TDRD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD7 35
  • 99.54 (n)
  • 99.64 (a)
TDRD7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TDRD7 35
  • 90.5 (n)
  • 90.35 (a)
TDRD7 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TDRD7 35
  • 91.5 (n)
  • 91.8 (a)
TDRD7 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrd7 35
  • 83.61 (n)
  • 84.81 (a)
Tdrd7 16
Tdrd7 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD7 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRD7 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrd7 35
  • 84.38 (n)
  • 85.82 (a)
chicken
(Gallus gallus)
Aves TDRD7 35
  • 62.83 (n)
  • 55.06 (a)
TDRD7 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRD7 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3586 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16511 35
tdrd7 35
  • 61.69 (n)
  • 56.9 (a)
zebrafish
(Danio rerio)
Actinopterygii tdrd7 36
  • 43 (a)
OneToMany
tdrd7b 35
  • 57.71 (n)
  • 51.75 (a)
TDRD7B 36
  • 48 (a)
OneToMany
wufi12c12 35
fruit fly
(Drosophila melanogaster)
Insecta papi 36
  • 12 (a)
OneToMany
Species with no ortholog for TDRD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD7 Gene

ENSEMBL:
Gene Tree for TDRD7 (if available)
TreeFam:
Gene Tree for TDRD7 (if available)

Paralogs for TDRD7 Gene

Paralogs for TDRD7 Gene

genes like me logo Genes that share paralogs with TDRD7: view

Variants for TDRD7 Gene

Sequence variations from dbSNP and Humsavar for TDRD7 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs728210 -- 97,413,196(-) GTTGC(C/G)TATCT intron-variant
rs732688 -- 97,419,576(-) CACTC(C/T)GAATG intron-variant
rs732689 -- 97,419,487(-) TTTGG(C/G)TCCTG intron-variant
rs1137640 -- 97,472,428(+) AGAAG(A/G)TGATA reference, missense
rs1381532 -- 97,428,498(-) GCTCG(C/T)AGCAT reference, synonymous-codon, intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TDRD7 Gene

Variant ID Type Subtype PubMed ID
nsv893609 CNV Gain 21882294

Relevant External Links for TDRD7 Gene

HapMap Linkage Disequilibrium report
TDRD7
Human Gene Mutation Database (HGMD)
TDRD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD7 Gene

Disorders for TDRD7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TDRD7 Gene including...

Search for TDRD7 Gene in MalaCards »

(1) OMIM Diseases for TDRD7 Gene (611258)

UniProtKB/Swiss-Prot

TDRD7_HUMAN
  • Cataract 36 (CTRCT36) [MIM:613887]: An opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269 PubMed:21436445}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TDRD7

Genetic Association Database (GAD)
TDRD7
genes like me logo Genes that share disorders with TDRD7: view

Publications for TDRD7 Gene

  1. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. (PMID: 21436445) Lachke S.A. … Maas R.L. (Science 2011) 2 3 4
  2. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. (PMID: 10727952) Hirose T. … Okada M. (Eur. J. Biochem. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for TDRD7 Gene

  • Addgene plasmids for TDRD7

Sources for TDRD7 Gene

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