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Aliases for SIRT5 Gene

Aliases for SIRT5 Gene

  • Sirtuin 5 2 3
  • SIR2L5 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 5 (S. Cerevisiae) 2
  • Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 5 2
  • NAD-Dependent Lysine Demalonylase And Desuccinylase Sirtuin-5, Mitochondrial 3
  • Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog 5 3
  • NAD-Dependent Protein Deacylase Sirtuin-5, Mitochondrial 3
  • NAD-Dependent Deacetylase Sirtuin-5 3
  • Regulatory Protein SIR2 Homolog 5 4
  • SIR2-Like Protein 5 4
  • Sirtuin Type 5 3
  • Sir2-Like 5 3
  • EC 3.5.1.- 4

External Ids for SIRT5 Gene

Summaries for SIRT5 Gene

Entrez Gene Summary for SIRT5 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

GeneCards Summary for SIRT5 Gene

SIRT5 (Sirtuin 5) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and protein-malonyllysine demalonylase activity. An important paralog of this gene is SIRT1.

UniProtKB/Swiss-Prot for SIRT5 Gene

  • NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.

Tocris Summary for SIRT5 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis. In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacteylases are involved in the normal ageing process through their role in resistance to cellular stress.

Gene Wiki entry for SIRT5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT5 Gene

Genomics for SIRT5 Gene

Genomic Location for SIRT5 Gene

Start:
13,574,274 bp from pter
End:
13,615,158 bp from pter
Size:
40,885 bases
Orientation:
Plus strand

Genomic View for SIRT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIRT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT5 Gene

Regulatory Elements for SIRT5 Gene

Proteins for SIRT5 Gene

  • Protein details for SIRT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXA8-SIR5_HUMAN
    Recommended name:
    NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Protein Accession:
    Q9NXA8
    Secondary Accessions:
    • B4DFM4
    • B4DYJ5
    • F5H5Z9
    • Q5T294
    • Q5T295
    • Q9Y6E6

    Protein attributes for SIRT5 Gene

    Size:
    310 amino acids
    Molecular mass:
    33881 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.
    Miscellaneous:
    • The mechanism of demalonylation and desuccinylation involves the presence of a 1,2-cyclic intermediate, suggesting that sirtuins use the ADP-ribose-peptidylamidate mechanism to remove acyl groups from substrate lysine residues.

    Three dimensional structures from OCA and Proteopedia for SIRT5 Gene

    Alternative splice isoforms for SIRT5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIRT5 Gene

Proteomics data for SIRT5 Gene at MOPED

Post-translational modifications for SIRT5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SIRT5 Gene

Domains for SIRT5 Gene

Suggested Antigen Peptide Sequences for SIRT5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXA8

UniProtKB/Swiss-Prot:

SIR5_HUMAN
Domain:
  • In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity (PubMed:22076378).:
    • Q9NXA8
  • Contains 1 deacetylase sirtuin-type domain.:
    • Q9NXA8
Family:
  • Belongs to the sirtuin family. Class III subfamily.:
    • Q9NXA8
genes like me logo Genes that share domains with SIRT5: view

No data available for Gene Families for SIRT5 Gene

Function for SIRT5 Gene

Molecular function for SIRT5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=6.1 uM for a synthetic histone H3K9 malonyllysine peptide {ECO:0000269 PubMed:22076378}; KM=5.8 uM for a synthetic histone H3K9 succinyllysine peptide {ECO:0000269 PubMed:22076378}; KM=8.7 uM for a synthetic GLUD1 peptide malonylated at Lys-503 {ECO:0000269 PubMed:22076378}; KM=14 uM for a synthetic GLUD1 peptide succinylated at Lys-503 {ECO:0000269 PubMed:22076378}; KM=150 uM for a synthetic ACSS1 peptide malonylated at Lys-628 {ECO:0000269 PubMed:22076378}; KM=450 uM for a synthetic ACSS1 peptide succinylated at Lys- 628 {ECO:0000269 PubMed:22076378};
UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + a malonylprotein = nicotinamide + O-malonyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + a succinylprotein = nicotinamide + O-succinyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by suramin. NAD-dependent lysine desuccinylase activity is inhibited by physiological nicotinamide concentrations, while deacetylase activity is not. In contrast, resveratrol activates deacetylase activity, while inhibiting desuccinylase activity.
UniProtKB/Swiss-Prot Function: NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.

Enzyme Numbers (IUBMB) for SIRT5 Gene

Gene Ontology (GO) - Molecular Function for SIRT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NOT NAD+ ADP-ribosyltransferase activity TAS 17456799
GO:0005515 protein binding --
GO:0008270 zinc ion binding IDA 22076378
GO:0036054 protein-malonyllysine demalonylase activity IDA 21908771
GO:0036055 protein-succinyllysine desuccinylase activity IDA 21908771
genes like me logo Genes that share ontologies with SIRT5: view
genes like me logo Genes that share phenotypes with SIRT5: view

Animal Models for SIRT5 Gene

MGI Knock Outs for SIRT5:

miRNA for SIRT5 Gene

miRTarBase miRNAs that target SIRT5

No data available for Transcription Factor Targeting and HOMER Transcription for SIRT5 Gene

Localization for SIRT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT5 Gene

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Note=Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.
Isoform 1: Cytoplasm. Mitochondrion.
Isoform 2: Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIRT5 Gene COMPARTMENTS Subcellular localization image for SIRT5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for SIRT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 23806337
GO:0005739 mitochondrion IDA --
GO:0005758 mitochondrial intermembrane space IDA 18680753
GO:0005759 mitochondrial matrix IDA 18680753
GO:0005829 cytosol IDA 23806337
genes like me logo Genes that share ontologies with SIRT5: view

Pathways for SIRT5 Gene

genes like me logo Genes that share pathways with SIRT5: view

Pathways by source for SIRT5 Gene

2 GeneGo (Thomson Reuters) pathways for SIRT5 Gene
1 Sino Biological pathway for SIRT5 Gene
2 Qiagen pathways for SIRT5 Gene
2 Cell Signaling Technology pathways for SIRT5 Gene
1 BioSystems pathway for SIRT5 Gene

Gene Ontology (GO) - Biological Process for SIRT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing TAS 10381378
GO:0006471 NOT protein ADP-ribosylation TAS 17456799
GO:0006476 NOT protein deacetylation IDA 22076378
GO:0036047 peptidyl-lysine demalonylation IDA 21908771
GO:0036048 protein desuccinylation IDA 24140062
genes like me logo Genes that share ontologies with SIRT5: view

Compounds for SIRT5 Gene

(6) ApexBio Compounds for SIRT5 Gene

Compound Action Cas Number
EX 527 (SEN0014196) novel, potential, and specific small-molecule inhibitor of SIRT1 [49843-98-3]
Sirtinol specific SIRT1 and SIRT2 inhibitor [410536-97-9]
sirtuin modulator sirtuin modulator. [1093403-33-8]
SRT1720 activating the sirtuin subtype SIRT1 in vitro. [1001645-58-4]
Tenovin-3 Tenovin-3 [1011301-27-1]
Tenovin-6 a potent SIRT1 and SIRT2 inhibitor as well as p53 activator. [1011557-82-6]

(5) Tocris Compounds for SIRT5 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor [304896-28-4]
AK 7 Selective SIRT2 inhibitor; brain penetrant [420831-40-9]
EX 527 Selective SIRT1 inhibitor [49843-98-3]
Sirtinol Selective sirtuin family deacetylase inhibitor [410536-97-9]
Splitomicin Sir2p inhibitor [5690-03-9]

(1) HMDB Compounds for SIRT5 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(5) Drugbank Compounds for SIRT5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-O-Acetyl Adenosine-5-Diphosphoribose
target
Adenosine-5-Diphosphoribose
target
Nicotinamide
98-92-0 target
Nicotinamide-Adenine-Dinucleotide
53-84-9 target
Suramin
  • Bayer 205
145-63-1 target inhibitor
genes like me logo Genes that share compounds with SIRT5: view

Transcripts for SIRT5 Gene

Unigene Clusters for SIRT5 Gene

Sirtuin 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4:
SP5: - -
SP6: - - - - - - -
SP7:
SP8:

Relevant External Links for SIRT5 Gene

GeneLoc Exon Structure for
SIRT5
ECgene alternative splicing isoforms for
SIRT5

Expression for SIRT5 Gene

mRNA expression in normal human tissues for SIRT5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIRT5 Gene

SOURCE GeneReport for Unigene cluster for SIRT5 Gene Hs.567431

mRNA Expression by UniProt/SwissProt for SIRT5 Gene

Q9NXA8-SIR5_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SIRT5: view

No data available for mRNA differential expression in normal tissues for SIRT5 Gene

Orthologs for SIRT5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIRT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT5 35
  • 98.92 (n)
  • 98.39 (a)
SIRT5 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIRT5 35
  • 86.45 (n)
  • 87.42 (a)
SIRT5 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIRT5 35
  • 86.77 (n)
  • 87.1 (a)
SIRT5 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sirt5 35
  • 84.09 (n)
  • 86.13 (a)
Sirt5 16
Sirt5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIRT5 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIRT5 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sirt5 35
  • 83.98 (n)
  • 85.48 (a)
chicken
(Gallus gallus)
Aves SIRT5 35
  • 73.66 (n)
  • 77.7 (a)
SIRT5 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIRT5 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15494 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt5 35
  • 71.78 (n)
  • 79 (a)
Str.16272 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10779 35
zebrafish
(Danio rerio)
Actinopterygii sirt5 35
  • 68.59 (n)
  • 75.18 (a)
sirt5 36
  • 69 (a)
OneToMany
SIRT5 (2 of 2) 36
  • 52 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL004W 35
  • 45.02 (n)
  • 40.3 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST1 36
  • 13 (a)
ManyToMany
SIR2 36
  • 11 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8513 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for SIRT5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SIRT5 Gene

ENSEMBL:
Gene Tree for SIRT5 (if available)
TreeFam:
Gene Tree for SIRT5 (if available)

Paralogs for SIRT5 Gene

Paralogs for SIRT5 Gene

Selected SIMAP similar genes for SIRT5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SIRT5 Gene

genes like me logo Genes that share paralogs with SIRT5: view

Variants for SIRT5 Gene

Sequence variations from dbSNP and Humsavar for SIRT5 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2253217 -- 13,600,227(-) TACGC(A/G)CCACA intron-variant
rs2328676 -- 13,576,476(-) GACAA(A/C)GAACC intron-variant
rs2804910 -- 13,578,906(+) AACCT(A/G)CCTAG intron-variant
rs2804911 -- 13,579,596(+) TTGGG(A/C)GAAAT utr-variant-5-prime
rs2804912 -- 13,579,676(+) GTTAC(G/T)GTTAG intron-variant

Relevant External Links for SIRT5 Gene

HapMap Linkage Disequilibrium report
SIRT5
Human Gene Mutation Database (HGMD)
SIRT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SIRT5 Gene

Disorders for SIRT5 Gene

Relevant External Links for SIRT5

Genetic Association Database (GAD)
SIRT5
Human Genome Epidemiology (HuGE) Navigator
SIRT5
genes like me logo Genes that share disorders with SIRT5: view

No data available for UniProtKB/Swiss-Prot for SIRT5 Gene

Publications for SIRT5 Gene

  1. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. (PMID: 18680753) Schlicker C. … Steegborn C. (J. Mol. Biol. 2008) 3 4 23
  2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PMID: 10381378) Frye R.A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SIRT5 Gene

  • Addgene plasmids for SIRT5

Sources for SIRT5 Gene

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