Aliases for EXOSC2 Gene
Aliases for EXOSC2 Gene
External Ids for EXOSC2 Gene
- HGNC: 17097
- Entrez Gene: 23404
- Ensembl: ENSG00000130713
- OMIM: 602238
- UniProtKB: Q13868
Previous GeneCards Identifiers for EXOSC2 Gene
- GC09P128846
- GC09P130598
- GC09P132558
- GC09P133569
- GC09P103055
Summaries for EXOSC2 Gene
GeneCards Summary for EXOSC2 Gene
EXOSC2 (Exosome Component 2) is a Protein Coding gene. Diseases associated with EXOSC2 include Short Stature, Hearing Loss, Retinitis Pigmentosa, And Distinctive Facies and Retinitis Pigmentosa. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and exoribonuclease activity.
UniProtKB/Swiss-Prot for EXOSC2 Gene
-
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
Additional gene information for EXOSC2 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC2 Gene
Genomics for EXOSC2 Gene
GeneHancer (GH) Regulatory Elements for EXOSC2 Gene
Promoters and enhancers for EXOSC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around EXOSC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for EXOSC2 Gene
Genomic Locations for EXOSC2 Gene
- chr9:130,693,721-130,704,894
- (GRCh38/hg38)
- Size:
- 11,174 bases
- Orientation:
- Plus strand
- chr9:133,569,108-133,580,452
- (GRCh37/hg19)
Genomic View for EXOSC2 Gene
Genes around EXOSC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.12 by Ensembl
- 9q34.12 by Entrez Gene
- 9q34.12 by HGNC
EXOSC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EXOSC2 Gene
Proteins for EXOSC2 Gene
-
Protein details for EXOSC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13868-EXOS2_HUMAN
- Recommended name:
- Exosome complex component RRP4
- Protein Accession:
- Q13868
- A3KFL3
- A3KFL4
- B4DKK6
- Q9NUY4
Protein attributes for EXOSC2 Gene
- Size:
- 293 amino acids
- Molecular mass:
- 32789 Da
- Quaternary structure:
-
- Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (PubMed:11719186, PubMed:20531389). Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure (PubMed:11719186, PubMed:20531389). Interacts with DIS3 (PubMed:20531389). Interacts with GTPBP1 (PubMed:21515746). Interacts with ZFP36L1 (via N-terminus) (PubMed:15687258).
- SequenceCaution:
-
- Sequence=AAB60392.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for EXOSC2 Gene
Post-translational modifications for EXOSC2 Gene
- Ubiquitination at posLast=2424
Other Protein References for EXOSC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EXOSC2
- Novus Biologicals Antibodies for EXOSC2
-
Abcam antibodies for EXOSC2
-
Cloud-Clone Corp. Antibodies for EXOSC2
- Invitrogen Antibodies for EXOSC2
- GeneTex EXOSC2 antibody for EXOSC2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC2
Protein Products
-
OriGene Purified Proteins for EXOSC2
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC2
- Origene Custom Protein Services for EXOSC2
-
Cloud-Clone Corp. Proteins for EXOSC2
- antibodies-online: Search results for 7 available EXOSC2 Proteins ranked by validation data
- Compare Top EXOSC2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for EXOSC2
-
Abcam proteins for EXOSC2
Assay Products
-
Cloud-Clone Corp. Assay Kits for EXOSC2
- antibodies-online: Search results for 5 available EXOSC2 Elisa Kits ranked by validation data
- Compare Top EXOSC2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for EXOSC2 Gene
Domains & Families for EXOSC2 Gene
Gene Families for EXOSC2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for EXOSC2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EXOSC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13868- Family:
-
- Belongs to the RRP4 family.
Function for EXOSC2 Gene
Molecular function for EXOSC2 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
Phenotypes From GWAS Catalog for EXOSC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000175 | 3-5-exoribonuclease activity | TAS | 8600032 |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0004532 | NOT exoribonuclease activity | IDA | 17174896 |
| GO:0005515 | protein binding | IPI | 11719186 |
| GO:0008312 | 7S RNA binding | TAS | 8600032 |
Phenotypes for EXOSC2 Gene
- GenomeRNAi human phenotypes for EXOSC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
- Search ViGene Biosciences for EXOSC2
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC2
- genomics-online: gRNA clones - Search results for available EXOSC2 gene related products
- Applied Biological Materials CRISPR for EXOSC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC2
- GenScript: Design CRISPR guide RNA sequences for EXOSC2
miRNA for EXOSC2 Gene
- miRTarBase miRNAs that target EXOSC2
-
- hsa-mir-155-5p (MIRT020557)
- hsa-mir-7-5p (MIRT025693)
- hsa-mir-484 (MIRT041732)
- hsa-mir-30a-3p (MIRT049922)
- hsa-mir-541-5p (MIRT324475)
- hsa-mir-1238-5p (MIRT324476)
- hsa-mir-3174 (MIRT324477)
- hsa-mir-3190-3p (MIRT324478)
- hsa-mir-4758-5p (MIRT324479)
- hsa-mir-1257 (MIRT409845)
- hsa-mir-3611 (MIRT409846)
- hsa-mir-4480 (MIRT441795)
- hsa-mir-382-5p (MIRT441796)
- hsa-mir-1276 (MIRT441797)
- hsa-mir-6516-5p (MIRT477200)
- hsa-mir-455-3p (MIRT477201)
- hsa-mir-6499-3p (MIRT477202)
- hsa-mir-4252 (MIRT477203)
- hsa-mir-4537 (MIRT477204)
- hsa-mir-519e-5p (MIRT562339)
- hsa-mir-515-5p (MIRT562340)
- hsa-mir-4320 (MIRT562341)
- hsa-mir-6077 (MIRT562342)
- hsa-mir-4312 (MIRT562343)
- hsa-mir-4745-5p (MIRT562344)
- hsa-mir-4481 (MIRT562345)
- hsa-mir-4645-3p (MIRT562346)
- hsa-mir-136-5p (MIRT562347)
- hsa-mir-96-5p (MIRT668470)
- hsa-mir-1271-5p (MIRT668471)
- hsa-mir-182-5p (MIRT668472)
- hsa-mir-4674 (MIRT668473)
- hsa-mir-4437 (MIRT668474)
- hsa-mir-7150 (MIRT668475)
- hsa-mir-24-3p (MIRT668476)
- hsa-mir-4736 (MIRT668477)
- hsa-mir-4763-3p (MIRT668478)
- hsa-mir-1207-5p (MIRT668479)
- hsa-mir-378g (MIRT668480)
- hsa-mir-194-3p (MIRT668481)
- hsa-mir-5693 (MIRT668482)
- hsa-mir-7977 (MIRT671688)
- hsa-mir-4284 (MIRT671689)
- hsa-mir-383-3p (MIRT671690)
- hsa-mir-7705 (MIRT674011)
- hsa-mir-665 (MIRT682527)
- hsa-mir-887-5p (MIRT682528)
- hsa-mir-6780a-5p (MIRT682529)
- hsa-mir-6779-5p (MIRT682530)
- hsa-mir-3689c (MIRT682531)
- hsa-mir-3689b-3p (MIRT682532)
- hsa-mir-3689a-3p (MIRT682533)
- hsa-mir-30b-3p (MIRT682534)
- hsa-mir-1273h-5p (MIRT682535)
- hsa-mir-6788-5p (MIRT682536)
- hsa-mir-30c-2-3p (MIRT682537)
- hsa-mir-30c-1-3p (MIRT682538)
- hsa-mir-1273e (MIRT682539)
- hsa-mir-6799-5p (MIRT682540)
- hsa-mir-6883-5p (MIRT682541)
- hsa-mir-6785-5p (MIRT682542)
- hsa-mir-4728-5p (MIRT682543)
- hsa-mir-149-3p (MIRT682544)
- hsa-mir-7106-5p (MIRT682545)
- hsa-mir-7160-5p (MIRT682546)
- hsa-mir-6884-5p (MIRT682547)
- hsa-mir-485-5p (MIRT682548)
- hsa-mir-1827 (MIRT682549)
- hsa-mir-219b-3p (MIRT682550)
- hsa-mir-4649-3p (MIRT682551)
- hsa-mir-5690 (MIRT682552)
- hsa-mir-4478 (MIRT682553)
- hsa-mir-4419b (MIRT682554)
- hsa-mir-3929 (MIRT682555)
- hsa-mir-6511a-5p (MIRT682556)
- hsa-mir-1910-3p (MIRT682557)
- hsa-mir-890 (MIRT682558)
- hsa-mir-302f (MIRT682559)
- hsa-mir-6736-5p (MIRT692905)
- hsa-mir-4701-3p (MIRT692906)
- hsa-mir-1262 (MIRT692907)
- hsa-mir-6720-5p (MIRT692908)
- hsa-mir-6512-3p (MIRT692909)
- hsa-mir-542-3p (MIRT692910)
- hsa-mir-661 (MIRT692911)
- hsa-mir-769-5p (MIRT692912)
- hsa-mir-4786-5p (MIRT692913)
- hsa-mir-4725-5p (MIRT692914)
- hsa-mir-6776-5p (MIRT692915)
- hsa-mir-766-3p (MIRT692916)
- hsa-mir-372-5p (MIRT692917)
- hsa-mir-371a-5p (MIRT692918)
- hsa-mir-616-5p (MIRT692919)
- hsa-mir-373-5p (MIRT692920)
- hsa-mir-371b-5p (MIRT692921)
- hsa-mir-5699-3p (MIRT692922)
- hsa-mir-4421 (MIRT692923)
- hsa-mir-6742-3p (MIRT692924)
- hsa-mir-339-5p (MIRT692925)
- hsa-mir-6849-3p (MIRT692926)
- hsa-mir-759 (MIRT692927)
- hsa-mir-5586-3p (MIRT692928)
- hsa-mir-508-5p (MIRT692929)
- hsa-mir-10b-5p (MIRT692930)
- hsa-mir-10a-5p (MIRT692931)
- hsa-mir-4797-5p (MIRT692932)
- hsa-mir-6514-3p (MIRT692933)
- hsa-mir-6771-5p (MIRT692934)
- hsa-mir-891a-3p (MIRT692935)
- hsa-mir-550a-5p (MIRT692936)
- hsa-mir-550a-3-5p (MIRT692937)
- hsa-mir-1271-3p (MIRT692938)
- hsa-mir-564 (MIRT692939)
- hsa-mir-6811-3p (MIRT692940)
- hsa-mir-214-5p (MIRT692941)
- hsa-mir-3188 (MIRT692942)
- hsa-mir-6746-5p (MIRT692943)
- hsa-mir-6767-3p (MIRT692944)
- hsa-mir-1285-3p (MIRT762200)
- hsa-mir-1-3p (MIRT762617)
- hsa-mir-196a-3p (MIRT763496)
- hsa-mir-206 (MIRT763734)
- hsa-mir-3187-5p (MIRT765303)
- hsa-mir-4433a-3p (MIRT768998)
- hsa-mir-4459 (MIRT769264)
- hsa-mir-4695-3p (MIRT771143)
- hsa-mir-4768-3p (MIRT772075)
- hsa-mir-5189-5p (MIRT773553)
- hsa-mir-6128 (MIRT775815)
- hsa-mir-612 (MIRT775844)
- hsa-mir-613 (MIRT775983)
- hsa-mir-6787-3p (MIRT779189)
- hsa-mir-6860 (MIRT780552)
- hsa-mir-7151-3p (MIRT781509)
- hsa-mir-939-3p (MIRT782799)
miRNA Products
- Search ViGene Biosciences for EXOSC2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EXOSC2
- Browse OriGene Inhibitory RNA Products For EXOSC2
- genomics-online: shRNA clones - Search results for available EXOSC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
Clone Products
- Sino Biological Human cDNA Clone for EXOSC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EXOSC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EXOSC2
- genomics-online: cdna clones - Search results for available EXOSC2 gene related products
- orf clones - Search results for available EXOSC2 gene related products
- Applied Biological Materials Clones for EXOSC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EXOSC2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC2 Gene
Localization for EXOSC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EXOSC2 Gene
- Cytoplasm. Nucleus, nucleolus. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
- Nucleoli (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000176 | nuclear exosome (RNase complex) | IBA | -- |
| GO:0000177 | cytoplasmic exosome (RNase complex) | IBA | -- |
| GO:0000178 | exosome (RNase complex) | IDA | 20531389 |
| GO:0005634 | nucleus | TAS,IDA | 17545563 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for EXOSC2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | Deadenylation-dependent mRNA decay |
.46
|
|
| 3 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 4 | PERK regulates gene expression | ||
| 5 | Gene Expression |
.48
|
|
Pathways by source for EXOSC2 Gene
14 Reactome pathways for EXOSC2 Gene
1 KEGG pathway for EXOSC2 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC2 Gene
Interacting Proteins for EXOSC2 Gene
Selected Interacting proteins:
ENSP00000361433
Q13868-EXOS2_HUMAN
for EXOSC2 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000467 | exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0030307 | positive regulation of cell growth | IMP | 17545563 |
| GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 | IBA | -- |
| GO:0034475 | U4 snRNA 3-end processing | IBA | -- |
No data available for SIGNOR curated interactions for EXOSC2 Gene
Transcripts for EXOSC2 Gene
mRNA/cDNA for EXOSC2 Gene
- (6) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (247) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC2
- genomics-online: gRNA clones - Search results for available EXOSC2 gene related products
- Applied Biological Materials CRISPR for EXOSC2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC2
- GenScript: Design CRISPR guide RNA sequences for EXOSC2
miRNA Products
- Search ViGene Biosciences for EXOSC2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for EXOSC2
- Browse OriGene Inhibitory RNA Products For EXOSC2
- genomics-online: shRNA clones - Search results for available EXOSC2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
Clone Products
- Sino Biological Human cDNA Clone for EXOSC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for EXOSC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EXOSC2
- genomics-online: cdna clones - Search results for available EXOSC2 gene related products
- orf clones - Search results for available EXOSC2 gene related products
- Applied Biological Materials Clones for EXOSC2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - |
Expression for EXOSC2 Gene
This gene is overexpressed in Pancreas (7.7) and Lymph node (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOSC2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EXOSC2 Gene:
EXOSC2SOURCE GeneReport for Unigene cluster for EXOSC2 Gene:
Hs.654643Evidence on tissue expression from TISSUES for EXOSC2 Gene
- Lung(4.4)
- Intestine(4.2)
- Nervous system(3.3)
Primer Products
-
OriGene qPCR primer pairs for EXOSC2
-
OriGene qPCR primer pairs and template standards for EXOSC2
- genomics-online: primer clones - Search results for available EXOSC2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC2 Gene
Orthologs for EXOSC2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EXOSC2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EXOSC2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EXOSC2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | EXOSC2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Exosc2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Exosc2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EXOSC2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EXOSC2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EXOSC2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | exosc2 33 |
|
||
| Str.5017 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | exosc2 33 34 |
|
||
| wufa97b01 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.183 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rrp4 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011211 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | exos-2 33 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E12739g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL034C 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RRP4 33 34 36 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RRP4 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0520000 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC2F7.14c 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04009 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8392 33 |
|
- Species where no ortholog for EXOSC2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EXOSC2 Gene
No data available for Paralogs for EXOSC2 Gene
Variants for EXOSC2 Gene
| SNP ID | Clin | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs537467155 | pathogenic, SHORT STATURE, HEARING LOSS, RETINITIS PIGMENTOSA, AND DISTINCTIVE FACIES | 130,693,880(+) | G/T | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs756204866 | pathogenic, SHORT STATURE, HEARING LOSS, RETINITIS PIGMENTOSA, AND DISTINCTIVE FACIES | 130,702,231(+) | G/A/C | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1000064620 | -- | 130,701,488(+) | G/T | intron_variant, non_coding_transcript_variant | |
| rs1000082707 | -- | 130,697,855(+) | A/G | 5_prime_UTR_variant, intron_variant | |
| rs1000158856 | -- | 130,691,850(+) | C/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.91;
35.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for EXOSC2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC2 Gene
Disorders for EXOSC2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| short stature, hearing loss, retinitis pigmentosa, and distinctive facies |
|
|
| retinitis pigmentosa |
|
|
Search EXOSC2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for EXOSC2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for EXOSC2 Gene
Publications for EXOSC2 Gene
- The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. (PMID: 9390555) Mitchell P … Tollervey D (Cell 1997) 3 4 22 58
- The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism. (PMID: 8600032) Mitchell P … Tollervey D (Genes & development 1996) 2 3 4 58
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals RH … Pruijn GJ (The EMBO journal 2010) 3 4 58
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PMID: 17545563) van Dijk EL … Pruijn GJ (RNA (New York, N.Y.) 2007) 3 4 58
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q … Lima CD (Cell 2006) 3 4 58
Products for EXOSC2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EXOSC2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EXOSC2
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC2
- Origene Custom Protein Services for EXOSC2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for EXOSC2
- Browse OriGene Inhibitory RNA Products For EXOSC2
- OriGene qPCR primer pairs and template standards for EXOSC2
- OriGene qPCR primer pairs for EXOSC2
- OriGene CRISPR knockouts for EXOSC2
- OriGene ORF clones in human for EXOSC2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EXOSC2
- GenScript: Next-day shipping of latest version cDNA ORF clones for EXOSC2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EXOSC2
- GenScript Custom Assay Services for EXOSC2
- GenScript Custom overexpressing Cell Line Services for EXOSC2
- GenScript: Design CRISPR guide RNA sequences for EXOSC2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EXOSC2
- Sino Biological Human cDNA Clone for EXOSC2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for EXOSC2
- Novus Biologicals proteins and lysates for EXOSC2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for EXOSC2
- Abcam proteins for EXOSC2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for EXOSC2
- Cloud-Clone Corp. Proteins for EXOSC2
- Cloud-Clone Corp. Assay Kits for EXOSC2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for EXOSC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC2
- VectorBuilder custom plasmid, inducible vectors for EXOSC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for EXOSC2
- antibodies-online: Search results for 39 available EXOSC2 Antibodies ranked by validation data
- Compare Top EXOSC2 Antibodies
- antibodies-online: Search results for 5 available EXOSC2 Elisa Kits ranked by validation data
- Compare Top EXOSC2 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 7 available EXOSC2 Proteins ranked by validation data
- Compare Top EXOSC2 Proteins
- Quality Products:
- GeneTex EXOSC2 antibody for EXOSC2
- Search GeneTex for Proteins for EXOSC2
- ViGene Biosciences adenoviral particle packaged cDNA for EXOSC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EXOSC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
- Search ViGene Biosciences for EXOSC2
- Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC2
- Search Santa Cruz Biotechnology (SCBT) for EXOSC2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC2
- genomics-online: cdna clones - Search results for available EXOSC2 gene related products
- orf clones - Search results for available EXOSC2 gene related products
- genomics-online: gRNA clones - Search results for available EXOSC2 gene related products
- genomics-online: primer clones - Search results for available EXOSC2 gene related products
- genomics-online: shRNA clones - Search results for available EXOSC2 gene related products
Sources for EXOSC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew