Aliases for EXOSC2 Gene
Aliases for EXOSC2 Gene
External Ids for EXOSC2 Gene
- HGNC: 17097
- Entrez Gene: 23404
- Ensembl: ENSG00000130713
- OMIM: 602238
- UniProtKB: Q13868
Previous GeneCards Identifiers for EXOSC2 Gene
- GC09P128846
- GC09P130598
- GC09P132558
- GC09P133569
- GC09P103055
Summaries for EXOSC2 Gene
GeneCards Summary for EXOSC2 Gene
EXOSC2 (Exosome Component 2) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and exoribonuclease activity.
UniProtKB/Swiss-Prot for EXOSC2 Gene
-
Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC2 Gene
Genomics for EXOSC2 Gene
Regulatory Elements for EXOSC2 Gene
Enhancers for EXOSC2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around EXOSC2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for EXOSC2 Gene
- Chromosome:
- 9
- Start:
- 130,693,721 bp from pter
- End:
- 130,704,894 bp from pter
- Size:
- 11,174 bases
- Orientation:
- Plus strand
Genomic View for EXOSC2 Gene
Genes around EXOSC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q34.12 by Ensembl
- 9q34.12 by Entrez Gene
- 9q34.12 by HGNC
EXOSC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EXOSC2 Gene
Proteins for EXOSC2 Gene
-
Protein details for EXOSC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13868-EXOS2_HUMAN
- Recommended name:
- Exosome complex component RRP4
- Protein Accession:
- Q13868
- A3KFL3
- A3KFL4
- B4DKK6
- Q9NUY4
Protein attributes for EXOSC2 Gene
- Size:
- 293 amino acids
- Molecular mass:
- 32789 Da
- Quaternary structure:
-
- Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms (PubMed:11719186, PubMed:20531389). Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure (PubMed:11719186, PubMed:20531389). Interacts with DIS3 (PubMed:20531389). Interacts with GTPBP1 (PubMed:21515746). Interacts with ZFP36L1 (via N-terminus) (PubMed:15687258).
- SequenceCaution:
-
- Sequence=AAB60392.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for EXOSC2 Gene
Post-translational modifications for EXOSC2 Gene
Other Protein References for EXOSC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for EXOSC2
- Novus Biologicals Antibodies for EXOSC2
- Invitrogen Antibodies for EXOSC2
- antibodies-online Antibodies for EXOSC2: See all 36
- GeneTex EXOSC2 antibody for EXOSC2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC2
Protein Products
-
OriGene Purified Proteins for EXOSC2
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC2
- Origene Custom Protein Services for EXOSC2
- antibodies-online Proteins for EXOSC2: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EXOSC2
No data available for DME Specific Peptides for EXOSC2 Gene
Domains & Families for EXOSC2 Gene
Gene Families for EXOSC2 Gene
- HGNC:
Protein Domains for EXOSC2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EXOSC2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13868- Family:
-
- Belongs to the RRP4 family.
Function for EXOSC2 Gene
Molecular function for EXOSC2 Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000175 | 3-5-exoribonuclease activity | TAS | 8600032 |
| GO:0003723 | RNA binding | IEA | -- |
| GO:0004532 | NOT exoribonuclease activity | IDA | 17174896 |
| GO:0005515 | protein binding | IPI | 11719186 |
| GO:0008312 | 7S RNA binding | TAS | 8600032 |
Phenotypes for EXOSC2 Gene
- GenomeRNAi human phenotypes for EXOSC2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
- Search ViGene Biosciences for EXOSC2
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC2
- GenScript: Design CRISPR guide RNA sequences for EXOSC2
miRNA for EXOSC2 Gene
- miRTarBase miRNAs that target EXOSC2
-
- hsa-mir-155-5p (MIRT020557)
- hsa-mir-7-5p (MIRT025693)
- hsa-mir-484 (MIRT041732)
- hsa-mir-30a-3p (MIRT049922)
- hsa-mir-541-5p (MIRT324475)
- hsa-mir-1238-5p (MIRT324476)
- hsa-mir-3174 (MIRT324477)
- hsa-mir-3190-3p (MIRT324478)
- hsa-mir-4758-5p (MIRT324479)
- hsa-mir-1257 (MIRT409845)
- hsa-mir-3611 (MIRT409846)
- hsa-mir-4480 (MIRT441795)
- hsa-mir-382-5p (MIRT441796)
- hsa-mir-1276 (MIRT441797)
- hsa-mir-6516-5p (MIRT477200)
- hsa-mir-455-3p (MIRT477201)
- hsa-mir-6499-3p (MIRT477202)
- hsa-mir-4252 (MIRT477203)
- hsa-mir-4537 (MIRT477204)
- hsa-mir-519e-5p (MIRT562339)
- hsa-mir-515-5p (MIRT562340)
- hsa-mir-4320 (MIRT562341)
- hsa-mir-6077 (MIRT562342)
- hsa-mir-4312 (MIRT562343)
- hsa-mir-4745-5p (MIRT562344)
- hsa-mir-4481 (MIRT562345)
- hsa-mir-4645-3p (MIRT562346)
- hsa-mir-136-5p (MIRT562347)
- hsa-mir-96-5p (MIRT668470)
- hsa-mir-1271-5p (MIRT668471)
- hsa-mir-182-5p (MIRT668472)
- hsa-mir-4674 (MIRT668473)
- hsa-mir-4437 (MIRT668474)
- hsa-mir-7150 (MIRT668475)
- hsa-mir-24-3p (MIRT668476)
- hsa-mir-4736 (MIRT668477)
- hsa-mir-4763-3p (MIRT668478)
- hsa-mir-1207-5p (MIRT668479)
- hsa-mir-378g (MIRT668480)
- hsa-mir-194-3p (MIRT668481)
- hsa-mir-5693 (MIRT668482)
- hsa-mir-7977 (MIRT671688)
- hsa-mir-4284 (MIRT671689)
- hsa-mir-383-3p (MIRT671690)
- hsa-mir-7705 (MIRT674011)
- hsa-mir-665 (MIRT682527)
- hsa-mir-887-5p (MIRT682528)
- hsa-mir-6780a-5p (MIRT682529)
- hsa-mir-6779-5p (MIRT682530)
- hsa-mir-3689c (MIRT682531)
- hsa-mir-3689b-3p (MIRT682532)
- hsa-mir-3689a-3p (MIRT682533)
- hsa-mir-30b-3p (MIRT682534)
- hsa-mir-1273h-5p (MIRT682535)
- hsa-mir-6788-5p (MIRT682536)
- hsa-mir-30c-2-3p (MIRT682537)
- hsa-mir-30c-1-3p (MIRT682538)
- hsa-mir-1273e (MIRT682539)
- hsa-mir-6799-5p (MIRT682540)
- hsa-mir-6883-5p (MIRT682541)
- hsa-mir-6785-5p (MIRT682542)
- hsa-mir-4728-5p (MIRT682543)
- hsa-mir-149-3p (MIRT682544)
- hsa-mir-7106-5p (MIRT682545)
- hsa-mir-7160-5p (MIRT682546)
- hsa-mir-6884-5p (MIRT682547)
- hsa-mir-485-5p (MIRT682548)
- hsa-mir-1827 (MIRT682549)
- hsa-mir-219b-3p (MIRT682550)
- hsa-mir-4649-3p (MIRT682551)
- hsa-mir-5690 (MIRT682552)
- hsa-mir-4478 (MIRT682553)
- hsa-mir-4419b (MIRT682554)
- hsa-mir-3929 (MIRT682555)
- hsa-mir-6511a-5p (MIRT682556)
- hsa-mir-1910-3p (MIRT682557)
- hsa-mir-890 (MIRT682558)
- hsa-mir-302f (MIRT682559)
- hsa-mir-6736-5p (MIRT692905)
- hsa-mir-4701-3p (MIRT692906)
- hsa-mir-1262 (MIRT692907)
- hsa-mir-6720-5p (MIRT692908)
- hsa-mir-6512-3p (MIRT692909)
- hsa-mir-542-3p (MIRT692910)
- hsa-mir-661 (MIRT692911)
- hsa-mir-769-5p (MIRT692912)
- hsa-mir-4786-5p (MIRT692913)
- hsa-mir-4725-5p (MIRT692914)
- hsa-mir-6776-5p (MIRT692915)
- hsa-mir-766-3p (MIRT692916)
- hsa-mir-372-5p (MIRT692917)
- hsa-mir-371a-5p (MIRT692918)
- hsa-mir-616-5p (MIRT692919)
- hsa-mir-373-5p (MIRT692920)
- hsa-mir-371b-5p (MIRT692921)
- hsa-mir-5699-3p (MIRT692922)
- hsa-mir-4421 (MIRT692923)
- hsa-mir-6742-3p (MIRT692924)
- hsa-mir-339-5p (MIRT692925)
- hsa-mir-6849-3p (MIRT692926)
- hsa-mir-759 (MIRT692927)
- hsa-mir-5586-3p (MIRT692928)
- hsa-mir-508-5p (MIRT692929)
- hsa-mir-10b-5p (MIRT692930)
- hsa-mir-10a-5p (MIRT692931)
- hsa-mir-4797-5p (MIRT692932)
- hsa-mir-6514-3p (MIRT692933)
- hsa-mir-6771-5p (MIRT692934)
- hsa-mir-891a-3p (MIRT692935)
- hsa-mir-550a-5p (MIRT692936)
- hsa-mir-550a-3-5p (MIRT692937)
- hsa-mir-1271-3p (MIRT692938)
- hsa-mir-564 (MIRT692939)
- hsa-mir-6811-3p (MIRT692940)
- hsa-mir-214-5p (MIRT692941)
- hsa-mir-3188 (MIRT692942)
- hsa-mir-6746-5p (MIRT692943)
- hsa-mir-6767-3p (MIRT692944)
miRNA Products
- Search ViGene Biosciences for EXOSC2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for EXOSC2
- Browse OriGene Inhibitory RNA Products For EXOSC2
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
Clone Products
- Sino Biological Human cDNA Clone for EXOSC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EXOSC2
- VectorBuilder custom plasmid, inducible vectors for EXOSC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EXOSC2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for EXOSC2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOSC2 Gene
Localization for EXOSC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for EXOSC2 Gene
- Cytoplasm. Nucleus, nucleolus. Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000176 | nuclear exosome (RNase complex) | IBA | -- |
| GO:0000177 | cytoplasmic exosome (RNase complex) | IBA | -- |
| GO:0000178 | exosome (RNase complex) | IDA | 20531389 |
| GO:0005634 | nucleus | IDA,TAS | 17545563 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for EXOSC2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 2 | Deadenylation-dependent mRNA decay |
.47
|
|
| 3 | rRNA processing in the nucleus and cytosol |
.89
|
|
| 4 | PERK regulates gene expression | ||
| 5 | Gene Expression |
.48
|
|
Pathways by source for EXOSC2 Gene
14 Reactome pathways for EXOSC2 Gene
1 KEGG pathway for EXOSC2 Gene
1 GeneGo (Thomson Reuters) pathway for EXOSC2 Gene
Interacting Proteins for EXOSC2 Gene
Selected Interacting proteins:
Q13868-EXOS2_HUMAN
ENSP00000361433
for EXOSC2 Gene via
MINT
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000467 | exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | -- |
| GO:0006364 | rRNA processing | TAS | -- |
| GO:0030307 | positive regulation of cell growth | IMP | 17545563 |
| GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5 | IBA | -- |
| GO:0034475 | U4 snRNA 3-end processing | IBA | -- |
No data available for SIGNOR curated interactions for EXOSC2 Gene
Transcripts for EXOSC2 Gene
mRNA/cDNA for EXOSC2 Gene
- (6) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (247) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for EXOSC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC2
- GenScript: Design CRISPR guide RNA sequences for EXOSC2
miRNA Products
- Search ViGene Biosciences for EXOSC2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for EXOSC2
- Browse OriGene Inhibitory RNA Products For EXOSC2
-
ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
Clone Products
- Sino Biological Human cDNA Clone for EXOSC2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for EXOSC2
- VectorBuilder custom plasmid, inducible vectors for EXOSC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - |
Expression for EXOSC2 Gene
This gene is overexpressed in Pancreas (7.7) and Lymph node (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for EXOSC2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of EXOSC2 Gene:
EXOSC2SOURCE GeneReport for Unigene cluster for EXOSC2 Gene:
Hs.654643Evidence on tissue expression from TISSUES for EXOSC2 Gene
- Lung(4.4)
- Intestine(4.2)
- Nervous system(3.3)
Primer Products
-
OriGene qPCR primer pairs for EXOSC2
-
OriGene qPCR primer pairs and template standards for EXOSC2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for EXOSC2 Gene
Orthologs for EXOSC2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | EXOSC2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | EXOSC2 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | EXOSC2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | EXOSC2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Exosc2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Exosc2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EXOSC2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EXOSC2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | EXOSC2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | exosc2 34 |
|
||
| Str.5017 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | exosc2 34 35 |
|
||
| wufa97b01 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.183 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rrp4 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011211 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | exos-2 34 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E12739g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAL034C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RRP4 34 35 37 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RRP4 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0520000 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC2F7.14c 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU04009 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.8392 34 |
|
- Species where no ortholog for EXOSC2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EXOSC2 Gene
No data available for Paralogs for EXOSC2 Gene
Variants for EXOSC2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000064620 | -- | 130,701,488(+) | TCTTA(G/T)CTTTA | intron-variant, nc-transcript-variant | |
| rs1000082707 | -- | 130,697,855(+) | GTGGC(A/G)TGATC | intron-variant, utr-variant-5-prime | |
| rs1000158856 | -- | 130,691,850(+) | ATTAG(C/G)CGAGC | upstream-variant-2KB | |
| rs1000645967 | -- | 130,695,164(+) | CAGAA(C/T)GTTAG | intron-variant | |
| rs1001414509 | -- | 130,703,285(+) | TCCGT(C/G)AGTAT | intron-variant |
Residual Variation Intolerance Score:
29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.91;
35.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EXOSC2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOSC2 Gene
Disorders for EXOSC2 Gene
Relevant External Links for EXOSC2
No disorders were found for EXOSC2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EXOSC2 Gene
Publications for EXOSC2 Gene
- The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. (PMID: 9390555) Mitchell P. … Tollervey D. (Cell 1997) 3 4 22 64
- The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism. (PMID: 8600032) Mitchell P. … Tollervey D. (Genes Dev. 1996) 2 3 4 64
- Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals R.H. … Pruijn G.J. (EMBO J. 2010) 3 4 64
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. (PMID: 17545563) van Dijk E.L. … Pruijn G.J. (RNA 2007) 3 4 64
- Reconstitution, activities, and structure of the eukaryotic RNA exosome. (PMID: 17174896) Liu Q. … Lima C.D. (Cell 2006) 3 4 64
Products for EXOSC2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for EXOSC2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for EXOSC2
- Search Origene for MassSpec and Protein Over-expression Lysates for EXOSC2
- Origene Custom Protein Services for EXOSC2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for EXOSC2
- Browse OriGene Inhibitory RNA Products For EXOSC2
- OriGene qPCR primer pairs and template standards for EXOSC2
- OriGene qPCR primer pairs for EXOSC2
- OriGene CRISPR knockouts for EXOSC2
- OriGene ORF clones in human for EXOSC2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For EXOSC2
- GenScript: Next-day shipping cDNA ORF clone for EXOSC2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for EXOSC2
- GenScript Custom Assay Services for EXOSC2
- GenScript Custom overexpressing Cell Line Services for EXOSC2
- GenScript: Design CRISPR guide RNA sequences for EXOSC2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for EXOSC2
- Sino Biological Human cDNA Clone for EXOSC2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for EXOSC2
- Novus Biologicals proteins and lysates for EXOSC2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Cloud-Clone Corp Assay Kits for EXOSC2
- Addgene plasmids for EXOSC2
- antibodies-online Antibodies for EXOSC2: See all 36
- antibodies-online Kits for EXOSC2: See all 4
- antibodies-online Proteins for EXOSC2: See all 8
- Search antibodies-online for peptides
- GeneTex EXOSC2 antibody for EXOSC2
- Search GeneTex for Proteins for EXOSC2
- ViGene Biosciences adenoviral particle packaged cDNA for EXOSC2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for EXOSC2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for EXOSC2 gene
- Search ViGene Biosciences for EXOSC2
- Santa Cruz Biotechnology (SCBT) Antibodies for EXOSC2
- Search Santa Cruz Biotechnology (SCBT) for EXOSC2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EXOSC2
- Cyagen custom Knockout/knockin (KOKI) mouse models for EXOSC2
- VectorBuilder custom plasmid, inducible vectors for EXOSC2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for EXOSC2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for EXOSC2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer