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Aliases for EXOSC2 Gene

Aliases for EXOSC2 Gene

  • Exosome Component 2 2 3 4
  • RRP4 3 4 6
  • Ribosomal RNA-Processing Protein 4 3 4
  • Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4), 3 5 Exoribonuclease (RRP4) 3
  • Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4), 3-5-Exoribonuclease 3
  • Homolog Of Yeast RRP4 (Ribosomal RNA Processing 4) 2
  • Exosome Complex Exonuclease RRP4 3
  • Exosome Complex Component RRP4 3
  • 3 5 Exoribonuclease (RRP4) 2
  • HRrp4p 3
  • Rrp4p 3
  • P7 3

External Ids for EXOSC2 Gene

Summaries for EXOSC2 Gene

GeneCards Summary for EXOSC2 Gene

EXOSC2 (Exosome Component 2) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include structural constituent of ribosome and exoribonuclease activity.

UniProtKB/Swiss-Prot for EXOSC2 Gene

  • Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

Gene Wiki entry for EXOSC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOSC2 Gene

Genomics for EXOSC2 Gene

Genomic Location for EXOSC2 Gene

Start:
130,693,721 bp from pter
End:
130,704,894 bp from pter
Size:
11,174 bases
Orientation:
Plus strand

Genomic View for EXOSC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOSC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOSC2 Gene

Regulatory Elements for EXOSC2 Gene

Proteins for EXOSC2 Gene

  • Protein details for EXOSC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13868-EXOS2_HUMAN
    Recommended name:
    Exosome complex component RRP4
    Protein Accession:
    Q13868
    Secondary Accessions:
    • A3KFL3
    • A3KFL4
    • B4DKK6
    • Q9NUY4

    Protein attributes for EXOSC2 Gene

    Size:
    293 amino acids
    Molecular mass:
    32789 Da
    Quaternary structure:
    • Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Interacts with GTPBP1.
    SequenceCaution:
    • Sequence=AAB60392.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EXOSC2 Gene

    Alternative splice isoforms for EXOSC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EXOSC2 Gene

Proteomics data for EXOSC2 Gene at MOPED

Post-translational modifications for EXOSC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24 and Lys180

Other Protein References for EXOSC2 Gene

No data available for DME Specific Peptides for EXOSC2 Gene

Domains for EXOSC2 Gene

Protein Domains for EXOSC2 Gene

UniProtKB/Swiss-Prot:

EXOS2_HUMAN
Domain:
  • Contains 1 S1 motif domain.:
    • Q13868
Family:
  • Belongs to the RRP4 family.:
    • Q13868
genes like me logo Genes that share domains with EXOSC2: view

No data available for Gene Families for EXOSC2 Gene

Function for EXOSC2 Gene

Molecular function for EXOSC2 Gene

UniProtKB/Swiss-Prot Function: Non-catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.

Gene Ontology (GO) - Molecular Function for EXOSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity TAS 8600032
GO:0003723 RNA binding --
GO:0004532 NOT exoribonuclease activity IDA 17174896
GO:0005515 protein binding IPI 11719186
GO:0008312 7S RNA binding TAS 8600032
genes like me logo Genes that share ontologies with EXOSC2: view

miRNA for EXOSC2 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for EXOSC2 Gene

Localization for EXOSC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOSC2 Gene

Cytoplasm. Nucleus, nucleolus. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOSC2 Gene COMPARTMENTS Subcellular localization image for EXOSC2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for EXOSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000176 nuclear exosome (RNase complex) IBA --
GO:0000177 cytoplasmic exosome (RNase complex) IBA --
GO:0000178 exosome (RNase complex) IDA 20531389
GO:0005634 nucleus IDA 17545563
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with EXOSC2: view

Pathways for EXOSC2 Gene

genes like me logo Genes that share pathways with EXOSC2: view

Pathways by source for EXOSC2 Gene

1 KEGG pathway for EXOSC2 Gene

Gene Ontology (GO) - Biological Process for EXOSC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000467 exonucleolytic trimming to generate mature 3-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS 8600032
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
genes like me logo Genes that share ontologies with EXOSC2: view

Transcripts for EXOSC2 Gene

Unigene Clusters for EXOSC2 Gene

Exosome component 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EXOSC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: -
SP9:
SP10:
SP11: -
SP12: - - - - - - -

Relevant External Links for EXOSC2 Gene

GeneLoc Exon Structure for
EXOSC2
ECgene alternative splicing isoforms for
EXOSC2

Expression for EXOSC2 Gene

mRNA expression in normal human tissues for EXOSC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOSC2 Gene

SOURCE GeneReport for Unigene cluster for EXOSC2 Gene Hs.654643

genes like me logo Genes that share expressions with EXOSC2: view

Orthologs for EXOSC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOSC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOSC2 36
  • 99.77 (n)
  • 100 (a)
EXOSC2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOSC2 36
  • 91.7 (n)
  • 96.25 (a)
EXOSC2 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOSC2 36
  • 90.07 (n)
  • 96.23 (a)
EXOSC2 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exosc2 36
  • 87.37 (n)
  • 93.86 (a)
Exosc2 16
Exosc2 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOSC2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOSC2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Exosc2 36
  • 86.23 (n)
  • 94.88 (a)
chicken
(Gallus gallus)
Aves EXOSC2 36
  • 76.37 (n)
  • 85.62 (a)
EXOSC2 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOSC2 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia exosc2 36
  • 70.19 (n)
  • 79.52 (a)
Str.5017 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.183 36
zebrafish
(Danio rerio)
Actinopterygii exosc2 36
  • 71.22 (n)
  • 78.5 (a)
exosc2 37
  • 78 (a)
OneToOne
wufa97b01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011211 36
  • 61.64 (n)
  • 63.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rrp4 36
  • 62.99 (n)
  • 61.6 (a)
Rrp4 37
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exos-2 36
  • 49.75 (n)
  • 43.61 (a)
exos-2 37
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL034C 36
  • 51.24 (n)
  • 47.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP4 36
  • 51.03 (n)
  • 47.31 (a)
RRP4 37
  • 34 (a)
OneToOne
RRP4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12739g 36
  • 52.16 (n)
  • 48.24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RRP4 36
  • 56.26 (n)
  • 52.6 (a)
rice
(Oryza sativa)
Liliopsida Os04g0520000 36
  • 52.1 (n)
  • 45.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04009 36
  • 49.93 (n)
  • 46.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC2F7.14c 36
  • 53.63 (n)
  • 48.71 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8392 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
OneToOne
Species with no ortholog for EXOSC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOSC2 Gene

ENSEMBL:
Gene Tree for EXOSC2 (if available)
TreeFam:
Gene Tree for EXOSC2 (if available)

Paralogs for EXOSC2 Gene

No data available for Paralogs for EXOSC2 Gene

Variants for EXOSC2 Gene

Sequence variations from dbSNP and Humsavar for EXOSC2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1061967 -- 130,704,571(+) GGAAT(A/C)TGATT utr-variant-3-prime, nc-transcript-variant
rs1139028 -- 130,704,366(+) ctcta(C/T)taaaa utr-variant-3-prime, nc-transcript-variant
rs1139029 -- 130,704,388(+) tagcc(A/G)ggtgt utr-variant-3-prime, nc-transcript-variant
rs1139032 -- 130,704,446(+) GAATC(A/G)CTTGA utr-variant-3-prime, nc-transcript-variant
rs2032420 -- 130,700,547(+) agaga(C/T)ggggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOSC2 Gene

Variant ID Type Subtype PubMed ID
nsv831735 CNV Loss 17160897
nsv825122 CNV Gain 20364138

Relevant External Links for EXOSC2 Gene

HapMap Linkage Disequilibrium report
EXOSC2

Disorders for EXOSC2 Gene

Relevant External Links for EXOSC2

Genetic Association Database (GAD)
EXOSC2
genes like me logo Genes that share disorders with EXOSC2: view

No data available for UniProtKB/Swiss-Prot for EXOSC2 Gene

Publications for EXOSC2 Gene

  1. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. (PMID: 9390555) Mitchell P. … Tollervey D. (Cell 1997) 3 4 23
  2. The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism. (PMID: 8600032) Mitchell P. … Tollervey D. (Genes Dev. 1996) 2 3 4
  3. The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases. (PMID: 10465791) Allmang C. … Mitchell P. (Genes Dev. 1999) 3 4
  4. Dis3-like 1: a novel exoribonuclease associated with the human exosome. (PMID: 20531389) Staals R.H. … Pruijn G.J. (EMBO J. 2010) 3 4
  5. Sequence identification of 2,375 human brain genes. (PMID: 1538749) Adams M.D. … Venter J.C. (Nature 1992) 2 3

Products for EXOSC2 Gene

Sources for EXOSC2 Gene

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