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Aliases for NCAPH Gene

Aliases for NCAPH Gene

  • Non-SMC Condensin I Complex Subunit H 2 3 4 5
  • Non-SMC Condensin I Complex, Subunit H 2 3
  • Chromosome-Associated Protein H 3 4
  • BRRN1 3 4
  • Barren Homolog 1 (Drosophila) 2
  • Barren (Drosophila) Homolog 2
  • Barren Homolog (Drosophila) 2
  • Barren Homolog Protein 1 4
  • Barren Homolog 1 3
  • XCAP-H Homolog 4
  • KIAA0074 4
  • HCAP-H 4
  • CAP-H 3
  • BRRN 4
  • CAPH 4

External Ids for NCAPH Gene

Previous HGNC Symbols for NCAPH Gene

  • BRRN1

Previous GeneCards Identifiers for NCAPH Gene

  • GC02P097001
  • GC02P090962

Summaries for NCAPH Gene

Entrez Gene Summary for NCAPH Gene

  • This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

GeneCards Summary for NCAPH Gene

NCAPH (Non-SMC Condensin I Complex Subunit H) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prometaphase.

UniProtKB/Swiss-Prot for NCAPH Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for NCAPH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPH Gene

Genomics for NCAPH Gene

Regulatory Elements for NCAPH Gene

Promoters for NCAPH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCAPH on UCSC Golden Path with GeneCards custom track

Genomic Location for NCAPH Gene

Chromosome:
2
Start:
96,335,741 bp from pter
End:
96,377,095 bp from pter
Size:
41,355 bases
Orientation:
Plus strand

Genomic View for NCAPH Gene

Genes around NCAPH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAPH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPH Gene

Proteins for NCAPH Gene

  • Protein details for NCAPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15003-CND2_HUMAN
    Recommended name:
    Condensin complex subunit 2
    Protein Accession:
    Q15003
    Secondary Accessions:
    • B4E189
    • Q8TB87

    Protein attributes for NCAPH Gene

    Size:
    741 amino acids
    Molecular mass:
    82563 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
    SequenceCaution:
    • Sequence=BAA07556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NCAPH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAPH Gene

Proteomics data for NCAPH Gene at MOPED

Post-translational modifications for NCAPH Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys 394, Lys 495, and Lys 648
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NCAPH Gene

Domains & Families for NCAPH Gene

Protein Domains for NCAPH Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NCAPH Gene

Graphical View of Domain Structure for InterPro Entry

Q15003

UniProtKB/Swiss-Prot:

CND2_HUMAN :
  • Belongs to the CND2 (condensin subunit 2) family.
Family:
  • Belongs to the CND2 (condensin subunit 2) family.
genes like me logo Genes that share domains with NCAPH: view

No data available for Gene Families for NCAPH Gene

Function for NCAPH Gene

Molecular function for NCAPH Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
genes like me logo Genes that share phenotypes with NCAPH: view

Animal Models for NCAPH Gene

MGI Knock Outs for NCAPH:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCAPH

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAPH Gene

Localization for NCAPH Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPH Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPH Gene COMPARTMENTS Subcellular localization image for NCAPH gene
Compartment Confidence
cytosol 5
nucleus 4

Gene Ontology (GO) - Cellular Components for NCAPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000796 condensin complex IEA,IDA 11136719
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NCAPH: view

Pathways & Interactions for NCAPH Gene

genes like me logo Genes that share pathways with NCAPH: view

Pathways by source for NCAPH Gene

1 BioSystems pathway for NCAPH Gene
1 GeneGo (Thomson Reuters) pathway for NCAPH Gene

Gene Ontology (GO) - Biological Process for NCAPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPH: view

No data available for SIGNOR curated interactions for NCAPH Gene

Drugs & Compounds for NCAPH Gene

No Compound Related Data Available

Transcripts for NCAPH Gene

Unigene Clusters for NCAPH Gene

Non-SMC condensin I complex, subunit H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -
SP7:
SP8: - - -

ExUns: 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NCAPH Gene

GeneLoc Exon Structure for
NCAPH
ECgene alternative splicing isoforms for
NCAPH

Expression for NCAPH Gene

mRNA expression in normal human tissues for NCAPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAPH Gene

This gene is overexpressed in Testis (x9.8).

Protein differential expression in normal tissues from HIPED for NCAPH Gene

This gene is overexpressed in Bone (28.1), Lung (10.3), Platelet (7.5), and Testis (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPH Gene



SOURCE GeneReport for Unigene cluster for NCAPH Gene Hs.308045

mRNA Expression by UniProt/SwissProt for NCAPH Gene

Q15003-CND2_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in proliferating cells.
genes like me logo Genes that share expression patterns with NCAPH: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for NCAPH Gene

Orthologs for NCAPH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCAPH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCAPH 35
  • 83.63 (n)
  • 81 (a)
NCAPH 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPH 35
  • 86.93 (n)
  • 85.42 (a)
NCAPH 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncaph 35
  • 81.74 (n)
  • 79.81 (a)
Ncaph 16
Ncaph 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCAPH 35
  • 99.51 (n)
  • 99.33 (a)
NCAPH 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCAPH 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPH 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAPH 35
  • 65.96 (n)
  • 61.19 (a)
NCAPH 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPH 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncaph 35
  • 62.69 (n)
  • 59.65 (a)
Str.10092 35
African clawed frog
(Xenopus laevis)
Amphibia brrn1-prov 35
zebrafish
(Danio rerio)
Actinopterygii ncaph 35
  • 58.51 (n)
  • 52.89 (a)
wufc69h06 35
ncaph 36
  • 49 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7620 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011508 35
  • 44.06 (n)
  • 33.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta barr 35
  • 41.75 (n)
  • 30.23 (a)
barr 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRN1 36
  • 20 (a)
OneToOne
BRN1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5013 36
  • 42 (a)
OneToOne
Species with no ortholog for NCAPH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAPH Gene

ENSEMBL:
Gene Tree for NCAPH (if available)
TreeFam:
Gene Tree for NCAPH (if available)

Paralogs for NCAPH Gene

No data available for Paralogs for NCAPH Gene

Variants for NCAPH Gene

Sequence variations from dbSNP and Humsavar for NCAPH Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2305935 - 96,364,509(+) TAGGG(C/T)AGAGA reference, missense
rs798202 -- 96,358,593(+) CCTCC(C/G)GAGTA intron-variant
rs772152 -- 96,350,497(-) TTTTT(C/T)CCCAT intron-variant
rs772153 -- 96,351,686(+) aaaaa(A/C)aaaaa intron-variant
rs772154 -- 96,355,926(+) ACTGC(G/T)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPH Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv834305 CNV Gain 17160897
nsv874679 CNV Gain 21882294
nsv508155 CNV Loss 20534489
nsv819311 CNV Loss 19587683

Variation tolerance for NCAPH Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAPH Gene

HapMap Linkage Disequilibrium report
NCAPH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPH Gene

Disorders for NCAPH Gene

Relevant External Links for NCAPH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAPH

No disorders were found for NCAPH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAPH Gene

Publications for NCAPH Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. (PMID: 9417923) Cabello O.A. … Belmont J.W. (Genomics 1997) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for NCAPH Gene

Sources for NCAPH Gene

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