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Aliases for NCAPH Gene

Aliases for NCAPH Gene

  • Non-SMC Condensin I Complex, Subunit H 2 3
  • BRRN1 3 4 6
  • Chromosome-Associated Protein H 3 4
  • Non-SMC Condensin I Complex Subunit H 4
  • Barren Homolog 1 (Drosophila) 2
  • Barren (Drosophila) Homolog 2
  • Barren Homolog (Drosophila) 2
  • Condensin Complex Subunit 2 3
  • Barren Homolog Protein 1 4
  • Barren Homolog 1 3
  • XCAP-H Homolog 4
  • KIAA0074 4
  • HCAP-H 4
  • CAP-H 3
  • BRRN 4
  • CAPH 4

External Ids for NCAPH Gene

Previous HGNC Symbols for NCAPH Gene

  • BRRN1

Previous GeneCards Identifiers for NCAPH Gene

  • GC02P097001
  • GC02P090962

Summaries for NCAPH Gene

Entrez Gene Summary for NCAPH Gene

  • This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

GeneCards Summary for NCAPH Gene

NCAPH (Non-SMC Condensin I Complex, Subunit H) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NCAPH Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for NCAPH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPH Gene

Genomics for NCAPH Gene

Regulatory Elements for NCAPH Gene

Genomic Location for NCAPH Gene

Start:
96,335,741 bp from pter
End:
96,377,095 bp from pter
Size:
41,355 bases
Orientation:
Plus strand

Genomic View for NCAPH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPH Gene

Proteins for NCAPH Gene

  • Protein details for NCAPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15003-CND2_HUMAN
    Recommended name:
    Condensin complex subunit 2
    Protein Accession:
    Q15003
    Secondary Accessions:
    • B4E189
    • Q8TB87

    Protein attributes for NCAPH Gene

    Size:
    741 amino acids
    Molecular mass:
    82563 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
    SequenceCaution:
    • Sequence=BAA07556.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NCAPH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAPH Gene

Proteomics data for NCAPH Gene at MOPED

Post-translational modifications for NCAPH Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys41, Lys394, Lys424, Lys495, and Lys648
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPH Gene

No data available for DME Specific Peptides for NCAPH Gene

Domains for NCAPH Gene

Protein Domains for NCAPH Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NCAPH Gene

Graphical View of Domain Structure for InterPro Entry

Q15003

UniProtKB/Swiss-Prot:

CND2_HUMAN :
  • Q15003
Family:
  • Belongs to the CND2 (condensin subunit 2) family.
genes like me logo Genes that share domains with NCAPH: view

No data available for Gene Families for NCAPH Gene

Function for NCAPH Gene

Molecular function for NCAPH Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Ontology (GO) - Molecular Function for NCAPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17268547
genes like me logo Genes that share ontologies with NCAPH: view
genes like me logo Genes that share phenotypes with NCAPH: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPH

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCAPH Gene

Localization for NCAPH Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPH Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPH Gene COMPARTMENTS Subcellular localization image for NCAPH gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for NCAPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000796 condensin complex IDA 11136719
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with NCAPH: view

Pathways for NCAPH Gene

genes like me logo Genes that share pathways with NCAPH: view

Pathways by source for NCAPH Gene

1 BioSystems pathway for NCAPH Gene
1 GeneGo (Thomson Reuters) pathway for NCAPH Gene

Gene Ontology (GO) - Biological Process for NCAPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007076 mitotic chromosome condensation IDA 11136719
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPH: view

Transcripts for NCAPH Gene

Unigene Clusters for NCAPH Gene

Non-SMC condensin I complex, subunit H:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPH

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NCAPH
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^
SP1: -
SP2: - - - - - - - - - - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - -
SP7:
SP8: - - -

ExUns: 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for NCAPH Gene

GeneLoc Exon Structure for
NCAPH
ECgene alternative splicing isoforms for
NCAPH

Expression for NCAPH Gene

mRNA expression in normal human tissues for NCAPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAPH Gene

This gene is overexpressed in Testis (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPH Gene

SOURCE GeneReport for Unigene cluster for NCAPH Gene Hs.308045

mRNA Expression by UniProt/SwissProt for NCAPH Gene

Q15003-CND2_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in proliferating cells.
genes like me logo Genes that share expressions with NCAPH: view

In Situ Assay Products

Orthologs for NCAPH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCAPH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAPH 35
  • 99.51 (n)
  • 99.33 (a)
NCAPH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCAPH 35
  • 83.63 (n)
  • 81 (a)
NCAPH 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPH 35
  • 86.93 (n)
  • 85.42 (a)
NCAPH 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncaph 35
  • 81.74 (n)
  • 79.81 (a)
Ncaph 16
Ncaph 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCAPH 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPH 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAPH 35
  • 65.96 (n)
  • 61.19 (a)
NCAPH 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPH 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia brrn1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ncaph 35
  • 62.69 (n)
  • 59.65 (a)
Str.10092 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7620 35
zebrafish
(Danio rerio)
Actinopterygii ncaph 35
  • 58.51 (n)
  • 52.89 (a)
ncaph 36
  • 49 (a)
OneToOne
wufc69h06 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011508 35
  • 44.06 (n)
  • 33.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta barr 35
  • 41.75 (n)
  • 30.23 (a)
barr 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRN1 36
  • 20 (a)
OneToOne
BRN1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5013 36
  • 42 (a)
OneToOne
Species with no ortholog for NCAPH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAPH Gene

ENSEMBL:
Gene Tree for NCAPH (if available)
TreeFam:
Gene Tree for NCAPH (if available)

Paralogs for NCAPH Gene

No data available for Paralogs for NCAPH Gene

Variants for NCAPH Gene

Sequence variations from dbSNP and Humsavar for NCAPH Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs772152 -- 96,350,497(-) TTTTT(C/T)CCCAT intron-variant
rs772153 -- 96,351,686(+) aaaaa(A/C)aaaaa intron-variant
rs772154 -- 96,355,926(+) ACTGC(G/T)CCTGG intron-variant
rs772155 -- 96,361,830(+) tatat(A/T)tTTTT intron-variant
rs772156 -- 96,364,092(+) TCACC(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPH Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv834305 CNV Gain 17160897
nsv874679 CNV Gain 21882294
nsv508155 CNV Loss 20534489
nsv819311 CNV Loss 19587683

Relevant External Links for NCAPH Gene

HapMap Linkage Disequilibrium report
NCAPH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPH Gene

Disorders for NCAPH Gene

No disorders were found for NCAPH Gene.

No data available for UniProtKB/Swiss-Prot for NCAPH Gene

Publications for NCAPH Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  3. Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2. (PMID: 9417923) Cabello O.A. … Belmont J.W. (Genomics 1997) 2 3
  4. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K. … Hirano T. (J. Biol. Chem. 2001) 3 4
  5. Cell cycle-dependent expression and nucleolar localization of hCAP- H. (PMID: 11694586) Cabello O.A. … Belmont J.W. (Mol. Biol. Cell 2001) 3 4

Products for NCAPH Gene

  • Addgene plasmids for NCAPH

Sources for NCAPH Gene

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