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Aliases for ADNP Gene

Aliases for ADNP Gene

  • Activity-Dependent Neuroprotector Homeobox 2 3
  • Activity-Dependent Neuroprotective Protein 3 4
  • ADNP Homeobox 1 2 3
  • ADNP1 3 4
  • Activity-Dependent Neuroprotector Homeobox Protein 3
  • Activity-Dependent Neuroprotector 2
  • KIAA0784 4
  • HVDAS 3
  • MRD28 3

External Ids for ADNP Gene

Summaries for ADNP Gene

Entrez Gene Summary for ADNP Gene

  • Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADNP Gene

ADNP (Activity-Dependent Neuroprotector Homeobox) is a Protein Coding gene. Diseases associated with ADNP include mental retardation, autosomal dominant, 28 and adnp-related multiple congenital anomalies-intellectual disability-autism spectrum disorder. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is ADNP2.

UniProtKB/Swiss-Prot for ADNP Gene

  • Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADNP Gene

Genomics for ADNP Gene

Genomic Location for ADNP Gene

Start:
50,888,918 bp from pter
End:
50,931,240 bp from pter
Size:
42,323 bases
Orientation:
Minus strand

Genomic View for ADNP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADNP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADNP Gene

Regulatory Elements for ADNP Gene

Proteins for ADNP Gene

  • Protein details for ADNP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2P0-ADNP_HUMAN
    Recommended name:
    Activity-dependent neuroprotector homeobox protein
    Protein Accession:
    Q9H2P0
    Secondary Accessions:
    • E1P5Y2
    • O94881
    • Q5BKU2
    • Q9UG34

    Protein attributes for ADNP Gene

    Size:
    1102 amino acids
    Molecular mass:
    123563 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the beta-amyloid peptide

neXtProt entry for ADNP Gene

Proteomics data for ADNP Gene at MOPED

Post-translational modifications for ADNP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys126, Lys773, and Lys777

No data available for DME Specific Peptides for ADNP Gene

Domains for ADNP Gene

Gene Families for ADNP Gene

HGNC:
  • ZFHX :Homeoboxes / ZF class

Protein Domains for ADNP Gene

UniProtKB/Swiss-Prot:

ADNP_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9H2P0
Similarity:
  • Contains 9 C2H2-type zinc fingers.:
    • Q9H2P0
genes like me logo Genes that share domains with ADNP: view

Function for ADNP Gene

Molecular function for ADNP Gene

UniProtKB/Swiss-Prot Function: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation

Gene Ontology (GO) - Molecular Function for ADNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 20562864
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADNP: view

Phenotypes for ADNP Gene

genes like me logo Genes that share phenotypes with ADNP: view

Animal Models for ADNP Gene

MGI Knock Outs for ADNP:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADNP Gene

Localization for ADNP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADNP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADNP Gene COMPARTMENTS Subcellular localization image for ADNP gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for ADNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ADNP: view

Pathways for ADNP Gene

SuperPathways for ADNP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADNP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0043524 negative regulation of neuron apoptotic process IEA --
genes like me logo Genes that share ontologies with ADNP: view

No data available for Pathways by source for ADNP Gene

Compounds for ADNP Gene

(2) Novoseek inferred chemical compound relationships for ADNP Gene

Compound -log(P) Hits PubMed IDs
h2o2 24.2 1
zinc 10.2 1
genes like me logo Genes that share compounds with ADNP: view

Transcripts for ADNP Gene

Unigene Clusters for ADNP Gene

Activity-dependent neuroprotector homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADNP Gene

No ASD Table

Relevant External Links for ADNP Gene

GeneLoc Exon Structure for
ADNP
ECgene alternative splicing isoforms for
ADNP

Expression for ADNP Gene

mRNA expression in normal human tissues for ADNP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADNP Gene

SOURCE GeneReport for Unigene cluster for ADNP Gene Hs.570355

mRNA Expression by UniProt/SwissProt for ADNP Gene

Q9H2P0-ADNP_HUMAN
Tissue specificity: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues
genes like me logo Genes that share expressions with ADNP: view

Orthologs for ADNP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADNP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADNP 36
  • 99.67 (n)
  • 99.73 (a)
ADNP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADNP 36
  • 92.13 (n)
  • 96.73 (a)
bta-mir-6527 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADNP 36
  • 94.46 (n)
  • 97.64 (a)
ADNP 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adnp 36
  • 90.12 (n)
  • 94.45 (a)
Adnp 16
Adnp 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADNP 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADNP 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adnp 36
  • 90.25 (n)
  • 94.28 (a)
chicken
(Gallus gallus)
Aves ADNP 36
  • 80.78 (n)
  • 85.79 (a)
ADNP 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADNP 37
  • 19 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia adnp 36
  • 69.87 (n)
  • 72.62 (a)
Str.4445 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4117 36
zebrafish
(Danio rerio)
Actinopterygii adnp 36
  • 63.34 (n)
  • 67.12 (a)
adnpa 37
  • 48 (a)
OneToMany
adnpb 37
  • 54 (a)
OneToMany
wufi72f04 36
Species with no ortholog for ADNP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADNP Gene

ENSEMBL:
Gene Tree for ADNP (if available)
TreeFam:
Gene Tree for ADNP (if available)

Paralogs for ADNP Gene

Paralogs for ADNP Gene

Selected SIMAP similar genes for ADNP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADNP: view

Variants for ADNP Gene

Sequence variations from dbSNP and Humsavar for ADNP Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1074 -- 50,900,043(+) gtagc(C/T)taagt intron-variant
rs761240 -- 50,891,355(+) CTGGA(G/T)ATCAG utr-variant-3-prime
rs875068 -- 50,889,658(+) GGCCA(C/G)TATCC utr-variant-3-prime
rs910072 -- 50,890,161(+) AAAAA(A/C)GAAAA utr-variant-3-prime
rs1010944 -- 50,908,897(+) ATTCA(A/G)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADNP Gene

Variant ID Type Subtype PubMed ID
nsv834002 CNV Loss 17160897

Relevant External Links for ADNP Gene

HapMap Linkage Disequilibrium report
ADNP
Human Gene Mutation Database (HGMD)
ADNP

Disorders for ADNP Gene

UniProtKB/Swiss-Prot

ADNP_HUMAN
  • Mental retardation, autosomal dominant 28 (MRD28) [MIM:615873]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD28 patients manifest intellectual disability, autism spectrum disorder, and dysmorphic facial features including prominent forehead, high hairline, downslanting palpebral fissures, notched eyelids, broad nasal bridge, thin upper lip, and smooth philtrum. {ECO:0000269 PubMed:24531329}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for ADNP Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for ADNP

Genetic Association Database (GAD)
ADNP
Human Genome Epidemiology (HuGE) Navigator
ADNP
genes like me logo Genes that share disorders with ADNP: view

Publications for ADNP Gene

  1. Cloning and characterization of the human activity-dependent neuroprotective protein. (PMID: 11013255) Zamostiano R. … Gozes I. (J. Biol. Chem. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis. (PMID: 19923857) Braitch M. … Constantinescu C.S. (Neuroimmunomodulation 2010) 3 23
  5. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. (PMID: 17878164) Mandel S. … Gozes I. (J. Biol. Chem. 2007) 3 23

Products for ADNP Gene

Sources for ADNP Gene

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