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Aliases for KIAA0368 Gene

Aliases for KIAA0368 Gene

  • KIAA0368 2 3
  • ECM29 3 4
  • ECM29 Homolog, Proteasome Accessory Protein 3
  • Proteasome-Associated Protein ECM29 Homolog 3
  • ECM29 Homolog (S. Cerevisiae) 2
  • Homolog Of Yeast Ecm29 3

External Ids for KIAA0368 Gene

Summaries for KIAA0368 Gene

GeneCards Summary for KIAA0368 Gene

KIAA0368 (KIAA0368) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KIAA0368 Gene

  • Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis.

Gene Wiki entry for KIAA0368 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KIAA0368 Gene

Genomics for KIAA0368 Gene

Genomic Location for KIAA0368 Gene

Start:
111,360,692 bp from pter
End:
111,484,745 bp from pter
Size:
124,054 bases
Orientation:
Minus strand

Genomic View for KIAA0368 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KIAA0368 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KIAA0368 Gene

Regulatory Elements for KIAA0368 Gene

Proteins for KIAA0368 Gene

  • Protein details for KIAA0368 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYK3-ECM29_HUMAN
    Recommended name:
    Proteasome-associated protein ECM29 homolog
    Protein Accession:
    Q5VYK3
    Secondary Accessions:
    • O15074
    • Q8WU82

    Protein attributes for KIAA0368 Gene

    Size:
    1845 amino acids
    Molecular mass:
    204291 Da
    Quaternary structure:
    • Non-stoichiometric component of the proteasome; associates with the 26S proteasome. Interacts (via N-terminus) with VPS11, VPS26A, VPS36, RAB11FIP4 and RABEP1. Interacts (via C-terminus) with DCTN1, DCTN2, KIF5B, MYH7, MYH10, MYO10 and ARF6.
    SequenceCaution:
    • Sequence=AAH21127.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH73240.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73465.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for KIAA0368 Gene

Proteomics data for KIAA0368 Gene at MOPED

Post-translational modifications for KIAA0368 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KIAA0368 Gene

No data available for DME Specific Peptides for KIAA0368 Gene

Domains for KIAA0368 Gene

Protein Domains for KIAA0368 Gene

UniProtKB/Swiss-Prot:

ECM29_HUMAN
Similarity:
  • Contains 27 HEAT repeats.:
    • Q5VYK3
genes like me logo Genes that share domains with KIAA0368: view

No data available for Gene Families for KIAA0368 Gene

Function for KIAA0368 Gene

Molecular function for KIAA0368 Gene

GENATLAS Biochemistry: cDNA sequence,expressed in brain,>100kDa,related to C elegans cosmid D2045
UniProtKB/Swiss-Prot Function: Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis.

Gene Ontology (GO) - Molecular Function for KIAA0368 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KIAA0368: view

Phenotypes for KIAA0368 Gene

GenomeRNAi human phenotypes for KIAA0368:
genes like me logo Genes that share phenotypes with KIAA0368: view

miRNA for KIAA0368 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KIAA0368 Gene

Localization for KIAA0368 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KIAA0368 Gene

Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Endosome, multivesicular body. Cytoplasmic vesicle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KIAA0368 Gene COMPARTMENTS Subcellular localization image for KIAA0368 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
endosome 5
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KIAA0368 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 colocalizes_with proteasome complex IDA 15496406
GO:0005634 nucleus IDA 15496406
GO:0005769 early endosome IDA 15496406
GO:0005770 late endosome IDA 15496406
GO:0005771 multivesicular body IDA 20682791
genes like me logo Genes that share ontologies with KIAA0368: view

Pathways for KIAA0368 Gene

SuperPathways for KIAA0368 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KIAA0368 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 15496406
genes like me logo Genes that share ontologies with KIAA0368: view

No data available for Pathways by source for KIAA0368 Gene

Transcripts for KIAA0368 Gene

Unigene Clusters for KIAA0368 Gene

KIAA0368:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KIAA0368 Gene

No ASD Table

Relevant External Links for KIAA0368 Gene

GeneLoc Exon Structure for
KIAA0368
ECgene alternative splicing isoforms for
KIAA0368

Expression for KIAA0368 Gene

mRNA expression in normal human tissues for KIAA0368 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KIAA0368 Gene

This gene is overexpressed in Muscle - Skeletal (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KIAA0368 Gene

SOURCE GeneReport for Unigene cluster for KIAA0368 Gene Hs.368255

genes like me logo Genes that share expressions with KIAA0368: view

Orthologs for KIAA0368 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KIAA0368 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0368 36
  • 99.45 (n)
  • 99.45 (a)
KIAA0368 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0368 36
  • 90.55 (n)
  • 95.71 (a)
KIAA0368 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0368 36
  • 92.18 (n)
  • 96.07 (a)
KIAA0368 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI314180 36
  • 89.91 (n)
  • 95.58 (a)
AI314180 16
AI314180 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0368 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 81 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves KIAA0368 36
  • 78.27 (n)
  • 85.74 (a)
KIAA0368 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0368 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.27912 36
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa0368 36
  • 72.69 (n)
  • 78.98 (a)
Str.14108 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9920 36
zebrafish
(Danio rerio)
Actinopterygii fbxo10 37
  • 73 (a)
OneToOne
LOC563777 36
  • 68.5 (n)
  • 74.88 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011822 36
  • 46.3 (n)
  • 38.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8858 36
  • 46.26 (n)
  • 35.72 (a)
CG8858 37
  • 29 (a)
OneToOne
CG8858 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea H04D03.3 37
  • 27 (a)
OneToOne
D2045.2 38
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM29 37
  • 23 (a)
OneToOne
ECM29 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G26780 36
  • 44.36 (n)
  • 32.16 (a)
rice
(Oryza sativa)
Liliopsida Os11g0137300 36
  • 45.64 (n)
  • 31.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
OneToOne
Species with no ortholog for KIAA0368:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KIAA0368 Gene

ENSEMBL:
Gene Tree for KIAA0368 (if available)
TreeFam:
Gene Tree for KIAA0368 (if available)

Paralogs for KIAA0368 Gene

Selected SIMAP similar genes for KIAA0368 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for KIAA0368 Gene

genes like me logo Genes that share paralogs with KIAA0368: view

No data available for Paralogs for KIAA0368 Gene

Variants for KIAA0368 Gene

Sequence variations from dbSNP and Humsavar for KIAA0368 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs395433 -- 111,405,221(-) attgg(G/T)ctatg intron-variant
rs744324 -- 111,430,765(+) CATTG(C/T)AGAAG intron-variant
rs868405 -- 111,422,197(+) GGCAT(C/T)CGACT synonymous-codon, reference
rs914732 -- 111,369,259(+) AACCA(A/G)GGCAG intron-variant
rs943690 -- 111,454,467(-) TCATA(A/C)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KIAA0368 Gene

Variant ID Type Subtype PubMed ID
nsv893722 CNV Gain 21882294
nsv525736 CNV Loss 19592680
nsv416941 CNV Loss 16902084
nsv825039 CNV Gain 20364138
esv2492334 CNV Deletion 19546169
nsv436620 CNV Deletion 17901297
esv2057050 CNV Deletion 18987734
esv2738934 CNV Deletion 23290073
esv2666027 CNV Deletion 23128226
esv29361 CNV Loss 19812545
esv2738935 CNV Deletion 23290073
nsv825040 CNV Gain 20364138
esv2659400 CNV Deletion 23128226

Relevant External Links for KIAA0368 Gene

HapMap Linkage Disequilibrium report
KIAA0368

Disorders for KIAA0368 Gene

(1) University of Copenhagen DISEASES for KIAA0368 Gene

Relevant External Links for KIAA0368

Genetic Association Database (GAD)
KIAA0368
Human Genome Epidemiology (HuGE) Navigator
KIAA0368
genes like me logo Genes that share disorders with KIAA0368: view

No data available for UniProtKB/Swiss-Prot for KIAA0368 Gene

Publications for KIAA0368 Gene

  1. A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (PMID: 20682791) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2010) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  3. Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesicles. (PMID: 15496406) Gorbea C. … Rechsteiner M. (J. Biol. Chem. 2004) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for KIAA0368 Gene

  • antibodies-online proteins for KIAA0368
  • antibodies-online antibodies for KIAA0368
  • antibodies-online kits for KIAA0368

Sources for KIAA0368 Gene

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