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Aliases for DNAJC13 Gene

Aliases for DNAJC13 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C13 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 13 2 3
  • Required For Receptor-Mediated Endocytosis 8 3 4
  • RME-8 3 4
  • RME8 3 4
  • DnaJ Domain-Containing Protein RME-8 3
  • KIAA0678 4
  • PARK21 3

External Ids for DNAJC13 Gene

Previous GeneCards Identifiers for DNAJC13 Gene

  • GC03P133442
  • GC03P133665
  • GC03P132136
  • GC03P129515

Summaries for DNAJC13 Gene

GeneCards Summary for DNAJC13 Gene

DNAJC13 (DnaJ Heat Shock Protein Family (Hsp40) Member C13) is a Protein Coding gene. Diseases associated with DNAJC13 include parkinson disease 21 and parkinson disease, late-onset. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for DNAJC13 Gene

  • Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).

Gene Wiki entry for DNAJC13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC13 Gene

Genomics for DNAJC13 Gene

Regulatory Elements for DNAJC13 Gene

Enhancers for DNAJC13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNAJC13 on UCSC Golden Path with GeneCards custom track

Promoters for DNAJC13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNAJC13 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNAJC13 Gene

Chromosome:
3
Start:
132,417,526 bp from pter
End:
132,539,032 bp from pter
Size:
121,507 bases
Orientation:
Plus strand

Genomic View for DNAJC13 Gene

Genes around DNAJC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC13 Gene

Proteins for DNAJC13 Gene

  • Protein details for DNAJC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75165-DJC13_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 13
    Protein Accession:
    O75165
    Secondary Accessions:
    • Q3L0T1
    • Q6PI82
    • Q6UJ77
    • Q6ZSW1
    • Q6ZUT5
    • Q86XG3
    • Q96DC1
    • Q9BWK9

    Protein attributes for DNAJC13 Gene

    Size:
    2243 amino acids
    Molecular mass:
    254415 Da
    Quaternary structure:
    • Interacts with FAM21C; mediates the association with the WASH complex (PubMed:24643499).
    SequenceCaution:
    • Sequence=AAH43583.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA31653.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86835.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86835.1; Type=Erroneous termination; Positions=1651; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for DNAJC13 Gene

Proteomics data for DNAJC13 Gene at MOPED

Post-translational modifications for DNAJC13 Gene

  • Ubiquitination at Lys 848 and Lys 1359
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DNAJC13 Gene

Domains & Families for DNAJC13 Gene

Gene Families for DNAJC13 Gene

Protein Domains for DNAJC13 Gene

Suggested Antigen Peptide Sequences for DNAJC13 Gene

Graphical View of Domain Structure for InterPro Entry

O75165

UniProtKB/Swiss-Prot:

DJC13_HUMAN :
  • Contains 1 J domain.
Domain:
  • Contains 1 J domain.
genes like me logo Genes that share domains with DNAJC13: view

Function for DNAJC13 Gene

Molecular function for DNAJC13 Gene

UniProtKB/Swiss-Prot Function:
Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).
genes like me logo Genes that share phenotypes with DNAJC13: view

Human Phenotype Ontology for DNAJC13 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for DNAJC13 Gene

miRTarBase miRNAs that target DNAJC13

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DNAJC13 Gene

Localization for DNAJC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC13 Gene

Early endosome. Early endosome membrane; Peripheral membrane protein. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC13 Gene COMPARTMENTS Subcellular localization image for DNAJC13 gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytosol 3
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DNAJC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0016021 integral component of membrane IEA --
GO:0031901 early endosome membrane IDA 18256511
GO:0071203 colocalizes_with WASH complex IDA 24643499
genes like me logo Genes that share ontologies with DNAJC13: view

Pathways & Interactions for DNAJC13 Gene

SuperPathways for DNAJC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:1902954 regulation of early endosome to recycling endosome transport IMP 18256511
genes like me logo Genes that share ontologies with DNAJC13: view

No data available for Pathways by source and SIGNOR curated interactions for DNAJC13 Gene

Drugs & Compounds for DNAJC13 Gene

No Compound Related Data Available

Transcripts for DNAJC13 Gene

Unigene Clusters for DNAJC13 Gene

DnaJ (Hsp40) homolog, subfamily C, member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC13 Gene

No ASD Table

Relevant External Links for DNAJC13 Gene

GeneLoc Exon Structure for
DNAJC13
ECgene alternative splicing isoforms for
DNAJC13

Expression for DNAJC13 Gene

mRNA expression in normal human tissues for DNAJC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC13 Gene



SOURCE GeneReport for Unigene cluster for DNAJC13 Gene Hs.12707

genes like me logo Genes that share expression patterns with DNAJC13: view

Protein tissue co-expression partners for DNAJC13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DNAJC13 Gene

Orthologs for DNAJC13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNAJC13 35
  • 93.65 (n)
  • 97.41 (a)
DNAJC13 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC13 35
  • 94.38 (n)
  • 98.08 (a)
DNAJC13 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc13 35
  • 89.63 (n)
  • 96.66 (a)
Dnajc13 16
Dnajc13 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNAJC13 35
  • 99.76 (n)
  • 99.78 (a)
DNAJC13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnajc13 35
  • 89.29 (n)
  • 96.26 (a)
oppossum
(Monodelphis domestica)
Mammalia DNAJC13 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
chicken
(Gallus gallus)
Aves DNAJC13 35
  • 82.68 (n)
  • 92.05 (a)
DNAJC13 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC13 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc13 35
  • 77.91 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii DNAJC13 (1 of 2) 36
  • 86 (a)
OneToMany
DNAJC13 (2 of 2) 36
  • 72 (a)
OneToMany
Dr.14056 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005771 35
  • 52.42 (n)
  • 52.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rme-8 35
  • 52.94 (n)
  • 51.09 (a)
Rme-8 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rme-8 35
  • 52.3 (n)
  • 46.53 (a)
rme-8 36
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons GRV2 35
  • 45.87 (n)
  • 35.42 (a)
rice
(Oryza sativa)
Liliopsida Os10g0575200 35
  • 46.56 (n)
  • 36.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10682 36
  • 59 (a)
OneToOne
Species with no ortholog for DNAJC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC13 Gene

ENSEMBL:
Gene Tree for DNAJC13 (if available)
TreeFam:
Gene Tree for DNAJC13 (if available)

Paralogs for DNAJC13 Gene

No data available for Paralogs for DNAJC13 Gene

Variants for DNAJC13 Gene

Sequence variations from dbSNP and Humsavar for DNAJC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs3762672 - 132,499,779(+) CTCGT(G/T)CTAGT reference, missense
rs4405917 - 132,500,837(+) TCAGT(G/T)TGAGG reference, missense
rs10935014 - 132,523,636(+) CCTGG(A/C/G)TTCTA reference, missense
rs55825559 - 132,502,295(+) GTATT(C/T)CCCGC reference, missense
VAR_073784 -

Structural Variations from Database of Genomic Variants (DGV) for DNAJC13 Gene

Variant ID Type Subtype PubMed ID
nsv829728 CNV Gain 17160897
nsv522333 CNV Loss 19592680
nsv4013 CNV Loss 18451855

Variation tolerance for DNAJC13 Gene

Residual Variation Intolerance Score: 1.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNAJC13 Gene

HapMap Linkage Disequilibrium report
DNAJC13
Human Gene Mutation Database (HGMD)
DNAJC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC13 Gene

Disorders for DNAJC13 Gene

MalaCards: The human disease database

(5) MalaCards diseases for DNAJC13 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 21
  • park21
parkinson disease, late-onset
  • parkinson disease
hereditary late-onset parkinson disease
  • autosomal dominant late-onset parkinson disease
chronic tic disorder
  • chronic motor or vocal tic disorder
tic disorder
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DJC13_HUMAN
  • Parkinson disease 21 (PARK21) [MIM:616361]: An autosomal dominant form of adult-onset Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269 PubMed:24218364}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DNAJC13

Genetic Association Database (GAD)
DNAJC13
Human Genome Epidemiology (HuGE) Navigator
DNAJC13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNAJC13
genes like me logo Genes that share disorders with DNAJC13: view

No data available for Genatlas for DNAJC13 Gene

Publications for DNAJC13 Gene

  1. RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation. (PMID: 24643499) Freeman C.L. … Seaman M.N. (J. Cell Sci. 2014) 3 4 67
  2. Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-LA,ken syndrome type 3. (PMID: 12438707) Volz A. … Omran H. (Cytogenet. Genome Res. 2002) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DNAJC13 Gene

Sources for DNAJC13 Gene

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