Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNAJC13 Gene

Aliases for DNAJC13 Gene

  • DnaJ (Hsp40) Homolog, Subfamily C, Member 13 2 3
  • RME8 3 4 6
  • Required For Receptor-Mediated Endocytosis 8 3 4
  • KIAA0678 4 6
  • RME-8 3 4
  • DnaJ Domain-Containing Protein RME-8 3
  • DnaJ Homolog Subfamily C Member 13 3

External Ids for DNAJC13 Gene

Summaries for DNAJC13 Gene

GeneCards Summary for DNAJC13 Gene

DNAJC13 (DnaJ (Hsp40) Homolog, Subfamily C, Member 13) is a Protein Coding gene. Diseases associated with DNAJC13 include insulin autoimmune syndrome and chronic tic disorder.

UniProtKB/Swiss-Prot for DNAJC13 Gene

  • Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).

Gene Wiki entry for DNAJC13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJC13 Gene

Genomics for DNAJC13 Gene

Genomic Location for DNAJC13 Gene

Start:
132,417,520 bp from pter
End:
132,539,032 bp from pter
Size:
121,513 bases
Orientation:
Plus strand

Genomic View for DNAJC13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNAJC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC13 Gene

Regulatory Elements for DNAJC13 Gene

Proteins for DNAJC13 Gene

  • Protein details for DNAJC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75165-DJC13_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 13
    Protein Accession:
    O75165
    Secondary Accessions:
    • Q3L0T1
    • Q6PI82
    • Q6UJ77
    • Q6ZSW1
    • Q6ZUT5
    • Q86XG3
    • Q96DC1
    • Q9BWK9

    Protein attributes for DNAJC13 Gene

    Size:
    2243 amino acids
    Molecular mass:
    254415 Da
    Quaternary structure:
    • Interacts with FAM21C; mediates the association with the WASH complex (PubMed:24643499).
    SequenceCaution:
    • Sequence=AAH43583.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA31653.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC86133.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86835.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86835.1; Type=Erroneous termination; Positions=1651; Note=Translated as Glu.; Evidence={ECO:0000305};

neXtProt entry for DNAJC13 Gene

Proteomics data for DNAJC13 Gene at MOPED

Post-translational modifications for DNAJC13 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys848 and Lys1359

Other Protein References for DNAJC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC13 Gene

Domains for DNAJC13 Gene

Gene Families for DNAJC13 Gene

HGNC:
  • DNAJ :Heat shock proteins / DNAJ (HSP40)

Protein Domains for DNAJC13 Gene

UniProtKB/Swiss-Prot:

DJC13_HUMAN
Domain:
  • Contains 1 J domain.:
    • O75165
genes like me logo Genes that share domains with DNAJC13: view

Function for DNAJC13 Gene

Molecular function for DNAJC13 Gene

UniProtKB/Swiss-Prot Function: Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499).

Gene Ontology (GO) - Molecular Function for DNAJC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 24643499
genes like me logo Genes that share ontologies with DNAJC13: view

Phenotypes for DNAJC13 Gene

genes like me logo Genes that share phenotypes with DNAJC13: view

miRNA for DNAJC13 Gene

miRTarBase miRNAs that target DNAJC13

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNAJC13 Gene

Localization for DNAJC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC13 Gene

Early endosome. Early endosome membrane; Peripheral membrane protein. Endosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNAJC13 Gene COMPARTMENTS Subcellular localization image for DNAJC13 gene
Compartment Confidence
plasma membrane 3
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DNAJC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0010008 endosome membrane IDA 24643499
GO:0016020 membrane IDA 16210410
GO:0031901 early endosome membrane IDA 18256511
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DNAJC13: view

Pathways for DNAJC13 Gene

SuperPathways for DNAJC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNAJC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0007032 endosome organization IMP 24643499
GO:0015031 protein transport IEA --
GO:1902954 regulation of early endosome to recycling endosome transport IMP 18256511
GO:2000641 regulation of early endosome to late endosome transport IMP 18256511
genes like me logo Genes that share ontologies with DNAJC13: view

No data available for Pathways by source for DNAJC13 Gene

Transcripts for DNAJC13 Gene

Unigene Clusters for DNAJC13 Gene

DnaJ (Hsp40) homolog, subfamily C, member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC13 Gene

No ASD Table

Relevant External Links for DNAJC13 Gene

GeneLoc Exon Structure for
DNAJC13
ECgene alternative splicing isoforms for
DNAJC13

Expression for DNAJC13 Gene

mRNA expression in normal human tissues for DNAJC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNAJC13 Gene

SOURCE GeneReport for Unigene cluster for DNAJC13 Gene Hs.12707

genes like me logo Genes that share expressions with DNAJC13: view

Orthologs for DNAJC13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC13 36
  • 99.76 (n)
  • 99.78 (a)
DNAJC13 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC13 36
  • 93.65 (n)
  • 97.41 (a)
DNAJC13 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC13 36
  • 94.38 (n)
  • 98.08 (a)
DNAJC13 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc13 36
  • 89.63 (n)
  • 96.66 (a)
Dnajc13 16
Dnajc13 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC13 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 94 (a)
OneToMany
-- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dnajc13 36
  • 89.29 (n)
  • 96.26 (a)
chicken
(Gallus gallus)
Aves DNAJC13 36
  • 82.68 (n)
  • 92.05 (a)
DNAJC13 37
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC13 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc13 36
  • 77.91 (n)
  • 88.12 (a)
zebrafish
(Danio rerio)
Actinopterygii DNAJC13 (1 of 2) 37
  • 86 (a)
OneToMany
DNAJC13 (2 of 2) 37
  • 72 (a)
OneToMany
Dr.14056 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005771 36
  • 52.42 (n)
  • 52.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rme-8 36
  • 52.94 (n)
  • 51.09 (a)
Rme-8 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rme-8 36
  • 52.3 (n)
  • 46.53 (a)
rme-8 37
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons GRV2 36
  • 45.87 (n)
  • 35.42 (a)
rice
(Oryza sativa)
Liliopsida Os10g0575200 36
  • 46.56 (n)
  • 36.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10682 37
  • 59 (a)
OneToOne
Species with no ortholog for DNAJC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC13 Gene

ENSEMBL:
Gene Tree for DNAJC13 (if available)
TreeFam:
Gene Tree for DNAJC13 (if available)

Paralogs for DNAJC13 Gene

No data available for Paralogs for DNAJC13 Gene

Variants for DNAJC13 Gene

Sequence variations from dbSNP and Humsavar for DNAJC13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6671 -- 132,538,903(+) TGAGT(A/G)TAATT utr-variant-3-prime
rs13576 -- 132,538,902(+) ATGAG(C/T)ATAAT utr-variant-3-prime
rs754993 -- 132,525,562(-) TACAG(C/T)CCTAA intron-variant
rs936165 -- 132,521,063(-) TGTCT(A/C)ATAAG intron-variant
rs953953 -- 132,515,634(-) TATGA(C/G)TTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC13 Gene

Variant ID Type Subtype PubMed ID
nsv829728 CNV Gain 17160897
nsv522333 CNV Loss 19592680
nsv4013 CNV Loss 18451855

Relevant External Links for DNAJC13 Gene

HapMap Linkage Disequilibrium report
DNAJC13
Human Gene Mutation Database (HGMD)
DNAJC13

Disorders for DNAJC13 Gene

(2) University of Copenhagen DISEASES for DNAJC13 Gene

Relevant External Links for DNAJC13

Genetic Association Database (GAD)
DNAJC13
Human Genome Epidemiology (HuGE) Navigator
DNAJC13
genes like me logo Genes that share disorders with DNAJC13: view

No data available for UniProtKB/Swiss-Prot for DNAJC13 Gene

Publications for DNAJC13 Gene

  1. Human RME-8 is involved in membrane trafficking through early endosomes. (PMID: 18256511) Fujibayashi A. … Sekiguchi K. (Cell Struct. Funct. 2008) 3 4
  2. RME-8 regulates trafficking of the epidermal growth factor receptor. (PMID: 18307993) Girard M. … McPherson P.S. (FEBS Lett. 2008) 3 4
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-LA,ken syndrome type 3. (PMID: 12438707) Volz A. … Omran H. (Cytogenet. Genome Res. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DNAJC13 Gene

Sources for DNAJC13 Gene

Back to Top

Content