Aliases for SLC9A8 Gene
External Ids for SLC9A8 Gene
Previous GeneCards Identifiers for SLC9A8 Gene
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
GeneCards Summary for SLC9A8 Gene
SLC9A8 (Solute Carrier Family 9, Subfamily A (NHE8, Cation Proton Antiporter 8), Member 8) is a Protein Coding gene. Diseases associated with SLC9A8 include proximal renal tubular acidosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include sodium:proton antiporter activity and potassium:proton antiporter activity. An important paralog of this gene is SLC9A4.
UniProtKB/Swiss-Prot for SLC9A8 Gene
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.