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Aliases for SLC9A8 Gene

Aliases for SLC9A8 Gene

  • Solute Carrier Family 9 Member A8 2 3
  • Solute Carrier Family 9, Subfamily A (NHE8, Cation Proton Antiporter 8), Member 8 2 3 5
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 8 2 3
  • Na(+)/H(+) Exchanger 8 3 4
  • NHE-8 3 4
  • NHE8 3 4
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 8 2
  • Solute Carrier Family 9 (Sodium/Hydrogen Exchanger) 3
  • Solute Carrier Family 9 Member 8 4
  • KIAA0939 4

External Ids for SLC9A8 Gene

Previous GeneCards Identifiers for SLC9A8 Gene

  • GC20P048117
  • GC20P049067
  • GC20P049113
  • GC20P047862
  • GC20P048429
  • GC20P045177

Summaries for SLC9A8 Gene

Entrez Gene Summary for SLC9A8 Gene

  • Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SLC9A8 Gene

SLC9A8 (Solute Carrier Family 9 Member A8) is a Protein Coding gene. Diseases associated with SLC9A8 include proximal renal tubular acidosis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include solute:proton antiporter activity and potassium:proton antiporter activity. An important paralog of this gene is SLC9A4.

UniProtKB/Swiss-Prot for SLC9A8 Gene

  • Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Gene Wiki entry for SLC9A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC9A8 Gene

Genomics for SLC9A8 Gene

Regulatory Elements for SLC9A8 Gene

Promoters for SLC9A8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC9A8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC9A8 Gene

Chromosome:
20
Start:
49,812,713 bp from pter
End:
49,892,242 bp from pter
Size:
79,530 bases
Orientation:
Plus strand

Genomic View for SLC9A8 Gene

Genes around SLC9A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC9A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC9A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC9A8 Gene

Proteins for SLC9A8 Gene

  • Protein details for SLC9A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2E8-SL9A8_HUMAN
    Recommended name:
    Sodium/hydrogen exchanger 8
    Protein Accession:
    Q9Y2E8
    Secondary Accessions:
    • B4DTQ8
    • Q2M1U9
    • Q68CZ8
    • Q9BX15
    • Q9Y507

    Protein attributes for SLC9A8 Gene

    Size:
    581 amino acids
    Molecular mass:
    65422 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76783.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC9A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC9A8 Gene

Proteomics data for SLC9A8 Gene at MOPED

Post-translational modifications for SLC9A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC9A8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC9A8 Gene

Domains & Families for SLC9A8 Gene

Gene Families for SLC9A8 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2E8

UniProtKB/Swiss-Prot:

SL9A8_HUMAN :
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Family:
  • Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
genes like me logo Genes that share domains with SLC9A8: view

Function for SLC9A8 Gene

Molecular function for SLC9A8 Gene

UniProtKB/Swiss-Prot Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Gene Ontology (GO) - Molecular Function for SLC9A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015299 solute:proton antiporter activity IEA --
genes like me logo Genes that share ontologies with SLC9A8: view
genes like me logo Genes that share phenotypes with SLC9A8: view

Animal Models for SLC9A8 Gene

MGI Knock Outs for SLC9A8:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC9A8

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC9A8 Gene

Localization for SLC9A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC9A8 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC9A8 Gene COMPARTMENTS Subcellular localization image for SLC9A8 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
endosome 1

Gene Ontology (GO) - Cellular Components for SLC9A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
genes like me logo Genes that share ontologies with SLC9A8: view

Pathways & Interactions for SLC9A8 Gene

genes like me logo Genes that share pathways with SLC9A8: view

Gene Ontology (GO) - Biological Process for SLC9A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport TAS --
GO:0006812 cation transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0035725 sodium ion transmembrane transport IEA --
GO:0051453 regulation of intracellular pH IEA --
genes like me logo Genes that share ontologies with SLC9A8: view

No data available for SIGNOR curated interactions for SLC9A8 Gene

Drugs & Compounds for SLC9A8 Gene

(1) Additional Compounds for SLC9A8 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC9A8: view

Transcripts for SLC9A8 Gene

Unigene Clusters for SLC9A8 Gene

Solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC9A8 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - -
SP2: -
SP3: - - - -
SP4:
SP5:

Relevant External Links for SLC9A8 Gene

GeneLoc Exon Structure for
SLC9A8
ECgene alternative splicing isoforms for
SLC9A8

Expression for SLC9A8 Gene

mRNA expression in normal human tissues for SLC9A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC9A8 Gene

This gene is overexpressed in Whole Blood (x8.9).

Protein differential expression in normal tissues from HIPED for SLC9A8 Gene

This gene is overexpressed in Neutrophil (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC9A8 Gene



SOURCE GeneReport for Unigene cluster for SLC9A8 Gene Hs.444202

mRNA Expression by UniProt/SwissProt for SLC9A8 Gene

Q9Y2E8-SL9A8_HUMAN
Tissue specificity: Ubiquitous. Strongly expressed in skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with SLC9A8: view

Protein tissue co-expression partners for SLC9A8 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC9A8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC9A8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC9A8 35
  • 92.39 (n)
  • 98.14 (a)
SLC9A8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC9A8 35
  • 99.43 (n)
  • 99.66 (a)
SLC9A8 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC9A8 36
  • 99 (a)
OneToOne
SLC9A8 35
  • 93.97 (n)
  • 98.66 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC9A8 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc9a8 36
  • 97 (a)
OneToOne
Slc9a8 16
Slc9a8 35
  • 88.7 (n)
  • 96.7 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9A8 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc9a8 35
  • 87.63 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves SLC9A8 35
  • 81.24 (n)
  • 93.21 (a)
SLC9A8 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC9A8 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc9a8 35
  • 78.65 (n)
  • 90.97 (a)
zebrafish
(Danio rerio)
Actinopterygii wufj61b02 35
slc9a8 36
  • 89 (a)
OneToOne
slc9a8 35
  • 76.69 (n)
  • 88.38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009446 35
  • 58.98 (n)
  • 58.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nhe1 35
  • 58.08 (n)
  • 58.46 (a)
Nhe1 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nhx-8 35
  • 51.52 (n)
  • 44.83 (a)
nhx-8 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHX1 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NHX6 35
  • 46.45 (n)
  • 38.72 (a)
rice
(Oryza sativa)
Liliopsida Os09g0286400 35
  • 46.86 (n)
  • 38.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5713 35
Species with no ortholog for SLC9A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC9A8 Gene

ENSEMBL:
Gene Tree for SLC9A8 (if available)
TreeFam:
Gene Tree for SLC9A8 (if available)

Paralogs for SLC9A8 Gene

Paralogs for SLC9A8 Gene

(3) SIMAP similar genes for SLC9A8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC9A8: view

Variants for SLC9A8 Gene

Sequence variations from dbSNP and Humsavar for SLC9A8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs483508 -- 49,883,072(-) AGGAG(A/G)CACAG intron-variant
rs487096 -- 49,882,722(-) GCCAC(A/C/G)GGGCA intron-variant
rs488255 -- 49,882,548(-) CGGGT(A/G)AGCGC intron-variant
rs967305 -- 49,843,409(+) TGAGC(C/G)TTTTT intron-variant
rs511268 -- 49,875,774(-) CTGGG(C/T)GACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC9A8 Gene

Variant ID Type Subtype PubMed ID
esv2722489 CNV Deletion 23290073
esv2722490 CNV Deletion 23290073
esv2722491 CNV Deletion 23290073
nsv912915 CNV Loss 21882294

Variation tolerance for SLC9A8 Gene

Residual Variation Intolerance Score: 4.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC9A8 Gene

HapMap Linkage Disequilibrium report
SLC9A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC9A8 Gene

Disorders for SLC9A8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC9A8 Gene - From: GeneCards

Disorder Aliases PubMed IDs
proximal renal tubular acidosis
  • renal tubular acidosis type 2
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC9A8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC9A8
genes like me logo Genes that share disorders with SLC9A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC9A8 Gene

Publications for SLC9A8 Gene

  1. Four Na+/H+ exchanger isoforms are distributed to Golgi and post- Golgi Compartments and are involved in organelle pH regulation. (PMID: 15522866) Nakamura N. … Kanazawa H. (J. Biol. Chem. 2005) 3 4 67
  2. Renal expression of novel Na+/H+ exchanger isoform NHE8. (PMID: 12409279) Goyal S. … Aronson P.S. (Am. J. Physiol. Renal Physiol. 2003) 2 3
  3. Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef. (PMID: 24874739) Hashimoto M. … Suzu S. (Cell Death Dis 2014) 3
  4. Organellar Na+/H+ exchangers: novel players in organelle pH regulation and their emerging functions. (PMID: 21171650) Ohgaki R. … Kanazawa H. (Biochemistry 2011) 3
  5. Nucleotide sequence of the Na+/H+ exchanger-8 in patients with congenital sodium diarrhea. (PMID: 21666503) Baum M. … Moe O. (J. Pediatr. Gastroenterol. Nutr. 2011) 3

Products for SLC9A8 Gene

Sources for SLC9A8 Gene

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