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Aliases for SIN3B Gene

Aliases for SIN3B Gene

  • SIN3 Transcription Regulator Family Member B 2 3
  • KIAA0700 4 6
  • SIN3 Homolog B, Transcription Regulator (Yeast) 2
  • SIN3 Transcription Regulator Homolog B (Yeast) 2
  • Histone Deacetylase Complex Subunit Sin3b 4
  • Transcriptional Corepressor Sin3b 4

External Ids for SIN3B Gene

Summaries for SIN3B Gene

GeneCards Summary for SIN3B Gene

SIN3B (SIN3 Transcription Regulator Family Member B) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Metabolism. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is SIN3A.

UniProtKB/Swiss-Prot for SIN3B Gene

  • Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).

Gene Wiki entry for SIN3B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIN3B Gene

Genomics for SIN3B Gene

Genomic Location for SIN3B Gene

Start:
16,829,398 bp from pter
End:
16,880,355 bp from pter
Size:
50,958 bases
Orientation:
Plus strand

Genomic View for SIN3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIN3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIN3B Gene

Regulatory Elements for SIN3B Gene

Proteins for SIN3B Gene

  • Protein details for SIN3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75182-SIN3B_HUMAN
    Recommended name:
    Paired amphipathic helix protein Sin3b
    Protein Accession:
    O75182
    Secondary Accessions:
    • Q2NL91
    • Q68GC2
    • Q6P4B8
    • Q8TB34
    • Q9BSC8

    Protein attributes for SIN3B Gene

    Size:
    1162 amino acids
    Molecular mass:
    133066 Da
    Quaternary structure:
    • Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1.
    SequenceCaution:
    • Sequence=BAA31675.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SIN3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SIN3B Gene

Proteomics data for SIN3B Gene at MOPED

Post-translational modifications for SIN3B Gene

  • Ubiquitinated by RNF220 that leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIN3B Gene

No data available for DME Specific Peptides for SIN3B Gene

Domains for SIN3B Gene

Protein Domains for SIN3B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SIN3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75182

UniProtKB/Swiss-Prot:

SIN3B_HUMAN
Domain:
  • Contains 3 PAH (paired amphipathic helix) domains.:
    • O75182
genes like me logo Genes that share domains with SIN3B: view

No data available for Gene Families for SIN3B Gene

Function for SIN3B Gene

Molecular function for SIN3B Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).

Gene Ontology (GO) - Molecular Function for SIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IBA --
GO:0003682 chromatin binding IEA --
GO:0003714 transcription corepressor activity --
GO:0004407 contributes_to histone deacetylase activity IBA --
GO:0005515 protein binding IPI 12670868
genes like me logo Genes that share ontologies with SIN3B: view
genes like me logo Genes that share phenotypes with SIN3B: view

Animal Models for SIN3B Gene

MGI Knock Outs for SIN3B:

miRNA for SIN3B Gene

miRTarBase miRNAs that target SIN3B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SIN3B Gene

Localization for SIN3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIN3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIN3B Gene COMPARTMENTS Subcellular localization image for SIN3B gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000805 X chromosome IEA --
GO:0000806 Y chromosome IEA --
GO:0001741 XY body IEA --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SIN3B: view

Pathways for SIN3B Gene

genes like me logo Genes that share pathways with SIN3B: view

Gene Ontology (GO) - Biological Process for SIN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007519 skeletal muscle tissue development IEA --
GO:0016575 histone deacetylation IBA --
genes like me logo Genes that share ontologies with SIN3B: view

Transcripts for SIN3B Gene

Unigene Clusters for SIN3B Gene

SIN3 transcription regulator homolog B (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIN3B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

ExUns: 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b · 25c · 25d
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SIN3B Gene

GeneLoc Exon Structure for
SIN3B
ECgene alternative splicing isoforms for
SIN3B

Expression for SIN3B Gene

mRNA expression in normal human tissues for SIN3B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIN3B Gene

SOURCE GeneReport for Unigene cluster for SIN3B Gene Hs.13999

genes like me logo Genes that share expressions with SIN3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SIN3B Gene

Orthologs for SIN3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SIN3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIN3B 35
  • 99.24 (n)
  • 99.74 (a)
SIN3B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIN3B 35
  • 90.95 (n)
  • 95.38 (a)
SIN3B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIN3B 35
  • 90.7 (n)
  • 95.82 (a)
SIN3B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sin3b 35
  • 85.37 (n)
  • 92.51 (a)
Sin3b 16
Sin3b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIN3B 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIN3B 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIN3B 35
  • 77.79 (n)
  • 88.45 (a)
SIN3B 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIN3B 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sin3b 35
  • 69.74 (n)
  • 77.09 (a)
zebrafish
(Danio rerio)
Actinopterygii sin3b 35
  • 68.84 (n)
  • 70.45 (a)
sin3b 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sin3A 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sin-3 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIN3 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3742 36
  • 33 (a)
OneToMany
Species with no ortholog for SIN3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIN3B Gene

ENSEMBL:
Gene Tree for SIN3B (if available)
TreeFam:
Gene Tree for SIN3B (if available)

Paralogs for SIN3B Gene

Paralogs for SIN3B Gene

Selected SIMAP similar genes for SIN3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SIN3B: view

Variants for SIN3B Gene

Sequence variations from dbSNP and Humsavar for SIN3B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10423 -- 16,880,163(+) GCCCC(A/G)GGTGC utr-variant-3-prime
rs706760 -- 16,843,069(-) CCAAG(C/T)GTTAG intron-variant
rs773865 -- 16,828,671(-) gcgat(C/T)tccgc upstream-variant-2KB
rs773866 -- 16,827,606(-) GACCA(A/G)CCTGG upstream-variant-2KB
rs773877 -- 16,842,156(-) gagcc(A/G)agtcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIN3B Gene

Variant ID Type Subtype PubMed ID
nsv911168 CNV Loss 21882294
nsv911169 CNV Loss 21882294
esv24348 CNV Loss 19812545
esv2718267 CNV Deletion 23290073
esv2718268 CNV Deletion 23290073
esv2718269 CNV Deletion 23290073
esv1088392 CNV Deletion 17803354

Relevant External Links for SIN3B Gene

HapMap Linkage Disequilibrium report
SIN3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIN3B Gene

Disorders for SIN3B Gene

Relevant External Links for SIN3B

Genetic Association Database (GAD)
SIN3B
Human Genome Epidemiology (HuGE) Navigator
SIN3B
genes like me logo Genes that share disorders with SIN3B: view

No data available for UniProtKB/Swiss-Prot for SIN3B Gene

Publications for SIN3B Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PMID: 12670868) Wysocka J. … Herr W. (Genes Dev. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues. (PMID: 18205948) Dhanda R.S. … Olsson I. (BMC Mol. Biol. 2008) 3 23

Products for SIN3B Gene

Sources for SIN3B Gene

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