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Aliases for FMO4 Gene

Aliases for FMO4 Gene

  • Flavin Containing Monooxygenase 4 2 3
  • Hepatic Flavin-Containing Monooxygenase 4 3 4
  • Dimethylaniline Oxidase 4 3 4
  • EC 1.14.13.8 4 63
  • FMO 4 3 4
  • FMO2 3 4
  • Dimethylaniline Monooxygenase [N-Oxide-Forming] 4 3

External Ids for FMO4 Gene

Previous Symbols for FMO4 Gene

  • FMO2

Summaries for FMO4 Gene

Entrez Gene Summary for FMO4 Gene

  • Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

GeneCards Summary for FMO4 Gene

FMO4 (Flavin Containing Monooxygenase 4) is a Protein Coding gene. Diseases associated with FMO4 include plasma cell neoplasm and trimethylaminuria. Among its related pathways are Metabolism and Busulfan Pathway, Pharmacodynamics. GO annotations related to this gene include flavin adenine dinucleotide binding and N,N-dimethylaniline monooxygenase activity. An important paralog of this gene is FMO6P.

UniProtKB/Swiss-Prot for FMO4 Gene

  • This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides

Gene Wiki entry for FMO4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO4 Gene

Genomics for FMO4 Gene

Genomic Location for FMO4 Gene

Start:
171,314,179 bp from pter
End:
171,342,084 bp from pter
Size:
27,906 bases
Orientation:
Plus strand

Genomic View for FMO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO4 Gene

Regulatory Elements for FMO4 Gene

Proteins for FMO4 Gene

  • Protein details for FMO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31512-FMO4_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 4
    Protein Accession:
    P31512
    Secondary Accessions:
    • Q53XR0

    Protein attributes for FMO4 Gene

    Size:
    558 amino acids
    Molecular mass:
    63343 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO4 Gene

Proteomics data for FMO4 Gene at MOPED

Post-translational modifications for FMO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FMO4 Gene

Suggested Antigen Peptide Sequences for FMO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31512

UniProtKB/Swiss-Prot:

FMO4_HUMAN
Family:
  • Belongs to the FMO family.:
    • P31512
genes like me logo Genes that share domains with FMO4: view

No data available for Gene Families for FMO4 Gene

Function for FMO4 Gene

Molecular function for FMO4 Gene

GENATLAS Biochemistry: flavin containing monooxygenase 4,microsomal
UniProtKB/Swiss-Prot CatalyticActivity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides

Enzyme Numbers (IUBMB) for FMO4 Gene

Gene Ontology (GO) - Molecular Function for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004499 N,N-dimethylaniline monooxygenase activity NAS 1417778
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO4: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FMO4 Gene

Localization for FMO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO4 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO4 Gene COMPARTMENTS Subcellular localization image for FMO4 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 2
peroxisome 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FMO4: view

Pathways for FMO4 Gene

genes like me logo Genes that share pathways with FMO4: view

Pathways by source for FMO4 Gene

Gene Ontology (GO) - Biological Process for FMO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042737 drug catabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FMO4: view

Compounds for FMO4 Gene

(7) HMDB Compounds for FMO4 Gene

Compound Synonyms Cas Number PubMed IDs
Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide
874-52-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
N,N-Dimethylaniline
  • Dimethylaminobenzene
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6
genes like me logo Genes that share compounds with FMO4: view

Transcripts for FMO4 Gene

Unigene Clusters for FMO4 Gene

Flavin containing monooxygenase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: - - - - -
SP2: -
SP3:

Relevant External Links for FMO4 Gene

GeneLoc Exon Structure for
FMO4
ECgene alternative splicing isoforms for
FMO4

Expression for FMO4 Gene

mRNA expression in normal human tissues for FMO4 Gene

mRNA differential expression in normal tissues according to GTEx for FMO4 Gene

This gene is overexpressed in Liver (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FMO4 Gene

SOURCE GeneReport for Unigene cluster for FMO4 Gene Hs.386502

mRNA Expression by UniProt/SwissProt for FMO4 Gene

P31512-FMO4_HUMAN
Tissue specificity: Liver
genes like me logo Genes that share expressions with FMO4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FMO4 Gene

Orthologs for FMO4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO4 35
  • 99.52 (n)
  • 99.46 (a)
FMO4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMO4 35
  • 87.76 (n)
  • 86 (a)
FMO4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO4 35
  • 88.05 (n)
  • 86.49 (a)
FMO4 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo4 35
  • 83.21 (n)
  • 80.69 (a)
Fmo4 16
Fmo4 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia FMO4 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo4 35
  • 82.61 (n)
  • 80.87 (a)
chicken
(Gallus gallus)
Aves FMO4 35
  • 59.31 (n)
  • 55.66 (a)
FMO4 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FMO4 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo1 35
  • 59.81 (n)
  • 52.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fmo-1 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea fmo-15 37
  • 42 (a)
fmo-13 37
  • 40 (a)
C01H6.4 37
  • 35 (a)
fmo-11 37
  • 39 (a)
Species with no ortholog for FMO4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO4 Gene

ENSEMBL:
Gene Tree for FMO4 (if available)
TreeFam:
Gene Tree for FMO4 (if available)

Paralogs for FMO4 Gene

Paralogs for FMO4 Gene

Selected SIMAP similar genes for FMO4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FMO4 Gene

genes like me logo Genes that share paralogs with FMO4: view

Variants for FMO4 Gene

Sequence variations from dbSNP and Humsavar for FMO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs714839 -- 171,329,801(+) ACTGG(C/T)CTCAC intron-variant
rs717023 -- 171,323,886(+) TTTCT(C/T)ACCAG intron-variant
rs717024 -- 171,323,825(+) ACAAT(A/G)AGGCA intron-variant
rs718016 -- 171,329,876(-) GGACA(C/G)TAAAC intron-variant
rs1042767 - 171,334,551(+) TGATG(C/T)TGTGA missense, reference, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO4 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
nsv831882 CNV Loss 17160897
nsv527149 CNV Gain 19592680

Relevant External Links for FMO4 Gene

HapMap Linkage Disequilibrium report
FMO4
Human Gene Mutation Database (HGMD)
FMO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO4 Gene

Disorders for FMO4 Gene

Relevant External Links for FMO4

Genetic Association Database (GAD)
FMO4
Human Genome Epidemiology (HuGE) Navigator
FMO4
genes like me logo Genes that share disorders with FMO4: view

No data available for UniProtKB/Swiss-Prot for FMO4 Gene

Publications for FMO4 Gene

  1. Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family. (PMID: 1417778) Dolphin C.T. … Phillips I.R. (Biochem. J. 1992) 3 4 23
  2. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. (PMID: 8311461) Lawton M.P. … Phillips I.R. (Arch. Biochem. Biophys. 1994) 2 3 23
  3. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B. … Schlenk D. (Drug Metab. Dispos. 2003) 3 4 23
  4. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. (PMID: 19307449) Novick R.M. … Elfarra A.A. (J. Pharmacol. Exp. Ther. 2009) 3 23
  5. Expression and characterization of a modified flavin-containing monooxygenase 4 from humans. (PMID: 8702731) Itagaki K. … Philpot R.M. (J. Biol. Chem. 1996) 3 23

Products for FMO4 Gene

Sources for FMO4 Gene

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