Aliases for FMO4 Gene
External Ids for FMO4 Gene
Previous HGNC Symbols for FMO4 Gene
Previous GeneCards Identifiers for FMO4 Gene
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]
GeneCards Summary for FMO4 Gene
FMO4 (Flavin Containing Monooxygenase 4) is a Protein Coding gene. Diseases associated with FMO4 include Trimethylaminuria. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Metabolism of xenobiotics by cytochrome P450. GO annotations related to this gene include oxidoreductase activity and NADP binding. An important paralog of this gene is FMO2.
UniProtKB/Swiss-Prot for FMO4 Gene
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.