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Aliases for ADGRL3 Gene

Aliases for ADGRL3 Gene

  • Adhesion G Protein-Coupled Receptor L3 2 3
  • Calcium-Independent Alpha-Latrotoxin Receptor 3 3 4
  • Latrophilin 3 2 3
  • CIRL-3 3 4
  • LPHN3 3 4
  • LEC3 3 4
  • Latrophilin Homolog 3 (Cow) 3
  • Latrophilin-3 3
  • Lectomedin 3 3
  • Lectomedin-3 4
  • KIAA0768 4
  • CIRL3 3

External Ids for ADGRL3 Gene

Previous Symbols for ADGRL3 Gene

  • LPHN3

Summaries for ADGRL3 Gene

Entrez Gene Summary for ADGRL3 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRL3 Gene

ADGRL3 (Adhesion G Protein-Coupled Receptor L3) is a Protein Coding gene. Among its related pathways are GPCRs, Other and GPCRs, Class B Secretin-like. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL3 Gene

  • May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex (By similarity).

Gene Wiki entry for ADGRL3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL3 Gene

Genomics for ADGRL3 Gene

Genomic Location for ADGRL3 Gene

61,201,258 bp from pter
62,078,335 bp from pter
877,078 bases
Plus strand

Genomic View for ADGRL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL3 Gene

No data available for Regulatory Elements for ADGRL3 Gene

Proteins for ADGRL3 Gene

  • Protein details for ADGRL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E9PE04
    • O94867
    • Q9NWK5

    Protein attributes for ADGRL3 Gene

    1447 amino acids
    Molecular mass:
    161812 Da
    Quaternary structure:
    • Interacts with FLRT3 and TEN1.
    • Sequence=BAA91375.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRL3 Gene


neXtProt entry for ADGRL3 Gene

Proteomics data for ADGRL3 Gene at MOPED

Post-translational modifications for ADGRL3 Gene

  • O-glycosylated (major) and N-glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRL3 Gene

Domains for ADGRL3 Gene

Gene Families for ADGRL3 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • The Olfactomedin-like domain is required for the synapse-promoting function and the interaction with FLRT3. The Olfactomedin-like and the SUEL-type lectin domains are required for the interaction with TEN1 (By similarity).:
    • Q9HAR2
  • Contains 1 GPS domain.:
    • Q9HAR2
  • Contains 1 olfactomedin-like domain.:
    • Q9HAR2
  • Contains 1 SUEL-type lectin domain.:
    • Q9HAR2
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • Q9HAR2
genes like me logo Genes that share domains with ADGRL3: view

No data available for Suggested Antigen Peptide Sequences for ADGRL3 Gene

Function for ADGRL3 Gene

Molecular function for ADGRL3 Gene

UniProtKB/Swiss-Prot Function: May be involved in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity NAS 10994649
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ADGRL3: view
genes like me logo Genes that share phenotypes with ADGRL3: view

miRNA for ADGRL3 Gene

miRTarBase miRNAs that target ADGRL3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGRL3 Gene

Localization for ADGRL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10994649
genes like me logo Genes that share ontologies with ADGRL3: view

No data available for Subcellular locations from COMPARTMENTS for ADGRL3 Gene

Pathways for ADGRL3 Gene

genes like me logo Genes that share pathways with ADGRL3: view

Pathways by source for ADGRL3 Gene

2 BioSystems pathways for ADGRL3 Gene

Interacting Proteins for ADGRL3 Gene

Gene Ontology (GO) - Biological Process for ADGRL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway NAS 10994649
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRL3: view

Transcripts for ADGRL3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL3 Gene

No ASD Table

Relevant External Links for ADGRL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRL3 Gene

mRNA expression in normal human tissues for ADGRL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRL3 Gene

genes like me logo Genes that share expressions with ADGRL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRL3 Gene

Orthologs for ADGRL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LPHN3 35
  • 99.71 (n)
  • 100 (a)
LPHN3 36
  • 91 (a)
(Bos Taurus)
Mammalia LPHN3 35
  • 94.26 (n)
  • 98.35 (a)
LPHN3 36
  • 95 (a)
(Canis familiaris)
Mammalia LOC482166 35
  • 94.39 (n)
  • 98.69 (a)
LPHN3 36
  • 98 (a)
(Mus musculus)
Mammalia Lphn3 35
  • 89.97 (n)
  • 97.18 (a)
Lphn3 16
Lphn3 36
  • 92 (a)
(Monodelphis domestica)
Mammalia LPHN3 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia LPHN3 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Lphn3 35
  • 89.46 (n)
  • 96.9 (a)
(Gallus gallus)
Aves LPHN3 35
  • 82.77 (n)
  • 92.46 (a)
LPHN3 36
  • 89 (a)
(Anolis carolinensis)
Reptilia LPHN3 36
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498069 35
  • 76.18 (n)
  • 83.91 (a)
(Danio rerio)
Actinopterygii lphn3.1 35
  • 68.33 (n)
  • 76.76 (a)
lphn3.1 36
  • 71 (a)
wufj36g07 35
(Caenorhabditis elegans)
Secernentea lat-1 36
  • 29 (a)
Species with no ortholog for ADGRL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL3 Gene

Gene Tree for ADGRL3 (if available)
Gene Tree for ADGRL3 (if available)

Paralogs for ADGRL3 Gene

genes like me logo Genes that share paralogs with ADGRL3: view

Variants for ADGRL3 Gene

Sequence variations from dbSNP and Humsavar for ADGRL3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs170842 -- 61,496,813(-) CAAGC(A/G)CCCAC upstream-variant-2KB
rs186750 -- 61,527,928(-) GAAAA(A/G)TGGAG intron-variant
rs335269 -- 61,500,007(-) tgtgt(A/G)tgtgt intron-variant
rs335270 -- 61,496,378(-) CTAAA(A/T)ATACA upstream-variant-2KB
rs335271 -- 61,495,741(-) TCAAA(C/T)ATTAA upstream-variant-2KB

Relevant External Links for ADGRL3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRL3 Gene

Disorders for ADGRL3 Gene

No disorders were found for ADGRL3 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRL3 Gene

Publications for ADGRL3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. (PMID: 10994649) Hayflick J.S. (J. Recept. Signal Transduct. Res. 2000) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Screening of human LPHN3 for variants with a potential impact on ADHD susceptibility. (PMID: 21184580) DomenAc S. … Muenke M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011) 3 4
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3

Products for ADGRL3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRL3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRL3
    • Block miRNA regulation of ADGRL3 using miScript Target Protectors
    • antibodies-online peptides for ADGRL3
    • antibodies-online antibodies for ADGRL3
    • antibodies-online kits for ADGRL3

    Sources for ADGRL3 Gene

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