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Aliases for FMO3 Gene

Aliases for FMO3 Gene

  • Flavin Containing Monooxygenase 3 2 3
  • Hepatic Flavin-Containing Monooxygenase 3 3 4
  • Trimethylamine Monooxygenase 3 4
  • Dimethylaniline Oxidase 3 3 4
  • EC 1.14.13.8 4 63
  • FMO Form 2 3 4
  • FMO II 3 4
  • FMO 3 3 4
  • TMAU 3 6
  • Dimethylaniline Monooxygenase [N-Oxide-Forming] 3 3
  • Hepatic Flavin-Containing Monooxygenase-3 3
  • EC 1.14.13.148 4
  • DJ127D3.1 3
  • FMOII 3

External Ids for FMO3 Gene

Previous GeneCards Identifiers for FMO3 Gene

  • GC01P168623
  • GC01P166689
  • GC0XP9N0049
  • GC01P168299
  • GC01P167791
  • GC01P169326
  • GC01P142283

Summaries for FMO3 Gene

Entrez Gene Summary for FMO3 Gene

  • Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009]

GeneCards Summary for FMO3 Gene

FMO3 (Flavin Containing Monooxygenase 3) is a Protein Coding gene. Diseases associated with FMO3 include trimethylaminuria and lymphocytic choriomeningitis. Among its related pathways are Metabolism and SIDS Susceptibility Pathways. GO annotations related to this gene include flavin adenine dinucleotide binding and amino acid binding. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot for FMO3 Gene

  • Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds

Gene Wiki entry for FMO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO3 Gene

Genomics for FMO3 Gene

Regulatory Elements for FMO3 Gene

Genomic Location for FMO3 Gene

Start:
171,090,877 bp from pter
End:
171,117,821 bp from pter
Size:
26,945 bases
Orientation:
Plus strand

Genomic View for FMO3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMO3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO3 Gene

Proteins for FMO3 Gene

  • Protein details for FMO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31513-FMO3_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 3
    Protein Accession:
    P31513
    Secondary Accessions:
    • B2R816
    • Q14854
    • Q8N5N5

    Protein attributes for FMO3 Gene

    Size:
    532 amino acids
    Molecular mass:
    60033 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

neXtProt entry for FMO3 Gene

Proteomics data for FMO3 Gene at MOPED

Post-translational modifications for FMO3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for FMO3 Gene

Suggested Antigen Peptide Sequences for FMO3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31513

UniProtKB/Swiss-Prot:

FMO3_HUMAN :
  • Belongs to the FMO family.
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO3: view

No data available for Gene Families for FMO3 Gene

Function for FMO3 Gene

Molecular function for FMO3 Gene

GENATLAS Biochemistry:
flavin containing monooxygenase 3,microsomal,major hepatic form
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for trimethylamine (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=31 uM for trimethylamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=43 uM for benzydamine (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=55.7 uM for ethylenethiourea (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=71.8 uM for methimazole (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=150.1 uM for sulindac (at pH 8.5) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949}; KM=248 uM for methyl p-tolyl sulfide (at pH 7.4 and 37 degrees Celsius) {ECO:0000269 PubMed:17050781, ECO:0000269 PubMed:17531949};
UniProtKB/Swiss-Prot CatalyticActivity:
N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot CatalyticActivity:
N,N,N-trimethylamine + NADPH + O(2) = N,N,N-trimethylamine N-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot Function:
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds

Enzyme Numbers (IUBMB) for FMO3 Gene

Gene Ontology (GO) - Molecular Function for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004499 N,N-dimethylaniline monooxygenase activity TAS --
GO:0016491 oxidoreductase activity --
GO:0016597 amino acid binding IEA --
GO:0034899 trimethylamine monooxygenase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with FMO3: view

Phenotypes for FMO3 Gene

genes like me logo Genes that share phenotypes with FMO3: view

Animal Model Products

miRNA for FMO3 Gene

miRTarBase miRNAs that target FMO3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FMO3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FMO3 Gene

Localization for FMO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO3 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO3 Gene COMPARTMENTS Subcellular localization image for FMO3 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
plasma membrane 3
cytoskeleton 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 9207220
genes like me logo Genes that share ontologies with FMO3: view

Pathways for FMO3 Gene

genes like me logo Genes that share pathways with FMO3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for FMO3 Gene

Gene Ontology (GO) - Biological Process for FMO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0017144 drug metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with FMO3: view

Drugs for FMO3 Gene

(9) Drugbank Compounds for FMO3 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Almotriptan
  • 1-(((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)sulfonyl)pyrrolidine
181183-52-8 123606 Enzyme substrate approved, investigational
Dapsone
  • 1,1'-Sulfonylbis(4-aminobenzene)
80-08-0 2955 Enzyme substrate approved, investigational
Dasatinib
  • Anh. dasatinib
302962-49-8 3062316 Enzyme substrate approved, investigational
Olanzapine
  • 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine
132539-06-1 Enzyme substrate approved, investigational
Voriconazole
  • (AlphaR,betas)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
137234-62-9 71616 Enzyme substrate approved, investigational

(18) HMDB Compounds for FMO3 Gene

Compound Synonyms Cas Number PubMed IDs
Almotriptan
181183-52-8
Cimetidine
  • Cimetidine Hcl
51481-61-9
Dasatinib
  • BMS-354825
302962-49-8
Dimethylaniline-N-oxide
  • Dimethyl(phenyl)amine oxide
874-52-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5

(30) Novoseek inferred chemical compound relationships for FMO3 Gene

Compound -log(P) Hits PubMed IDs
methyl p-tolyl sulfide 90.2 4
benzydamine 85.7 8
sulindac sulfide 83.7 5
tmao 83 10
methimazole 81.7 5

(6) PharmGKB related drug/compound annotations for FMO3 Gene

Drug/compound Annotation
afatinib Clinical Annotation,DrugLabel
anthracyclines and related substances Clinical Annotation,DrugLabel
dasatinib Clinical Annotation,DrugLabel
itopride Clinical Annotation,DrugLabel
olanzapine Clinical Annotation,DrugLabel
rosuvastatin Clinical Annotation,DrugLabel
genes like me logo Genes that share compounds with FMO3: view

Transcripts for FMO3 Gene

Unigene Clusters for FMO3 Gene

Flavin containing monooxygenase 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FMO3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FMO3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for FMO3 Gene

GeneLoc Exon Structure for
FMO3
ECgene alternative splicing isoforms for
FMO3

Expression for FMO3 Gene

mRNA expression in normal human tissues for FMO3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO3 Gene

This gene is overexpressed in Liver (33.9).

Protein differential expression in normal tissues for FMO3 Gene

This gene is overexpressed in Gallbladder (31.6), Nasal epithelium (22.5), and Liver (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FMO3 Gene

SOURCE GeneReport for Unigene cluster for FMO3 Gene Hs.445350

mRNA Expression by UniProt/SwissProt for FMO3 Gene

P31513-FMO3_HUMAN
Tissue specificity: Liver
genes like me logo Genes that share expressions with FMO3: view

Primer Products

In Situ Assay Products

No data available for Expression partners for FMO3 Gene

Orthologs for FMO3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FMO3 35
  • 84.68 (n)
  • 82.3 (a)
FMO3 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO3 35
  • 86.25 (n)
  • 83.43 (a)
FMO3 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo3 35
  • 83.11 (n)
  • 79.66 (a)
Fmo3 16
Fmo3 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FMO3 35
  • 99.62 (n)
  • 99.81 (a)
FMO3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fmo3 35
  • 82.89 (n)
  • 81.32 (a)
oppossum
(Monodelphis domestica)
Mammalia FMO3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves FMO3 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
ManyToMany
-- 36
  • 70 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo3 35
  • 63.26 (n)
  • 60.98 (a)
worm
(Caenorhabditis elegans)
Secernentea C01H6.4 37
  • 34 (a)
fmo-11 37
  • 39 (a)
fmo-12 37
  • 40 (a)
fmo-13 37
  • 42 (a)
fmo-14 37
  • 36 (a)
fmo-15 37
  • 42 (a)
Species with no ortholog for FMO3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO3 Gene

ENSEMBL:
Gene Tree for FMO3 (if available)
TreeFam:
Gene Tree for FMO3 (if available)

Paralogs for FMO3 Gene

Paralogs for FMO3 Gene

(6) SIMAP similar genes for FMO3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FMO3: view

Variants for FMO3 Gene

Sequence variations from dbSNP and Humsavar for FMO3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs151017943 -- 171,108,476(+) ATCTC(A/G)GATCA intron-variant
rs151072108 -- 171,104,830(+) GATCA(C/T)GCCAC intron-variant
rs150908941 -- 171,107,593(+) TTAAC(C/T)CACTT intron-variant
rs150792597 -- 171,094,302(+) TTTGT(A/G)ATGGT intron-variant
rs150603219 -- 171,115,184(+) TCTCT(A/C)TGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO3 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545

Relevant External Links for FMO3 Gene

HapMap Linkage Disequilibrium report
FMO3
Human Gene Mutation Database (HGMD)
FMO3
Locus Specific Mutation Databases (LSDB)
FMO3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO3 Gene

Disorders for FMO3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FMO3 Gene in MalaCards »

(2) Diseases for FMO3 Gene

(1) OMIM Diseases for FMO3 Gene (136132)

UniProtKB/Swiss-Prot

FMO3_HUMAN
  • Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. {ECO:0000269 PubMed:10338091, ECO:0000269 PubMed:10479479, ECO:0000269 PubMed:11191884, ECO:0000269 PubMed:12893987, ECO:0000269 PubMed:9536088}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FMO3 Gene

(5) Novoseek inferred disease relationships for FMO3 Gene

Disease -log(P) Hits PubMed IDs
trimethylaminuria 98.2 48
metabolic disorder 40.6 3
familial adenomatous polyposis 27.1 1
polyposis 25.4 3
adenoma 0 1

Relevant External Links for FMO3

GeneTests
FMO3
GeneReviews
FMO3
Genetic Association Database (GAD)
FMO3
Human Genome Epidemiology (HuGE) Navigator
FMO3
genes like me logo Genes that share disorders with FMO3: view

No data available for Genatlas for FMO3 Gene

Publications for FMO3 Gene

  1. Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. (PMID: 9417913) Dolphin C.T. … Phillips I.R. (Genomics 1997) 2 3 4 23
  2. Role of hepatic flavin-containing monooxygenase 3 in drug and chemical metabolism in adult humans. (PMID: 7720103) Cashman J.R. … Cashman L.E. (Chem. Biol. Interact. 1995) 3 23 25 26
  3. Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin- containing monooxygenase family of man, FMO1, FMO3 and FM04. (PMID: 8654418) Dolphin C.T. … Phillips I.R. (Eur. J. Biochem. 1996) 3 4 23
  4. Compound heterozygosity for missense mutations in the flavin- containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome. (PMID: 11191884) Dolphin C.T. … Phillips I.R. (Pharmacogenetics 2000) 3 4 23
  5. Two novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in Japanese. (PMID: 15618753) Fujieda M. … Kamataki T. (Drug Metab. Pharmacokinet. 2003) 3 4 23

Products for FMO3 Gene

Sources for FMO3 Gene

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