Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRL2 Gene

Aliases for ADGRL2 Gene

  • Adhesion G Protein-Coupled Receptor L2 2 3
  • LPHN2 3 4 6
  • LPHH1 3 4 6
  • Calcium-Independent Alpha-Latrotoxin Receptor 2 3 4
  • Latrophilin Homolog 1 3 4
  • Latrophilin 2 2 3
  • Lectomedin-1 3 4
  • LEC1 3 4
  • Latrophilin 1 2
  • Latrophilin-2 3
  • KIAA0786 4
  • CIRL-2 4
  • CIRL2 3
  • CL2 3

External Ids for ADGRL2 Gene

Previous Symbols for ADGRL2 Gene

  • LPHH1
  • LPHN2

Summaries for ADGRL2 Gene

Entrez Gene Summary for ADGRL2 Gene

  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for ADGRL2 Gene

ADGRL2 (Adhesion G Protein-Coupled Receptor L2) is a Protein Coding gene. Among its related pathways are GPCRs, Other and GPCRs, Class B Secretin-like. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRL2 Gene

  • Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity).

Gene Wiki entry for ADGRL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRL2 Gene

Genomics for ADGRL2 Gene

Genomic Location for ADGRL2 Gene

Start:
81,306,160 bp from pter
End:
81,992,436 bp from pter
Size:
686,277 bases
Orientation:
Plus strand

Genomic View for ADGRL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRL2 Gene

No data available for Regulatory Elements for ADGRL2 Gene

Proteins for ADGRL2 Gene

  • Protein details for ADGRL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95490-LPHN2_HUMAN
    Recommended name:
    Latrophilin-2
    Protein Accession:
    O95490
    Secondary Accessions:
    • A5XEI2
    • B1ALT8
    • B1ALT9
    • B1ALU0
    • B1ALU2
    • B1ALU4
    • B1ALU5
    • B1ALU6
    • O94882
    • Q5VX76
    • Q9UKY5
    • Q9UKY6

    Protein attributes for ADGRL2 Gene

    Size:
    1459 amino acids
    Molecular mass:
    163349 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85).
    SequenceCaution:
    • Sequence=CAI22406.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRL2 Gene

neXtProt entry for ADGRL2 Gene

Proteomics data for ADGRL2 Gene at MOPED

Post-translational modifications for ADGRL2 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRL2 Gene

Domains for ADGRL2 Gene

Gene Families for ADGRL2 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

UniProtKB/Swiss-Prot:

LPHN2_HUMAN
Domain:
  • Contains 1 GPS domain.:
    • O95490
  • Contains 1 olfactomedin-like domain.:
    • O95490
  • Contains 1 SUEL-type lectin domain.:
    • O95490
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • O95490
genes like me logo Genes that share domains with ADGRL2: view

Function for ADGRL2 Gene

Molecular function for ADGRL2 Gene

UniProtKB/Swiss-Prot Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding --
GO:0016524 latrotoxin receptor activity NAS 10030676
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with ADGRL2: view

Phenotypes for ADGRL2 Gene

genes like me logo Genes that share phenotypes with ADGRL2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGRL2 Gene

Localization for ADGRL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRL2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10030676
genes like me logo Genes that share ontologies with ADGRL2: view

Pathways for ADGRL2 Gene

genes like me logo Genes that share pathways with ADGRL2: view

Pathways by source for ADGRL2 Gene

2 BioSystems pathways for ADGRL2 Gene

Interacting Proteins for ADGRL2 Gene

Gene Ontology (GO) - Biological Process for ADGRL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway NAS 10030676
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRL2: view

Compounds for ADGRL2 Gene

(3) Novoseek inferred chemical compound relationships for ADGRL2 Gene

Compound -log(P) Hits PubMed IDs
alpha-latrotoxin 81.6 1
abscisic acid 57.7 2
dexamethasone 14 1
genes like me logo Genes that share compounds with ADGRL2: view

Transcripts for ADGRL2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRL2 Gene

No ASD Table

Relevant External Links for ADGRL2 Gene

GeneLoc Exon Structure for
ADGRL2
ECgene alternative splicing isoforms for
ADGRL2

Expression for ADGRL2 Gene

mRNA expression in normal human tissues for ADGRL2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRL2 Gene

mRNA Expression by UniProt/SwissProt for ADGRL2 Gene

O95490-LPHN2_HUMAN
Tissue specificity: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.
genes like me logo Genes that share expressions with ADGRL2: view

Orthologs for ADGRL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LPHN2 36
  • 99.74 (n)
  • 99.71 (a)
LPHN2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LPHN2 36
  • 94.54 (n)
  • 98.29 (a)
LPHN2 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LPHN2 36
  • 93.8 (n)
  • 98.22 (a)
LPHN2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lphn2 36
  • 87.41 (n)
  • 95.79 (a)
Lphn2 16
Lphn2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LPHN2 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7431 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lphn2 36
  • 86.77 (n)
  • 94.65 (a)
chicken
(Gallus gallus)
Aves LPHN2 36
  • 85.97 (n)
  • 94.08 (a)
LPHN2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LPHN2 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16778 36
tropical clawed frog
(Silurana tropicalis)
Amphibia lphn2 36
  • 81.53 (n)
  • 90.34 (a)
Str.1058 36
zebrafish
(Danio rerio)
Actinopterygii CABZ01074906.1 37
  • 74 (a)
ManyToMany
CABZ01096573.1 37
  • 54 (a)
ManyToMany
CU467642.1 37
  • 71 (a)
ManyToMany
FP245444.1 37
  • 46 (a)
ManyToMany
lphn2a 36
  • 71.06 (n)
  • 76.09 (a)
lphn2a 37
  • 73 (a)
ManyToMany
wufb72a08 36
worm
(Caenorhabditis elegans)
Secernentea lat-1 36
  • 45.4 (n)
  • 33.06 (a)
lat-1 37
  • 28 (a)
OneToMany
Species with no ortholog for ADGRL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRL2 Gene

ENSEMBL:
Gene Tree for ADGRL2 (if available)
TreeFam:
Gene Tree for ADGRL2 (if available)

Paralogs for ADGRL2 Gene

genes like me logo Genes that share paralogs with ADGRL2: view

Variants for ADGRL2 Gene

Sequence variations from dbSNP and Humsavar for ADGRL2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1552 -- 81,818,096(-) tactc(A/C)tgggc intron-variant
rs284211 -- 81,893,014(-) AACTT(G/T)AAGAA intron-variant
rs284212 -- 81,892,876(-) AACAG(C/T)CCCTT intron-variant
rs284213 -- 81,892,256(-) ACAGT(A/G)AAAAG intron-variant
rs284214 -- 81,892,102(-) CAGTG(A/T)TGGTA intron-variant

Relevant External Links for ADGRL2 Gene

HapMap Linkage Disequilibrium report
ADGRL2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRL2 Gene

Disorders for ADGRL2 Gene

No disorders were found for ADGRL2 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRL2 Gene

Publications for ADGRL2 Gene

  1. Isolation and characterisation of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. (PMID: 10030676) White G.R.M. … Heighway J. (Oncogene 1998) 3 4 23
  2. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. (PMID: 10760572) White G.R.M. … Heighway J. (Biochim. Biophys. Acta 2000) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Discovery of tissue-specific exons using comprehensive human exon microarrays. (PMID: 17456239) Clark T.A. … Blume J.E. (Genome Biol. 2007) 3 4
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3

Products for ADGRL2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRL2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRL2
    • Block miRNA regulation of ADGRL2 using miScript Target Protectors

    Sources for ADGRL2 Gene

    Back to Top

    Content