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Aliases for EXOC7 Gene

Aliases for EXOC7 Gene

  • Exocyst Complex Component 7 2 3
  • Exocyst Complex Component Exo70 3 4
  • EXO70 3 4
  • KIAA1067 4
  • YJL085W 3
  • 2-5-3p 3
  • Exo70p 3
  • EX070 3
  • EXOC1 3

External Ids for EXOC7 Gene

Previous GeneCards Identifiers for EXOC7 Gene

  • GC17M074674
  • GC17M071588
  • GC17M074077
  • GC17M069506

Summaries for EXOC7 Gene

Entrez Gene Summary for EXOC7 Gene

  • The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for EXOC7 Gene

EXOC7 (Exocyst Complex Component 7) is a Protein Coding gene. Diseases associated with EXOC7 include bardet-biedl syndrome. Among its related pathways are Organelle biogenesis and maintenance and Actin Nucleation by ARP-WASP Complex.

UniProtKB/Swiss-Prot for EXOC7 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Wiki entry for EXOC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC7 Gene

Genomics for EXOC7 Gene

Regulatory Elements for EXOC7 Gene

Genomic Location for EXOC7 Gene

Chromosome:
17
Start:
76,080,993 bp from pter
End:
76,121,576 bp from pter
Size:
40,584 bases
Orientation:
Minus strand

Genomic View for EXOC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC7 Gene

Proteins for EXOC7 Gene

  • Protein details for EXOC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT5-EXOC7_HUMAN
    Recommended name:
    Exocyst complex component 7
    Protein Accession:
    Q9UPT5
    Secondary Accessions:
    • B5MC69
    • B8XXP2
    • Q8ND93
    • Q8WV91
    • Q96FF0
    • Q9H8C3
    • Q9H9X3
    • Q9HA32

    Protein attributes for EXOC7 Gene

    Size:
    735 amino acids
    Molecular mass:
    83382 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).
    SequenceCaution:
    • Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC7 Gene

neXtProt entry for EXOC7 Gene

Proteomics data for EXOC7 Gene at MOPED

Post-translational modifications for EXOC7 Gene

  • Ubiquitination at Lys 40 and Lys 65
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for EXOC7 Gene

Domains & Families for EXOC7 Gene

Gene Families for EXOC7 Gene

Protein Domains for EXOC7 Gene

Suggested Antigen Peptide Sequences for EXOC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPT5

UniProtKB/Swiss-Prot:

EXOC7_HUMAN :
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • Belongs to the EXO70 family.
Domain:
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • The C-terminus is required for translocation to the plasma membrane.
Family:
  • Belongs to the EXO70 family.
genes like me logo Genes that share domains with EXOC7: view

Function for EXOC7 Gene

Molecular function for EXOC7 Gene

UniProtKB/Swiss-Prot Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Ontology (GO) - Molecular Function for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15705715
genes like me logo Genes that share ontologies with EXOC7: view
genes like me logo Genes that share phenotypes with EXOC7: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for EXOC7 Gene

Localization for EXOC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC7 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC7 Gene COMPARTMENTS Subcellular localization image for EXOC7 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
plasma membrane 4
endosome 2
golgi apparatus 2
vacuole 1

Gene Ontology (GO) - Cellular Components for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005815 microtubule organizing center IDA 18000879
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EXOC7: view

Pathways & Interactions for EXOC7 Gene

genes like me logo Genes that share pathways with EXOC7: view

Pathways by source for EXOC7 Gene

SIGNOR curated interactions for EXOC7 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006996 organelle organization TAS --
GO:0015031 protein transport IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with EXOC7: view

Drugs & Compounds for EXOC7 Gene

(1) Drugs for EXOC7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with EXOC7: view

Transcripts for EXOC7 Gene

Unigene Clusters for EXOC7 Gene

Exocyst complex component 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12:
SP13: - -
SP14: -
SP15: - - - -

ExUns: 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:

Relevant External Links for EXOC7 Gene

GeneLoc Exon Structure for
EXOC7
ECgene alternative splicing isoforms for
EXOC7

Expression for EXOC7 Gene

mRNA expression in normal human tissues for EXOC7 Gene

Protein differential expression in normal tissues from HIPED for EXOC7 Gene

This gene is overexpressed in Bone (48.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC7 Gene



SOURCE GeneReport for Unigene cluster for EXOC7 Gene Hs.514496

genes like me logo Genes that share expression patterns with EXOC7: view

Protein tissue co-expression partners for EXOC7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC7 Gene

Orthologs for EXOC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EXOC7 35
  • 91.12 (n)
  • 96.32 (a)
EXOC7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC7 35
  • 90.35 (n)
  • 96.02 (a)
EXOC7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc7 35
  • 89.99 (n)
  • 96.48 (a)
Exoc7 16
Exoc7 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911734 35
  • 90.25 (n)
  • 96.63 (a)
oppossum
(Monodelphis domestica)
Mammalia EXOC7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC7 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EXOC7 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves EXOC7 35
  • 80.13 (n)
  • 88.02 (a)
EXOC7 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC7 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4315 35
zebrafish
(Danio rerio)
Actinopterygii exoc7 35
  • 76.12 (n)
  • 80.52 (a)
wufj67f11 35
exoc7 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9364 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006682 35
  • 50.16 (n)
  • 35.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta exo70 35
  • 48.17 (n)
  • 35.14 (a)
exo70 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exoc-7 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EXO70A1 35
  • 43.41 (n)
  • 31.42 (a)
rice
(Oryza sativa)
Liliopsida Os12g0159700 35
  • 45.62 (n)
  • 33.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for EXOC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC7 Gene

ENSEMBL:
Gene Tree for EXOC7 (if available)
TreeFam:
Gene Tree for EXOC7 (if available)

Paralogs for EXOC7 Gene

(1) SIMAP similar genes for EXOC7 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for EXOC7 Gene

genes like me logo Genes that share paralogs with EXOC7: view

No data available for Paralogs for EXOC7 Gene

Variants for EXOC7 Gene

Sequence variations from dbSNP and Humsavar for EXOC7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1868820 -- 76,092,270(+) GCACC(A/G)CACAA intron-variant
rs1979132 -- 76,103,159(+) GAAGT(A/G)CAGCC intron-variant
rs2084666 -- 76,088,931(+) GAGGG(A/G)GCAGG intron-variant
rs2243481 -- 76,087,824(+) GGATC(C/T)GCCCA intron-variant
rs2243486 -- 76,087,948(+) AGGTG(C/T)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC7 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294
nsv509674 CNV Insertion 20534489
nsv2142 CNV Insertion 18451855

Variation tolerance for EXOC7 Gene

Residual Variation Intolerance Score: 27.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EXOC7 Gene

HapMap Linkage Disequilibrium report
EXOC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC7 Gene

Disorders for EXOC7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for EXOC7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • biedl-bardet syndrome
- elite association
Search EXOC7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for EXOC7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EXOC7
genes like me logo Genes that share disorders with EXOC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for EXOC7 Gene

Publications for EXOC7 Gene

  1. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. (PMID: 16601687) Gerges N.Z. … Esteban J.A. (EMBO J. 2006) 23 67
  2. Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake. (PMID: 16477018) Shen X. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2006) 23 67
  3. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide- exchange protein, with exocyst protein Exo70. (PMID: 15705715) Xu K.F. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 23 67
  4. BIG1 and BIG2, brefeldin A-inhibited guanine nucleotide-exchange factors for ADP-ribosylation factors. (PMID: 16413268) Jones H.D. … Vaughan M. (Meth. Enzymol. 2005) 23 67
  5. Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p. (PMID: 15583030) Wiederkehr A. … Novick P. (J. Cell Biol. 2004) 23 67

Products for EXOC7 Gene

Sources for EXOC7 Gene

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