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Aliases for EXOC7 Gene

Aliases for EXOC7 Gene

  • Exocyst Complex Component 7 2 3
  • Exocyst Complex Component Exo70 3 4
  • KIAA1067 4 6
  • EX070 3 6
  • EXOC1 3 6
  • EXO70 3 4
  • YJL085W 3
  • 2-5-3p 3
  • Exo70p 3

External Ids for EXOC7 Gene

Previous GeneCards Identifiers for EXOC7 Gene

  • GC17M074674
  • GC17M071588
  • GC17M074077
  • GC17M069506

Summaries for EXOC7 Gene

Entrez Gene Summary for EXOC7 Gene

  • The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for EXOC7 Gene

EXOC7 (Exocyst Complex Component 7) is a Protein Coding gene. Diseases associated with EXOC7 include eastern equine encephalitis. Among its related pathways are Actin Nucleation by ARP-WASP Complex and CDC42 signaling events.

UniProtKB/Swiss-Prot for EXOC7 Gene

  • Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Wiki entry for EXOC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EXOC7 Gene

Genomics for EXOC7 Gene

Regulatory Elements for EXOC7 Gene

Genomic Location for EXOC7 Gene

Start:
76,080,993 bp from pter
End:
76,121,576 bp from pter
Size:
40,584 bases
Orientation:
Minus strand

Genomic View for EXOC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EXOC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EXOC7 Gene

Proteins for EXOC7 Gene

  • Protein details for EXOC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPT5-EXOC7_HUMAN
    Recommended name:
    Exocyst complex component 7
    Protein Accession:
    Q9UPT5
    Secondary Accessions:
    • B5MC69
    • B8XXP2
    • Q8ND93
    • Q8WV91
    • Q96FF0
    • Q9H8C3
    • Q9H9X3
    • Q9HA32

    Protein attributes for EXOC7 Gene

    Size:
    735 amino acids
    Molecular mass:
    83382 Da
    Quaternary structure:
    • The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with ARHQ in a GTP-dependent manner. Interacts with RAB11FIP3 (By similarity).
    SequenceCaution:
    • Sequence=BAA83019.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB14095.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for EXOC7 Gene

neXtProt entry for EXOC7 Gene

Proteomics data for EXOC7 Gene at MOPED

Post-translational modifications for EXOC7 Gene

  • Ubiquitination at Lys40 and Lys65
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for EXOC7 Gene

Domains for EXOC7 Gene

Protein Domains for EXOC7 Gene

Suggested Antigen Peptide Sequences for EXOC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPT5

UniProtKB/Swiss-Prot:

EXOC7_HUMAN :
  • Q9UPT5
Domain:
  • The N-terminus is involved in SEC8 and ARHQ binding.
  • The C-terminus is required for translocation to the plasma membrane.
Family:
  • Belongs to the EXO70 family.
genes like me logo Genes that share domains with EXOC7: view

No data available for Gene Families for EXOC7 Gene

Function for EXOC7 Gene

Molecular function for EXOC7 Gene

UniProtKB/Swiss-Prot Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).

Gene Ontology (GO) - Molecular Function for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15705715
genes like me logo Genes that share ontologies with EXOC7: view
genes like me logo Genes that share phenotypes with EXOC7: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EXOC7 Gene

Localization for EXOC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EXOC7 Gene

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EXOC7 Gene COMPARTMENTS Subcellular localization image for EXOC7 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 3
golgi apparatus 3
endosome 2
nucleus 2

Gene Ontology (GO) - Cellular Components for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 exocyst IEA --
GO:0005815 microtubule organizing center IDA 18000879
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EXOC7: view

Pathways for EXOC7 Gene

genes like me logo Genes that share pathways with EXOC7: view

Pathways by source for EXOC7 Gene

Gene Ontology (GO) - Biological Process for EXOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0006996 organelle organization TAS --
GO:0015031 protein transport IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with EXOC7: view

Compounds for EXOC7 Gene

(1) HMDB Compounds for EXOC7 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with EXOC7: view

Transcripts for EXOC7 Gene

Unigene Clusters for EXOC7 Gene

Exocyst complex component 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EXOC7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for EXOC7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EXOC7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4:
SP5:
SP6: - - -
SP7: - - - -
SP8: - - - - - - - - - - - - - - - - - - - - -
SP9:
SP10: - - - - -
SP11: - - - -
SP12:
SP13: - -
SP14: -
SP15: - - - -

ExUns: 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26
SP1: - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5: -
SP6:
SP7:
SP8: - - - - - - - - - - - - - - - -
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:

Relevant External Links for EXOC7 Gene

GeneLoc Exon Structure for
EXOC7
ECgene alternative splicing isoforms for
EXOC7

Expression for EXOC7 Gene

mRNA expression in normal human tissues for EXOC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EXOC7 Gene

SOURCE GeneReport for Unigene cluster for EXOC7 Gene Hs.514496

genes like me logo Genes that share expressions with EXOC7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EXOC7 Gene

Orthologs for EXOC7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EXOC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EXOC7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EXOC7 35
  • 91.12 (n)
  • 96.32 (a)
EXOC7 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EXOC7 35
  • 90.35 (n)
  • 96.02 (a)
EXOC7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Exoc7 35
  • 89.99 (n)
  • 96.48 (a)
Exoc7 16
Exoc7 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EXOC7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EXOC7 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911734 35
  • 90.25 (n)
  • 96.63 (a)
chicken
(Gallus gallus)
Aves EXOC7 35
  • 80.13 (n)
  • 88.02 (a)
EXOC7 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EXOC7 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4315 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9364 35
zebrafish
(Danio rerio)
Actinopterygii exoc7 35
  • 76.12 (n)
  • 80.52 (a)
exoc7 36
  • 80 (a)
OneToOne
wufj67f11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006682 35
  • 50.16 (n)
  • 35.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta exo70 35
  • 48.17 (n)
  • 35.14 (a)
exo70 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea exoc-7 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons EXO70A1 35
  • 43.41 (n)
  • 31.42 (a)
rice
(Oryza sativa)
Liliopsida Os12g0159700 35
  • 45.62 (n)
  • 33.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for EXOC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EXOC7 Gene

ENSEMBL:
Gene Tree for EXOC7 (if available)
TreeFam:
Gene Tree for EXOC7 (if available)

Paralogs for EXOC7 Gene

Selected SIMAP similar genes for EXOC7 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for EXOC7 Gene

genes like me logo Genes that share paralogs with EXOC7: view

No data available for Paralogs for EXOC7 Gene

Variants for EXOC7 Gene

Sequence variations from dbSNP and Humsavar for EXOC7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1868820 -- 76,092,270(+) GCACC(A/G)CACAA intron-variant
rs1979132 -- 76,103,159(+) GAAGT(A/G)CAGCC intron-variant
rs2084666 -- 76,088,931(+) GAGGG(A/G)GCAGG intron-variant
rs2243481 -- 76,087,824(+) GGATC(C/T)GCCCA intron-variant
rs2243486 -- 76,087,948(+) AGGTG(C/T)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EXOC7 Gene

Variant ID Type Subtype PubMed ID
nsv908824 CNV Loss 21882294
nsv833546 CNV Loss 17160897
dgv3270n71 CNV Loss 21882294
nsv509674 CNV Insertion 20534489
nsv2142 CNV Insertion 18451855

Relevant External Links for EXOC7 Gene

HapMap Linkage Disequilibrium report
EXOC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EXOC7 Gene

Disorders for EXOC7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for EXOC7 Gene including...

Search for EXOC7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for EXOC7 Gene

genes like me logo Genes that share disorders with EXOC7: view

No data available for UniProtKB/Swiss-Prot for EXOC7 Gene

Publications for EXOC7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis. (PMID: 16148947) Fielding A.B. … Gould G.W. (EMBO J. 2005) 3 4
  3. Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide- exchange protein, with exocyst protein Exo70. (PMID: 15705715) Xu K.F. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  5. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. (PMID: 12687004) Inoue M. … Saltiel A.R. (Nature 2003) 3 23

Products for EXOC7 Gene

  • Addgene plasmids for EXOC7

Sources for EXOC7 Gene

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