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Aliases for FMO1 Gene

Aliases for FMO1 Gene

  • Flavin Containing Monooxygenase 1 2 3
  • EC 1.14.13.8 4 63
  • Fetal Hepatic Flavin-Containing Monooxygenase 1 4
  • Dimethylaniline Oxidase 1 4
  • FMO 1 4

External Ids for FMO1 Gene

Previous GeneCards Identifiers for FMO1 Gene

  • GC01P168781
  • GC01P166846
  • GC01P167798
  • GC01P168457
  • GC01P167949
  • GC01P169484
  • GC01P142440

Summaries for FMO1 Gene

Entrez Gene Summary for FMO1 Gene

  • Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for FMO1 Gene

FMO1 (Flavin Containing Monooxygenase 1) is a Protein Coding gene. Diseases associated with FMO1 include trimethylaminuria. Among its related pathways are Metabolism and Busulfan Pathway, Pharmacodynamics. GO annotations related to this gene include flavin adenine dinucleotide binding and monooxygenase activity. An important paralog of this gene is FMO4.

UniProtKB/Swiss-Prot for FMO1 Gene

  • This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines

Gene Wiki entry for FMO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FMO1 Gene

Genomics for FMO1 Gene

Regulatory Elements for FMO1 Gene

Genomic Location for FMO1 Gene

Start:
171,248,471 bp from pter
End:
171,285,978 bp from pter
Size:
37,508 bases
Orientation:
Plus strand

Genomic View for FMO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FMO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FMO1 Gene

Proteins for FMO1 Gene

  • Protein details for FMO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01740-FMO1_HUMAN
    Recommended name:
    Dimethylaniline monooxygenase [N-oxide-forming] 1
    Protein Accession:
    Q01740
    Secondary Accessions:
    • A8K248
    • B7Z3P4
    • Q5QPT2
    • Q9UJC2

    Protein attributes for FMO1 Gene

    Size:
    532 amino acids
    Molecular mass:
    60311 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FMO1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FMO1 Gene

Proteomics data for FMO1 Gene at MOPED

Post-translational modifications for FMO1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FMO1 Gene

Domains for FMO1 Gene

Suggested Antigen Peptide Sequences for FMO1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q01740

UniProtKB/Swiss-Prot:

FMO1_HUMAN :
  • Q01740
Family:
  • Belongs to the FMO family.
genes like me logo Genes that share domains with FMO1: view

No data available for Gene Families for FMO1 Gene

Function for FMO1 Gene

Molecular function for FMO1 Gene

GENATLAS Biochemistry: flavin containing monooxygenase 1,microsomal,expressed in fetal liver
UniProtKB/Swiss-Prot CatalyticActivity: N,N-dimethylaniline + NADPH + O(2) = N,N-dimethylaniline N-oxide + NADP(+) + H(2)O
UniProtKB/Swiss-Prot Function: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines

Enzyme Numbers (IUBMB) for FMO1 Gene

Gene Ontology (GO) - Molecular Function for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004497 monooxygenase activity IDA 19262426
GO:0004499 N,N-dimethylaniline monooxygenase activity TAS --
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding IEA --
GO:0050661 NADP binding IEA --
genes like me logo Genes that share ontologies with FMO1: view

miRNA for FMO1 Gene

miRTarBase miRNAs that target FMO1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FMO1 Gene

Localization for FMO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FMO1 Gene

Microsome membrane. Endoplasmic reticulum membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FMO1 Gene COMPARTMENTS Subcellular localization image for FMO1 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
cytosol 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle --
genes like me logo Genes that share ontologies with FMO1: view

Pathways for FMO1 Gene

genes like me logo Genes that share pathways with FMO1: view

Interacting Proteins for FMO1 Gene

Gene Ontology (GO) - Biological Process for FMO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006082 organic acid metabolic process IDA 15144220
GO:0006805 xenobiotic metabolic process TAS --
GO:0006970 response to osmotic stress IEA --
GO:0009404 toxin metabolic process IDA 15144220
GO:0017144 drug metabolic process IEA --
genes like me logo Genes that share ontologies with FMO1: view

Compounds for FMO1 Gene

(7) HMDB Compounds for FMO1 Gene

Compound Synonyms Cas Number PubMed IDs
Dimethylaniline-N-oxide
  • Dimethylaniline N-oxide
874-52-2
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
N,N-Dimethylaniline
  • Dimethylaminobenzene
121-69-7
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8
NADPH
  • 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
53-57-6

(6) Drugbank Compounds for FMO1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cevimeline
  • Cevimeline hydrochloride
107233-08-9 enzyme substrate
Cimetidine
51481-61-9 enzyme substrate
Lorcaserin
  • APD-356
846589-98-8 enzyme substrate
Tamoxifen
  • ICI-46474
10540-29-1 enzyme substrate
Vandetanib
  • 4-quinazolinamine, N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methyl-4-piperidinyl)methoxy]-
443913-73-3 enzyme substrate

(18) Novoseek inferred chemical compound relationships for FMO1 Gene

Compound -log(P) Hits PubMed IDs
methyl p-tolyl sulfide 91.7 4
thiobenzamide 80.3 1
methimazole 80.2 4
n-octylamine 72.5 1
imipramine 66.6 3

(1) PharmGKB related drug/compound annotations for FMO1 Gene

Drug/compound Annotation
olanzapine CA
genes like me logo Genes that share compounds with FMO1: view

Transcripts for FMO1 Gene

Unigene Clusters for FMO1 Gene

Flavin containing monooxygenase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FMO1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b
SP1: - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - -

Relevant External Links for FMO1 Gene

GeneLoc Exon Structure for
FMO1
ECgene alternative splicing isoforms for
FMO1

Expression for FMO1 Gene

mRNA expression in normal human tissues for FMO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FMO1 Gene

This gene is overexpressed in Kidney - Cortex (14.5) and Minor Salivary Gland (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FMO1 Gene

SOURCE GeneReport for Unigene cluster for FMO1 Gene Hs.1424

mRNA Expression by UniProt/SwissProt for FMO1 Gene

Q01740-FMO1_HUMAN
Tissue specificity: Expressed mainly in fetal liver, adult kidney and, to a lesser extent, the intestine
genes like me logo Genes that share expressions with FMO1: view

Orthologs for FMO1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FMO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FMO1 35
  • 99.5 (n)
  • 99.25 (a)
FMO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FMO1 35
  • 88.1 (n)
  • 85.9 (a)
FMO1 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FMO1 35
  • 89.6 (n)
  • 88.53 (a)
FMO1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fmo1 35
  • 84.71 (n)
  • 83.27 (a)
Fmo1 16
Fmo1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Fmo1 35
  • 84.02 (n)
  • 82.14 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fmo2 35
  • 59.23 (n)
  • 50.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fmo-2 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea fmo-12 37
  • 41 (a)
fmo-15 37
  • 39 (a)
fmo-13 37
  • 38 (a)
Species with no ortholog for FMO1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FMO1 Gene

ENSEMBL:
Gene Tree for FMO1 (if available)
TreeFam:
Gene Tree for FMO1 (if available)

Paralogs for FMO1 Gene

Paralogs for FMO1 Gene

Selected SIMAP similar genes for FMO1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FMO1: view

Variants for FMO1 Gene

Sequence variations from dbSNP and Humsavar for FMO1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7877 -- 171,285,751(-) CAGAA(A/G)TCTTA utr-variant-3-prime, downstream-variant-500B
rs12954 -- 171,285,655(-) GGGTG(A/G)CCTTT utr-variant-3-prime, downstream-variant-500B
rs742349 -- 171,280,504(+) CTTAC(A/G)TAGAC intron-variant
rs742350 -- 171,280,905(-) ATTGG(A/G)GTTGG reference, synonymous-codon
rs1126692 -- 171,283,148(+) GGTGT(A/C/G)AATAA reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FMO1 Gene

Variant ID Type Subtype PubMed ID
esv28731 CNV Gain+Loss 19812545
nsv831882 CNV Loss 17160897

Relevant External Links for FMO1 Gene

HapMap Linkage Disequilibrium report
FMO1
Human Gene Mutation Database (HGMD)
FMO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FMO1 Gene

Disorders for FMO1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FMO1 Gene including...

Search for FMO1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for FMO1 Gene

Disease -log(P) Hits PubMed IDs
trimethylaminuria 75.8 1

Relevant External Links for FMO1

Genetic Association Database (GAD)
FMO1
Human Genome Epidemiology (HuGE) Navigator
FMO1
genes like me logo Genes that share disorders with FMO1: view

No data available for UniProtKB/Swiss-Prot for FMO1 Gene

Publications for FMO1 Gene

  1. Cloning, primary sequence, and chromosomal mapping of a human flavin- containing monooxygenase (FMO1). (PMID: 1712018) Dolphin C.T. … Phillips I.R. (J. Biol. Chem. 1991) 3 4 23
  2. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. (PMID: 12527699) Furnes B. … Schlenk D. (Drug Metab. Dispos. 2003) 3 4 23
  3. Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis. (PMID: 17127561) Cereda C. … Ceroni M. (Amyotroph Lateral Scler 2006) 3 23 48
  4. Deletion of the mouse Fmo1 gene results in enhanced pharmacological behavioural responses to imipramine. (PMID: 19262426) Hernandez D. … Shephard E.A. (Pharmacogenet. Genomics 2009) 3 23
  5. Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. (PMID: 12642475) Attar M. … Tang-Liu D.D. (Drug Metab. Dispos. 2003) 3 23

Products for FMO1 Gene

Sources for FMO1 Gene

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