Aliases for FMO1 Gene
External Ids for FMO1 Gene
Previous GeneCards Identifiers for FMO1 Gene
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
GeneCards Summary for FMO1 Gene
FMO1 (Flavin Containing Monooxygenase 1) is a Protein Coding gene. Diseases associated with FMO1 include Trimethylaminuria and Kabuki Syndrome 1. Among its related pathways are Tamoxifen Pathway, Pharmacokinetics and Drug metabolism - cytochrome P450. GO annotations related to this gene include oxidoreductase activity and monooxygenase activity. An important paralog of this gene is FMO2.
UniProtKB/Swiss-Prot for FMO1 Gene
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.