Aliases for PDS5A Gene
External Ids for PDS5A Gene
Previous GeneCards Identifiers for PDS5A Gene
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
GeneCards Summary for PDS5A Gene
PDS5A (PDS5 Cohesin Associated Factor A) is a Protein Coding gene. Diseases associated with PDS5A include cornelia de lange syndrome. Among its related pathways are Cell Cycle, Mitotic and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include binding. An important paralog of this gene is PDS5B.
UniProtKB/Swiss-Prot for PDS5A Gene
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.