Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SIK2 Gene

Aliases for SIK2 Gene

  • Salt-Inducible Kinase 2 2 3 4
  • Serine/Threonine-Protein Kinase SNF1-Like Kinase 2 3 4
  • SNF1-Like Kinase 2 2 3
  • Qin-Induced Kinase 3 4
  • EC 2.7.11.1 4 64
  • KIAA0781 4 6
  • SNF1LK2 3 4
  • SIK-2 3 4
  • QIK 3 4
  • Salt-Inducible Serine/Threonine Kinase 2 3
  • Serine/Threonine-Protein Kinase SIK2 3
  • Salt-Inducible Protein Kinase 2 3
  • LOH11CR1I 3
  • EC 2.7.11 64

External Ids for SIK2 Gene

Previous Symbols for SIK2 Gene

  • SNF1LK2

Summaries for SIK2 Gene

GeneCards Summary for SIK2 Gene

SIK2 (Salt-Inducible Kinase 2) is a Protein Coding gene. Among its related pathways are Glucose / Energy Metabolism and LKB1 signaling events. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MARK4.

UniProtKB/Swiss-Prot for SIK2 Gene

  • Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Gene Wiki entry for SIK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIK2 Gene

Genomics for SIK2 Gene

Genomic Location for SIK2 Gene

Start:
111,602,391 bp from pter
End:
111,730,853 bp from pter
Size:
128,463 bases
Orientation:
Plus strand

Genomic View for SIK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SIK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIK2 Gene

Regulatory Elements for SIK2 Gene

Proteins for SIK2 Gene

  • Protein details for SIK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0K1-SIK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase SIK2
    Protein Accession:
    Q9H0K1
    Secondary Accessions:
    • A8K5B8
    • B0YJ94
    • O94878
    • Q17RV0
    • Q6AZE2
    • Q76N03
    • Q8NCV7
    • Q96CZ8

    Protein attributes for SIK2 Gene

    Size:
    926 amino acids
    Molecular mass:
    103915 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with and phosphorylates TORC2/CRTC2.
    SequenceCaution:
    • Sequence=BAA34501.3; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SIK2 Gene

Proteomics data for SIK2 Gene at MOPED

Post-translational modifications for SIK2 Gene

  • Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.
  • Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys692

Other Protein References for SIK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for SIK2 Gene

Gene Families for SIK2 Gene

UniProtKB/Swiss-Prot:

SIK2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9H0K1
  • Contains 1 UBA domain.:
    • Q9H0K1
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.:
    • Q9H0K1
genes like me logo Genes that share domains with SIK2: view

Function for SIK2 Gene

Molecular function for SIK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-175.
UniProtKB/Swiss-Prot Function: Phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.

Enzyme Numbers (IUBMB) for SIK2 Gene

Gene Ontology (GO) - Molecular Function for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 20708153
genes like me logo Genes that share ontologies with SIK2: view
genes like me logo Genes that share phenotypes with SIK2: view

miRNA for SIK2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SIK2 Gene

Localization for SIK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIK2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SIK2 Gene COMPARTMENTS Subcellular localization image for SIK2 gene
Compartment Confidence
golgi apparatus 4
cytosol 3
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with SIK2: view

Pathways for SIK2 Gene

genes like me logo Genes that share pathways with SIK2: view

Pathways by source for SIK2 Gene

1 Cell Signaling Technology pathway for SIK2 Gene
1 BioSystems pathway for SIK2 Gene

Gene Ontology (GO) - Biological Process for SIK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14976552
GO:0008286 insulin receptor signaling pathway IEA --
GO:0032870 cellular response to hormone stimulus IBA --
GO:0035556 intracellular signal transduction IDA 14976552
GO:0046626 regulation of insulin receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with SIK2: view

Compounds for SIK2 Gene

(1) HMDB Compounds for SIK2 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4

(23) Novoseek inferred chemical compound relationships for SIK2 Gene

Compound -log(P) Hits PubMed IDs
pd 98,059 72.2 6
phosphatidylinositol 54.3 6
ly294002 48.8 5
sb 203580 42.9 1
tyrosine 34.4 3
genes like me logo Genes that share compounds with SIK2: view

Transcripts for SIK2 Gene

mRNA/cDNA for SIK2 Gene

Unigene Clusters for SIK2 Gene

Salt-inducible kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SIK2 Gene

No ASD Table

Relevant External Links for SIK2 Gene

GeneLoc Exon Structure for
SIK2
ECgene alternative splicing isoforms for
SIK2

Expression for SIK2 Gene

mRNA expression in normal human tissues for SIK2 Gene

mRNA differential expression in normal tissues according to GTEx for SIK2 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SIK2 Gene

SOURCE GeneReport for Unigene cluster for SIK2 Gene Hs.269128

genes like me logo Genes that share expressions with SIK2: view

Orthologs for SIK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SIK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIK2 36
  • 99.89 (n)
  • 99.77 (a)
SIK2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SIK2 36
  • 88.57 (n)
  • 89.6 (a)
SIK2 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SIK2 36
  • 89.18 (n)
  • 90.82 (a)
SIK2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sik2 36
  • 88.7 (n)
  • 90.9 (a)
Sik2 16
Sik2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SIK2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SIK2 37
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIK2 36
  • 74.31 (n)
  • 77.87 (a)
SIK2 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SIK2 37
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sik2 36
  • 70.52 (n)
  • 74.49 (a)
zebrafish
(Danio rerio)
Actinopterygii sik2a 37
  • 64 (a)
OneToMany
sik2b 36
  • 65.15 (n)
  • 69.17 (a)
sik2b 37
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta KP78b 37
  • 32 (a)
ManyToMany
Sik3 37
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea kin-29 37
  • 28 (a)
OneToMany
Species with no ortholog for SIK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIK2 Gene

ENSEMBL:
Gene Tree for SIK2 (if available)
TreeFam:
Gene Tree for SIK2 (if available)

Paralogs for SIK2 Gene

Paralogs for SIK2 Gene

Selected SIMAP similar genes for SIK2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SIK2 Gene

genes like me logo Genes that share paralogs with SIK2: view

Variants for SIK2 Gene

Sequence variations from dbSNP and Humsavar for SIK2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471210 -- 111,652,295(-) AGAAG(C/T)AATTC intron-variant
rs479667 -- 111,613,310(+) CCCTT(C/T)TTTCC intron-variant
rs484013 -- 111,625,055(+) aagga(A/G/T)gaaga intron-variant
rs487985 -- 111,647,184(+) gatgg(A/G)cattt intron-variant
rs489783 -- 111,649,798(+) GAAGG(A/G)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIK2 Gene

Variant ID Type Subtype PubMed ID
nsv510273 CNV Loss 20534489
esv2745076 CNV Deletion 23290073
nsv832269 CNV Loss 17160897

Relevant External Links for SIK2 Gene

HapMap Linkage Disequilibrium report
SIK2

Disorders for SIK2 Gene

(9) Novoseek inferred disease relationships for SIK2 Gene

Disease -log(P) Hits PubMed IDs
cancer 26.8 2
tumors 20.6 3
insulin resistance 13.5 2
breast cancer 11.7 1
necrosis 10.8 1

Relevant External Links for SIK2

Genetic Association Database (GAD)
SIK2
Human Genome Epidemiology (HuGE) Navigator
SIK2
genes like me logo Genes that share disorders with SIK2: view

No data available for UniProtKB/Swiss-Prot for SIK2 Gene

Publications for SIK2 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M. … Katoh M. (Int. J. Oncol. 2004) 2 3 23
  2. Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats. (PMID: 14532992) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 3 23
  3. Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt- inducible kinase-2. (PMID: 12624099) Horike N. … Okamoto M. (J. Biol. Chem. 2003) 3 23
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for SIK2 Gene

Sources for SIK2 Gene

Back to Top

Content