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Aliases for SULF1 Gene

Aliases for SULF1 Gene

  • Sulfatase 1 2 3 5
  • Sulfatase FP 3
  • EC 3.1.6.14 63
  • EC 3.1.6.- 4
  • KIAA1077 4
  • EC 3.1.6 63
  • HSulf-1 4
  • SULF-1 3

External Ids for SULF1 Gene

Previous GeneCards Identifiers for SULF1 Gene

  • GC08P070345
  • GC08P070102
  • GC08P070428
  • GC08P070541
  • GC08P065873
  • GC08P070378

Summaries for SULF1 Gene

Entrez Gene Summary for SULF1 Gene

  • This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SULF1 Gene

SULF1 (Sulfatase 1) is a Protein Coding gene. Diseases associated with SULF1 include mesomelia-synostoses syndrome and mesomelia. GO annotations related to this gene include calcium ion binding and arylsulfatase activity. An important paralog of this gene is SULF2.

UniProtKB/Swiss-Prot for SULF1 Gene

  • Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Gene Wiki entry for SULF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULF1 Gene

Genomics for SULF1 Gene

Regulatory Elements for SULF1 Gene

Enhancers for SULF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SULF1 on UCSC Golden Path with GeneCards custom track

Promoters for SULF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SULF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SULF1 Gene

Chromosome:
8
Start:
69,466,624 bp from pter
End:
69,660,915 bp from pter
Size:
194,292 bases
Orientation:
Plus strand

Genomic View for SULF1 Gene

Genes around SULF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SULF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SULF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULF1 Gene

Proteins for SULF1 Gene

  • Protein details for SULF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU6-SULF1_HUMAN
    Recommended name:
    Extracellular sulfatase Sulf-1
    Protein Accession:
    Q8IWU6
    Secondary Accessions:
    • Q86YV8
    • Q8NCA2
    • Q9UPS5

    Protein attributes for SULF1 Gene

    Size:
    871 amino acids
    Molecular mass:
    101027 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for SULF1 Gene

Proteomics data for SULF1 Gene at MOPED

Post-translational modifications for SULF1 Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn 64, Asn 111, Asn 131, Asn 148, Asn 170, Asn 197, Asn 240, Asn 623, Asn 773, and Asn 783
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for SULF1 Gene

Gene Families for SULF1 Gene

Suggested Antigen Peptide Sequences for SULF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWU6

UniProtKB/Swiss-Prot:

SULF1_HUMAN :
  • Belongs to the sulfatase family.
Family:
  • Belongs to the sulfatase family.
genes like me logo Genes that share domains with SULF1: view

Function for SULF1 Gene

Molecular function for SULF1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function:
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Enzyme Numbers (IUBMB) for SULF1 Gene

genes like me logo Genes that share phenotypes with SULF1: view

Animal Models for SULF1 Gene

MGI Knock Outs for SULF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SULF1

miRNA for SULF1 Gene

miRTarBase miRNAs that target SULF1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SULF1 Gene

Localization for SULF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULF1 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULF1 Gene COMPARTMENTS Subcellular localization image for SULF1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
plasma membrane 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 18687675
GO:0009986 cell surface IEA,IDA 12368295
genes like me logo Genes that share ontologies with SULF1: view

Pathways & Interactions for SULF1 Gene

SuperPathways for SULF1 Gene

No Data Available

Interacting Proteins for SULF1 Gene

Gene Ontology (GO) - Biological Process for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 16778174
GO:0003094 glomerular filtration IEA,ISS --
GO:0006915 apoptotic process IEA --
GO:0030177 positive regulation of Wnt signaling pathway IDA 19520866
genes like me logo Genes that share ontologies with SULF1: view

No data available for Pathways by source and SIGNOR curated interactions for SULF1 Gene

Drugs & Compounds for SULF1 Gene

(3) Drugs for SULF1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(1) Additional Compounds for SULF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SULF1: view

Transcripts for SULF1 Gene

Unigene Clusters for SULF1 Gene

Sulfatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - -
SP9:
SP10:
SP11: - -
SP12: - - - - -
SP13: - - - -
SP14: - -
SP15:
SP16:
SP17: -

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:

Relevant External Links for SULF1 Gene

GeneLoc Exon Structure for
SULF1
ECgene alternative splicing isoforms for
SULF1

Expression for SULF1 Gene

mRNA expression in normal human tissues for SULF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULF1 Gene

This gene is overexpressed in Artery - Aorta (x8.9), Artery - Coronary (x5.9), and Artery - Tibial (x5.7).

Protein differential expression in normal tissues from HIPED for SULF1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SULF1 Gene



SOURCE GeneReport for Unigene cluster for SULF1 Gene Hs.409602

mRNA Expression by UniProt/SwissProt for SULF1 Gene

Q8IWU6-SULF1_HUMAN
Tissue specificity: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines.
genes like me logo Genes that share expression patterns with SULF1: view

Protein tissue co-expression partners for SULF1 Gene

Primer Products

In Situ Assay Products

Orthologs for SULF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SULF1 35
  • 88.55 (n)
  • 91.93 (a)
SULF1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULF1 35
  • 91.35 (n)
  • 95.04 (a)
SULF1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sulf1 35
  • 86.38 (n)
  • 92.87 (a)
Sulf1 16
Sulf1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SULF1 35
  • 99.54 (n)
  • 99.19 (a)
SULF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sulf1 35
  • 86.96 (n)
  • 93.21 (a)
oppossum
(Monodelphis domestica)
Mammalia SULF1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULF1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SULF1 35
  • 79.67 (n)
  • 85.66 (a)
SULF1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SULF1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10720 35
sulf1 35
  • 74.68 (n)
  • 78.71 (a)
zebrafish
(Danio rerio)
Actinopterygii sulf1 35
  • 68.88 (n)
  • 73.9 (a)
sulf1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sulf1 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sul-1 35
  • 55.14 (n)
  • 52.71 (a)
sul-1 36
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5614 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for SULF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULF1 Gene

ENSEMBL:
Gene Tree for SULF1 (if available)
TreeFam:
Gene Tree for SULF1 (if available)

Paralogs for SULF1 Gene

Paralogs for SULF1 Gene

genes like me logo Genes that share paralogs with SULF1: view

Variants for SULF1 Gene

Sequence variations from dbSNP and Humsavar for SULF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2028442 -- 69,498,315(+) AATTT(A/G)TTATT intron-variant
rs2028443 -- 69,498,379(+) TAAAC(C/T)CTAAA intron-variant
rs2028444 -- 69,614,787(-) TCTTT(C/T)AGCCT intron-variant
rs2067937 -- 69,581,247(+) TATCA(A/G)TTACG intron-variant
rs2099800 -- 69,469,326(-) GGATA(C/T)CCCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULF1 Gene

Variant ID Type Subtype PubMed ID
esv268742 CNV Insertion 20981092
dgv892n27 CNV Gain 19166990
nsv890990 CNV Gain 21882294
nsv890991 CNV Loss 21882294
nsv890992 CNV Loss 21882294
dgv92n68 CNV Loss 17160897
esv2737141 CNV Deletion 23290073
esv2282827 CNV Deletion 18987734
esv2737142 CNV Deletion 23290073

Variation tolerance for SULF1 Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SULF1 Gene

HapMap Linkage Disequilibrium report
SULF1
Human Gene Mutation Database (HGMD)
SULF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SULF1 Gene

Disorders for SULF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SULF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mesomelia-synostoses syndrome
  • dominant mesomelic shortness of stature with acral synostoses, umbilical anomalies, and soft palate agenesis
mesomelia
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search SULF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SULF1

Genetic Association Database (GAD)
SULF1
Human Genome Epidemiology (HuGE) Navigator
SULF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SULF1
genes like me logo Genes that share disorders with SULF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SULF1 Gene

Publications for SULF1 Gene

  1. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PMID: 12368295) Morimoto-Tomita M. … Rosen S.D. (J. Biol. Chem. 2002) 2 3 4 67
  2. Gene expression analysis identifies over-expression of CXCL1, SPARC, SPP1, and SULF1 in gastric cancer. (PMID: 19780053) Junnila S. … Monni O. (Genes Chromosomes Cancer 2010) 3 23
  3. Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88. (PMID: 19822709) Hossain M.M. … Uchimura K. (Glycobiology 2010) 3 23
  4. Common genetic variants and risk for HPV persistence and progression to cervical cancer. (PMID: 20084279) Wang S.S. … Hildesheim A. (PLoS ONE 2010) 3 23
  5. Promoter hypermethylation correlates with the Hsulf-1 silencing in human breast and gastric cancer. (PMID: 19006069) Chen Z. … Zhou H.M. (Int. J. Cancer 2009) 3 23

Products for SULF1 Gene

Sources for SULF1 Gene

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