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Aliases for SULF1 Gene

Aliases for SULF1 Gene

  • Sulfatase 1 2 3
  • KIAA1077 4 6
  • HSULF-1 3 4
  • Extracellular Sulfatase Sulf-1 3
  • Sulfatase FP 3
  • EC 3.1.6.14 64
  • EC 3.1.6.- 4
  • EC 3.1.6 64
  • SULF-1 3

External Ids for SULF1 Gene

Summaries for SULF1 Gene

Entrez Gene Summary for SULF1 Gene

  • This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SULF1 Gene

SULF1 (Sulfatase 1) is a Protein Coding gene. Diseases associated with SULF1 include mesomelia and mesomelia-synostoses syndrome. GO annotations related to this gene include calcium ion binding and N-acetylglucosamine-6-sulfatase activity. An important paralog of this gene is SULF2.

UniProtKB/Swiss-Prot for SULF1 Gene

  • Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation

Gene Wiki entry for SULF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SULF1 Gene

Genomics for SULF1 Gene

Genomic Location for SULF1 Gene

Start:
69,466,624 bp from pter
End:
69,660,915 bp from pter
Size:
194,292 bases
Orientation:
Plus strand

Genomic View for SULF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SULF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SULF1 Gene

Regulatory Elements for SULF1 Gene

Proteins for SULF1 Gene

  • Protein details for SULF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU6-SULF1_HUMAN
    Recommended name:
    Extracellular sulfatase Sulf-1
    Protein Accession:
    Q8IWU6
    Secondary Accessions:
    • Q86YV8
    • Q8NCA2
    • Q9UPS5

    Protein attributes for SULF1 Gene

    Size:
    871 amino acids
    Molecular mass:
    101027 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for SULF1 Gene

Proteomics data for SULF1 Gene at MOPED

Post-translational modifications for SULF1 Gene

  • The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
  • Glycosylation at Asn64, Asn111, Asn131, Asn148, Asn170, Asn197, Asn240, Asn623, Asn773, and Asn783

Domains for SULF1 Gene

UniProtKB/Swiss-Prot:

SULF1_HUMAN
Family:
  • Belongs to the sulfatase family.:
    • Q8IWU6
genes like me logo Genes that share domains with SULF1: view

No data available for Gene Families for SULF1 Gene

Function for SULF1 Gene

Molecular function for SULF1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 7.0-8.0.;
UniProtKB/Swiss-Prot Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation

Enzyme Numbers (IUBMB) for SULF1 Gene

Gene Ontology (GO) - Molecular Function for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004065 arylsulfatase activity IMP 19520866
GO:0005509 calcium ion binding IEA --
GO:0008449 N-acetylglucosamine-6-sulfatase activity IMP 19520866
GO:0008484 sulfuric ester hydrolase activity --
genes like me logo Genes that share ontologies with SULF1: view
genes like me logo Genes that share phenotypes with SULF1: view

Animal Models for SULF1 Gene

MGI Knock Outs for SULF1:

miRNA for SULF1 Gene

miRTarBase miRNAs that target SULF1

No data available for Transcription Factor Targeting and HOMER Transcription for SULF1 Gene

Localization for SULF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SULF1 Gene

Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface. Note=Also localized on the cell surface. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SULF1 Gene COMPARTMENTS Subcellular localization image for SULF1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 4
plasma membrane 4
lysosome 1

Gene Ontology (GO) - Cellular Components for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space NAS 12368295
GO:0005783 endoplasmic reticulum IDA 18687675
GO:0005794 Golgi apparatus ISS --
GO:0005795 Golgi stack IEA --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with SULF1: view

Pathways for SULF1 Gene

SuperPathways for SULF1 Gene

No Data Available

Interacting Proteins for SULF1 Gene

Gene Ontology (GO) - Biological Process for SULF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development ISS --
GO:0001937 negative regulation of endothelial cell proliferation IDA 16778174
GO:0002063 chondrocyte development ISS --
GO:0003094 glomerular filtration ISS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with SULF1: view

No data available for Pathways by source for SULF1 Gene

Compounds for SULF1 Gene

(1) HMDB Compounds for SULF1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Novoseek inferred chemical compound relationships for SULF1 Gene

Compound -log(P) Hits PubMed IDs
heparan sulfate 63 3
cisplatin 13.1 3
tyrosine 8.76 2
genes like me logo Genes that share compounds with SULF1: view

Transcripts for SULF1 Gene

Unigene Clusters for SULF1 Gene

Sulfatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SULF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3:
SP4:
SP5: - - - - -
SP6: - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - -
SP9:
SP10:
SP11: - -
SP12: - - - - -
SP13: - - - -
SP14: - -
SP15:
SP16:
SP17: -

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:

Relevant External Links for SULF1 Gene

GeneLoc Exon Structure for
SULF1
ECgene alternative splicing isoforms for
SULF1

Expression for SULF1 Gene

mRNA expression in normal human tissues for SULF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SULF1 Gene

This gene is overexpressed in Artery - Aorta (8.9), Artery - Coronary (5.9), and Artery - Tibial (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SULF1 Gene

SOURCE GeneReport for Unigene cluster for SULF1 Gene Hs.409602

mRNA Expression by UniProt/SwissProt for SULF1 Gene

Q8IWU6-SULF1_HUMAN
Tissue specificity: Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal and hepatocellular carcinoma cell lines
genes like me logo Genes that share expressions with SULF1: view

Orthologs for SULF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SULF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SULF1 36
  • 99.54 (n)
  • 99.19 (a)
SULF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SULF1 36
  • 88.55 (n)
  • 91.93 (a)
SULF1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SULF1 36
  • 91.35 (n)
  • 95.04 (a)
SULF1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sulf1 36
  • 86.38 (n)
  • 92.87 (a)
Sulf1 16
Sulf1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SULF1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SULF1 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sulf1 36
  • 86.96 (n)
  • 93.21 (a)
chicken
(Gallus gallus)
Aves SULF1 36
  • 79.67 (n)
  • 85.66 (a)
SULF1 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SULF1 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10720 36
sulf1 36
  • 74.68 (n)
  • 78.71 (a)
zebrafish
(Danio rerio)
Actinopterygii sulf1 36
  • 68.88 (n)
  • 73.9 (a)
sulf1 37
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sulf1 37
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sul-1 36
  • 55.14 (n)
  • 52.71 (a)
sul-1 37
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5614 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToMany
Species with no ortholog for SULF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SULF1 Gene

ENSEMBL:
Gene Tree for SULF1 (if available)
TreeFam:
Gene Tree for SULF1 (if available)

Paralogs for SULF1 Gene

Paralogs for SULF1 Gene

Selected SIMAP similar genes for SULF1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SULF1: view

Variants for SULF1 Gene

Sequence variations from dbSNP and Humsavar for SULF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs723290 -- 69,573,167(+) CTGTA(C/T)TCTTA intron-variant
rs752037 -- 69,601,586(-) TGTTG(C/T)CACGA intron-variant
rs752038 -- 69,601,485(-) GGGAA(A/G)GGTCC intron-variant
rs752039 -- 69,601,242(-) CACGT(C/T)TTGTT intron-variant
rs752040 -- 69,601,620(-) ATCAA(C/T)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SULF1 Gene

Variant ID Type Subtype PubMed ID
esv268742 CNV Insertion 20981092
dgv892n27 CNV Gain 19166990
nsv890990 CNV Gain 21882294
nsv890991 CNV Loss 21882294
nsv890992 CNV Loss 21882294
dgv92n68 CNV Loss 17160897
esv2737141 CNV Deletion 23290073
esv2282827 CNV Deletion 18987734
esv2737142 CNV Deletion 23290073

Relevant External Links for SULF1 Gene

HapMap Linkage Disequilibrium report
SULF1
Human Gene Mutation Database (HGMD)
SULF1

Disorders for SULF1 Gene

(7) Novoseek inferred disease relationships for SULF1 Gene

Disease -log(P) Hits PubMed IDs
hepatocellular carcinoma 38.5 1
pancreatic cancer 37.3 7
cancer 31.7 11
ovarian cancer 18 2
tumors 16.6 11

Relevant External Links for SULF1

Genetic Association Database (GAD)
SULF1
Human Genome Epidemiology (HuGE) Navigator
SULF1
genes like me logo Genes that share disorders with SULF1: view

No data available for UniProtKB/Swiss-Prot for SULF1 Gene

Publications for SULF1 Gene

  1. Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. (PMID: 12686563) Lai J. … Shridhar V. (J. Biol. Chem. 2003) 3 4 23
  2. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. (PMID: 12368295) Morimoto-Tomita M. … Rosen S.D. (J. Biol. Chem. 2002) 2 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. (PMID: 14699503) Lai J.P. … Roberts L.R. (Gastroenterology 2004) 3 23
  5. HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. (PMID: 14973553) Lai J.P. … Shridhar V. (Oncogene 2004) 3 23

Products for SULF1 Gene

  • Addgene plasmids for SULF1

Sources for SULF1 Gene

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