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Aliases for FLT1 Gene

Aliases for FLT1 Gene

  • Fms-Related Tyrosine Kinase 1 2 3
  • Vascular Permeability Factor Receptor 2 3 4
  • Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor) 2 3
  • Tyrosine-Protein Kinase Receptor FLT 3 4
  • Tyrosine-Protein Kinase FRT 3 4
  • Fms-Like Tyrosine Kinase 1 3 4
  • EC 2.7.10.1 4 63
  • VEGFR-1 3 4
  • VEGFR1 3 4
  • FLT-1 3 4
  • FLT 3 4
  • Vascular Endothelial Growth Factor Receptor 1 2
  • EC 2.7.10 63
  • FRT 4

External Ids for FLT1 Gene

Previous HGNC Symbols for FLT1 Gene

  • FLT

Previous GeneCards Identifiers for FLT1 Gene

  • GC13M026854
  • GC13M022854
  • GC13M027805
  • GC13M026673
  • GC13M027773
  • GC13M028874
  • GC13M009695

Summaries for FLT1 Gene

Entrez Gene Summary for FLT1 Gene

  • This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

GeneCards Summary for FLT1 Gene

FLT1 (Fms-Related Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with FLT1 include lipodermatosclerosis and anal canal squamous cell carcinoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot for FLT1 Gene

  • Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at Ser-473. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at Tyr-418 by unknown means and promotes tumor cell invasion.

Tocris Summary for FLT1 Gene

  • Vascular endothelial growth factor is a signaling protein involved in the regulation of angiogenesis and vasculogenesis. VEGF binds to and activates a receptor tyrosine kinase, VEGFR, through transphosphorylation. Three VEGFR isoforms have been identified in humans.

Gene Wiki entry for FLT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLT1 Gene

Genomics for FLT1 Gene

Regulatory Elements for FLT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FLT1 Gene

Chromosome:
13
Start:
28,300,344 bp from pter
End:
28,495,128 bp from pter
Size:
194,785 bases
Orientation:
Minus strand

Genomic View for FLT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FLT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FLT1 Gene

Proteins for FLT1 Gene

  • Protein details for FLT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17948-VGFR1_HUMAN
    Recommended name:
    Vascular endothelial growth factor receptor 1
    Protein Accession:
    P17948
    Secondary Accessions:
    • A3E342
    • A3E344
    • A8KA71
    • B0LPF1
    • B2BF46
    • B2BF47
    • B2BF48
    • B3FR89
    • B5A923
    • F5H5L6
    • O60722
    • P16057
    • Q12954

    Protein attributes for FLT1 Gene

    Size:
    1338 amino acids
    Molecular mass:
    150769 Da
    Quaternary structure:
    • Interacts with VEGFA, VEGFB and PGF. Monomer in the absence of bound VEGFA, VEGFB or PGF. Homodimer in the presence of bound VEGFA, VEGFB and PGF. Can also form a heterodimer with KDR. Interacts (when tyrosine phosphorylated) with CBL, CRK, GRB2, NCK1, PIK3R1, PLCG, PSEN1 and PTPN11. Probably interacts also with PTPRB. Interacts with GNB2L1/RACK1. Identified in a complex with CBL and CD2AP.

    Three dimensional structures from OCA and Proteopedia for FLT1 Gene

    Alternative splice isoforms for FLT1 Gene

neXtProt entry for FLT1 Gene

Proteomics data for FLT1 Gene at MOPED

Post-translational modifications for FLT1 Gene

  • Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.
  • N-glycosylated.
  • Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.
  • Glycosylation at Asn 100, Asn 164, Asn 196, Asn 251, Asn 323, Asn 402, Asn 417, Asn 474, Asn 547, Asn 597, Asn 620, Asn 625, and Asn 666
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FLT1 (VEGFR1)

Protein Products

Domains & Families for FLT1 Gene

Graphical View of Domain Structure for InterPro Entry

P17948

UniProtKB/Swiss-Prot:

VGFR1_HUMAN :
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Domain:
  • The second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFA binding.
  • Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
genes like me logo Genes that share domains with FLT1: view

Function for FLT1 Gene

Molecular function for FLT1 Gene

GENATLAS Biochemistry:
fms-related receptor tyrosine kinase 1,expressed on the surface on endothelial cells
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Binding of VEGFA, VEGFB or PGF leads to dimerization and activation by autophosphorylation on tyrosine residues
UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at Ser-473. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain; it increases phosphorylation of SRC at Tyr-418 by unknown means and promotes tumor cell invasion.
UniProtKB/Swiss-Prot Induction:
Up-regulated in coculture of VSMC/endothelial cell (EC) or by direct exposure to VEGF of VSMC monoculture. Up-regulated from the second trimester of pregnancy to the term and in the placenta of women with preeclampsia (PE). Up-regulated in monocytes exposed to bacterial lipopolysaccharide (LPS).

Enzyme Numbers (IUBMB) for FLT1 Gene

Gene Ontology (GO) - Molecular Function for FLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 8248162
GO:0005021 vascular endothelial growth factor-activated receptor activity IMP 11312102
GO:0005515 protein binding IPI 1312256
genes like me logo Genes that share ontologies with FLT1: view
genes like me logo Genes that share phenotypes with FLT1: view

Animal Models for FLT1 Gene

MGI Knock Outs for FLT1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLT1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for FLT1 Gene

Localization for FLT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FLT1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.
Isoform 7: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FLT1 Gene COMPARTMENTS Subcellular localization image for FLT1 gene
Compartment Confidence
endosome 5
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 8248162
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 11513746
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with FLT1: view

Pathways & Interactions for FLT1 Gene

genes like me logo Genes that share pathways with FLT1: view

PCR Array Products

SIGNOR curated interactions for FLT1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FLT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0002548 monocyte chemotaxis IDA 8605350
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 2158038
GO:0008284 positive regulation of cell proliferation TAS 10748050
genes like me logo Genes that share ontologies with FLT1: view

Drugs & Compounds for FLT1 Gene

(87) Drugs for FLT1 Gene - From: NovoSeek, HMDB, DGIdb, IUPHAR, ApexBio, Tocris, DrugBank, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sunitinib Approved, Investigational Pharma inhibitor, Target, antagonist VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors, Potent VEGFR, PDGFRbeta and KIT inhibitor 472
Pazopanib Approved Pharma inhibitor, Target VEFGR, c-Kit, and PDGFR inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
regorafenib Approved Pharma inhibitor, Target Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Axitinib Approved, Investigational Pharma Inhibition, inhibitor, Target Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 92
lenvatinib Approved Pharma inhibitor, Target Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0

(27) Additional Compounds for FLT1 Gene - From: NovoSeek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
XL 184
849217-68-1
ZM 306416 hydrochloride
196603-47-1
ZM 323881 hydrochloride
193000-39-4
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
genes like me logo Genes that share compounds with FLT1: view

Drug Products

Transcripts for FLT1 Gene

Unigene Clusters for FLT1 Gene

Fms-related tyrosine kinase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FLT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FLT1 Gene

No ASD Table

Relevant External Links for FLT1 Gene

GeneLoc Exon Structure for
FLT1
ECgene alternative splicing isoforms for
FLT1

Expression for FLT1 Gene

mRNA expression in normal human tissues for FLT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FLT1 Gene

This gene is overexpressed in Heart (19.3), Placenta (18.5), Pancreatic juice (11.0), and Plasma (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FLT1 Gene



SOURCE GeneReport for Unigene cluster for FLT1 Gene Hs.594454

mRNA Expression by UniProt/SwissProt for FLT1 Gene

P17948-VGFR1_HUMAN
Tissue specificity: Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).
genes like me logo Genes that share expression patterns with FLT1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for FLT1 Gene

Orthologs for FLT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FLT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FLT1 35
  • 85.19 (n)
  • 84.34 (a)
FLT1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FLT1 35
  • 90.3 (n)
  • 89.98 (a)
FLT1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Flt1 35
  • 81.89 (n)
  • 82.12 (a)
Flt1 16
Flt1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FLT1 35
  • 99.43 (n)
  • 99.33 (a)
FLT1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FLT1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FLT1 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FLT1 35
  • 73.02 (n)
  • 70.66 (a)
FLT1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FLT1 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
flt1 35
  • 58.31 (n)
  • 54.07 (a)
flt1 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3277 37
  • 34 (a)
tor 37
  • 46 (a)
Cad96Ca 36
  • 29 (a)
ManyToMany
Pvr 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea kin-16 37
  • 32 (a)
R09D1.12 37
  • 30 (a)
ver-2 37
  • 27 (a)
ver-3 37
  • 22 (a)
Y50D4B.6 37
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3210 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for FLT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FLT1 Gene

ENSEMBL:
Gene Tree for FLT1 (if available)
TreeFam:
Gene Tree for FLT1 (if available)

Paralogs for FLT1 Gene

Paralogs for FLT1 Gene

Pseudogenes.org Pseudogenes for FLT1 Gene

genes like me logo Genes that share paralogs with FLT1: view

Variants for FLT1 Gene

Sequence variations from dbSNP and Humsavar for FLT1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_042045 -
VAR_042046 -
VAR_042047 -
VAR_042048 A lung adenocarcinoma sample
VAR_042049 A glioma low grade oligodendroglioma sample

Structural Variations from Database of Genomic Variants (DGV) for FLT1 Gene

Variant ID Type Subtype PubMed ID
esv34052 CNV Loss 18971310
nsv455850 CNV Loss 19166990

Variation tolerance for FLT1 Gene

Residual Variation Intolerance Score: 3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FLT1 Gene

HapMap Linkage Disequilibrium report
FLT1
Human Gene Mutation Database (HGMD)
FLT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLT1 Gene

Disorders for FLT1 Gene

MalaCards: The human disease database

(43) MalaCards diseases for FLT1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
lipodermatosclerosis
  • acute lipodermatosclerosis
anal canal squamous cell carcinoma
  • squamous cell carcinoma of anal canal
angiokeratoma circumscriptum
cerebral angioma
  • hemangioma of cerebrum
brain angioma
  • brain hemangioma
- elite association
Search FLT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

VGFR1_HUMAN
  • Note=Abnormally high expression of soluble isoforms (isoform 2, isoform 3 or isoform 4) may be a cause of preeclampsia.
  • Note=Can contribute to cancer cell survival, proliferation, migration, and invasion, and tumor angiogenesis and metastasis. May contribute to cancer pathogenesis by promoting inflammatory responses and recruitment of tumor-infiltrating macrophages.

Relevant External Links for FLT1

Genetic Association Database (GAD)
FLT1
Human Genome Epidemiology (HuGE) Navigator
FLT1
Tumor Gene Database (TGDB):
FLT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FLT1
genes like me logo Genes that share disorders with FLT1: view

No data available for Genatlas for FLT1 Gene

Publications for FLT1 Gene

  1. Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. (PMID: 17367763) Roskoski R. (Biochem. Biophys. Res. Commun. 2007) 23 25 26 67
  2. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. (PMID: 2158038) Shibuya M. … Sato M. (Oncogene 1990) 2 23 67
  3. Quantitative expression of VEGF, VEGF-R1, VEGF-R2, and VEGF-R3 in melanoma tissue microarrays. (PMID: 20004943) Mehnert J.M. … Kluger H.M. (Hum. Pathol. 2010) 23 67
  4. Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray. (PMID: 20052735) Kim H.S. … Ahn M.J. (Cancer 2010) 23 67
  5. Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management. (PMID: 20104492) Emamaullee J.A. … Shapiro A.M. (Liver Transpl. 2010) 23 67

Products for FLT1 Gene

  • Addgene plasmids for FLT1

Sources for FLT1 Gene

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