Aliases for SYT11 Gene
External Ids for SYT11 Gene
Previous GeneCards Identifiers for SYT11 Gene
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]
GeneCards Summary for SYT11 Gene
SYT11 (Synaptotagmin XI) is a Protein Coding gene. Diseases associated with SYT11 include schizophrenia. Among its related pathways are Parkinsons Disease Pathway and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYT5.
UniProtKB/Swiss-Prot for SYT11 Gene
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.