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Aliases for SYT11 Gene

Aliases for SYT11 Gene

  • Synaptotagmin 11 2 3 5
  • Synaptotagmin XI 2 3 4
  • SytXI 3 4
  • Synaptotagmin 12 3
  • KIAA0080 4
  • SYT12 3

External Ids for SYT11 Gene

Previous GeneCards Identifiers for SYT11 Gene

  • GC01U990248
  • GC01P151576
  • GC01P152607
  • GC01P153046
  • GC01P152642
  • GC01P154095
  • GC01P127190

Summaries for SYT11 Gene

Entrez Gene Summary for SYT11 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

GeneCards Summary for SYT11 Gene

SYT11 (Synaptotagmin 11) is a Protein Coding gene. Among its related pathways are Parkinsons Disease Pathway and Chks in Checkpoint Regulation. GO annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT11 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Wiki entry for SYT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT11 Gene

Genomics for SYT11 Gene

Regulatory Elements for SYT11 Gene

Promoters for SYT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SYT11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SYT11 Gene

Chromosome:
1
Start:
155,859,469 bp from pter
End:
155,885,199 bp from pter
Size:
25,731 bases
Orientation:
Plus strand

Genomic View for SYT11 Gene

Genes around SYT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT11 Gene

Proteins for SYT11 Gene

  • Protein details for SYT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT88-SYT11_HUMAN
    Recommended name:
    Synaptotagmin-11
    Protein Accession:
    Q9BT88
    Secondary Accessions:
    • Q14998
    • Q5W0D4
    • Q68CT5
    • Q8IXU3
    • Q96SU2

    Protein attributes for SYT11 Gene

    Size:
    431 amino acids
    Molecular mass:
    48297 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.
    SequenceCaution:
    • Sequence=BAA07527.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SYT11 Gene

Proteomics data for SYT11 Gene at MOPED

Post-translational modifications for SYT11 Gene

  • Ubiquitinated and targeted to the proteasome complex for degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT11 Gene

Domains & Families for SYT11 Gene

Gene Families for SYT11 Gene

Protein Domains for SYT11 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SYT11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BT88

UniProtKB/Swiss-Prot:

SYT11_HUMAN :
  • Contains 2 C2 domains.
  • Belongs to the synaptotagmin family.
Domain:
  • Contains 2 C2 domains.
Family:
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT11: view

Function for SYT11 Gene

Molecular function for SYT11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005544 calcium-dependent phospholipid binding ISS --
genes like me logo Genes that share ontologies with SYT11: view
genes like me logo Genes that share phenotypes with SYT11: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT11 Gene

Localization for SYT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT11 Gene

Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT11 Gene COMPARTMENTS Subcellular localization image for SYT11 gene
Compartment Confidence
cytosol 3
plasma membrane 3
lysosome 1

Gene Ontology (GO) - Cellular Components for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008021 synaptic vesicle TAS 21563316
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SYT11: view

Pathways & Interactions for SYT11 Gene

genes like me logo Genes that share pathways with SYT11: view

Pathways by source for SYT11 Gene

1 BioSystems pathway for SYT11 Gene
1 Qiagen pathway for SYT11 Gene

Gene Ontology (GO) - Biological Process for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter IBA --
genes like me logo Genes that share ontologies with SYT11: view

No data available for SIGNOR curated interactions for SYT11 Gene

Drugs & Compounds for SYT11 Gene

(1) Drugs for SYT11 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SYT11: view

Transcripts for SYT11 Gene

mRNA/cDNA for SYT11 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(283) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SYT11 Gene

Synaptotagmin XI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2:
SP3: -

Relevant External Links for SYT11 Gene

GeneLoc Exon Structure for
SYT11
ECgene alternative splicing isoforms for
SYT11

Expression for SYT11 Gene

mRNA expression in normal human tissues for SYT11 Gene

mRNA differential expression in normal tissues according to GTEx for SYT11 Gene

This gene is overexpressed in Brain - Cortex (x4.2) and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for SYT11 Gene

This gene is overexpressed in Heart (36.2), Serum (20.1), and Frontal cortex (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYT11 Gene



SOURCE GeneReport for Unigene cluster for SYT11 Gene Hs.32984

genes like me logo Genes that share expression patterns with SYT11: view

Protein tissue co-expression partners for SYT11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SYT11 Gene

Orthologs for SYT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT11 35
  • 99.61 (n)
  • 99.77 (a)
SYT11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT11 36
  • 97 (a)
OneToOne
SYT11 35
  • 93.81 (n)
  • 97.45 (a)
dog
(Canis familiaris)
Mammalia SYT11 35
  • 91.01 (n)
  • 94.19 (a)
SYT11 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt11 16
Syt11 35
  • 90 (n)
  • 95.35 (a)
Syt11 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT11 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt11 35
  • 90.05 (n)
  • 95.34 (a)
chicken
(Gallus gallus)
Aves SYT11 35
  • 78.63 (n)
  • 88.34 (a)
SYT11 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT11 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt11a 36
  • 63 (a)
OneToMany
syt11b 36
  • 58 (a)
OneToMany
syt11a 35
  • 65.89 (n)
  • 67.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt4 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-4 36
  • 32 (a)
OneToMany
Species with no ortholog for SYT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT11 Gene

ENSEMBL:
Gene Tree for SYT11 (if available)
TreeFam:
Gene Tree for SYT11 (if available)

Paralogs for SYT11 Gene

Paralogs for SYT11 Gene

(19) SIMAP similar genes for SYT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT11: view

Variants for SYT11 Gene

Sequence variations from dbSNP and Humsavar for SYT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs822522 - 155,868,074(-) TTCTT(C/G)TGCTT reference, missense
rs17853892 - 155,868,622(+) CTATG(G/T)CATCC reference, missense
rs822505 -- 155,876,737(+) CACAG(C/T)CCTAG intron-variant
rs822506 -- 155,877,029(+) tgact(A/G)caatc intron-variant
rs822507 -- 155,879,929(+) tggct(C/T)atgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT11 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV Loss 17666407
esv2664479 CNV Deletion 23128226

Variation tolerance for SYT11 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SYT11 Gene

HapMap Linkage Disequilibrium report
SYT11
Human Gene Mutation Database (HGMD)
SYT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT11 Gene

Disorders for SYT11 Gene

Relevant External Links for SYT11

Genetic Association Database (GAD)
SYT11
Human Genome Epidemiology (HuGE) Navigator
SYT11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SYT11

No disorders were found for SYT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT11 Gene

Publications for SYT11 Gene

  1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. (PMID: 12925569) Huynh D.P. … Pulst S.M. (Hum. Mol. Genet. 2003) 3 4 23 67
  2. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. (PMID: 17192956) Inoue S. … Oishi M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  3. Screening for mutations in synaptotagmin XI in Parkinson's disease. (PMID: 15354386) Glass A.S. … Riess O. (J. Neural Transm. Suppl. 2004) 3 23
  4. Genomic analysis of synaptotagmin genes. (PMID: 11543631) Craxton M.A. (Genomics 2001) 2 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for SYT11 Gene

Sources for SYT11 Gene

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