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Aliases for SYT11 Gene

Aliases for SYT11 Gene

  • Synaptotagmin XI 2 3 4
  • SytXI 3 4
  • Synaptotagmin 12 3
  • Synaptotagmin-11 3
  • KIAA0080 4
  • SYT12 3

External Ids for SYT11 Gene

Summaries for SYT11 Gene

Entrez Gene Summary for SYT11 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

GeneCards Summary for SYT11 Gene

SYT11 (Synaptotagmin XI) is a Protein Coding gene. Diseases associated with SYT11 include schizophrenia. Among its related pathways are Parkinsons Disease Pathway and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transporter activity. An important paralog of this gene is SYT5.

UniProtKB/Swiss-Prot for SYT11 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Wiki entry for SYT11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT11 Gene

Genomics for SYT11 Gene

Genomic Location for SYT11 Gene

Start:
155,859,469 bp from pter
End:
155,885,199 bp from pter
Size:
25,731 bases
Orientation:
Plus strand

Genomic View for SYT11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SYT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT11 Gene

Regulatory Elements for SYT11 Gene

Proteins for SYT11 Gene

  • Protein details for SYT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT88-SYT11_HUMAN
    Recommended name:
    Synaptotagmin-11
    Protein Accession:
    Q9BT88
    Secondary Accessions:
    • Q14998
    • Q5W0D4
    • Q68CT5
    • Q8IXU3
    • Q96SU2

    Protein attributes for SYT11 Gene

    Size:
    431 amino acids
    Molecular mass:
    48297 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.;
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity). Interacts with PARK2.
    SequenceCaution:
    • Sequence=BAA07527.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SYT11 Gene

Proteomics data for SYT11 Gene at MOPED

Post-translational modifications for SYT11 Gene

  • Ubiquitinated and targeted to the proteasome complex for degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SYT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT11 Gene

Domains for SYT11 Gene

Gene Families for SYT11 Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for SYT11 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SYT11_HUMAN
Domain:
  • Contains 2 C2 domains.:
    • Q9BT88
Family:
  • Belongs to the synaptotagmin family.:
    • Q9BT88
genes like me logo Genes that share domains with SYT11: view

Function for SYT11 Gene

Molecular function for SYT11 Gene

UniProtKB/Swiss-Prot Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Ontology (GO) - Molecular Function for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 16189514
GO:0005544 calcium-dependent phospholipid binding ISS --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with SYT11: view

Phenotypes for SYT11 Gene

MGI mutant phenotypes for SYT11:
inferred from 1 alleles
GenomeRNAi human phenotypes for SYT11:
genes like me logo Genes that share phenotypes with SYT11: view

miRNA for SYT11 Gene

miRTarBase miRNAs that target SYT11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SYT11 Gene

Localization for SYT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT11 Gene

Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SYT11 Gene COMPARTMENTS Subcellular localization image for SYT11 gene
Compartment Confidence
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane IEA --
GO:0008021 synaptic vesicle TAS 21563316
GO:0030054 cell junction IEA --
GO:0030672 synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SYT11: view

Pathways for SYT11 Gene

genes like me logo Genes that share pathways with SYT11: view

Pathways by source for SYT11 Gene

1 Qiagen pathway for SYT11 Gene
1 BioSystems pathway for SYT11 Gene

Gene Ontology (GO) - Biological Process for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0006906 vesicle fusion IBA --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0046929 negative regulation of neurotransmitter secretion TAS 21563316
genes like me logo Genes that share ontologies with SYT11: view

Compounds for SYT11 Gene

(1) HMDB Compounds for SYT11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for SYT11 Gene

Compound -log(P) Hits PubMed IDs
calcium 8.92 1
genes like me logo Genes that share compounds with SYT11: view

Transcripts for SYT11 Gene

mRNA/cDNA for SYT11 Gene

Unigene Clusters for SYT11 Gene

Synaptotagmin XI:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SYT11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP2:
SP3: -

Relevant External Links for SYT11 Gene

GeneLoc Exon Structure for
SYT11
ECgene alternative splicing isoforms for
SYT11

Expression for SYT11 Gene

mRNA expression in normal human tissues for SYT11 Gene

mRNA differential expression in normal tissues according to GTEx for SYT11 Gene

This gene is overexpressed in Brain - Cortex (4.2) and Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SYT11 Gene

SOURCE GeneReport for Unigene cluster for SYT11 Gene Hs.32984

genes like me logo Genes that share expressions with SYT11: view

Orthologs for SYT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SYT11 36
  • 99.61 (n)
  • 99.77 (a)
SYT11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SYT11 36
  • 93.81 (n)
  • 97.45 (a)
SYT11 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SYT11 36
  • 91.01 (n)
  • 94.19 (a)
SYT11 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Syt11 36
  • 90 (n)
  • 95.35 (a)
Syt11 16
Syt11 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SYT11 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Syt11 36
  • 90.05 (n)
  • 95.34 (a)
chicken
(Gallus gallus)
Aves SYT11 36
  • 78.63 (n)
  • 88.34 (a)
SYT11 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SYT11 37
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii syt11a 36
  • 65.89 (n)
  • 67.06 (a)
syt11a 37
  • 63 (a)
OneToMany
syt11b 37
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Syt4 37
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snt-4 37
  • 32 (a)
OneToMany
Species with no ortholog for SYT11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT11 Gene

ENSEMBL:
Gene Tree for SYT11 (if available)
TreeFam:
Gene Tree for SYT11 (if available)

Paralogs for SYT11 Gene

Paralogs for SYT11 Gene

Selected SIMAP similar genes for SYT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT11: view

Variants for SYT11 Gene

Sequence variations from dbSNP and Humsavar for SYT11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15408 -- 155,884,983(+) TCTTT(C/T)TTTAC utr-variant-3-prime
rs729022 -- 155,882,332(-) AAGAT(A/G)GGAAT utr-variant-3-prime
rs822505 -- 155,876,737(+) CACAG(C/T)CCTAG intron-variant
rs822506 -- 155,877,029(+) tgact(A/G)caatc intron-variant
rs822507 -- 155,879,929(+) tggct(C/T)atgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SYT11 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV Loss 17666407
esv2664479 CNV Deletion 23128226

Relevant External Links for SYT11 Gene

HapMap Linkage Disequilibrium report
SYT11
Human Gene Mutation Database (HGMD)
SYT11

Disorders for SYT11 Gene

(1) MalaCards Diseases for SYT11 Gene

Search for SYT11 Gene in MalaCards »

(1) Novoseek inferred disease relationships for SYT11 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 31 5

Relevant External Links for SYT11

Genetic Association Database (GAD)
SYT11
Human Genome Epidemiology (HuGE) Navigator
SYT11
genes like me logo Genes that share disorders with SYT11: view

No data available for UniProtKB/Swiss-Prot for SYT11 Gene

Publications for SYT11 Gene

  1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. (PMID: 12925569) Huynh D.P. … Pulst S.M. (Hum. Mol. Genet. 2003) 3 4 23
  2. Screening for mutations in synaptotagmin XI in Parkinson's disease. (PMID: 15354386) Glass A.S. … Riess O. (J. Neural Transm. Suppl. 2004) 3 23
  3. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. (PMID: 17192956) Inoue S. … Oishi M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23
  4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SYT11 Gene

Sources for SYT11 Gene

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