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Aliases for SYT11 Gene

Aliases for SYT11 Gene

  • Synaptotagmin 11 2 3 5
  • Synaptotagmin XI 2 3 4
  • SytXI 3 4
  • Synaptotagmin 12 3
  • Synaptotagmin-11 3
  • KIAA0080 4
  • SYT12 3

External Ids for SYT11 Gene

Previous GeneCards Identifiers for SYT11 Gene

  • GC01U990248
  • GC01P151576
  • GC01P152607
  • GC01P153046
  • GC01P152642
  • GC01P154095
  • GC01P127190

Summaries for SYT11 Gene

Entrez Gene Summary for SYT11 Gene

  • This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

GeneCards Summary for SYT11 Gene

SYT11 (Synaptotagmin 11) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and syntaxin binding. An important paralog of this gene is SYT4.

UniProtKB/Swiss-Prot for SYT11 Gene

  • May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Gene Wiki entry for SYT11 Gene

Additional gene information for SYT11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SYT11 Gene

Genomics for SYT11 Gene

GeneHancer (GH) Regulatory Elements for SYT11 Gene

Promoters and enhancers for SYT11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I155856 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.5 -519 5.7 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 GON4L SYT11 PYGO2 GBA KHDC4 LOC101928120 CCT3 RRNAD1 ENSG00000271267 MSTO2P
GH01I156111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 +261.9 261920 19.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LMNA GON4L CLK2 RRNAD1 KHDC4 LOC246784 MSTO1 MSTO2P PRCC ISG20L2
GH01I156740 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.2 +887.4 887393 13.6 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 HDGF MRPL24 KHDC4 GON4L RRNAD1 LOC246784 PRCC CCT3 SYT11 ISG20L2
GH01I155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 14.2 -615.2 -615227 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA KHDC4 GON4L CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01I155930 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.4 +73.4 73422 5.4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 KHDC4 GON4L RRNAD1 ISG20L2 CCT3 MSTO2P MSTO1 LOC101928120 CLK2 ENSG00000271267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SYT11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SYT11 gene promoter:

Genomic Locations for SYT11 Gene

Genomic Locations for SYT11 Gene
25,731 bases
Plus strand

Genomic View for SYT11 Gene

Genes around SYT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SYT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SYT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SYT11 Gene

Proteins for SYT11 Gene

  • Protein details for SYT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q14998
    • Q5W0D4
    • Q68CT5
    • Q8IXU3
    • Q96SU2

    Protein attributes for SYT11 Gene

    431 amino acids
    Molecular mass:
    48297 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Homodimer. Can also form heterodimers (By similarity). Interacts with PRKN.
    • Sequence=BAA07527.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SYT11 Gene

Post-translational modifications for SYT11 Gene

  • Ubiquitinated and targeted to the proteasome complex for degradation.

Other Protein References for SYT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SYT11 Gene

Domains & Families for SYT11 Gene

Gene Families for SYT11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SYT11 Gene

Suggested Antigen Peptide Sequences for SYT11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the synaptotagmin family.
  • Belongs to the synaptotagmin family.
genes like me logo Genes that share domains with SYT11: view

Function for SYT11 Gene

Molecular function for SYT11 Gene

UniProtKB/Swiss-Prot Function:
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.

Phenotypes From GWAS Catalog for SYT11 Gene

Gene Ontology (GO) - Molecular Function for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 NOT calcium ion binding ISS --
GO:0005515 protein binding IPI 16189514
GO:0005544 NOT calcium-dependent phospholipid binding ISS --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with SYT11: view
genes like me logo Genes that share phenotypes with SYT11: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SYT11 Gene

Localization for SYT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SYT11 Gene

Membrane; Single-pass membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SYT11 gene
Compartment Confidence
plasma membrane 3
cytosol 3
lysosome 3
endosome 2

Gene Ontology (GO) - Cellular Components for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IEA --
GO:0005737 cytoplasm IEA --
GO:0005764 lysosome IEA --
GO:0005886 plasma membrane IBA --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with SYT11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SYT11 Gene

Pathways & Interactions for SYT11 Gene

genes like me logo Genes that share pathways with SYT11: view

Pathways by source for SYT11 Gene

Gene Ontology (GO) - Biological Process for SYT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001778 plasma membrane repair ISS,IEA --
GO:0006906 vesicle fusion IBA --
GO:0009611 response to wounding IEA --
GO:0017158 NOT regulation of calcium ion-dependent exocytosis IBA --
GO:0046929 negative regulation of neurotransmitter secretion TAS 21563316
genes like me logo Genes that share ontologies with SYT11: view

No data available for SIGNOR curated interactions for SYT11 Gene

Drugs & Compounds for SYT11 Gene

(1) Drugs for SYT11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with SYT11: view

Transcripts for SYT11 Gene

mRNA/cDNA for SYT11 Gene

Unigene Clusters for SYT11 Gene

Synaptotagmin XI:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SYT11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b
SP1: -
SP3: -

Relevant External Links for SYT11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SYT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SYT11 Gene

mRNA differential expression in normal tissues according to GTEx for SYT11 Gene

This gene is overexpressed in Brain - Cortex (x4.2) and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for SYT11 Gene

This gene is overexpressed in Heart (36.2), Serum (20.1), and Frontal cortex (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SYT11 Gene

Protein tissue co-expression partners for SYT11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SYT11 Gene:


SOURCE GeneReport for Unigene cluster for SYT11 Gene:


Evidence on tissue expression from TISSUES for SYT11 Gene

  • Nervous system(5)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with SYT11: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SYT11 Gene

Orthologs for SYT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SYT11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SYT11 33 34
  • 99.61 (n)
(Bos Taurus)
Mammalia SYT11 33 34
  • 93.81 (n)
(Monodelphis domestica)
Mammalia SYT11 34
  • 93 (a)
(Canis familiaris)
Mammalia SYT11 33 34
  • 91.01 (n)
(Rattus norvegicus)
Mammalia Syt11 33
  • 90.05 (n)
(Mus musculus)
Mammalia Syt11 33 16 34
  • 90 (n)
(Gallus gallus)
Aves SYT11 33 34
  • 78.63 (n)
(Anolis carolinensis)
Reptilia SYT11 34
  • 87 (a)
(Danio rerio)
Actinopterygii syt11a 33 34
  • 65.89 (n)
syt11b 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syt4 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea snt-4 34
  • 32 (a)
Species where no ortholog for SYT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SYT11 Gene

Gene Tree for SYT11 (if available)
Gene Tree for SYT11 (if available)

Paralogs for SYT11 Gene

Paralogs for SYT11 Gene

(19) SIMAP similar genes for SYT11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SYT11: view

Variants for SYT11 Gene

Sequence variations from dbSNP and Humsavar for SYT11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000057973 -- 155,879,516(+) A/G intron_variant
rs1000202077 -- 155,875,463(+) G/T intron_variant
rs1000520410 -- 155,858,768(+) G/A upstream_transcript_variant
rs1000588592 -- 155,860,292(+) C/T intron_variant
rs1000888528 -- 155,875,754(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SYT11 Gene

Variant ID Type Subtype PubMed ID
esv2664479 CNV deletion 23128226
esv2849680 CNV deletion 24192839
esv33869 CNV loss 17666407
esv3541067 CNV deletion 23714750
nsv1003170 CNV gain 25217958
nsv957176 CNV deletion 24416366

Variation tolerance for SYT11 Gene

Residual Variation Intolerance Score: 21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SYT11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SYT11 Gene

Disorders for SYT11 Gene

Additional Disease Information for SYT11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SYT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SYT11 Gene

Publications for SYT11 Gene

  1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. (PMID: 12925569) Huynh DP … Pulst SM (Human molecular genetics 2003) 3 4 22 58
  2. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) International Parkinson Disease Genomics Consortium … Wood NW (Lancet (London, England) 2011) 3 44 58
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need AC … Goldstein DB (European journal of human genetics : EJHG 2009) 3 44 58
  4. Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia. (PMID: 17192956) Inoue S … Oishi M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SYT11 Gene

Sources for SYT11 Gene

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