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Aliases for GANAB Gene

Aliases for GANAB Gene

  • Glucosidase, Alpha; Neutral AB 2 3
  • Glucosidase II Subunit Alpha 3 4
  • Alpha-Glucosidase 2 3 4
  • EC 3.2.1.84 4 63
  • G2AN 3 4
  • Epididymis Secretory Sperm Binding Protein Li 164nA 3
  • Alpha Glucosidase II Alpha Subunit 3
  • HEL-S-164nA 3
  • KIAA0088 4
  • EC 3.2.1 63
  • GLUII 3

External Ids for GANAB Gene

Previous GeneCards Identifiers for GANAB Gene

  • GC11U990054
  • GC11M062166
  • GC11M062148
  • GC11M062430
  • GC11M058721
  • GC11M062481
  • GC11M062675

Summaries for GANAB Gene

GeneCards Summary for GANAB Gene

GANAB (Glucosidase, Alpha; Neutral AB) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is MGAM.

UniProtKB/Swiss-Prot for GANAB Gene

  • Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.

Tocris Summary for GANAB Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Gene Wiki entry for GANAB Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GANAB Gene

Genomics for GANAB Gene

Regulatory Elements for GANAB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for GANAB Gene

Chromosome:
11
Start:
62,624,826 bp from pter
End:
62,646,726 bp from pter
Size:
21,901 bases
Orientation:
Minus strand

Genomic View for GANAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for GANAB Gene

Proteins for GANAB Gene

  • Protein details for GANAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14697-GANAB_HUMAN
    Recommended name:
    Neutral alpha-glucosidase AB
    Protein Accession:
    Q14697
    Secondary Accessions:
    • A6NC20
    • Q8WTS9
    • Q9P0X0

    Protein attributes for GANAB Gene

    Size:
    944 amino acids
    Molecular mass:
    106874 Da
    Quaternary structure:
    • Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC (By similarity).
    SequenceCaution:
    • Sequence=AAH65266.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for GANAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GANAB Gene

Proteomics data for GANAB Gene at MOPED

Post-translational modifications for GANAB Gene

  • Ubiquitination at Lys 48, Lys 269, Lys 462, Lys 472, Lys 491, Lys 899, Lys 908, and Lys 930
  • Glycosylation at Asn 97
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for GANAB Gene

Suggested Antigen Peptide Sequences for GANAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14697

UniProtKB/Swiss-Prot:

GANAB_HUMAN :
  • Belongs to the glycosyl hydrolase 31 family.
Family:
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with GANAB: view

No data available for Gene Families for GANAB Gene

Function for GANAB Gene

Molecular function for GANAB Gene

GENATLAS Biochemistry:
glucosidase,alpha-,neutral AB
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans
UniProtKB/Swiss-Prot Function:
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.

Enzyme Numbers (IUBMB) for GANAB Gene

Gene Ontology (GO) - Molecular Function for GANAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0030246 carbohydrate binding IEA --
GO:0033919 glucan 1,3-alpha-glucosidase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with GANAB: view

Phenotypes for GANAB Gene

GenomeRNAi human phenotypes for GANAB:
genes like me logo Genes that share phenotypes with GANAB: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GANAB

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for GANAB Gene

Localization for GANAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GANAB Gene

Endoplasmic reticulum. Golgi apparatus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GANAB Gene COMPARTMENTS Subcellular localization image for GANAB gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
golgi apparatus 3
cytosol 2
nucleus 2
chloroplast 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for GANAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA 19946888
GO:0042470 melanosome IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GANAB: view

Pathways & Interactions for GANAB Gene

genes like me logo Genes that share pathways with GANAB: view

PCR Array Products

UniProtKB/Swiss-Prot Q14697-GANAB_HUMAN

  • Pathway: Glycan metabolism; N-glycan metabolism

Gene Ontology (GO) - Biological Process for GANAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006457 protein folding TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GANAB: view

No data available for SIGNOR curated interactions for GANAB Gene

Drugs & Compounds for GANAB Gene

(3) Drugs for GANAB Gene - From: Tocris, HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Miglitol Approved Pharma Target, antagonist 12
Voglibose Approved, Investigational Pharma α-glucosidases inhibitor 23
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 0

(6) Additional Compounds for GANAB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
1-Deoxymannojirimycin hydrochloride
73465-43-7
castanospermine
79831-76-8
Miglustat hydrochloride
210110-90-0
genes like me logo Genes that share compounds with GANAB: view

Transcripts for GANAB Gene

Unigene Clusters for GANAB Gene

Glucosidase, alpha; neutral AB:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GANAB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GANAB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11: - -
SP12: - - - - -
SP13: - - - -
SP14:
SP15:
SP16: - - - - - - -
SP17: -

ExUns: 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for GANAB Gene

GeneLoc Exon Structure for
GANAB
ECgene alternative splicing isoforms for
GANAB

Expression for GANAB Gene

mRNA expression in normal human tissues for GANAB Gene

Protein differential expression in normal tissues from HIPED for GANAB Gene

This gene is overexpressed in Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for GANAB Gene



SOURCE GeneReport for Unigene cluster for GANAB Gene Hs.595071

mRNA Expression by UniProt/SwissProt for GANAB Gene

Q14697-GANAB_HUMAN
Tissue specificity: Detected in placenta.
genes like me logo Genes that share expression patterns with GANAB: view

Protein tissue co-expression partners for GANAB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for GANAB Gene

Orthologs for GANAB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GANAB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GANAB 36
  • 92 (a)
OneToOne
GANAB 35
  • 89.75 (n)
  • 92.44 (a)
dog
(Canis familiaris)
Mammalia GANAB 36
  • 93 (a)
OneToOne
GANAB 35
  • 90.91 (n)
  • 93.07 (a)
oppossum
(Monodelphis domestica)
Mammalia GANAB 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ganab 36
  • 92 (a)
OneToOne
Ganab 16
Ganab 35
  • 87.62 (n)
  • 91.92 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia GANAB 36
  • 100 (a)
OneToOne
GANAB 35
  • 99.59 (n)
  • 99.59 (a)
rat
(Rattus norvegicus)
Mammalia Ganab 35
  • 87.35 (n)
  • 91.29 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3740 35
ganab 35
  • 65.6 (n)
  • 68.55 (a)
zebrafish
(Danio rerio)
Actinopterygii GANAB (1 of 3) 36
  • 66 (a)
OneToMany
GANAB (2 of 3) 36
  • 59 (a)
OneToMany
GANAB (3 of 3) 36
  • 64 (a)
OneToMany
LOC100334924 35
  • 66.53 (n)
  • 68.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14476 36
  • 47 (a)
OneToMany
CG14476 35
  • 55.02 (n)
  • 47.86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000862 35
  • 53.8 (n)
  • 49.46 (a)
worm
(Caenorhabditis elegans)
Secernentea aagr-3 36
  • 45 (a)
ManyToMany
aagr-4 36
  • 45 (a)
ManyToMany
aagr-3 35
  • 52.11 (n)
  • 48.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 36
  • 35 (a)
OneToMany
ROT2 38
ROT2 35
  • 47.12 (n)
  • 43.61 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09735g 35
  • 47.11 (n)
  • 39.72 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR173C 35
  • 47.55 (n)
  • 39.22 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3471 35
thale cress
(Arabidopsis thaliana)
eudicotyledons RSW3 35
  • 53.53 (n)
  • 50 (a)
rice
(Oryza sativa)
Liliopsida Os03g0216600 35
  • 56.51 (n)
  • 52.39 (a)
Os.6168 35
barley
(Hordeum vulgare)
Liliopsida Hv.10182 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gls2 35
  • 49.28 (n)
  • 44.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04203 35
  • 52.05 (n)
  • 44.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3796 35
Species with no ortholog for GANAB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GANAB Gene

ENSEMBL:
Gene Tree for GANAB (if available)
TreeFam:
Gene Tree for GANAB (if available)

Paralogs for GANAB Gene

Paralogs for GANAB Gene

(2) SIMAP similar genes for GANAB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GANAB: view

Variants for GANAB Gene

Sequence variations from dbSNP and Humsavar for GANAB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6916 -- 62,625,404(-) TTAGG(G/T)CTCCT utr-variant-3-prime
rs489886 -- 62,645,502(-) ctgga(C/G)tgcag intron-variant
rs511750 -- 62,645,461(-) cctcc(C/T)gggtt intron-variant
rs511912 -- 62,645,408(-) caggc(A/G)cccgc intron-variant
rs529170 -- 62,638,772(-) attat(G/T)gcttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GANAB Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897
nsv825939 CNV Gain 20364138

Variation tolerance for GANAB Gene

Residual Variation Intolerance Score: 27.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GANAB Gene

HapMap Linkage Disequilibrium report
GANAB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GANAB Gene

Disorders for GANAB Gene

Relevant External Links for GANAB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GANAB
genes like me logo Genes that share disorders with GANAB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GANAB Gene

Publications for GANAB Gene

  1. Proteomics-based safety evaluation of multi-walled carbon nanotubes. (PMID: 19874835) Haniu H. … Endo M. (Toxicol. Appl. Pharmacol. 2010) 23 67
  2. The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. (PMID: 19818342) Fukaya N. … Goda T. (Eur. J. Pharmacol. 2009) 25 26
  3. Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats. (PMID: 19085811) Hirata A. … Tominaga M. (Horm. Metab. Res. 2009) 25 26
  4. Cloning and characterization of the glucosidase II alpha subunit gene of Trichoderma reesei: a frameshift mutation results in the aberrant glycosylation profile of the hypercellulolytic strain Rut-C30. (PMID: 15932985) Geysens S. … Contreras R. (Appl. Environ. Microbiol. 2005) 23 67
  5. Blood-based biomarkers for detecting mild osteoarthritis in the human knee. (PMID: 16139532) Marshall K.W. … Liew C.C. (Osteoarthr. Cartil. 2005) 23 67

Products for GANAB Gene

Sources for GANAB Gene

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