Aliases for GANAB Gene
External Ids for GANAB Gene
Previous GeneCards Identifiers for GANAB Gene
GeneCards Summary for GANAB Gene
GANAB (Glucosidase, Alpha; Neutral AB) is a Protein Coding gene. Diseases associated with GANAB include glycogen storage disease ii and polycystic liver disease. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding and glucan 1,3-alpha-glucosidase activity. An important paralog of this gene is MGAM.
UniProtKB/Swiss-Prot for GANAB Gene
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, alpha- and beta-glucosidase (EC numbers 18.104.22.168 and 22.214.171.124 respectively), which are both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose respectively