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Aliases for GANAB Gene

Aliases for GANAB Gene

  • Glucosidase, Alpha; Neutral AB 2 3
  • Glucosidase II Subunit Alpha 3 4
  • Alpha-Glucosidase 2 3 4
  • EC 3.2.1.84 4 64
  • G2AN 3 4
  • Epididymis Secretory Sperm Binding Protein Li 164nA 3
  • Alpha Glucosidase II Alpha Subunit 3
  • Neutral Alpha-Glucosidase AB 3
  • HEL-S-164nA 3
  • KIAA0088 4
  • EC 3.2.1 64
  • GLUII 3

External Ids for GANAB Gene

Summaries for GANAB Gene

GeneCards Summary for GANAB Gene

GANAB (Glucosidase, Alpha; Neutral AB) is a Protein Coding gene. Diseases associated with GANAB include glycogen storage disease ii and polycystic liver disease. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding and glucan 1,3-alpha-glucosidase activity. An important paralog of this gene is MGAM.

UniProtKB/Swiss-Prot for GANAB Gene

  • Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.

Tocris Summary for GANAB Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, alpha- and beta-glucosidase (EC numbers 3.2.1.20 and 3.2.1.21 respectively), which are both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose respectively.

Gene Wiki entry for GANAB Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GANAB Gene

Genomics for GANAB Gene

Genomic Location for GANAB Gene

Start:
62,624,826 bp from pter
End:
62,646,726 bp from pter
Size:
21,901 bases
Orientation:
Minus strand

Genomic View for GANAB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GANAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GANAB Gene

Regulatory Elements for GANAB Gene

Proteins for GANAB Gene

  • Protein details for GANAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14697-GANAB_HUMAN
    Recommended name:
    Neutral alpha-glucosidase AB
    Protein Accession:
    Q14697
    Secondary Accessions:
    • A6NC20
    • Q8WTS9
    • Q9P0X0

    Protein attributes for GANAB Gene

    Size:
    944 amino acids
    Molecular mass:
    106874 Da
    Quaternary structure:
    • Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC (By similarity).
    SequenceCaution:
    • Sequence=AAH65266.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for GANAB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GANAB Gene

Proteomics data for GANAB Gene at MOPED

Post-translational modifications for GANAB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48, Lys269, Lys462, Lys472, Lys491, Lys899, Lys908, and Lys930
  • Glycosylation at Asn97

Domains for GANAB Gene

UniProtKB/Swiss-Prot:

GANAB_HUMAN
Family:
  • Belongs to the glycosyl hydrolase 31 family.:
    • Q14697
genes like me logo Genes that share domains with GANAB: view

No data available for Gene Families for GANAB Gene

Function for GANAB Gene

Molecular function for GANAB Gene

GENATLAS Biochemistry: glucosidase,alpha-,neutral AB
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans
UniProtKB/Swiss-Prot Function: Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.

Enzyme Numbers (IUBMB) for GANAB Gene

Gene Ontology (GO) - Molecular Function for GANAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0005515 protein binding --
GO:0030246 carbohydrate binding IEA --
GO:0033919 glucan 1,3-alpha-glucosidase activity IEA --
genes like me logo Genes that share ontologies with GANAB: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for GANAB Gene

Localization for GANAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for GANAB Gene

Endoplasmic reticulum. Golgi apparatus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GANAB Gene COMPARTMENTS Subcellular localization image for GANAB gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 2
plasma membrane 2
extracellular 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GANAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA 19946888
GO:0017177 glucosidase II complex IEA --
GO:0042470 melanosome IEA --
genes like me logo Genes that share ontologies with GANAB: view

Pathways for GANAB Gene

genes like me logo Genes that share pathways with GANAB: view

UniProtKB/Swiss-Prot Q14697-GANAB_HUMAN

  • Pathway: Glycan metabolism; N-glycan metabolism

Gene Ontology (GO) - Biological Process for GANAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006457 protein folding TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with GANAB: view

Compounds for GANAB Gene

(5) Tocris Compounds for GANAB Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor [73465-43-7]
1-Deoxynojirimycin Glucosidase I and II inhibitor [19130-96-2]
Kifunensine Inhibitor of class I alpha-mannosidases [109944-15-2]
Miglitol alpha-glucosidase inhibitor [72432-03-2]
OGT 2115 Antiangiogenic. Heparanase inhibitor [853929-59-6]

(2) HMDB Compounds for GANAB Gene

Compound Synonyms Cas Number PubMed IDs
D-Glucose
  • (+)-Glucose
50-99-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with GANAB: view

Transcripts for GANAB Gene

Unigene Clusters for GANAB Gene

Glucosidase, alpha; neutral AB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GANAB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - -
SP7: - - - -
SP8: - - - -
SP9:
SP10:
SP11: - -
SP12: - - - - -
SP13: - - - -
SP14:
SP15:
SP16: - - - - - - -
SP17: -

ExUns: 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b · 25c
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for GANAB Gene

GeneLoc Exon Structure for
GANAB
ECgene alternative splicing isoforms for
GANAB

Expression for GANAB Gene

mRNA expression in normal human tissues for GANAB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GANAB Gene

SOURCE GeneReport for Unigene cluster for GANAB Gene Hs.595071

mRNA Expression by UniProt/SwissProt for GANAB Gene

Q14697-GANAB_HUMAN
Tissue specificity: Detected in placenta.
genes like me logo Genes that share expressions with GANAB: view

Orthologs for GANAB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for GANAB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GANAB 36
  • 99.59 (n)
  • 99.59 (a)
GANAB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GANAB 36
  • 89.75 (n)
  • 92.44 (a)
GANAB 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GANAB 36
  • 90.91 (n)
  • 93.07 (a)
GANAB 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ganab 36
  • 87.62 (n)
  • 91.92 (a)
Ganab 16
Ganab 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GANAB 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 20 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ganab 36
  • 87.35 (n)
  • 91.29 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 65 (a)
OneToMany
-- 37
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ganab 36
  • 65.6 (n)
  • 68.55 (a)
Str.3740 36
zebrafish
(Danio rerio)
Actinopterygii GANAB (1 of 3) 37
  • 66 (a)
OneToMany
GANAB (2 of 3) 37
  • 59 (a)
OneToMany
GANAB (3 of 3) 37
  • 64 (a)
OneToMany
LOC100334924 36
  • 66.53 (n)
  • 68.55 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000862 36
  • 53.8 (n)
  • 49.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14476 36
  • 55.02 (n)
  • 47.86 (a)
CG14476 37
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aagr-3 36
  • 52.11 (n)
  • 48.87 (a)
aagr-3 37
  • 45 (a)
ManyToMany
aagr-4 37
  • 45 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR173C 36
  • 47.55 (n)
  • 39.22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 36
  • 47.12 (n)
  • 43.61 (a)
ROT2 37
  • 35 (a)
OneToMany
ROT2 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F09735g 36
  • 47.11 (n)
  • 39.72 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.3471 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RSW3 36
  • 53.53 (n)
  • 50 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.10182 36
rice
(Oryza sativa)
Liliopsida Os.6168 36
Os03g0216600 36
  • 56.51 (n)
  • 52.39 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04203 36
  • 52.05 (n)
  • 44.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gls2 36
  • 49.28 (n)
  • 44.42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3796 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToMany
Species with no ortholog for GANAB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GANAB Gene

ENSEMBL:
Gene Tree for GANAB (if available)
TreeFam:
Gene Tree for GANAB (if available)

Paralogs for GANAB Gene

Paralogs for GANAB Gene

Selected SIMAP similar genes for GANAB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with GANAB: view

Variants for GANAB Gene

Sequence variations from dbSNP and Humsavar for GANAB Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6916 -- 62,625,404(-) TTAGG(G/T)CTCCT utr-variant-3-prime
rs489886 -- 62,645,502(-) ctgga(C/G)tgcag intron-variant
rs511750 -- 62,645,461(-) cctcc(C/T)gggtt intron-variant
rs511912 -- 62,645,408(-) caggc(A/G)cccgc intron-variant
rs529170 -- 62,638,772(-) attat(G/T)gcttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GANAB Gene

Variant ID Type Subtype PubMed ID
nsv832182 CNV Gain+Loss 17160897
nsv825939 CNV Gain 20364138

Relevant External Links for GANAB Gene

HapMap Linkage Disequilibrium report
GANAB

Disorders for GANAB Gene

(1) University of Copenhagen DISEASES for GANAB Gene

genes like me logo Genes that share disorders with GANAB: view

No data available for UniProtKB/Swiss-Prot for GANAB Gene

Publications for GANAB Gene

  1. Identity of neutral alpha-glucosidase AB and the glycoprotein processing enzyme glucosidase II. Biochemical and genetic studies. (PMID: 3881423) Martiniuk F. … Hirschhorn R. (J. Biol. Chem. 1985) 3 4
  2. Assignment of the gene for neutral alpha-glucosidase AB to chromosome 11. (PMID: 6342981) Martiniuk F. … Hirschhorn R. (Cytogenet. Cell Genet. 1983) 2 3
  3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  4. The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. (PMID: 10929008) Pelletier M.F. … Thomas D.Y. (Glycobiology 2000) 3 4
  5. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A. … Hunt D.F. (J. Proteome Res. 2006) 3 4

Products for GANAB Gene

Sources for GANAB Gene

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