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Aliases for CEP68 Gene

Aliases for CEP68 Gene

  • Centrosomal Protein 68 2 3
  • Centrosomal Protein 68kDa 2 3 5
  • KIAA0582 2 3 4
  • Cep68 4

External Ids for CEP68 Gene

Previous HGNC Symbols for CEP68 Gene

  • KIAA0582

Previous GeneCards Identifiers for CEP68 Gene

  • GC02P065196
  • GC02P065283
  • GC02P065017

Summaries for CEP68 Gene

GeneCards Summary for CEP68 Gene

CEP68 (Centrosomal Protein 68) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is AKAP6.

UniProtKB/Swiss-Prot for CEP68 Gene

  • Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).

Gene Wiki entry for CEP68 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP68 Gene

Genomics for CEP68 Gene

Regulatory Elements for CEP68 Gene

Enhancers for CEP68 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEP68 on UCSC Golden Path with GeneCards custom track

Promoters for CEP68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP68 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP68 Gene

Chromosome:
2
Start:
65,056,361 bp from pter
End:
65,087,008 bp from pter
Size:
30,648 bases
Orientation:
Plus strand

Genomic View for CEP68 Gene

Genes around CEP68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP68 Gene

Proteins for CEP68 Gene

  • Protein details for CEP68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76N32-CEP68_HUMAN
    Recommended name:
    Centrosomal protein of 68 kDa
    Protein Accession:
    Q76N32
    Secondary Accessions:
    • B4DRQ1
    • D6W5F1
    • D6W5F2
    • O60326
    • Q9BQ18
    • Q9UDM9

    Protein attributes for CEP68 Gene

    Size:
    757 amino acids
    Molecular mass:
    81102 Da
    Quaternary structure:
    • Interacts with CNTLN; the interaction recruits CEP68 to the centrosome (PubMed:24554434). Interacts with the SCF(FBXW11) complex which contains SKP1, CUL1 and FBXW11; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT (PubMed:25503564). Also interacts with F-box protein BTRC (PubMed:25704143, PubMed:25503564). Interacts with serine/threonine-protein kinase PLK1; the interaction leads to phosphorylation of CEP68 and its subsequent degradation (PubMed:25503564). Interacts with NEK2; the interaction leads to phosphorylation of CEP68 (PubMed:24554434).
    SequenceCaution:
    • Sequence=BAA25508.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP68 Gene

Proteomics data for CEP68 Gene at MOPED

Post-translational modifications for CEP68 Gene

  • Phosphorylation by PLK1 is required for binding to BTRC in prometaphase (PubMed:25503564). Phosphorylated directly or indirectly by NEK2 (PubMed:24554434). NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143).
  • Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes (PubMed:25704143, PubMed:25503564). Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation (PubMed:25503564).
  • Ubiquitination at Lys 317
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP68 Gene

No data available for DME Specific Peptides for CEP68 Gene

Domains & Families for CEP68 Gene

Protein Domains for CEP68 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP68 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP68 Gene

Function for CEP68 Gene

Molecular function for CEP68 Gene

UniProtKB/Swiss-Prot Function:
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).
genes like me logo Genes that share phenotypes with CEP68: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP68 Gene

Localization for CEP68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP68 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. {ECO:0000269 PubMed:18042621, ECO:0000269 PubMed:25503564, ECO:0000269 PubMed:25704143}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP68 Gene COMPARTMENTS Subcellular localization image for CEP68 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
endosome 1

Gene Ontology (GO) - Cellular Components for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with CEP68: view

Pathways & Interactions for CEP68 Gene

SuperPathways for CEP68 Gene

No Data Available

Interacting Proteins for CEP68 Gene

Gene Ontology (GO) - Biological Process for CEP68 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP68 Gene

Drugs & Compounds for CEP68 Gene

(1) Drugs for CEP68 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 1059
genes like me logo Genes that share compounds with CEP68: view

Transcripts for CEP68 Gene

Unigene Clusters for CEP68 Gene

Centrosomal protein 68kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP68 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -

Relevant External Links for CEP68 Gene

GeneLoc Exon Structure for
CEP68
ECgene alternative splicing isoforms for
CEP68

Expression for CEP68 Gene

mRNA expression in normal human tissues for CEP68 Gene

Protein differential expression in normal tissues from HIPED for CEP68 Gene

This gene is overexpressed in CD8 Tcells (30.6), Testis (20.6), and Fetal ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CEP68 Gene



SOURCE GeneReport for Unigene cluster for CEP68 Gene Hs.709257

genes like me logo Genes that share expression patterns with CEP68: view

Protein tissue co-expression partners for CEP68 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP68 Gene

Orthologs for CEP68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP68 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP68 35
  • 77.53 (n)
  • 70.09 (a)
CEP68 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP68 35
  • 77.55 (n)
  • 68.6 (a)
CEP68 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep68 35
  • 74.87 (n)
  • 62.65 (a)
Cep68 16
Cep68 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP68 35
  • 99.21 (n)
  • 98.68 (a)
CEP68 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep68 35
  • 75.25 (n)
  • 64.66 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP68 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP68 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP68 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP68 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cep68 36
  • 22 (a)
OneToOne
Species with no ortholog for CEP68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP68 Gene

ENSEMBL:
Gene Tree for CEP68 (if available)
TreeFam:
Gene Tree for CEP68 (if available)

Paralogs for CEP68 Gene

Paralogs for CEP68 Gene

(1) SIMAP similar genes for CEP68 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP68: view

Variants for CEP68 Gene

Sequence variations from dbSNP and Humsavar for CEP68 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs7572857 - 65,069,664(+) CTGGC(A/G)GCCCC nc-transcript-variant, reference, missense
rs12611491 - 65,069,523(+) GCTGC(A/G)GGGAG nc-transcript-variant, reference, missense
VAR_050795 -
VAR_050796 -
VAR_050797 -

Structural Variations from Database of Genomic Variants (DGV) for CEP68 Gene

Variant ID Type Subtype PubMed ID
nsv834246 CNV Loss 17160897
esv2666088 CNV Deletion 23128226
esv2674666 CNV Deletion 23128226

Variation tolerance for CEP68 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP68 Gene

Human Gene Mutation Database (HGMD)
CEP68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP68 Gene

Disorders for CEP68 Gene

Relevant External Links for CEP68

Genetic Association Database (GAD)
CEP68
Human Genome Epidemiology (HuGE) Navigator
CEP68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP68

No disorders were found for CEP68 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP68 Gene

Publications for CEP68 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 2 3
  4. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. (PMID: 25503564) Pagan J.K. … Pagano M. (Nat. Cell Biol. 2015) 3
  5. Cep68 can be regulated by Nek2 and SCF complex. (PMID: 25704143) Man X. … Lim Y.P. (Eur. J. Cell Biol. 2015) 3

Products for CEP68 Gene

Sources for CEP68 Gene

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