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Aliases for CEP68 Gene

Aliases for CEP68 Gene

  • Centrosomal Protein 68kDa 2 3
  • KIAA0582 2 3 4
  • Centrosomal Protein Of 68 KDa 3
  • CEP68 4

External Ids for CEP68 Gene

Previous HGNC Symbols for CEP68 Gene

  • KIAA0582

Previous GeneCards Identifiers for CEP68 Gene

  • GC02P065196
  • GC02P065283
  • GC02P065017

Summaries for CEP68 Gene

GeneCards Summary for CEP68 Gene

CEP68 (Centrosomal Protein 68kDa) is a Protein Coding gene.

Gene Wiki entry for CEP68 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP68 Gene

Genomics for CEP68 Gene

Regulatory Elements for CEP68 Gene

Genomic Location for CEP68 Gene

Start:
65,056,361 bp from pter
End:
65,087,008 bp from pter
Size:
30,648 bases
Orientation:
Plus strand

Genomic View for CEP68 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP68 Gene

Proteins for CEP68 Gene

  • Protein details for CEP68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76N32-CEP68_HUMAN
    Recommended name:
    Centrosomal protein of 68 kDa
    Protein Accession:
    Q76N32
    Secondary Accessions:
    • B4DRQ1
    • D6W5F1
    • D6W5F2
    • O60326
    • Q9BQ18
    • Q9UDM9

    Protein attributes for CEP68 Gene

    Size:
    757 amino acids
    Molecular mass:
    81102 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25508.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP68 Gene

Proteomics data for CEP68 Gene at MOPED

Post-translational modifications for CEP68 Gene

  • Ubiquitination at Lys317
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP68 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEP68 Gene

Domains for CEP68 Gene

Protein Domains for CEP68 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP68 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP68 Gene

Function for CEP68 Gene

Gene Ontology (GO) - Molecular Function for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IPI 24554434
GO:0019904 protein domain specific binding IPI 24554434
genes like me logo Genes that share ontologies with CEP68: view

miRNA for CEP68 Gene

miRTarBase miRNAs that target CEP68

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP68 Gene

Localization for CEP68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP68 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP68 Gene COMPARTMENTS Subcellular localization image for CEP68 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
endosome 1

Gene Ontology (GO) - Cellular Components for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 18042621
GO:0005815 microtubule organizing center IDA --
genes like me logo Genes that share ontologies with CEP68: view

Pathways for CEP68 Gene

SuperPathways for CEP68 Gene

No Data Available

Interacting Proteins for CEP68 Gene

Gene Ontology (GO) - Biological Process for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010457 centriole-centriole cohesion IMP 24554434
GO:0033365 protein localization to organelle IMP 24554434
GO:0051297 centrosome organization IMP 18042621
genes like me logo Genes that share ontologies with CEP68: view

No data available for Pathways by source for CEP68 Gene

Compounds for CEP68 Gene

(1) PharmGKB related drug/compound annotations for CEP68 Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with CEP68: view

Transcripts for CEP68 Gene

Unigene Clusters for CEP68 Gene

Centrosomal protein 68kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP68 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -

Relevant External Links for CEP68 Gene

GeneLoc Exon Structure for
CEP68
ECgene alternative splicing isoforms for
CEP68

Expression for CEP68 Gene

mRNA expression in normal human tissues for CEP68 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP68 Gene

SOURCE GeneReport for Unigene cluster for CEP68 Gene Hs.709257

genes like me logo Genes that share expressions with CEP68: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP68 Gene

Orthologs for CEP68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP68 35
  • 99.21 (n)
  • 98.68 (a)
CEP68 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP68 35
  • 77.53 (n)
  • 70.09 (a)
CEP68 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP68 35
  • 77.55 (n)
  • 68.6 (a)
CEP68 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep68 35
  • 74.87 (n)
  • 62.65 (a)
Cep68 16
Cep68 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP68 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP68 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep68 35
  • 75.25 (n)
  • 64.66 (a)
chicken
(Gallus gallus)
Aves CEP68 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP68 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cep68 36
  • 22 (a)
OneToOne
Species with no ortholog for CEP68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP68 Gene

ENSEMBL:
Gene Tree for CEP68 (if available)
TreeFam:
Gene Tree for CEP68 (if available)

Paralogs for CEP68 Gene

Selected SIMAP similar genes for CEP68 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP68: view

No data available for Paralogs for CEP68 Gene

Variants for CEP68 Gene

Sequence variations from dbSNP and Humsavar for CEP68 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1228 -- 65,084,421(+) GGGAA(C/T)GGATA utr-variant-3-prime
rs1229 -- 65,084,304(-) CATGA(C/T)TGTAG utr-variant-3-prime
rs1050675 -- 65,083,897(-) TCTTA(C/T)TTTAT utr-variant-3-prime
rs1050676 -- 65,083,697(-) GAAGG(A/T)TTTTT utr-variant-3-prime
rs1055676 -- 65,071,672(+) GCTCA(A/G)CCTTC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CEP68 Gene

Variant ID Type Subtype PubMed ID
nsv834246 CNV Loss 17160897
esv2666088 CNV Deletion 23128226
esv2674666 CNV Deletion 23128226

Relevant External Links for CEP68 Gene

HapMap Linkage Disequilibrium report
CEP68
Human Gene Mutation Database (HGMD)
CEP68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP68 Gene

Disorders for CEP68 Gene

Relevant External Links for CEP68

Genetic Association Database (GAD)
CEP68
Human Genome Epidemiology (HuGE) Navigator
CEP68
genes like me logo Genes that share disorders with CEP68: view

No data available for UniProtKB/Swiss-Prot for CEP68 Gene

Publications for CEP68 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 2 3
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CEP68 Gene

Sources for CEP68 Gene

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