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Aliases for CEP68 Gene

Aliases for CEP68 Gene

  • Centrosomal Protein 68 2 3 5
  • KIAA0582 2 3 4
  • Centrosomal Protein 68kDa 2 3
  • Centrosomal Protein Of 68 KDa 3
  • Cep68 4

External Ids for CEP68 Gene

Previous HGNC Symbols for CEP68 Gene

  • KIAA0582

Previous GeneCards Identifiers for CEP68 Gene

  • GC02P065196
  • GC02P065283
  • GC02P065017

Summaries for CEP68 Gene

GeneCards Summary for CEP68 Gene

CEP68 (Centrosomal Protein 68) is a Protein Coding gene. Diseases associated with CEP68 include Retinitis Pigmentosa 28. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is AKAP6.

UniProtKB/Swiss-Prot for CEP68 Gene

  • Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).

Gene Wiki entry for CEP68 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP68 Gene

Genomics for CEP68 Gene

Regulatory Elements for CEP68 Gene

Enhancers for CEP68 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G065055 1.6 Ensembl ENCODE dbSUPER 34.1 +1.1 1067 5.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 CEP68 RAB1A RNU6-548P ACTR2 LOC105374779
GH02G065126 1.4 ENCODE dbSUPER 33.7 +73.9 73862 8.2 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 CEP68 LOC102724233 ACTR2 SERTAD2 RAB1A GC02P065109
GH02G065060 1.5 Ensembl ENCODE dbSUPER 30.5 +7.2 7157 5.8 HDGF PKNOX1 FOXA2 ATF1 WRNIP1 FEZF1 TCF12 ZNF121 ZNF766 ZNF143 CEP68 RAB1A RNU6-548P ACTR2 LOC105374779
GH02G065068 1.4 Ensembl ENCODE dbSUPER 30.5 +13.6 13590 3.8 HDAC1 ATF1 FOXA2 ARNT ARID4B RAD21 ZNF766 GATA2 EGR1 FOS CEP68 RAB1A RN7SL211P LOC105374779
GH02G065075 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24 +19.8 19781 1.8 HDAC1 PKNOX1 ATF1 SAP130 TBL1XR1 TAL1 RAD21 TCF12 POLR2A NCOR1 CEP68 RAB1A LOC102724233 ACTR2 SERTAD2 SLC1A4 LOC105374779
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP68 on UCSC Golden Path with GeneCards custom track

Promoters for CEP68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000118063 39 2001 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for CEP68 Gene

Chromosome:
2
Start:
65,056,361 bp from pter
End:
65,087,008 bp from pter
Size:
30,648 bases
Orientation:
Plus strand

Genomic View for CEP68 Gene

Genes around CEP68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP68 Gene

Proteins for CEP68 Gene

  • Protein details for CEP68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76N32-CEP68_HUMAN
    Recommended name:
    Centrosomal protein of 68 kDa
    Protein Accession:
    Q76N32
    Secondary Accessions:
    • B4DRQ1
    • D6W5F1
    • D6W5F2
    • O60326
    • Q9BQ18
    • Q9UDM9

    Protein attributes for CEP68 Gene

    Size:
    757 amino acids
    Molecular mass:
    81102 Da
    Quaternary structure:
    • Interacts with CNTLN; the interaction recruits CEP68 to the centrosome (PubMed:24554434). Interacts with the SCF(FBXW11) complex which contains SKP1, CUL1 and FBXW11; the interaction is probably mediated by FBXW11 and the complex also contains CDK5RAP2 and PCNT (PubMed:25503564). Also interacts with F-box protein BTRC (PubMed:25704143, PubMed:25503564). Interacts with serine/threonine-protein kinase PLK1; the interaction leads to phosphorylation of CEP68 and its subsequent degradation (PubMed:25503564). Interacts with NEK2; the interaction leads to phosphorylation of CEP68 (PubMed:24554434).
    SequenceCaution:
    • Sequence=BAA25508.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP68 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP68 Gene

Post-translational modifications for CEP68 Gene

  • Phosphorylation by PLK1 is required for binding to BTRC in prometaphase (PubMed:25503564). Phosphorylated directly or indirectly by NEK2 (PubMed:24554434). NEK2-mediated phosphorylation promotes CEP68 dissociation from the centrosome and its degradation at the onset of mitosis (PubMed:25704143).
  • Ubiquitinated and targeted for proteasomal degradation in early mitosis by the SCF(BTRC) and/or SCF(FBXW11) E3 ubiquitin-protein ligase complexes (PubMed:25704143, PubMed:25503564). Degradation is complete by prometaphase and is required for removal of CDK5RAP2 from the peripheral pericentriolar material and subsequent centriole separation (PubMed:25503564).
  • Ubiquitination at posLast=317317
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP68 Gene

No data available for DME Specific Peptides for CEP68 Gene

Domains & Families for CEP68 Gene

Protein Domains for CEP68 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP68 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP68: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP68 Gene

Function for CEP68 Gene

Molecular function for CEP68 Gene

UniProtKB/Swiss-Prot Function:
Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:25503564).

Gene Ontology (GO) - Molecular Function for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019901 protein kinase binding IPI 24554434
GO:0019904 protein domain specific binding IPI 24554434
genes like me logo Genes that share ontologies with CEP68: view
genes like me logo Genes that share phenotypes with CEP68: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP68 Gene

Localization for CEP68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP68 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to thin fibers protruding away from the proximal ends of the two centrioles. Dissociates from interphase centrosomes at the onset of mitosis. {ECO:0000269 PubMed:18042621, ECO:0000269 PubMed:25503564, ECO:0000269 PubMed:25704143}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP68 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endosome 1

Gene Ontology (GO) - Cellular Components for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 18042621
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with CEP68: view

Pathways & Interactions for CEP68 Gene

SuperPathways for CEP68 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007098 centrosome cycle IMP 18042621
GO:0010457 centriole-centriole cohesion IMP 24554434
GO:0033365 protein localization to organelle IMP 24554434
GO:0051297 centrosome organization IMP --
genes like me logo Genes that share ontologies with CEP68: view

No data available for Pathways by source and SIGNOR curated interactions for CEP68 Gene

Drugs & Compounds for CEP68 Gene

(1) Drugs for CEP68 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1152
genes like me logo Genes that share compounds with CEP68: view

Transcripts for CEP68 Gene

Unigene Clusters for CEP68 Gene

Centrosomal protein 68kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP68 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -

Relevant External Links for CEP68 Gene

GeneLoc Exon Structure for
CEP68
ECgene alternative splicing isoforms for
CEP68

Expression for CEP68 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP68 Gene

Protein differential expression in normal tissues from HIPED for CEP68 Gene

This gene is overexpressed in CD8 Tcells (30.6), Testis (20.6), and Fetal ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP68 Gene



Protein tissue co-expression partners for CEP68 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP68 Gene:

CEP68

SOURCE GeneReport for Unigene cluster for CEP68 Gene:

Hs.709257

Evidence on tissue expression from TISSUES for CEP68 Gene

  • Nervous system(4.8)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CEP68: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP68 Gene

Orthologs for CEP68 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP68 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP68 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia CEP68 34 35
  • 77.55 (n)
cow
(Bos Taurus)
Mammalia CEP68 34 35
  • 77.53 (n)
rat
(Rattus norvegicus)
Mammalia Cep68 34
  • 75.25 (n)
mouse
(Mus musculus)
Mammalia Cep68 34 16 35
  • 74.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP68 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP68 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP68 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP68 35
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cep68 35
  • 22 (a)
OneToOne
Species where no ortholog for CEP68 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP68 Gene

ENSEMBL:
Gene Tree for CEP68 (if available)
TreeFam:
Gene Tree for CEP68 (if available)

Paralogs for CEP68 Gene

Paralogs for CEP68 Gene

(1) SIMAP similar genes for CEP68 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP68: view

Variants for CEP68 Gene

Sequence variations from dbSNP and Humsavar for CEP68 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000215502 -- 65,066,101(+) GGCAC(A/G)CTCAC intron-variant
rs1000421607 -- 65,069,310(+) CAAAA(A/G)TATGT intron-variant
rs1000535970 -- 65,070,175(+) GGAGT(A/G)TCCAG intron-variant
rs1000639279 -- 65,087,299(+) CAATT(A/G)TCATT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000710044 -- 65,081,311(+) CTCTG(C/G)CAACT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEP68 Gene

Variant ID Type Subtype PubMed ID
esv2666088 CNV deletion 23128226
esv2674666 CNV deletion 23128226
esv3591092 CNV loss 21293372
esv3591093 CNV loss 21293372
nsv834246 CNV loss 17160897

Variation tolerance for CEP68 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.22; 84.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP68 Gene

Human Gene Mutation Database (HGMD)
CEP68
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP68

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP68 Gene

Disorders for CEP68 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CEP68 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 28
  • rp28
- elite association - COSMIC cancer census association via MalaCards
Search CEP68 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEP68

Genetic Association Database (GAD)
CEP68
Human Genome Epidemiology (HuGE) Navigator
CEP68
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP68
genes like me logo Genes that share disorders with CEP68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEP68 Gene

Publications for CEP68 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. (PMID: 25503564) Pagan J.K. … Pagano M. (Nat. Cell Biol. 2015) 3 4 64
  4. Cep68 can be regulated by Nek2 and SCF complex. (PMID: 25704143) Man X. … Lim Y.P. (Eur. J. Cell Biol. 2015) 3 4 64
  5. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. (PMID: 24554434) Fang G. … Yuan L. (J. Cell. Sci. 2014) 3 4 64

Products for CEP68 Gene

Sources for CEP68 Gene

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