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Aliases for CLCC1 Gene

Aliases for CLCC1 Gene

  • Chloride Channel CLIC Like 1 2 3 5
  • Mid-1-Related Chloride Channel Protein 1 3 4
  • MCLC 3 4
  • Mid1-Related Chloride Channel (Yeast) 2
  • Chloride Channel CLIC-Like Protein 1 3
  • Chloride Channel CLIC-Like 1 2
  • KIAA0761 4

External Ids for CLCC1 Gene

Previous GeneCards Identifiers for CLCC1 Gene

  • GC01M109185
  • GC01M108820
  • GC01M109472
  • GC01M107364

Summaries for CLCC1 Gene

GeneCards Summary for CLCC1 Gene

CLCC1 (Chloride Channel CLIC Like 1) is a Protein Coding gene. GO annotations related to this gene include chloride channel activity.

UniProtKB/Swiss-Prot for CLCC1 Gene

  • Seems to act as a chloride ion channel.

Gene Wiki entry for CLCC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCC1 Gene

Genomics for CLCC1 Gene

Regulatory Elements for CLCC1 Gene

Enhancers for CLCC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G108875 1.4 Ensembl ENCODE 6.4 +85.6 85614 3.9 HNRNPUL1 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 RPL17P7 PRPF38B RPS27P6 SPATA42 CLCC1 GPSM2 GC01P108959
GH01G108851 1 Ensembl ENCODE 5.7 +111.2 111231 1.9 HDGF BCOR ATF1 ZMYM3 CEBPG ZNF384 FOSL1 ZNF121 NR2F6 NFE2 SPATA42 CLCC1 GPSM2 GC01M108838
GH01G108925 0.5 FANTOM5 7.9 +38.0 37984 0.7 EZH2 AKNAD1 CLCC1 GPSM2 SORT1 WDR47 CELSR2 PSRC1 GC01P108959
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLCC1 on UCSC Golden Path with GeneCards custom track

Promoters for CLCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CLCC1 Gene

108,929,508 bp from pter
108,963,499 bp from pter
33,992 bases
Minus strand

Genomic View for CLCC1 Gene

Genes around CLCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCC1 Gene

Proteins for CLCC1 Gene

  • Protein details for CLCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chloride channel CLIC-like protein 1
    Protein Accession:
    Secondary Accessions:
    • O94861
    • Q8WYP8
    • Q8WYP9
    • Q9BU25

    Protein attributes for CLCC1 Gene

    551 amino acids
    Molecular mass:
    62023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCC1 Gene


neXtProt entry for CLCC1 Gene

Post-translational modifications for CLCC1 Gene

  • Ubiquitination at Lys414
  • Glycosylation at Thr407 and posLast=474474
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLCC1 Gene

Domains & Families for CLCC1 Gene

Protein Domains for CLCC1 Gene


Suggested Antigen Peptide Sequences for CLCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chloride channel MCLC family.
  • Belongs to the chloride channel MCLC family.
genes like me logo Genes that share domains with CLCC1: view

No data available for Gene Families for CLCC1 Gene

Function for CLCC1 Gene

Molecular function for CLCC1 Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a chloride ion channel.

Gene Ontology (GO) - Molecular Function for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with CLCC1: view
genes like me logo Genes that share phenotypes with CLCC1: view

Animal Model Products

CRISPR Products

miRNA for CLCC1 Gene

miRTarBase miRNAs that target CLCC1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLCC1 Gene

Localization for CLCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCC1 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLCC1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
golgi apparatus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLCC1: view

Pathways & Interactions for CLCC1 Gene

SuperPathways for CLCC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport IEA --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLCC1: view

No data available for Pathways by source and SIGNOR curated interactions for CLCC1 Gene

Drugs & Compounds for CLCC1 Gene

(1) Additional Compounds for CLCC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with CLCC1: view

Transcripts for CLCC1 Gene

Unigene Clusters for CLCC1 Gene

Chloride channel CLIC-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLCC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP4: -
SP6: - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CLCC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLCC1 Gene

Protein differential expression in normal tissues from HIPED for CLCC1 Gene

This gene is overexpressed in Breast (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLCC1 Gene

Protein tissue co-expression partners for CLCC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLCC1 Gene:


SOURCE GeneReport for Unigene cluster for CLCC1 Gene:


Evidence on tissue expression from TISSUES for CLCC1 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CLCC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLCC1 Gene

Orthologs for CLCC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLCC1 34 35
  • 99.4 (n)
(Bos Taurus)
Mammalia CLCC1 34 35
  • 87.64 (n)
(Canis familiaris)
Mammalia CLCC1 34 35
  • 87.44 (n)
(Rattus norvegicus)
Mammalia Clcc1 34
  • 80.96 (n)
(Mus musculus)
Mammalia Clcc1 34 16 35
  • 79.85 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
-- 35
  • 60 (a)
(Gallus gallus)
Aves CLCC1 34 35
  • 65.24 (n)
(Anolis carolinensis)
Reptilia CLCC1 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clcc1 34
  • 59.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397947 34
(Danio rerio)
Actinopterygii LOC100332460 34
  • 52.14 (n)
CLCC1 35
  • 35 (a)
Species where no ortholog for CLCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCC1 Gene

Gene Tree for CLCC1 (if available)
Gene Tree for CLCC1 (if available)

Paralogs for CLCC1 Gene

No data available for Paralogs for CLCC1 Gene

Variants for CLCC1 Gene

Sequence variations from dbSNP and Humsavar for CLCC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1051868 Likely benign 108,930,151(+) TCATC(A/G)TCTGT intron-variant, utr-variant-3-prime
rs10607 Likely benign 108,930,395(-) TTTTA(A/G)TAAGA intron-variant, utr-variant-3-prime
rs12030 Likely benign 108,930,191(-) ATCTC(A/G)CAAGC intron-variant, utr-variant-3-prime
rs142663817 Uncertain significance 108,929,925(+) AAAAA(A/G)TCGGC reference, synonymous-codon, utr-variant-3-prime
rs189033496 Uncertain significance 108,929,794(+) TTTTA(C/T)GGTCC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLCC1 Gene

Variant ID Type Subtype PubMed ID
dgv15n21 CNV gain 19592680
dgv251n100 CNV loss 25217958
esv2421924 CNV deletion 20811451
esv24963 CNV loss 19812545
esv2662481 CNV deletion 23128226
esv2715940 CNV deletion 23290073
esv2760082 CNV loss 21179565
esv3567237 CNV deletion 23714750
esv3587142 CNV loss 21293372
esv3587143 CNV loss 21293372
nsv1137793 CNV deletion 24896259
nsv437236 CNV loss 16327808
nsv441708 CNV loss 18776908
nsv514000 CNV loss 21397061
nsv526049 CNV loss 19592680
nsv547425 CNV gain 21841781
nsv831026 CNV loss 17160897

Variation tolerance for CLCC1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCC1 Gene

Disorders for CLCC1 Gene

Relevant External Links for CLCC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLCC1 Gene

Publications for CLCC1 Gene

  1. Identification of a novel chloride channel expressed in the endoplasmic reticulum, Golgi apparatus, and nucleus. (PMID: 11279057) Nagasawa M. … Kojima I. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban H.J. … Park K.J. (BMC Genet. 2010) 3 46 64
  4. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64
  5. KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation. (PMID: 25582440) Hong J.H. … Raught B. (Mol. Cell Proteomics 2015) 3 64

Products for CLCC1 Gene

Sources for CLCC1 Gene

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