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Aliases for CLCC1 Gene

Aliases for CLCC1 Gene

  • Chloride Channel CLIC Like 1 2 3 5
  • Mid-1-Related Chloride Channel Protein 1 3 4
  • MCLC 3 4
  • Mid1-Related Chloride Channel (Yeast) 2
  • Chloride Channel CLIC-Like Protein 1 3
  • Chloride Channel CLIC-Like 1 2
  • KIAA0761 4

External Ids for CLCC1 Gene

Previous GeneCards Identifiers for CLCC1 Gene

  • GC01M109185
  • GC01M108820
  • GC01M109472
  • GC01M107364

Summaries for CLCC1 Gene

GeneCards Summary for CLCC1 Gene

CLCC1 (Chloride Channel CLIC Like 1) is a Protein Coding gene. GO annotations related to this gene include chloride channel activity.

UniProtKB/Swiss-Prot for CLCC1 Gene

  • Seems to act as a chloride ion channel.

Gene Wiki entry for CLCC1 Gene

Additional gene information for CLCC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLCC1 Gene

Genomics for CLCC1 Gene

Regulatory Elements for CLCC1 Gene

Enhancers for CLCC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H109482 1.2 ENCODE 36.7 -520.6 -520605 2.3 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZFP41 ENSG00000258634 RPL17P7 PRPF38B STRIP1 SYPL2 CLCC1 RPS27P6 ENSG00000273373 GSTM2 RBM15
GH01H108048 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +912.1 912114 5.2 SIX4 CTCF FOXA2 JUN FEZF1 ZNF384 RAD21 ZFHX2 ZNF547 NR2F6 ENSG00000226822 VAV3 VAV3-AS1 CLCC1 GC01M108027 PIR34712
GH01H109132 1.5 Ensembl ENCODE dbSUPER 12.1 -172.8 -172766 7.4 PKNOX1 ATF1 ARNT ARID4B FEZF1 TCF12 ZNF766 GATA2 ELK1 NCOA1 TMEM167B ENSG00000258634 CLCC1 SARS SORT1 C1orf194 KIAA1324 GPSM2 GC01M109207
GH01H108745 1.2 ENCODE 14.9 +216.2 216244 3.1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZNF610 ZNF585B NBN PRPF38B CLCC1 RPL17P7 STXBP3 GC01M108761
GH01H109112 1 ENCODE 17 -150.1 -150071 2.5 PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZNF766 GATA2 ZNF207 ZNF143 ATF7 C1orf194 CLCC1 RPL17P7 GSTM2 KIAA1324 LOC100420092
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CLCC1 on UCSC Golden Path with GeneCards custom track

Promoters for CLCC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CLCC1 Gene

Genomic Locations for CLCC1 Gene
33,992 bases
Minus strand

Genomic View for CLCC1 Gene

Genes around CLCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLCC1 Gene

Proteins for CLCC1 Gene

  • Protein details for CLCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chloride channel CLIC-like protein 1
    Protein Accession:
    Secondary Accessions:
    • O94861
    • Q8WYP8
    • Q8WYP9
    • Q9BU25

    Protein attributes for CLCC1 Gene

    551 amino acids
    Molecular mass:
    62023 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CLCC1 Gene


neXtProt entry for CLCC1 Gene

Post-translational modifications for CLCC1 Gene

  • Ubiquitination at posLast=414414
  • Glycosylation at Thr407 and Thr474
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CLCC1 Gene

Domains & Families for CLCC1 Gene

Gene Families for CLCC1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for CLCC1 Gene


Suggested Antigen Peptide Sequences for CLCC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chloride channel MCLC family.
  • Belongs to the chloride channel MCLC family.
genes like me logo Genes that share domains with CLCC1: view

Function for CLCC1 Gene

Molecular function for CLCC1 Gene

UniProtKB/Swiss-Prot Function:
Seems to act as a chloride ion channel.

Phenotypes From GWAS Catalog for CLCC1 Gene

Gene Ontology (GO) - Molecular Function for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity IEA --
genes like me logo Genes that share ontologies with CLCC1: view
genes like me logo Genes that share phenotypes with CLCC1: view

Animal Model Products

CRISPR Products

miRNA for CLCC1 Gene

miRTarBase miRNAs that target CLCC1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CLCC1 Gene

Localization for CLCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLCC1 Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CLCC1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
golgi apparatus 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CLCC1: view

Pathways & Interactions for CLCC1 Gene

SuperPathways for CLCC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CLCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport IEA --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with CLCC1: view

No data available for Pathways by source and SIGNOR curated interactions for CLCC1 Gene

Drugs & Compounds for CLCC1 Gene

(1) Additional Compounds for CLCC1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with CLCC1: view

Transcripts for CLCC1 Gene

Unigene Clusters for CLCC1 Gene

Chloride channel CLIC-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CLCC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP2: - - -
SP4: -
SP6: - -
SP7: - - - -
SP8: - - - -

Relevant External Links for CLCC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CLCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CLCC1 Gene

Protein differential expression in normal tissues from HIPED for CLCC1 Gene

This gene is overexpressed in Breast (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CLCC1 Gene

Protein tissue co-expression partners for CLCC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CLCC1 Gene:


SOURCE GeneReport for Unigene cluster for CLCC1 Gene:


Evidence on tissue expression from TISSUES for CLCC1 Gene

  • Nervous system(4.4)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CLCC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CLCC1 Gene

Orthologs for CLCC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CLCC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLCC1 33 34
  • 99.4 (n)
(Bos Taurus)
Mammalia CLCC1 33 34
  • 87.64 (n)
(Canis familiaris)
Mammalia CLCC1 33 34
  • 87.44 (n)
(Rattus norvegicus)
Mammalia Clcc1 33
  • 80.96 (n)
(Mus musculus)
Mammalia Clcc1 33 16 34
  • 79.85 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
-- 34
  • 60 (a)
(Gallus gallus)
Aves CLCC1 33 34
  • 65.24 (n)
(Anolis carolinensis)
Reptilia CLCC1 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia clcc1 33
  • 59.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397947 33
(Danio rerio)
Actinopterygii LOC100332460 33
  • 52.14 (n)
CLCC1 34
  • 35 (a)
Species where no ortholog for CLCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLCC1 Gene

Gene Tree for CLCC1 (if available)
Gene Tree for CLCC1 (if available)

Paralogs for CLCC1 Gene

No data available for Paralogs for CLCC1 Gene

Variants for CLCC1 Gene

Sequence variations from dbSNP and Humsavar for CLCC1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1051868 Likely benign 108,930,151(+) TCATC(A/G)TCTGT intron-variant, utr-variant-3-prime
rs10607 Likely benign 108,930,395(-) TTTTA(A/G)TAAGA intron-variant, utr-variant-3-prime
rs12030 Likely benign 108,930,191(-) ATCTC(A/G)CAAGC intron-variant, utr-variant-3-prime
rs142663817 Uncertain significance 108,929,925(+) AAAAA(A/G)TCGGC reference, synonymous-codon, utr-variant-3-prime
rs189033496 Uncertain significance 108,929,794(+) TTTTA(C/T)GGTCC reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CLCC1 Gene

Variant ID Type Subtype PubMed ID
nsv831026 CNV loss 17160897
nsv547425 CNV gain 21841781
nsv526049 CNV loss 19592680
nsv514000 CNV loss 21397061
nsv441708 CNV loss 18776908
nsv437236 CNV loss 16327808
nsv1137793 CNV deletion 24896259
esv3587143 CNV loss 21293372
esv3587142 CNV loss 21293372
esv3567237 CNV deletion 23714750
esv2760082 CNV loss 21179565
esv2715940 CNV deletion 23290073
esv2662481 CNV deletion 23128226
esv24963 CNV loss 19812545
esv2421924 CNV deletion 20811451
dgv251n100 CNV loss 25217958
dgv15n21 CNV gain 19592680

Variation tolerance for CLCC1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.51; 77.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLCC1 Gene

Disorders for CLCC1 Gene

Relevant External Links for CLCC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CLCC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CLCC1 Gene

Publications for CLCC1 Gene

  1. Identification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus. (PMID: 11279057) Nagasawa M … Kojima I (The Journal of biological chemistry 2001) 2 3 4 22 60
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  3. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 45 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L … Hanemann CO (Oncogene 2016) 3 60

Products for CLCC1 Gene

Sources for CLCC1 Gene

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