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Aliases for SSPO Gene

Aliases for SSPO Gene

  • SCO-Spondin 2 3 5
  • Thrombospondin Domain Containing 2
  • SCO-Spondin Homolog (Bos Taurus) 2
  • Subcommissural Organ Spondin 2
  • EC 3.4.24.82 63
  • SCO Protein 2
  • EC 3.4.21.9 63
  • KIAA2036 4

External Ids for SSPO Gene

Previous GeneCards Identifiers for SSPO Gene

  • GC07P148912
  • GC07P149143
  • GC07P149108
  • GC07P149473
  • GC07P143550

Summaries for SSPO Gene

GeneCards Summary for SSPO Gene

SSPO (SCO-Spondin) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is OTOG.

UniProtKB/Swiss-Prot for SSPO Gene

  • Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Gene Wiki entry for SSPO Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSPO Gene

Genomics for SSPO Gene

Regulatory Elements for SSPO Gene

Genomic Location for SSPO Gene

Chromosome:
7
Start:
149,776,042 bp from pter
End:
149,833,979 bp from pter
Size:
57,938 bases
Orientation:
Plus strand

Genomic View for SSPO Gene

Genes around SSPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSPO Gene

Proteins for SSPO Gene

  • Protein details for SSPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VEC9-SSPO_HUMAN
    Recommended name:
    SCO-spondin
    Protein Accession:
    A2VEC9
    Secondary Accessions:
    • Q76B61

    Protein attributes for SSPO Gene

    Size:
    5147 amino acids
    Molecular mass:
    547504 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC98376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSPO Gene

Proteomics data for SSPO Gene at MOPED

Selected DME Specific Peptides for SSPO Gene

Post-translational modifications for SSPO Gene

  • Glycosylation at Asn 88, Asn 130, Asn 261, Asn 514, Asn 819, Asn 911, Asn 944, Asn 986, Asn 1352, Asn 1650, Asn 1663, Asn 1809, Asn 1993, Asn 2030, Asn 2133, Asn 2645, Asn 2694, Asn 2936, Asn 2967, Asn 3062, Asn 3116, Asn 3163, Asn 3173, Asn 3310, Asn 3399, Asn 3512, Asn 3522, Asn 3599, Asn 3626, Asn 3792, Asn 3914, Asn 3946, Asn 4139, Asn 4346, Asn 4417, Asn 4731, Asn 4748, Asn 4753, Asn 4863, Asn 4903, Asn 4948, Asn 4955, and Asn 5061
  • Modification sites at PhosphoSitePlus

Other Protein References for SSPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SSPO Gene

Suggested Antigen Peptide Sequences for SSPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2VEC9

UniProtKB/Swiss-Prot:

SSPO_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the thrombospondin family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 2 EGF-like domains.
  • Contains 1 EMI domain.
  • Contains 1 F5/8 type C domain.
  • Contains 10 LDL-receptor class A domains.
  • Contains 6 TIL (trypsin inhibitory-like) domains.
  • Contains 24 TSP type-1 domains.
  • Contains 3 VWFC domains.
  • Contains 3 VWFD domains.
Family:
  • Belongs to the thrombospondin family.
genes like me logo Genes that share domains with SSPO: view

No data available for Gene Families for SSPO Gene

Function for SSPO Gene

Molecular function for SSPO Gene

UniProtKB/Swiss-Prot Function:
Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Enzyme Numbers (IUBMB) for SSPO Gene

genes like me logo Genes that share phenotypes with SSPO: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSPO

miRNA for SSPO Gene

miRTarBase miRNAs that target SSPO

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSPO Gene

Localization for SSPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSPO Gene

Secreted, extracellular space.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SSPO Gene

Pathways & Interactions for SSPO Gene

genes like me logo Genes that share pathways with SSPO: view

Interacting Proteins for SSPO Gene

Selected Interacting proteins: A2VEC9-SSPO_HUMAN for SSPO Gene via I2D

Gene Ontology (GO) - Biological Process for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IEA --
genes like me logo Genes that share ontologies with SSPO: view

No data available for SIGNOR curated interactions for SSPO Gene

Drugs & Compounds for SSPO Gene

No Compound Related Data Available

Transcripts for SSPO Gene

Unigene Clusters for SSPO Gene

SCO-spondin homolog (Bos taurus):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSPO Gene

No ASD Table

Relevant External Links for SSPO Gene

GeneLoc Exon Structure for
SSPO
ECgene alternative splicing isoforms for
SSPO

Expression for SSPO Gene

mRNA expression in normal human tissues for SSPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSPO Gene

This gene is overexpressed in Brain - Cerebellum (x5.9) and Brain - Cerebellar Hemisphere (x5.0).

Protein differential expression in normal tissues from HIPED for SSPO Gene

This gene is overexpressed in Colon (46.8), Platelet (15.7), and Stomach (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSPO Gene



SOURCE GeneReport for Unigene cluster for SSPO Gene Hs.632022

genes like me logo Genes that share expression patterns with SSPO: view

Protein tissue co-expression partners for SSPO Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SSPO Gene

Orthologs for SSPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSPO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSPO 35
  • 83.47 (n)
  • 80.15 (a)
dog
(Canis familiaris)
Mammalia SSPO 35
  • 83.67 (n)
  • 79.54 (a)
mouse
(Mus musculus)
Mammalia Sspo 35
  • 79.5 (n)
  • 76.18 (a)
Sspo 16
chimpanzee
(Pan troglodytes)
Mammalia SSPO 35
  • 98.44 (n)
  • 97.16 (a)
rat
(Rattus norvegicus)
Mammalia Sspo 35
  • 79.55 (n)
  • 76.45 (a)
chicken
(Gallus gallus)
Aves SSPO 35
  • 62.54 (n)
  • 53.89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497129 35
  • 57.42 (n)
  • 51.73 (a)
zebrafish
(Danio rerio)
Actinopterygii scospondin 35
  • 52.3 (n)
  • 44.44 (a)
Species with no ortholog for SSPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSPO Gene

ENSEMBL:
Gene Tree for SSPO (if available)
TreeFam:
Gene Tree for SSPO (if available)

Paralogs for SSPO Gene

Paralogs for SSPO Gene

(1) SIMAP similar genes for SSPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSPO: view

Variants for SSPO Gene

Sequence variations from dbSNP and Humsavar for SSPO Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_052660 -
rs17754559 - 149,778,837(+) GGGTC(A/G)TGGTG reference, missense
rs709060 -, - 149,787,971(-) CTCAC(A/G)GCAGA reference, missense
rs855677 - 149,780,456(-) GCGCA(C/T)GGTGT reference, missense
rs855691 - 149,789,206(-) GGAGC(C/T)GCAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SSPO Gene

Variant ID Type Subtype PubMed ID
nsv469576 CNV Complex 16826518
nsv831184 CNV Gain 17160897
dgv2151e1 CNV Complex 17122850
dgv844n27 CNV Loss 19166990
dgv7529n71 CNV Loss 21882294
nsv517242 CNV Loss 19592680
dgv7530n71 CNV Loss 21882294
nsv521861 CNV Loss 19592680
nsv889409 CNV Loss 21882294
esv1010383 CNV Deletion 20482838
nsv824389 CNV Gain 20364138
esv1058616 CNV Deletion 17803354
esv2735334 CNV Deletion 23290073

Relevant External Links for SSPO Gene

HapMap Linkage Disequilibrium report
SSPO
Human Gene Mutation Database (HGMD)
SSPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSPO Gene

Disorders for SSPO Gene

Relevant External Links for SSPO

Genetic Association Database (GAD)
SSPO
Human Genome Epidemiology (HuGE) Navigator
SSPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSPO

No disorders were found for SSPO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSPO Gene

Publications for SSPO Gene

  1. Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. (PMID: 11008217) Gobron S. … Meiniel A. (Glia 2000) 2 3 23 67
  2. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. (PMID: 17126404) Meiniel O. … Meiniel A. (Brain Res. Brain Res. Rev. 2007) 3 23
  3. Placental expression of SCO-spondin during mouse and human development. (PMID: 15053980) GonAsalves-Mendes N. … Sapin V. (Gene Expr. Patterns 2004) 3 23
  4. The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. (PMID: 14692680) Meiniel A. … Dastugue B. (Int. Rev. Cytol. 2003) 3 23
  5. SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. (PMID: 8743952) Gobron S. … Meiniel A. (J. Cell. Sci. 1996) 2 3

Products for SSPO Gene

Sources for SSPO Gene

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