Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSPO Gene

Aliases for SSPO Gene

  • SCO-Spondin 2 3 3 5
  • SCO Protein, Thrombospondin Domain Containing 2 3
  • SCO-Spondin Homolog (Bos Taurus) 2 3
  • Subcommissural Organ Spondin 2 3
  • EC 3.4.24.82 61
  • EC 3.4.21.9 61
  • KIAA2036 4

External Ids for SSPO Gene

Previous GeneCards Identifiers for SSPO Gene

  • GC07P148912
  • GC07P149143
  • GC07P149108
  • GC07P149473
  • GC07P143550

Summaries for SSPO Gene

GeneCards Summary for SSPO Gene

SSPO (SCO-Spondin) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Diseases of glycosylation. GO annotations related to this gene include peptidase inhibitor activity. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot for SSPO Gene

  • Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Gene Wiki entry for SSPO Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSPO Gene

Genomics for SSPO Gene

Regulatory Elements for SSPO Gene

Enhancers for SSPO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G149883 1.2 Ensembl ENCODE 18.5 +108.7 108653 3.4 FOXA2 CBX3 RB1 ZFP64 ARID4B DMAP1 ZNF2 RAD21 YY1 GATA2 ATP6V0E2 ATP6V0E2-AS1 SSPO ZNF862 ENSG00000273011 PIR51338
GH07G149771 1.3 FANTOM5 ENCODE 16.8 -3.2 -3163 3.5 PKNOX1 ARNT SIN3A ZBTB7B ZNF766 ZNF263 SP3 ZNF610 SMARCA4 GLIS1 SSPO ZNF467 ATP6V0E2 GC07M149505 GC07P149773
GH07G149863 1.4 Ensembl ENCODE dbSUPER 12.2 +91.9 91857 8.1 PKNOX1 ZNF133 TCF12 ZNF766 IKZF2 KLF13 ZNF263 CAVIN1 HDAC8 ZNF592 ATP6V0E2 ATP6V0E2-AS1 ZNF862 SSPO ENSG00000273011 PIR59309
GH07G149837 1.1 ENCODE 15.3 +62.5 62530 1.8 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 SSPO ZNF862 ENSG00000280149
GH07G149718 1.3 ENCODE dbSUPER 11.7 -56.2 -56219 2.2 HDGF PKNOX1 CREB3L1 ARNT ZNF2 CBX5 ZNF302 FOS SP3 JUNB SSPO ZNF862 GC07M149707 GC07M149505
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSPO on UCSC Golden Path with GeneCards custom track

Genomic Location for SSPO Gene

Chromosome:
7
Start:
149,776,042 bp from pter
End:
149,833,979 bp from pter
Size:
57,938 bases
Orientation:
Plus strand

Genomic View for SSPO Gene

Genes around SSPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSPO Gene

Proteins for SSPO Gene

  • Protein details for SSPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VEC9-SSPO_HUMAN
    Recommended name:
    SCO-spondin
    Protein Accession:
    A2VEC9
    Secondary Accessions:
    • Q76B61

    Protein attributes for SSPO Gene

    Size:
    5147 amino acids
    Molecular mass:
    547504 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC98376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSPO Gene

Selected DME Specific Peptides for SSPO Gene

A2VEC9:
  • CPDGSDE
  • CSRSCGGG

Post-translational modifications for SSPO Gene

  • Glycosylation at posLast=8888, posLast=130130, isoforms=261, Asn514, Asn819, posLast=911911, Asn944, Asn986, Asn1352, Asn1650, Asn1663, posLast=18091809, posLast=19931993, Asn2030, isoforms=22133, Asn2645, Asn2694, isoforms=2936, posLast=29672967, posLast=30623062, posLast=31163116, posLast=31633163, Asn3173, posLast=33103310, isoforms=3399, Asn3512, Asn3522, posLast=35993599, Asn3626, Asn3792, posLast=39143914, isoforms=3946, posLast=41394139, Asn4346, Asn4417, Asn4731, Asn4748, isoforms=4753, Asn4863, isoforms=4903, isoforms=4948, posLast=49554955, and Asn5061
  • Modification sites at PhosphoSitePlus

Other Protein References for SSPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for SSPO Gene

Suggested Antigen Peptide Sequences for SSPO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2VEC9

UniProtKB/Swiss-Prot:

SSPO_HUMAN :
  • Belongs to the thrombospondin family.
Family:
  • Belongs to the thrombospondin family.
genes like me logo Genes that share domains with SSPO: view

No data available for Gene Families for SSPO Gene

Function for SSPO Gene

Molecular function for SSPO Gene

UniProtKB/Swiss-Prot Function:
Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Enzyme Numbers (IUBMB) for SSPO Gene

Gene Ontology (GO) - Molecular Function for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SSPO: view
genes like me logo Genes that share phenotypes with SSPO: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSPO

miRNA for SSPO Gene

miRTarBase miRNAs that target SSPO

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSPO Gene

Localization for SSPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSPO Gene

Secreted, extracellular space.

Gene Ontology (GO) - Cellular Components for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 22261194
genes like me logo Genes that share ontologies with SSPO: view

No data available for Subcellular locations from COMPARTMENTS for SSPO Gene

Pathways & Interactions for SSPO Gene

genes like me logo Genes that share pathways with SSPO: view

Interacting Proteins for SSPO Gene

Selected Interacting proteins: A2VEC9-SSPO_HUMAN for SSPO Gene via IID

Gene Ontology (GO) - Biological Process for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SSPO: view

No data available for SIGNOR curated interactions for SSPO Gene

Transcripts for SSPO Gene

mRNA/cDNA for SSPO Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSPO Gene

SCO-spondin homolog (Bos taurus):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSPO Gene

No ASD Table

Relevant External Links for SSPO Gene

GeneLoc Exon Structure for
SSPO
ECgene alternative splicing isoforms for
SSPO

Expression for SSPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSPO Gene

This gene is overexpressed in Brain - Cerebellum (x5.9) and Brain - Cerebellar Hemisphere (x5.0).

Protein differential expression in normal tissues from HIPED for SSPO Gene

This gene is overexpressed in Colon (46.8), Platelet (15.7), and Stomach (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSPO Gene



Protein tissue co-expression partners for SSPO Gene

NURSA nuclear receptor signaling pathways regulating expression of SSPO Gene:

SSPO

SOURCE GeneReport for Unigene cluster for SSPO Gene:

Hs.632022
genes like me logo Genes that share expression patterns with SSPO: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSPO Gene

Orthologs for SSPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSPO 34
  • 98.44 (n)
dog
(Canis familiaris)
Mammalia SSPO 34
  • 83.67 (n)
cow
(Bos Taurus)
Mammalia SSPO 34
  • 83.47 (n)
rat
(Rattus norvegicus)
Mammalia Sspo 34
  • 79.55 (n)
mouse
(Mus musculus)
Mammalia Sspo 34 16
  • 79.5 (n)
chicken
(Gallus gallus)
Aves SSPO 34
  • 62.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497129 34
  • 57.42 (n)
zebrafish
(Danio rerio)
Actinopterygii scospondin 34
  • 52.3 (n)
Species where no ortholog for SSPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSPO Gene

ENSEMBL:
Gene Tree for SSPO (if available)
TreeFam:
Gene Tree for SSPO (if available)

Paralogs for SSPO Gene

Paralogs for SSPO Gene

(1) SIMAP similar genes for SSPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSPO: view

Variants for SSPO Gene

Sequence variations from dbSNP and Humsavar for SSPO Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000114805 -- 149,778,201(+) TGAAG(C/T)GCAGA intron-variant, upstream-variant-2KB
rs1000147266 -- 149,820,584(+) GTCCC(C/T)AGTAG intron-variant
rs1000205191 -- 149,814,229(+) CAATC(A/G)TAAGG intron-variant
rs1000257504 -- 149,784,583(+) GGACA(C/G)AAAGG intron-variant
rs1000325957 -- 149,804,829(+) CAGGA(C/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSPO Gene

Variant ID Type Subtype PubMed ID
dgv11714n54 CNV loss 21841781
dgv11715n54 CNV loss 21841781
dgv11716n54 CNV loss 21841781
dgv844n27 CNV loss 19166990
esv1010383 CNV deletion 20482838
esv1058616 CNV deletion 17803354
esv2735334 CNV deletion 23290073
esv2759571 CNV gain 17122850
esv3576480 CNV gain 25503493
esv3615438 CNV gain 21293372
nsv1033095 CNV gain 25217958
nsv469576 CNV loss 16826518
nsv517242 CNV loss 19592680
nsv521861 CNV loss 19592680
nsv608987 CNV loss 21841781
nsv824389 CNV gain 20364138
nsv831184 CNV gain 17160897
nsv951643 CNV deletion 24416366

Relevant External Links for SSPO Gene

Human Gene Mutation Database (HGMD)
SSPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSPO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SSPO Gene

Disorders for SSPO Gene

Relevant External Links for SSPO

Genetic Association Database (GAD)
SSPO
Human Genome Epidemiology (HuGE) Navigator
SSPO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSPO

No disorders were found for SSPO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSPO Gene

Publications for SSPO Gene

  1. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. (PMID: 17126404) Meiniel O. … Meiniel A. (Brain Res. Brain Res. Rev. 2007) 3 4 22 64
  2. Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. (PMID: 11008217) Gobron S. … Meiniel A. (Glia 2000) 2 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Placental expression of SCO-spondin during mouse and human development. (PMID: 15053980) GonAsalves-Mendes N. … Sapin V. (Gene Expr. Patterns 2004) 3 22 64
  5. The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. (PMID: 14692680) Meiniel A. … Dastugue B. (Int. Rev. Cytol. 2003) 3 22 64

Products for SSPO Gene

Sources for SSPO Gene

Content
Loading form....