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Aliases for MAST2 Gene

Aliases for MAST2 Gene

  • Microtubule Associated Serine/Threonine Kinase 2 2 3
  • MAST205 3 4 6
  • EC 2.7.11.1 4 64
  • KIAA0807 4 6
  • Microtubule Associated Testis Specific Serine/Threonine Protein Kinase 3
  • Microtubule-Associated Serine/Threonine-Protein Kinase 2 3
  • EC 2.7.11 64
  • MTSSK 3

External Ids for MAST2 Gene

Summaries for MAST2 Gene

GeneCards Summary for MAST2 Gene

MAST2 (Microtubule Associated Serine/Threonine Kinase 2) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and microtubule binding. An important paralog of this gene is MAST4.

UniProtKB/Swiss-Prot for MAST2 Gene

  • Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).

Gene Wiki entry for MAST2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAST2 Gene

Genomics for MAST2 Gene

Genomic Location for MAST2 Gene

Start:
45,786,987 bp from pter
End:
46,036,124 bp from pter
Size:
249,138 bases
Orientation:
Plus strand

Genomic View for MAST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAST2 Gene

Proteins for MAST2 Gene

  • Protein details for MAST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P0Q8-MAST2_HUMAN
    Recommended name:
    Microtubule-associated serine/threonine-protein kinase 2
    Protein Accession:
    Q6P0Q8
    Secondary Accessions:
    • O94899
    • Q5VT07
    • Q5VT08
    • Q7LGC4
    • Q8NDG1
    • Q96B94
    • Q9BYE8

    Protein attributes for MAST2 Gene

    Size:
    1798 amino acids
    Molecular mass:
    196436 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with CDHR2.
    SequenceCaution:
    • Sequence=AAH15816.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15816.2; Type=Frameshift; Positions=1114, 1387; Evidence={ECO:0000305}; Sequence=BAB40778.1; Type=Frameshift; Positions=1688; Evidence={ECO:0000305}; Sequence=CAH73245.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16563.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21706.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAST2 Gene

    Alternative splice isoforms for MAST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAST2 Gene

Proteomics data for MAST2 Gene at MOPED

Post-translational modifications for MAST2 Gene

  • Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MAST2 Gene

UniProtKB/Swiss-Prot:

MAST2_HUMAN
Domain:
  • Contains 1 AGC-kinase C-terminal domain.:
    • Q6P0Q8
  • Contains 1 PDZ (DHR) domain.:
    • Q6P0Q8
  • Contains 1 protein kinase domain.:
    • Q6P0Q8
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.:
    • Q6P0Q8
genes like me logo Genes that share domains with MAST2: view

Function for MAST2 Gene

Molecular function for MAST2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).

Enzyme Numbers (IUBMB) for MAST2 Gene

Gene Ontology (GO) - Molecular Function for MAST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12117771
genes like me logo Genes that share ontologies with MAST2: view

Phenotypes for MAST2 Gene

genes like me logo Genes that share phenotypes with MAST2: view

miRNA for MAST2 Gene

miRTarBase miRNAs that target MAST2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAST2 Gene

Localization for MAST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAST2 Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the sub-membranous area on interaction with CDHR2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAST2 Gene COMPARTMENTS Subcellular localization image for MAST2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0015630 microtubule cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAST2: view

Pathways for MAST2 Gene

SuperPathways for MAST2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0045075 regulation of interleukin-12 biosynthetic process ISS --
GO:0048515 spermatid differentiation ISS --
genes like me logo Genes that share ontologies with MAST2: view

No data available for Pathways by source for MAST2 Gene

Compounds for MAST2 Gene

(3) HMDB Compounds for MAST2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with MAST2: view

Transcripts for MAST2 Gene

Unigene Clusters for MAST2 Gene

Microtubule associated serine/threonine kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - - -
SP3: -
SP4: -
SP5:
SP6:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for MAST2 Gene

GeneLoc Exon Structure for
MAST2
ECgene alternative splicing isoforms for
MAST2

Expression for MAST2 Gene

mRNA expression in normal human tissues for MAST2 Gene

mRNA differential expression in normal tissues according to GTEx for MAST2 Gene

This gene is overexpressed in Muscle - Skeletal (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAST2 Gene

SOURCE GeneReport for Unigene cluster for MAST2 Gene Hs.319481

mRNA Expression by UniProt/SwissProt for MAST2 Gene

Q6P0Q8-MAST2_HUMAN
Tissue specificity: Abundant in the testis.
genes like me logo Genes that share expressions with MAST2: view

Orthologs for MAST2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAST2 36
  • 99.54 (n)
  • 99.75 (a)
MAST2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAST2 36
  • 88.41 (n)
  • 89.69 (a)
MAST2 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAST2 36
  • 89.14 (n)
  • 89.51 (a)
MAST2 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mast2 36
  • 86.09 (n)
  • 88.16 (a)
Mast2 16
Mast2 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MAST2 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mast2 36
  • 86.7 (n)
  • 88.64 (a)
chicken
(Gallus gallus)
Aves MAST2 36
  • 73.66 (n)
  • 82.24 (a)
MAST2 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAST2 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mast2 36
  • 71.39 (n)
  • 81.4 (a)
zebrafish
(Danio rerio)
Actinopterygii mast2 36
  • 71.35 (n)
  • 79.25 (a)
mast2 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6498 37
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-4 37
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPK1 37
  • 25 (a)
ManyToMany
KIN82 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToMany
Species with no ortholog for MAST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAST2 Gene

ENSEMBL:
Gene Tree for MAST2 (if available)
TreeFam:
Gene Tree for MAST2 (if available)

Paralogs for MAST2 Gene

Paralogs for MAST2 Gene

genes like me logo Genes that share paralogs with MAST2: view

Variants for MAST2 Gene

Sequence variations from dbSNP and Humsavar for MAST2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs785477 -- 46,024,982(+) atggc(A/G)gcaga intron-variant
rs785478 -- 46,025,963(-) GGGGG(A/G)CTAGA intron-variant
rs785479 -- 46,026,472(+) GGGGC(C/T)TAGAG intron-variant
rs785480 -- 46,026,492(+) AGGGT(C/G)TGCTA intron-variant
rs884111 -- 46,020,987(+) CATCA(G/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAST2 Gene

Variant ID Type Subtype PubMed ID
nsv871928 CNV Gain 21882294
nsv871233 CNV Gain 21882294
dgv218n71 CNV Gain 21882294
dgv219n71 CNV Loss 21882294
nsv870911 CNV Gain 21882294
nsv461417 CNV Gain 19166990
nsv524147 CNV Gain 19592680
nsv437479 CNV Loss 16327808
esv271472 CNV Insertion 20981092
nsv10139 CNV Gain 18304495
nsv829737 CNV Gain 17160897
esv2583928 CNV Deletion 19546169
esv1000231 CNV Deletion 20482838
esv2747885 CNV Deletion 23290073
esv5205 CNV Deletion 18987735
esv9144 CNV Loss 19470904
esv1778390 CNV Deletion 17803354
esv2663245 CNV Deletion 23128226
nsv522438 CNV Loss 19592680
esv2662133 CNV Deletion 23128226
nsv515934 CNV Loss 19592680

Relevant External Links for MAST2 Gene

HapMap Linkage Disequilibrium report
MAST2

Disorders for MAST2 Gene

(1) University of Copenhagen DISEASES for MAST2 Gene

Relevant External Links for MAST2

Genetic Association Database (GAD)
MAST2
genes like me logo Genes that share disorders with MAST2: view

No data available for UniProtKB/Swiss-Prot for MAST2 Gene

Publications for MAST2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Increased activity associated with the MAST205 protein kinase complex during mammalian spermiogenesis. (PMID: 8902215) Walden P.D. … Millette C.F. (Biol. Reprod. 1996) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. (PMID: 12117771) Okazaki N. … Koga H. (Carcinogenesis 2002) 3 4

Products for MAST2 Gene

Sources for MAST2 Gene

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