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Aliases for ARHGAP26 Gene

Aliases for ARHGAP26 Gene

  • Rho GTPase Activating Protein 26 2 3
  • GRAF 3 4 6
  • Oligophrenin-1-Like Protein 3 4
  • OPHN1L 3 4
  • GTPase Regulator Associated With Focal Adhesion Kinase Pp125(FAK) 3
  • GTPase Regulator Associated With The Focal Adhesion Kinase Pp125 2
  • GTPase Regulator Associated With Focal Adhesion Kinase 4
  • Rho-Type GTPase-Activating Protein 26 4
  • Rho GTPase-Activating Protein 26 3
  • KIAA0621 4
  • OPHN1L1 3
  • GRAF1 3

External Ids for ARHGAP26 Gene

Previous GeneCards Identifiers for ARHGAP26 Gene

  • GC05P142179
  • GC05P142130
  • GC05P137297

Summaries for ARHGAP26 Gene

Entrez Gene Summary for ARHGAP26 Gene

  • Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for ARHGAP26 Gene

ARHGAP26 (Rho GTPase Activating Protein 26) is a Protein Coding gene. Diseases associated with ARHGAP26 include leukemia, juvenile myelomonocytic. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include phospholipid binding. An important paralog of this gene is CHN1.

UniProtKB/Swiss-Prot for ARHGAP26 Gene

  • GTPase-activating protein for RHOA and CDC42

Gene Wiki entry for ARHGAP26 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGAP26 Gene

Genomics for ARHGAP26 Gene

Regulatory Elements for ARHGAP26 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGAP26 Gene

142,770,378 bp from pter
143,229,011 bp from pter
458,634 bases
Plus strand

Genomic View for ARHGAP26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGAP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGAP26 Gene

Proteins for ARHGAP26 Gene

  • Protein details for ARHGAP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho GTPase-activating protein 26
    Protein Accession:
    Secondary Accessions:
    • O75117
    • Q5D035
    • Q9BYS6
    • Q9BYS7
    • Q9UJ00

    Protein attributes for ARHGAP26 Gene

    814 amino acids
    Molecular mass:
    92235 Da
    Quaternary structure:
    • Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1.

    Three dimensional structures from OCA and Proteopedia for ARHGAP26 Gene

    Alternative splice isoforms for ARHGAP26 Gene


neXtProt entry for ARHGAP26 Gene

Proteomics data for ARHGAP26 Gene at MOPED

Post-translational modifications for ARHGAP26 Gene

  • Ubiquitination at Lys454
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARHGAP26 (ARHGAP26)

No data available for DME Specific Peptides for ARHGAP26 Gene

Domains for ARHGAP26 Gene

Gene Families for ARHGAP26 Gene

Suggested Antigen Peptide Sequences for ARHGAP26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PH domain.
  • Contains 1 PH domain.
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGAP26: view

Function for ARHGAP26 Gene

Molecular function for ARHGAP26 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for RHOA and CDC42

Gene Ontology (GO) - Molecular Function for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity NAS 10908648
GO:0005515 protein binding IPI 11432776
GO:0005543 phospholipid binding IDA 18954304
GO:0008093 cytoskeletal adaptor activity --
GO:0017124 SH3 domain binding --
genes like me logo Genes that share ontologies with ARHGAP26: view

Phenotypes for ARHGAP26 Gene

genes like me logo Genes that share phenotypes with ARHGAP26: view

Animal Model Products

CRISPR Products

miRNA for ARHGAP26 Gene

miRTarBase miRNAs that target ARHGAP26

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP26

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGAP26 Gene

Localization for ARHGAP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGAP26 Gene

Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ARHGAP26 Gene COMPARTMENTS Subcellular localization image for ARHGAP26 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with ARHGAP26: view

Pathways for ARHGAP26 Gene

genes like me logo Genes that share pathways with ARHGAP26: view

Pathways by source for ARHGAP26 Gene

1 Qiagen pathway for ARHGAP26 Gene
1 Cell Signaling Technology pathway for ARHGAP26 Gene
1 BioSystems pathway for ARHGAP26 Gene
3 Reactome pathways for ARHGAP26 Gene
1 GeneGo (Thomson Reuters) pathway for ARHGAP26 Gene

Gene Ontology (GO) - Biological Process for ARHGAP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007009 plasma membrane organization IEA --
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007399 nervous system development NAS 9582072
GO:0030036 actin cytoskeleton organization NAS 11998687
genes like me logo Genes that share ontologies with ARHGAP26: view

Drugs for ARHGAP26 Gene

(1) ApexBio Compounds for ARHGAP26 Gene

Compound Action Cas Number
HJC 0350 [885434-70-8]
genes like me logo Genes that share compounds with ARHGAP26: view

Transcripts for ARHGAP26 Gene

Unigene Clusters for ARHGAP26 Gene

Rho GTPase activating protein 26:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGAP26

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGAP26 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ·
SP1: - - - -
SP2: - -

ExUns: 23c ^ 24
SP1: -

Relevant External Links for ARHGAP26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGAP26 Gene

mRNA expression in normal human tissues for ARHGAP26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGAP26 Gene

This gene is overexpressed in Whole Blood (8.3).

Protein differential expression in normal tissues for ARHGAP26 Gene

This gene is overexpressed in Frontal cortex (16.3), Breast (13.8), and Cerebrospinal fluid (13.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGAP26 Gene

SOURCE GeneReport for Unigene cluster for ARHGAP26 Gene Hs.654668

genes like me logo Genes that share expressions with ARHGAP26: view

Expression partners for ARHGAP26 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGAP26 Gene

Orthologs for ARHGAP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGAP26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGAP26 35
  • 93.86 (n)
  • 98.16 (a)
  • 98 (a)
(Canis familiaris)
Mammalia ARHGAP26 35
  • 94.31 (n)
  • 97.91 (a)
  • 98 (a)
(Mus musculus)
Mammalia Arhgap26 35
  • 90.95 (n)
  • 96.93 (a)
Arhgap26 16
Arhgap26 36
  • 97 (a)
(Pan troglodytes)
Mammalia ARHGAP26 35
  • 99.63 (n)
  • 99.39 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Arhgap26 35
  • 90.65 (n)
  • 96.93 (a)
(Monodelphis domestica)
Mammalia ARHGAP26 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGAP26 36
  • 93 (a)
(Gallus gallus)
Aves ARHGAP26 35
  • 81.14 (n)
  • 90.93 (a)
  • 93 (a)
(Anolis carolinensis)
Reptilia ARHGAP26 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgap26 35
  • 73.99 (n)
  • 82.04 (a)
(Danio rerio)
Actinopterygii arhgap42a 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013143 35
  • 51.58 (n)
  • 46.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Graf 35
  • 52.74 (n)
  • 47.16 (a)
Graf 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea T04C9.1 35
  • 53.57 (n)
  • 47.07 (a)
T04C9.1 36
  • 35 (a)
Species with no ortholog for ARHGAP26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGAP26 Gene

Gene Tree for ARHGAP26 (if available)
Gene Tree for ARHGAP26 (if available)

Paralogs for ARHGAP26 Gene Pseudogenes for ARHGAP26 Gene

genes like me logo Genes that share paralogs with ARHGAP26: view

Variants for ARHGAP26 Gene

Sequence variations from dbSNP and Humsavar for ARHGAP26 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs712178 -- 142,939,736(-) TTCCA(A/G)TTTGA intron-variant
rs712180 -- 142,950,342(+) ATTAG(C/T)GTATA intron-variant
rs712181 -- 142,955,770(-) AACCG(A/G)TCATT intron-variant
rs712177 -- 142,931,944(-) TGCTA(A/G)GGTTA intron-variant
rs712176 -- 142,931,877(-) AAGGA(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGAP26 Gene

Variant ID Type Subtype PubMed ID
nsv830510 CNV Gain 17160897
esv25431 CNV Loss 19812545
esv2673894 CNV Deletion 23128226
nsv830511 CNV Gain 17160897
esv270471 CNV Insertion 20981092
esv273367 CNV Insertion 20981092
nsv522807 CNV Loss 19592680
nsv507298 CNV Insertion 20534489
nsv5040 CNV Insertion 18451855

Relevant External Links for ARHGAP26 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGAP26 Gene

Disorders for ARHGAP26 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ARHGAP26 Gene in MalaCards »

(1) Disease for ARHGAP26 Gene

(1) OMIM Diseases for ARHGAP26 Gene (605370)


  • Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal translocation t(5;11)(q31;q23) with KMT2A/MLL1 has been found in leukemic cells from JMML patients, also carrying inactivating mutations on the second allele (PubMed:10908648). {ECO:0000269 PubMed:10908648}.

Relevant External Links for ARHGAP26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGAP26: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ARHGAP26 Gene

Publications for ARHGAP26 Gene

  1. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. (PMID: 10908648) Borkhardt A. … Lampert F. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4 23
  2. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. (PMID: 9858476) Taylor J.M. … Parsons J.T. (J. Cell. Sci. 1999) 2 3
  3. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. (PMID: 8649427) Hildebrand J.D. … Parsons J.T. (Mol. Cell. Biol. 1996) 2 3
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  5. Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish. (PMID: 18759275) McArdle P.F. … Shuldiner A.R. (Arthritis Rheum. 2008) 3 48

Products for ARHGAP26 Gene

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