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Aliases for RRP1B Gene

Aliases for RRP1B Gene

  • Ribosomal RNA Processing 1B 2 3 5
  • KIAA0179 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 136 2 3
  • RRP1-Like Protein B 3 4
  • Ribosomal RNA Processing 1 Homolog B (S. Cerevisiae) 2
  • Ribosomal RNA Processing Protein 1 Homolog B 3
  • Ribosomal RNA Processing 1 Homolog B 3
  • PPP1R136 3
  • NNP1L 3
  • RRP1 3
  • NNP1 3

External Ids for RRP1B Gene

Previous HGNC Symbols for RRP1B Gene

  • KIAA0179

Previous GeneCards Identifiers for RRP1B Gene

  • GC21P043904
  • GC21P045079
  • GC21P030447

Summaries for RRP1B Gene

GeneCards Summary for RRP1B Gene

RRP1B (Ribosomal RNA Processing 1B) is a Protein Coding gene. Diseases associated with RRP1B include Influenza. An important paralog of this gene is RRP1.

UniProtKB/Swiss-Prot for RRP1B Gene

  • Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015).

  • (Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.

Gene Wiki entry for RRP1B Gene

Additional gene information for RRP1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RRP1B Gene

Genomics for RRP1B Gene

GeneHancer (GH) Regulatory Elements for RRP1B Gene

Promoters and enhancers for RRP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I043658 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 587 +0.6 625 2.8 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B RRP1B HSF2BP WDR4 U2AF1 PWP2 ENSG00000233754 ENSG00000184441 PKNOX1 C21orf2 TRAPPC10
GH21I043657 Enhancer 0.6 Ensembl ENCODE 550.8 -1.9 -1919 0.7 NFIC JUN HSF2BP RRP1B MIR6070
GH21I043659 Promoter 0.5 EPDnew 550.8 -1.4 -1384 0.1 HSF2BP RRP1B MIR6070
GH21I043660 Enhancer 0.4 ENCODE 550.8 -1.0 -953 0.1 ZFP36 ZBTB33 RRP1B HSF2BP MIR6070
GH21I043158 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 98.8 -497.0 -496992 7.7 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B YBX1 DMAP1 IRF4 ENSG00000228120 WDR4 RRP1B U2AF1 ENSG00000233754 PWP2 SIK1 TRAPPC10 HSF2BP CRYAA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RRP1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RRP1B gene promoter:

Genomic Locations for RRP1B Gene

Genomic Locations for RRP1B Gene
chr21:43,659,548-43,696,079
(GRCh38/hg38)
Size:
36,532 bases
Orientation:
Plus strand
chr21:45,079,429-45,115,960
(GRCh37/hg19)

Genomic View for RRP1B Gene

Genes around RRP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RRP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RRP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RRP1B Gene

Proteins for RRP1B Gene

  • Protein details for RRP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14684-RRP1B_HUMAN
    Recommended name:
    Ribosomal RNA processing protein 1 homolog B
    Protein Accession:
    Q14684
    Secondary Accessions:
    • Q8TBZ4

    Protein attributes for RRP1B Gene

    Size:
    758 amino acids
    Molecular mass:
    84428 Da
    Quaternary structure:
    • Interacts with the transcriptional activator E2F1 (PubMed:20040599). Interacts with serine/threonine-protein phosphatase PP1 subunits PPP1CB and PPP1CC but not with PPP1CA (PubMed:20926688). Interacts with 60S ribosomal proteins RPL5 and RPL27, ribosomal processing protein RRP1/NNP1 and other nucleolar proteins including NOP2/NOL1 and FBL (PubMed:20926688). Also interacts with nucleolar protein NPM1/B23 (PubMed:20926688, PubMed:19710015). Interacts with splicing factor SRSF1 and with LUC7L3/CROP (PubMed:23604122). Interacts with GTPase activator SIPA1 (By similarity). Interacts with CBX5/HP1alpha, H1FX, NCL, PARP1, TRIM28 and YBX3 (PubMed:19710015).
    • (Microbial infection) Interacts with influenza A virus nucleoprotein NP and with RNA-directed RNA polymerase subunits PB1 and PB2.
    SequenceCaution:
    • Sequence=BAA11496.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RRP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RRP1B Gene

Post-translational modifications for RRP1B Gene

Other Protein References for RRP1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RRP1B Gene

Domains & Families for RRP1B Gene

Gene Families for RRP1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RRP1B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RRP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14684

UniProtKB/Swiss-Prot:

RRP1B_HUMAN :
  • Belongs to the RRP1 family.
Family:
  • Belongs to the RRP1 family.
genes like me logo Genes that share domains with RRP1B: view

Function for RRP1B Gene

Molecular function for RRP1B Gene

UniProtKB/Swiss-Prot Function:
Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (PubMed:20040599). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (PubMed:20926688). Involved in regulation of mRNA splicing (By similarity). Inhibits SIPA1 GTPase activity (By similarity). Involved in regulating expression of extracellular matrix genes (By similarity). Associates with chromatin and may play a role in modulating chromatin structure (PubMed:19710015).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Following influenza A virus (IAV) infection, promotes viral mRNA transcription by facilitating the binding of IAV RNA-directed RNA polymerase to capped mRNA.
UniProtKB/Swiss-Prot Induction:
By DNA damage.

Phenotypes From GWAS Catalog for RRP1B Gene

Gene Ontology (GO) - Molecular Function for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001105 RNA polymerase II transcription coactivator activity IMP 20040599
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005515 protein binding IPI 20040599
genes like me logo Genes that share ontologies with RRP1B: view

Phenotypes for RRP1B Gene

genes like me logo Genes that share phenotypes with RRP1B: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RRP1B Gene

Localization for RRP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RRP1B Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Predominantly located in the nucleolus with a small amount found in the nucleoplasm (PubMed:20926688). Associates with the perichromatin region during metaphase and with cytoplasmic foci during telophase before reaccumulation in the nucleolus during G2 (PubMed:20926688). Associates with heterochromatin and euchromatin (PubMed:19710015). {ECO:0000269 PubMed:19710015, ECO:0000269 PubMed:20926688}.
Nucleus, nucleoplasm. Note=(Microbial infection) Following infection by influenza A virus, partially translocates from the nucleolus to the nucleoplasm. {ECO:0000269 PubMed:26311876}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RRP1B gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000791 euchromatin IEA --
GO:0000792 heterochromatin IEA --
GO:0001652 granular component IDA 20926688
GO:0005634 nucleus IEA,HDA 16780588
GO:0005654 nucleoplasm IEA --
genes like me logo Genes that share ontologies with RRP1B: view

Pathways & Interactions for RRP1B Gene

SuperPathways for RRP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006364 rRNA processing IBA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with RRP1B: view

No data available for Pathways by source and SIGNOR curated interactions for RRP1B Gene

Drugs & Compounds for RRP1B Gene

No Compound Related Data Available

Transcripts for RRP1B Gene

mRNA/cDNA for RRP1B Gene

Unigene Clusters for RRP1B Gene

Ribosomal RNA processing 1 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RRP1B Gene

No ASD Table

Relevant External Links for RRP1B Gene

GeneLoc Exon Structure for
RRP1B
ECgene alternative splicing isoforms for
RRP1B

Expression for RRP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RRP1B Gene

Protein differential expression in normal tissues from HIPED for RRP1B Gene

This gene is overexpressed in Lung (14.6), CD8 Tcells (11.3), Peripheral blood mononuclear cells (7.9), and NK cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RRP1B Gene



Protein tissue co-expression partners for RRP1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RRP1B Gene:

RRP1B

SOURCE GeneReport for Unigene cluster for RRP1B Gene:

Hs.565725

Evidence on tissue expression from TISSUES for RRP1B Gene

  • Liver(4.2)
  • Bone marrow(4.1)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with RRP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RRP1B Gene

Orthologs for RRP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RRP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RRP1B 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia RRP1B 33 34
  • 77.42 (n)
cow
(Bos Taurus)
Mammalia RRP1B 33 34
  • 76.8 (n)
rat
(Rattus norvegicus)
Mammalia Rrp1b 33
  • 74.82 (n)
mouse
(Mus musculus)
Mammalia Rrp1b 33 16 34
  • 74.65 (n)
oppossum
(Monodelphis domestica)
Mammalia RRP1B 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RRP1B 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves RRP1B 33 34
  • 59.26 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rrp1b 33
  • 57.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53743 33
zebrafish
(Danio rerio)
Actinopterygii rrp1 33 34
  • 52.09 (n)
Dr.16314 33
fruit fly
(Drosophila melanogaster)
Insecta Nnp-1 34
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C47E12.7 34
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RRP1 34 36
  • 28 (a)
OneToMany
Species where no ortholog for RRP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RRP1B Gene

ENSEMBL:
Gene Tree for RRP1B (if available)
TreeFam:
Gene Tree for RRP1B (if available)

Paralogs for RRP1B Gene

Paralogs for RRP1B Gene

(1) SIMAP similar genes for RRP1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RRP1B: view

Variants for RRP1B Gene

Sequence variations from dbSNP and Humsavar for RRP1B Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000081028 -- 43,672,951(+) A/T intron_variant
rs1000153507 -- 43,667,499(+) G/C/T intron_variant
rs1000203357 -- 43,679,426(+) G/A intron_variant
rs1000208564 -- 43,682,672(+) T/C intron_variant
rs1000270136 -- 43,676,196(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RRP1B Gene

Variant ID Type Subtype PubMed ID
esv2723614 CNV deletion 23290073
esv2723615 CNV deletion 23290073
esv3647110 CNV gain 21293372
esv999311 CNV deletion 20482838
nsv1066728 CNV loss 25217958
nsv1123566 CNV deletion 24896259
nsv587700 CNV loss 21841781
nsv834106 CNV loss 17160897

Variation tolerance for RRP1B Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RRP1B Gene

Human Gene Mutation Database (HGMD)
RRP1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RRP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RRP1B Gene

Disorders for RRP1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RRP1B Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
- elite association - COSMIC cancer census association via MalaCards
Search RRP1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RRP1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RRP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RRP1B Gene

Publications for RRP1B Gene

  1. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. (PMID: 18081427) Crawford NP … Hunter KW (PLoS genetics 2007) 3 4 44 58
  2. A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription. (PMID: 26311876) Su WC … Lai MM (Journal of virology 2015) 3 4 58
  3. RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1. (PMID: 23604122) Lee M … Crawford NP (Oncogene 2014) 3 4 58
  4. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. (PMID: 20040599) Paik JC … Lin WC (The Journal of biological chemistry 2010) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for RRP1B Gene

Sources for RRP1B Gene

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