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Aliases for WAPL Gene

Aliases for WAPL Gene

  • WAPL Cohesin Release Factor 2 3 4 5
  • KIAA0261 2 3 4
  • Friend Of EBNA2 Protein 3 4
  • WAPAL 3 4
  • FOE 3 4
  • Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2) 3
  • Wings Apart-Like Homolog (Drosophila) 2
  • Wings Apart-Like Protein Homolog 3
  • Friend Of EBNA2 2

External Ids for WAPL Gene

Previous HGNC Symbols for WAPL Gene

  • KIAA0261
  • WAPAL

Summaries for WAPL Gene

GeneCards Summary for WAPL Gene

WAPL (WAPL Cohesin Release Factor) is a Protein Coding gene. Among its related pathways are DNA Damage and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for WAPL Gene

  • Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Gene Wiki entry for WAPL Gene

Additional gene information for WAPL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WAPL Gene

Genomics for WAPL Gene

Regulatory Elements for WAPL Gene

Enhancers for WAPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H087091 1.4 ENCODE dbSUPER 39.1 -572.1 -572080 6 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 NUTM2A-AS1 WAPL ENSG00000272631 FAM35A RN7SL78P BMPR1A CFL1P1 RPL11P3 ENSG00000223761 RPS26P38
GH10H086752 2 FANTOM5 Ensembl ENCODE dbSUPER 22.3 -234.3 -234275 7 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 WAPL ENSG00000272631 ENSG00000223761 RPS26P38 ENSG00000196566 NUTM2A-AS1 BMPR1A FAM35A GLUD1
GH10H086436 1.5 Ensembl ENCODE dbSUPER 11.5 +81.6 81577 7 FOXA2 MLX ARID4B DMAP1 TCF12 FOS ATF7 SP5 ZHX2 MXD4 RNU6-780P ENSG00000227896 WAPL LDB3 OPN4 BMPR1A GC10P086443 GC10M086380
GH10H087341 1 ENCODE 15.8 -820.9 -820891 2 ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ATF7 SP3 YY2 REST WAPL NUTM2D NUTM2A-AS1 NUTM2A PIR41183
GH10H086585 1.1 Ensembl ENCODE 11.2 -63.7 -63681 0 ELF3 ARID4B RAD21 RFX5 GLIS2 ZNF143 KLF7 MIXL1 DEK THAP11 WAPL ENSG00000227896 RNU6-780P MIR346 OPN4 GC10P086567 RPL7AP8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WAPL on UCSC Golden Path with GeneCards custom track

Promoters for WAPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000030944 216 2801 PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 ETS1 ZNF121 ZNF766 ZNF207

Genomic Location for WAPL Gene

Chromosome:
10
Start:
86,435,256 bp from pter
End:
86,521,816 bp from pter
Size:
86,561 bases
Orientation:
Minus strand

Genomic View for WAPL Gene

Genes around WAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WAPL Gene

Proteins for WAPL Gene

  • Protein details for WAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5K2-WAPL_HUMAN
    Recommended name:
    Wings apart-like protein homolog
    Protein Accession:
    Q7Z5K2
    Secondary Accessions:
    • A7E2B5
    • Q5VSK5
    • Q8IX10
    • Q92549

    Protein attributes for WAPL Gene

    Size:
    1190 amino acids
    Molecular mass:
    132946 Da
    Quaternary structure:
    • Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with CDCA5/SORORIN. Interacts (via FGF motifs) with PDS5B; the interaction is direct. Interacts with a SMC1 protein (SMC1A or SMC1B) and SMC3. Isoform 2 interacts with Epstein-Barr virus EBNA2.
    SequenceCaution:
    • Sequence=BAA13391.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH73376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16708.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WAPL Gene

    Alternative splice isoforms for WAPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WAPL Gene

Post-translational modifications for WAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WAPL Gene

Domains & Families for WAPL Gene

Gene Families for WAPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WAPL Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5K2

UniProtKB/Swiss-Prot:

WAPL_HUMAN :
  • Belongs to the WAPL family.
Family:
  • Belongs to the WAPL family.
genes like me logo Genes that share domains with WAPL: view

Function for WAPL Gene

Molecular function for WAPL Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Phenotypes From GWAS Catalog for WAPL Gene

Gene Ontology (GO) - Molecular Function for WAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17112726
genes like me logo Genes that share ontologies with WAPL: view
genes like me logo Genes that share phenotypes with WAPL: view

Animal Models for WAPL Gene

MGI Knock Outs for WAPL:

Animal Model Products

  • Taconic Biosciences Mouse Models for WAPL

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WAPL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WAPL Gene

Localization for WAPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for WAPL Gene

Isoform 2: Nucleus.
Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WAPL gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for WAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region TAS --
GO:0000785 chromatin IDA 17113138
GO:0000795 synaptonemal complex IEA --
GO:0005634 nucleus IDA,IEA 17113138
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with WAPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WAPL Gene

Pathways & Interactions for WAPL Gene

genes like me logo Genes that share pathways with WAPL: view

Pathways by source for WAPL Gene

Gene Ontology (GO) - Biological Process for WAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007064 mitotic sister chromatid cohesion IBA --
GO:0008156 negative regulation of DNA replication IMP 19907496
GO:0009636 response to toxic substance IEA --
genes like me logo Genes that share ontologies with WAPL: view

No data available for SIGNOR curated interactions for WAPL Gene

Drugs & Compounds for WAPL Gene

No Compound Related Data Available

Transcripts for WAPL Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WAPL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WAPL Gene

No ASD Table

Relevant External Links for WAPL Gene

GeneLoc Exon Structure for
WAPL
ECgene alternative splicing isoforms for
WAPL

Expression for WAPL Gene

NURSA nuclear receptor signaling pathways regulating expression of WAPL Gene:

WAPL

mRNA Expression by UniProt/SwissProt for WAPL Gene:

Q7Z5K2-WAPL_HUMAN
Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for WAPL Gene

  • Liver(4.3)
  • Bone marrow(4.2)
  • Nervous system(3.9)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WAPL Gene

Orthologs for WAPL Gene

This gene was present in the common ancestor of animals.

Orthologs for WAPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WAPAL 33 34
  • 99.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia WAPAL 33 34
  • 94.29 (n)
cow
(Bos Taurus)
Mammalia WAPAL 33 34
  • 93.26 (n)
rat
(Rattus norvegicus)
Mammalia Wapal 33
  • 91.4 (n)
mouse
(Mus musculus)
Mammalia Wapal 33 34
  • 91.29 (n)
Wapl 16
oppossum
(Monodelphis domestica)
Mammalia WAPAL 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves WAPAL 33 34
  • 79.96 (n)
lizard
(Anolis carolinensis)
Reptilia WAPAL 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wapal 33
  • 71.89 (n)
Str.3158 33
zebrafish
(Danio rerio)
Actinopterygii wapala 33 34
  • 65.23 (n)
wapalb 34
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3357 33
fruit fly
(Drosophila melanogaster)
Insecta wapl 34
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wapl-1 33 34
  • 42.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
CSA.5314 34
  • 28 (a)
OneToMany
Species where no ortholog for WAPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WAPL Gene

ENSEMBL:
Gene Tree for WAPL (if available)
TreeFam:
Gene Tree for WAPL (if available)

Paralogs for WAPL Gene

No data available for Paralogs for WAPL Gene

Variants for WAPL Gene

Sequence variations from dbSNP and Humsavar for WAPL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000003930 -- 86,499,175(+) CTCAA(A/C)TATGA intron-variant
rs1000015941 -- 86,471,225(+) ATACA(C/T)GATCA intron-variant
rs1000114847 -- 86,476,269(+) CTGAG(A/G)GAGGA intron-variant
rs1000137605 -- 86,510,961(+) AGCTG(C/G/T)AACTA intron-variant
rs1000197551 -- 86,469,159(+) GCAGG(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WAPL Gene

Variant ID Type Subtype PubMed ID
dgv947n100 CNV gain 25217958
esv1003241 CNV insertion 20482838
esv1688003 CNV insertion 17803354
esv3624091 CNV loss 21293372
nsv1141879 OTHER inversion 24896259
nsv479637 CNV novel sequence insertion 20440878
nsv480431 CNV novel sequence insertion 20440878
nsv509361 CNV insertion 20534489
nsv7478 CNV insertion 18451855
nsv7480 CNV insertion 18451855

Variation tolerance for WAPL Gene

Residual Variation Intolerance Score: 5.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WAPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WAPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WAPL Gene

Disorders for WAPL Gene

Relevant External Links for WAPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WAPL

No disorders were found for WAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WAPL Gene

Publications for WAPL Gene

  1. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. (PMID: 17112726) Gandhi R … Hirano T (Current biology : CB 2006) 2 3 4 60
  2. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PMID: 15383329) Kwiatkowski BA … Schubach WH (Experimental cell research 2004) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 60
  4. Structure of the human cohesin inhibitor Wapl. (PMID: 23776203) Ouyang Z … Yu H (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 60
  5. Sororin mediates sister chromatid cohesion by antagonizing Wapl. (PMID: 21111234) Nishiyama T … Peters JM (Cell 2010) 3 4 60

Products for WAPL Gene

Sources for WAPL Gene

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