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Aliases for WAPL Gene

Aliases for WAPL Gene

  • WAPL Cohesin Release Factor 2 3 4 5
  • KIAA0261 2 3 4
  • Friend Of EBNA2 Protein 3 4
  • WAPAL 3 4
  • FOE 3 4
  • Friend Of EBNA2 (Epstein-Barr Virus Nuclear Protein 2) 3
  • Wings Apart-Like Homolog (Drosophila) 2
  • Friend Of EBNA2 2

External Ids for WAPL Gene

Previous HGNC Symbols for WAPL Gene

  • KIAA0261
  • WAPAL

Summaries for WAPL Gene

GeneCards Summary for WAPL Gene

WAPL (WAPL Cohesin Release Factor) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and DNA Damage.

UniProtKB/Swiss-Prot for WAPL Gene

  • Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Gene Wiki entry for WAPL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WAPL Gene

Genomics for WAPL Gene

Regulatory Elements for WAPL Gene

Enhancers for WAPL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WAPL on UCSC Golden Path with GeneCards custom track

Promoters for WAPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WAPL on UCSC Golden Path with GeneCards custom track

Genomic Location for WAPL Gene

Chromosome:
10
Start:
86,435,256 bp from pter
End:
86,521,816 bp from pter
Size:
86,561 bases
Orientation:
Minus strand

Genomic View for WAPL Gene

Genes around WAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WAPL Gene

Proteins for WAPL Gene

  • Protein details for WAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5K2-WAPL_HUMAN
    Recommended name:
    Wings apart-like protein homolog
    Protein Accession:
    Q7Z5K2
    Secondary Accessions:
    • A7E2B5
    • Q5VSK5
    • Q8IX10
    • Q92549

    Protein attributes for WAPL Gene

    Size:
    1190 amino acids
    Molecular mass:
    132946 Da
    Quaternary structure:
    • Interacts with the cohesin complex throughout the cell cycle; interacts with both chromatin-bound and soluble pools of the complex. Interacts with RAD21; the interaction is direct. Interacts with PDS5A; the interaction is direct, cohesin-dependent and competitive with CDCA5/SORORIN. Interacts (via FGF motifs) with PDS5B; the interaction is direct. Interacts with a SMC1 protein (SMC1A or SMC1B) and SMC3. Isoform 2 interacts with Epstein-Barr virus EBNA2.
    SequenceCaution:
    • Sequence=BAA13391.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH73376.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16708.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WAPL Gene

    Alternative splice isoforms for WAPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WAPL Gene

Proteomics data for WAPL Gene at MOPED

Post-translational modifications for WAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WAPL Gene

No data available for DME Specific Peptides for WAPL Gene

Domains & Families for WAPL Gene

Protein Domains for WAPL Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5K2

UniProtKB/Swiss-Prot:

WAPL_HUMAN :
  • Contains 1 WAPL domain.
  • Belongs to the WAPL family.
Domain:
  • Contains 1 WAPL domain.
Family:
  • Belongs to the WAPL family.
genes like me logo Genes that share domains with WAPL: view

No data available for Gene Families for WAPL Gene

Function for WAPL Gene

Molecular function for WAPL Gene

UniProtKB/Swiss-Prot Function:
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
genes like me logo Genes that share phenotypes with WAPL: view

Animal Models for WAPL Gene

MGI Knock Outs for WAPL:

Animal Model Products

  • Taconic Biosciences Mouse Models for WAPL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WAPL Gene

Localization for WAPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for WAPL Gene

Isoform 2: Nucleus.
Nucleus. Chromosome. Cytoplasm. Note=Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.

Gene Ontology (GO) - Cellular Components for WAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 17113138
GO:0005737 cytoplasm IDA 17113138
GO:0005829 cytosol TAS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with WAPL: view

No data available for Subcellular locations from COMPARTMENTS for WAPL Gene

Pathways & Interactions for WAPL Gene

genes like me logo Genes that share pathways with WAPL: view

Pathways by source for WAPL Gene

Gene Ontology (GO) - Biological Process for WAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0009636 response to toxic substance IEA --
GO:0016032 viral process IEA --
GO:0035562 negative regulation of chromatin binding IMP 17113138
genes like me logo Genes that share ontologies with WAPL: view

No data available for SIGNOR curated interactions for WAPL Gene

Drugs & Compounds for WAPL Gene

No Compound Related Data Available

Transcripts for WAPL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for WAPL Gene

No ASD Table

Relevant External Links for WAPL Gene

GeneLoc Exon Structure for
WAPL
ECgene alternative splicing isoforms for
WAPL

Expression for WAPL Gene

mRNA Expression by UniProt/SwissProt for WAPL Gene

Q7Z5K2-WAPL_HUMAN
Tissue specificity: Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for WAPL Gene

Orthologs for WAPL Gene

This gene was present in the common ancestor of animals.

Orthologs for WAPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WAPAL 35
  • 93.26 (n)
  • 95.62 (a)
WAPAL 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WAPAL 35
  • 94.29 (n)
  • 95.97 (a)
WAPAL 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wapal 35
  • 91.29 (n)
  • 93.61 (a)
Wapl 16
Wapal 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WAPAL 35
  • 99.51 (n)
  • 99.3 (a)
WAPAL 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wapal 35
  • 91.4 (n)
  • 93.53 (a)
oppossum
(Monodelphis domestica)
Mammalia WAPAL 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
chicken
(Gallus gallus)
Aves WAPAL 35
  • 79.96 (n)
  • 81.96 (a)
WAPAL 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WAPAL 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3158 35
wapal 35
  • 71.89 (n)
  • 73.18 (a)
zebrafish
(Danio rerio)
Actinopterygii wapala 35
  • 65.23 (n)
  • 69.85 (a)
wapala 36
  • 59 (a)
OneToMany
wapalb 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3357 35
fruit fly
(Drosophila melanogaster)
Insecta wapl 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wapl-1 35
  • 42.79 (n)
  • 31.44 (a)
wapl-1 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
CSA.5314 36
  • 28 (a)
OneToMany
Species with no ortholog for WAPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WAPL Gene

ENSEMBL:
Gene Tree for WAPL (if available)
TreeFam:
Gene Tree for WAPL (if available)

Paralogs for WAPL Gene

No data available for Paralogs for WAPL Gene

Variants for WAPL Gene

Sequence variations from dbSNP and Humsavar for WAPL Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10887621 - 86,517,700(+) TTCAA(A/C/T)GACCA reference, missense
rs15299 -- 86,435,344(-) GGCAG(A/G)AAAAA utr-variant-3-prime
rs1896512 -- 86,439,400(-) AGAGG(C/T)GTACT intron-variant
rs1896513 -- 86,435,893(-) TACCC(A/G)TAAAA utr-variant-3-prime
rs3758519 -- 86,435,634(+) GTGCT(C/T)GACAA utr-variant-3-prime

Variation tolerance for WAPL Gene

Residual Variation Intolerance Score: 5.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WAPL Gene

HapMap Linkage Disequilibrium report
WAPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WAPL Gene

Disorders for WAPL Gene

Relevant External Links for WAPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WAPL

No disorders were found for WAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WAPL Gene

Publications for WAPL Gene

  1. Human Wapl is a cohesin-binding protein that promotes sister- chromatid resolution in mitotic prophase. (PMID: 17112726) Gandhi R. … Hirano T. (Curr. Biol. 2006) 2 3 4 67
  2. Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia. (PMID: 18662753) Oikawa K. … Kuroda M. (Gene 2008) 3 23
  3. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. (PMID: 15383329) Kwiatkowski B.A. … Schubach W.H. (Exp. Cell Res. 2004) 3 23
  4. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 2 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for WAPL Gene

Sources for WAPL Gene

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