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Aliases for NCOA6 Gene

Aliases for NCOA6 Gene

  • Nuclear Receptor Coactivator 6 2 3 5
  • Nuclear Receptor Coactivator RAP250 2 3 4
  • Peroxisome Proliferator-Activated Receptor Interacting Protein 2 3
  • Cancer-Amplified Transcriptional Coactivator ASC-2 3 4
  • Nuclear Receptor-Activating Protein, 250 KDa 3 4
  • Amplified In Breast Cancer Protein 3 3 4
  • Activating Signal Cointegrator-2 2 3
  • PPAR-Interacting Protein 3 4
  • NRC RAP250 3 4
  • RAP250 3 4
  • AIB3 3 4
  • PRIP 3 4
  • TRBP 3 4
  • Peroxisome Proliferator-Activated Receptor-Interacting Protein 4
  • Thyroid Hormone Receptor Binding Protein 3
  • Thyroid Hormone Receptor-Binding Protein 4
  • Amplified In Breast Cancer-3 Protein 3
  • Activating Signal Cointegrator 2 4
  • KIAA0181 4
  • ASC-2 4
  • ASC2 3
  • NRC 3

External Ids for NCOA6 Gene

Previous GeneCards Identifiers for NCOA6 Gene

  • GC20M033061
  • GC20M033971
  • GC20M034018
  • GC20M032766
  • GC20M033302
  • GC20M030081

Summaries for NCOA6 Gene

Entrez Gene Summary for NCOA6 Gene

  • The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NCOA6 Gene

NCOA6 (Nuclear Receptor Coactivator 6) is a Protein Coding gene. Diseases associated with NCOA6 include Breast Cancer and Malignant Melanoma, Somatic. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Metabolism. GO annotations related to this gene include chromatin binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for NCOA6 Gene

  • Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Gene Wiki entry for NCOA6 Gene

Additional gene information for NCOA6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA6 Gene

Genomics for NCOA6 Gene

Regulatory Elements for NCOA6 Gene

Enhancers for NCOA6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H035765 1.8 FANTOM5 ENCODE dbSUPER 54.4 -943.9 -943897 9.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF548 SP3 NFYC SSRP1 CPNE1 RBM12 RBM39 NCOA6 ERGIC3 PHF20 AAR2 DLGAP4-AS1 TRPC4AP PROCR
GH20H034954 1.4 ENCODE dbSUPER 34.4 -130.3 -130296 2.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RBM12 RBM39 NCOA6 CPNE1 ERGIC3 ENSG00000272945 PROCR RPL36P4 MYH7B TRPC4AP
GH20H035091 1.2 ENCODE 38.8 -267.0 -266982 3.2 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 NCOA6 RBM12 RBM39 RPL36P4 CEP250 PROCR MMP24-AS1 TRPC4AP PIR41538
GH20H034578 1.4 Ensembl ENCODE dbSUPER 30.2 +245.1 245058 4 HDGF PKNOX1 ARID4B FEZF1 BATF RAD21 RFX5 SLC30A9 ATF7 ETV6 NCOA6 MAP1LC3A PIGU TP53INP2 ERGIC3 GC20P034589 GC20M034549
GH20H035283 1.4 ENCODE dbSUPER 28.5 -459.5 -459531 3.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 RBM12 EIF6 RBM39 AAR2 NCOA6 ERGIC3 CPNE1 TRPC4AP RPL36P4 FAM83C-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCOA6 on UCSC Golden Path with GeneCards custom track

Promoters for NCOA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136460 449 1601 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for NCOA6 Gene

Genomic Locations for NCOA6 Gene
chr20:34,689,097-34,825,649
(GRCh38/hg38)
Size:
136,553 bases
Orientation:
Minus strand
chr20:33,284,722-33,413,452
(GRCh37/hg19)

Genomic View for NCOA6 Gene

Genes around NCOA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCOA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCOA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA6 Gene

Proteins for NCOA6 Gene

  • Protein details for NCOA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14686-NCOA6_HUMAN
    Recommended name:
    Nuclear receptor coactivator 6
    Protein Accession:
    Q14686
    Secondary Accessions:
    • A6NLF1
    • B2RMN5
    • E1P5P7
    • Q9NTZ9
    • Q9UH74
    • Q9UK86

    Protein attributes for NCOA6 Gene

    Size:
    2063 amino acids
    Molecular mass:
    219145 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and PRMT2/HRMT1L1. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors.
    Miscellaneous:
    • Frequently amplified or overexpressed in colon, breast and lung cancers.
    SequenceCaution:
    • Sequence=AAF16403.1; Type=Frameshift; Positions=88; Evidence={ECO:0000305}; Sequence=BAA11498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NCOA6 Gene

Post-translational modifications for NCOA6 Gene

No data available for DME Specific Peptides for NCOA6 Gene

Domains & Families for NCOA6 Gene

Gene Families for NCOA6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NCOA6 Gene

Graphical View of Domain Structure for InterPro Entry

Q14686

UniProtKB/Swiss-Prot:

NCOA6_HUMAN :
  • Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors.
Domain:
  • Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors.
genes like me logo Genes that share domains with NCOA6: view

Function for NCOA6 Gene

Molecular function for NCOA6 Gene

UniProtKB/Swiss-Prot Function:
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Phenotypes From GWAS Catalog for NCOA6 Gene

Gene Ontology (GO) - Molecular Function for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0003713 transcription coactivator activity IDA 10567404
GO:0005515 protein binding IPI 10866662
GO:0019899 enzyme binding IPI 12039952
GO:0030331 estrogen receptor binding TAS 11443112
genes like me logo Genes that share ontologies with NCOA6: view
genes like me logo Genes that share phenotypes with NCOA6: view

Animal Model Products

Clone Products

  • Addgene plasmids for NCOA6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCOA6 Gene

Localization for NCOA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCOA6 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10567404
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex TAS 11443112
GO:0005829 cytosol IDA --
GO:0035097 histone methyltransferase complex IDA 17500065
genes like me logo Genes that share ontologies with NCOA6: view

Pathways & Interactions for NCOA6 Gene

genes like me logo Genes that share pathways with NCOA6: view

Gene Ontology (GO) - Biological Process for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS 11443112
GO:0006281 DNA repair NAS 11443112
GO:0006310 DNA recombination NAS 11443112
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IDA 10567404
genes like me logo Genes that share ontologies with NCOA6: view

No data available for SIGNOR curated interactions for NCOA6 Gene

Drugs & Compounds for NCOA6 Gene

(2) Drugs for NCOA6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cholecalciferol Approved Nutra Fat-soluble secosteroids 894,888

(2) Additional Compounds for NCOA6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NCOA6: view

Transcripts for NCOA6 Gene

Unigene Clusters for NCOA6 Gene

Nuclear receptor coactivator 6:
Representative Sequences:

Clone Products

  • Addgene plasmids for NCOA6

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
SP1: -
SP2: - -
SP3: -
SP4: -
SP5: - - - - -
SP6:
SP7: -
SP8:
SP9:
SP10: - -
SP11:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NCOA6 Gene

GeneLoc Exon Structure for
NCOA6
ECgene alternative splicing isoforms for
NCOA6

Expression for NCOA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCOA6 Gene

Protein differential expression in normal tissues from HIPED for NCOA6 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCOA6 Gene



NURSA nuclear receptor signaling pathways regulating expression of NCOA6 Gene:

NCOA6

SOURCE GeneReport for Unigene cluster for NCOA6 Gene:

Hs.368971

mRNA Expression by UniProt/SwissProt for NCOA6 Gene:

Q14686-NCOA6_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.

Evidence on tissue expression from TISSUES for NCOA6 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Bone marrow(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with NCOA6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCOA6 Gene

Orthologs for NCOA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA6 33 34
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia NCOA6 33 34
  • 95.31 (n)
cow
(Bos Taurus)
Mammalia NCOA6 33 34
  • 92.66 (n)
mouse
(Mus musculus)
Mammalia Ncoa6 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa6 33
  • 90.67 (n)
oppossum
(Monodelphis domestica)
Mammalia NCOA6 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA6 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCOA6 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA6 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16504 33
zebrafish
(Danio rerio)
Actinopterygii ncoa6 33 34
  • 52.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5036 34
  • 40 (a)
OneToOne
Species where no ortholog for NCOA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA6 Gene

ENSEMBL:
Gene Tree for NCOA6 (if available)
TreeFam:
Gene Tree for NCOA6 (if available)

Paralogs for NCOA6 Gene

Pseudogenes.org Pseudogenes for NCOA6 Gene

genes like me logo Genes that share paralogs with NCOA6: view

No data available for Paralogs for NCOA6 Gene

Variants for NCOA6 Gene

Sequence variations from dbSNP and Humsavar for NCOA6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_036551 A breast cancer sample
VAR_036552 A breast cancer sample
rs1000011722 -- 34,807,858(+) AAACA(C/G)TATCT intron-variant
rs1000017610 -- 34,823,028(+) TTATC(A/G)GATCC intron-variant, upstream-variant-2KB
rs1000048148 -- 34,807,665(+) GGACT(-/A)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA6 Gene

Variant ID Type Subtype PubMed ID
nsv820037 CNV loss 19587683
nsv819225 CNV loss 19587683
nsv475687 CNV novel sequence insertion 20440878
nsv472516 CNV novel sequence insertion 20440878
nsv3361 CNV insertion 18451855
nsv1131587 CNV deletion 24896259
nsv1117284 CNV tandem duplication 24896259
nsv1112789 CNV deletion 24896259
nsv1066181 CNV gain 25217958
nsv1055447 CNV loss 25217958
esv3645706 CNV loss 21293372
esv2668087 CNV deletion 23128226

Variation tolerance for NCOA6 Gene

Residual Variation Intolerance Score: 5.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCOA6 Gene

Human Gene Mutation Database (HGMD)
NCOA6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCOA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCOA6 Gene

Disorders for NCOA6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NCOA6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
malignant melanoma, somatic
  • dysplastic nevus syndrome
- elite association - COSMIC cancer census association via MalaCards
Search NCOA6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCOA6

Genetic Association Database (GAD)
NCOA6
Human Genome Epidemiology (HuGE) Navigator
NCOA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCOA6
genes like me logo Genes that share disorders with NCOA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCOA6 Gene

Publications for NCOA6 Gene

  1. The nuclear receptor coactivator AIB3 is a modulator of HOMA beta-cell function in nondiabetic children. (PMID: 18462265) Burghardt H … Zorzano A (Clinical endocrinology 2008) 3 22 45 60
  2. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. (PMID: 11773444) Ko L … Chin WW (Molecular endocrinology (Baltimore, Md.) 2002) 3 4 22 60
  3. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PMID: 11443112) Iwasaki T … Ko L (The Journal of biological chemistry 2001) 3 4 22 60
  4. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. (PMID: 11517327) Zhu Y … Reddy JK (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 60
  5. Cloning and characterization of RAP250, a novel nuclear receptor coactivator. (PMID: 10681503) Caira F … Gustafsson JA (The Journal of biological chemistry 2000) 3 4 22 60

Products for NCOA6 Gene

  • Addgene plasmids for NCOA6

Sources for NCOA6 Gene

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