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Aliases for NCOA6 Gene

Aliases for NCOA6 Gene

  • Nuclear Receptor Coactivator 6 2 3
  • Nuclear Receptor Coactivator RAP250 2 3 4
  • RAP250 3 4 6
  • PRIP 3 4 6
  • Peroxisome Proliferator-Activated Receptor Interacting Protein 2 3
  • Peroxisome Proliferator-Activated Receptor-Interacting Protein 3 4
  • Cancer-Amplified Transcriptional Coactivator ASC-2 3 4
  • Nuclear Receptor-Activating Protein, 250 KDa 3 4
  • Thyroid Hormone Receptor-Binding Protein 3 4
  • Amplified In Breast Cancer Protein 3 3 4
  • Activating Signal Cointegrator-2 2 3
  • Activating Signal Cointegrator 2 3 4
  • PPAR-Interacting Protein 3 4
  • NRC RAP250 3 4
  • TRBP 3 4
  • ASC2 3 6
  • AIB3 3 4
  • NRC 3 6
  • Thyroid Hormone Receptor Binding Protein 3
  • Amplified In Breast Cancer-3 Protein 3
  • KIAA0181 4
  • ASC-2 4

External Ids for NCOA6 Gene

Summaries for NCOA6 Gene

Entrez Gene Summary for NCOA6 Gene

  • The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NCOA6 Gene

NCOA6 (Nuclear Receptor Coactivator 6) is a Protein Coding gene. Diseases associated with NCOA6 include breast cancer. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include chromatin binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for NCOA6 Gene

  • Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins

Gene Wiki entry for NCOA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCOA6 Gene

Genomics for NCOA6 Gene

Genomic Location for NCOA6 Gene

Start:
34,696,918 bp from pter
End:
34,825,649 bp from pter
Size:
128,732 bases
Orientation:
Minus strand

Genomic View for NCOA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCOA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCOA6 Gene

Regulatory Elements for NCOA6 Gene

Proteins for NCOA6 Gene

  • Protein details for NCOA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14686-NCOA6_HUMAN
    Recommended name:
    Nuclear receptor coactivator 6
    Protein Accession:
    Q14686
    Secondary Accessions:
    • A6NLF1
    • B2RMN5
    • E1P5P7
    • Q9NTZ9
    • Q9UH74
    • Q9UK86

    Protein attributes for NCOA6 Gene

    Size:
    2063 amino acids
    Molecular mass:
    219145 Da
    Quaternary structure:
    • Monomer and homodimer. Interacts with RBM39 (By similarity). Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function. Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferases EP300 and CREBBP, and with the methyltransferases NCOA6IP and PRMT2/HRMT1L1. Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin. Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors.
    Miscellaneous:
    • Frequently amplified or overexpressed in colon, breast and lung cancers
    SequenceCaution:
    • Sequence=AAF16403.1; Type=Frameshift; Positions=88; Evidence={ECO:0000305}; Sequence=BAA11498.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for NCOA6 Gene

Proteomics data for NCOA6 Gene at MOPED

Post-translational modifications for NCOA6 Gene

Other Protein References for NCOA6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NCOA6 Gene

Domains for NCOA6 Gene

Protein Domains for NCOA6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NCOA6_HUMAN
Domain:
  • Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors, while adjacent Ser-884 displays selectivity for nuclear receptors:
    • Q14686
genes like me logo Genes that share domains with NCOA6: view

No data available for Gene Families for NCOA6 Gene

Function for NCOA6 Gene

Molecular function for NCOA6 Gene

UniProtKB/Swiss-Prot Function: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins

Gene Ontology (GO) - Molecular Function for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0003713 transcription coactivator activity IDA 10567404
GO:0005515 protein binding IPI 10866662
GO:0019899 enzyme binding IPI 12039952
GO:0030331 estrogen receptor binding TAS 11443112
genes like me logo Genes that share ontologies with NCOA6: view
genes like me logo Genes that share phenotypes with NCOA6: view

Animal Models for NCOA6 Gene

MGI Knock Outs for NCOA6:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NCOA6 Gene

Localization for NCOA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCOA6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCOA6 Gene COMPARTMENTS Subcellular localization image for NCOA6 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10567404
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex TAS 11443112
GO:0035097 histone methyltransferase complex IDA 17500065
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with NCOA6: view

Pathways for NCOA6 Gene

genes like me logo Genes that share pathways with NCOA6: view

Gene Ontology (GO) - Biological Process for NCOA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication NAS 11443112
GO:0006281 DNA repair NAS 11443112
GO:0006310 DNA recombination NAS 11443112
GO:0006352 DNA-templated transcription, initiation IDA 10567404
GO:0006367 transcription initiation from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with NCOA6: view

Compounds for NCOA6 Gene

(1) HMDB Compounds for NCOA6 Gene

Compound Synonyms Cas Number PubMed IDs
Vitamin D3
  • (+)-Vitamin D3
67-97-0

(3) Novoseek inferred chemical compound relationships for NCOA6 Gene

Compound -log(P) Hits PubMed IDs
estrogen 33.4 3
retinoic acid 28.3 6
steroid 0 1
genes like me logo Genes that share compounds with NCOA6: view

Transcripts for NCOA6 Gene

Unigene Clusters for NCOA6 Gene

Nuclear receptor coactivator 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCOA6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a ·
SP1: -
SP2: - -
SP3: -
SP4: -
SP5: - - - - -
SP6:
SP7: -
SP8:
SP9:
SP10: - -
SP11:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NCOA6 Gene

GeneLoc Exon Structure for
NCOA6
ECgene alternative splicing isoforms for
NCOA6

Expression for NCOA6 Gene

mRNA expression in normal human tissues for NCOA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCOA6 Gene

SOURCE GeneReport for Unigene cluster for NCOA6 Gene Hs.368971

mRNA Expression by UniProt/SwissProt for NCOA6 Gene

Q14686-NCOA6_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine
genes like me logo Genes that share expressions with NCOA6: view

Orthologs for NCOA6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NCOA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCOA6 36
  • 99.42 (n)
  • 99.47 (a)
NCOA6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NCOA6 36
  • 92.66 (n)
  • 93.36 (a)
NCOA6 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCOA6 36
  • 95.31 (n)
  • 96.56 (a)
NCOA6 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncoa6 16
Ncoa6 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCOA6 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCOA6 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncoa6 36
  • 90.67 (n)
  • 91.69 (a)
chicken
(Gallus gallus)
Aves NCOA6 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCOA6 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16504 36
zebrafish
(Danio rerio)
Actinopterygii ncoa6 36
  • 52.52 (n)
  • 46.82 (a)
ncoa6 37
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5036 37
  • 40 (a)
OneToOne
Species with no ortholog for NCOA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCOA6 Gene

ENSEMBL:
Gene Tree for NCOA6 (if available)
TreeFam:
Gene Tree for NCOA6 (if available)

Paralogs for NCOA6 Gene

Pseudogenes.org Pseudogenes for NCOA6 Gene

genes like me logo Genes that share paralogs with NCOA6: view

No data available for Paralogs for NCOA6 Gene

Variants for NCOA6 Gene

Sequence variations from dbSNP and Humsavar for NCOA6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs16440 -- 34,714,998(+) AATAC(-/ATC)ATTAG cds-indel
rs722452 -- 34,809,230(+) AATAA(A/G)ACATG intron-variant
rs724257 -- 34,791,026(+) gaggt(A/C)taggg intron-variant
rs910871 -- 34,745,404(+) GCAAG(A/C)AGGCA intron-variant
rs910872 -- 34,746,736(+) TTCCT(C/T)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCOA6 Gene

Variant ID Type Subtype PubMed ID
nsv819225 CNV Loss 19587683
nsv3361 CNV Insertion 18451855
nsv820037 CNV Loss 19587683
esv2668087 CNV Deletion 23128226

Relevant External Links for NCOA6 Gene

HapMap Linkage Disequilibrium report
NCOA6
Human Gene Mutation Database (HGMD)
NCOA6

Disorders for NCOA6 Gene

(1) MalaCards Diseases for NCOA6 Gene

Search for NCOA6 Gene in MalaCards »

(2) Novoseek inferred disease relationships for NCOA6 Gene

Disease -log(P) Hits PubMed IDs
cancer 0.799 5
tumors 0 3

Relevant External Links for NCOA6

Genetic Association Database (GAD)
NCOA6
Human Genome Epidemiology (HuGE) Navigator
NCOA6
genes like me logo Genes that share disorders with NCOA6: view

No data available for UniProtKB/Swiss-Prot for NCOA6 Gene

Publications for NCOA6 Gene

  1. A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PMID: 10567404) Lee S.-K. … Lee J.W. (J. Biol. Chem. 1999) 3 4 23
  2. Cloning and characterization of RAP250, a nuclear receptor coactivator. (PMID: 10681503) Caira F. … Gustafsson J.-A. (J. Biol. Chem. 2000) 3 4 23
  3. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). (PMID: 11443112) Iwasaki T. … Ko L. (J. Biol. Chem. 2001) 3 4 23
  4. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. (PMID: 11517327) Zhu Y.-J. … Reddy J.K. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  5. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. (PMID: 11773444) Ko L. … Chin W.W. (Mol. Endocrinol. 2002) 3 4 23

Products for NCOA6 Gene

Sources for NCOA6 Gene

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