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Aliases for ZHX3 Gene

Aliases for ZHX3 Gene

  • Zinc Fingers And Homeoboxes 3 2 3
  • Zinc Finger And Homeodomain Protein 3 3 4
  • Triple Homeobox Protein 1 3 4
  • Triple Homeobox 1 2 3
  • KIAA0395 4 6
  • TIX1 3 4
  • Zinc Fingers And Homeoboxes Protein 3 3

External Ids for ZHX3 Gene

Previous Symbols for ZHX3 Gene

  • TIX1

Summaries for ZHX3 Gene

Entrez Gene Summary for ZHX3 Gene

  • This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZHX3 Gene

ZHX3 (Zinc Fingers And Homeoboxes 3) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for ZHX3 Gene

  • Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.

Gene Wiki entry for ZHX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZHX3 Gene

Genomics for ZHX3 Gene

Genomic Location for ZHX3 Gene

41,178,448 bp from pter
41,317,672 bp from pter
139,225 bases
Minus strand

Genomic View for ZHX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZHX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZHX3 Gene

Regulatory Elements for ZHX3 Gene

Proteins for ZHX3 Gene

  • Protein details for ZHX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc fingers and homeoboxes protein 3
    Protein Accession:
    Secondary Accessions:
    • E1P5W5
    • F5H820
    • O43145
    • Q6NUJ7

    Protein attributes for ZHX3 Gene

    956 amino acids
    Molecular mass:
    104658 Da
    Quaternary structure:
    • Homodimer (via homeobox domain). Also forms heterodimers with ZHX1 and ZHX2. Heterodimerization with ZHX1 is a prerequisite for repressor activity. Interacts with NFYA.
    • Sequence=BAA23691.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ZHX3 Gene

    Alternative splice isoforms for ZHX3 Gene


neXtProt entry for ZHX3 Gene

Proteomics data for ZHX3 Gene at MOPED

Post-translational modifications for ZHX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZHX3 Gene

Domains for ZHX3 Gene

Gene Families for ZHX3 Gene

  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

Protein Domains for ZHX3 Gene


  • Contains 5 homeobox DNA-binding domains.:
    • Q9H4I2
  • Belongs to the ZHX family.:
    • Q9H4I2
  • Contains 2 C2H2-type zinc fingers.:
    • Q9H4I2
genes like me logo Genes that share domains with ZHX3: view

Function for ZHX3 Gene

Molecular function for ZHX3 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.
UniProtKB/Swiss-Prot Induction: Up-regulated during osteogenic differentiation of mesenchymal stem cells.

Gene Ontology (GO) - Molecular Function for ZHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 12659632
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 12659632
GO:0042803 protein homodimerization activity IDA 12659632
genes like me logo Genes that share ontologies with ZHX3: view

miRNA for ZHX3 Gene

miRTarBase miRNAs that target ZHX3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZHX3 Gene

Localization for ZHX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZHX3 Gene

Subcellular locations from

Jensen Localization Image for ZHX3 Gene COMPARTMENTS Subcellular localization image for ZHX3 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ZHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12659632
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZHX3: view

Pathways for ZHX3 Gene

SuperPathways for ZHX3 Gene

No Data Available

Interacting Proteins for ZHX3 Gene

Gene Ontology (GO) - Biological Process for ZHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0045669 positive regulation of osteoblast differentiation IMP 21174497
GO:0045892 negative regulation of transcription, DNA-templated IDA 12659632
genes like me logo Genes that share ontologies with ZHX3: view

No data available for Pathways by source for ZHX3 Gene

Transcripts for ZHX3 Gene

Unigene Clusters for ZHX3 Gene

Zinc fingers and homeoboxes 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZHX3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b
SP2: - -
SP4: - - -
SP6: -

Relevant External Links for ZHX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZHX3 Gene

mRNA expression in normal human tissues for ZHX3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ZHX3 Gene

SOURCE GeneReport for Unigene cluster for ZHX3 Gene Hs.380133

mRNA Expression by UniProt/SwissProt for ZHX3 Gene

Tissue specificity: Widely expressed. High expression in kidney. Expressed during osteogenic differentiation.
genes like me logo Genes that share expressions with ZHX3: view

Orthologs for ZHX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZHX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZHX3 36
  • 99.69 (n)
  • 99.37 (a)
ZHX3 37
  • 99 (a)
(Bos Taurus)
Mammalia ZHX3 36
  • 82.34 (n)
  • 83.69 (a)
ZHX3 37
  • 84 (a)
(Canis familiaris)
Mammalia ZHX3 36
  • 82.35 (n)
  • 83.65 (a)
ZHX3 37
  • 84 (a)
(Mus musculus)
Mammalia Zhx3 36
  • 84.93 (n)
  • 85.8 (a)
Zhx3 16
Zhx3 37
  • 86 (a)
(Monodelphis domestica)
Mammalia ZHX3 37
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ZHX3 37
  • 69 (a)
(Rattus norvegicus)
Mammalia Zhx3 36
  • 84.33 (n)
  • 85.67 (a)
(Gallus gallus)
Aves ZHX3 36
  • 68.1 (n)
  • 66.27 (a)
ZHX3 37
  • 66 (a)
(Anolis carolinensis)
Reptilia ZHX3 37
  • 61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3322 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.577 36
zhx3 36
  • 58.3 (n)
  • 52.91 (a)
(Danio rerio)
Actinopterygii tix1 36
zhx3 37
  • 36 (a)
Species with no ortholog for ZHX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZHX3 Gene

Gene Tree for ZHX3 (if available)
Gene Tree for ZHX3 (if available)

Paralogs for ZHX3 Gene

Paralogs for ZHX3 Gene

genes like me logo Genes that share paralogs with ZHX3: view

Variants for ZHX3 Gene

Sequence variations from dbSNP and Humsavar for ZHX3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs12609 -- 41,179,039(-) CACCC(A/T)TTTGC utr-variant-3-prime
rs714193 -- 41,280,893(+) TTTTT(A/T)AAAGG intron-variant
rs1013710 -- 41,254,141(+) GAAGA(A/G)AGGAA intron-variant
rs1018389 -- 41,281,464(+) AAATA(C/G)ACATT intron-variant
rs1057825 -- 41,179,087(-) AAGGC(C/T)TGTAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZHX3 Gene

Variant ID Type Subtype PubMed ID
nsv833983 CNV Loss 17160897
esv1745872 CNV Insertion 17803354
nsv833984 CNV Loss 17160897
nsv3380 CNV Loss 18451855
nsv498970 CNV Loss 21111241
esv29587 CNV Loss 19812545
esv2722416 CNV Deletion 23290073
esv2673884 CNV Deletion 23128226
nsv512615 CNV Loss 21212237
dgv786e199 CNV Deletion 23128226
esv2722418 CNV Deletion 23290073
dgv700n67 CNV Loss 20364138
esv990825 CNV Gain 20482838
nsv821330 CNV Deletion 20802225
esv27181 CNV Gain+Loss 19812545
nsv3381 CNV Loss 18451855

Relevant External Links for ZHX3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ZHX3 Gene

Relevant External Links for ZHX3

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZHX3: view

No data available for UniProtKB/Swiss-Prot for ZHX3 Gene

Publications for ZHX3 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. (PMID: 14659886) Kawata H. … Miyamoto K. (Gene 2003) 3 23
  4. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. (PMID: 17056598) Liu G. … Chugh S.S. (J. Biol. Chem. 2006) 3 23
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for ZHX3 Gene

Sources for ZHX3 Gene

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